Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise

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Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise. / Li, Mengyao; Verdijk, Lex B.; Sakamoto, Kei; Ely, Brian; van Loon, Luc J.C.; Musi, Nicolas.

In: Mechanisms of Ageing and Development, Vol. 133, No. 11-12, 01.11.2012, p. 655-664.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Li, M, Verdijk, LB, Sakamoto, K, Ely, B, van Loon, LJC & Musi, N 2012, 'Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise', Mechanisms of Ageing and Development, vol. 133, no. 11-12, pp. 655-664. https://doi.org/10.1016/j.mad.2012.09.001

APA

Li, M., Verdijk, L. B., Sakamoto, K., Ely, B., van Loon, L. J. C., & Musi, N. (2012). Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise. Mechanisms of Ageing and Development, 133(11-12), 655-664. https://doi.org/10.1016/j.mad.2012.09.001

Vancouver

Li M, Verdijk LB, Sakamoto K, Ely B, van Loon LJC, Musi N. Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise. Mechanisms of Ageing and Development. 2012 Nov 1;133(11-12):655-664. https://doi.org/10.1016/j.mad.2012.09.001

Author

Li, Mengyao ; Verdijk, Lex B. ; Sakamoto, Kei ; Ely, Brian ; van Loon, Luc J.C. ; Musi, Nicolas. / Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise. In: Mechanisms of Ageing and Development. 2012 ; Vol. 133, No. 11-12. pp. 655-664.

Bibtex

@article{5cd25d0d6f2e4c6d87977c55c238daa6,
title = "Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise",
abstract = "AMP-activated protein kinase (AMPK) is a key energy-sensitive enzyme that controls numerous metabolic and cellular processes. Mammalian target of rapamycin (mTOR) is another energy/nutrient-sensitive kinase that controls protein synthesis and cell growth. In this study we determined whether older versus younger men have alterations in the AMPK and mTOR pathways in skeletal muscle, and examined the effect of a long term resistance type exercise training program on these signaling intermediaries. Older men had decreased AMPKα2 activity and lower phosphorylation of AMPK and its downstream signaling substrate acetyl-CoA carboxylase (ACC). mTOR phosphylation also was reduced in muscle from older men. Exercise training increased AMPKα1 activity in older men, however, AMPKα2 activity, and the phosphorylation of AMPK, ACC and mTOR, were not affected. In conclusion, older men have alterations in the AMPK-ACC and mTOR pathways in muscle. In addition, prolonged resistance type exercise training induces an isoform-selective up regulation of AMPK activity.",
keywords = "Aging, AMPK, MTOR, Resistance exercise, Skeletal muscle",
author = "Mengyao Li and Verdijk, {Lex B.} and Kei Sakamoto and Brian Ely and {van Loon}, {Luc J.C.} and Nicolas Musi",
year = "2012",
month = nov,
day = "1",
doi = "10.1016/j.mad.2012.09.001",
language = "English",
volume = "133",
pages = "655--664",
journal = "Mechanisms of Ageing and Development",
issn = "0047-6374",
publisher = "Elsevier Ireland Ltd",
number = "11-12",

}

RIS

TY - JOUR

T1 - Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise

AU - Li, Mengyao

AU - Verdijk, Lex B.

AU - Sakamoto, Kei

AU - Ely, Brian

AU - van Loon, Luc J.C.

AU - Musi, Nicolas

PY - 2012/11/1

Y1 - 2012/11/1

N2 - AMP-activated protein kinase (AMPK) is a key energy-sensitive enzyme that controls numerous metabolic and cellular processes. Mammalian target of rapamycin (mTOR) is another energy/nutrient-sensitive kinase that controls protein synthesis and cell growth. In this study we determined whether older versus younger men have alterations in the AMPK and mTOR pathways in skeletal muscle, and examined the effect of a long term resistance type exercise training program on these signaling intermediaries. Older men had decreased AMPKα2 activity and lower phosphorylation of AMPK and its downstream signaling substrate acetyl-CoA carboxylase (ACC). mTOR phosphylation also was reduced in muscle from older men. Exercise training increased AMPKα1 activity in older men, however, AMPKα2 activity, and the phosphorylation of AMPK, ACC and mTOR, were not affected. In conclusion, older men have alterations in the AMPK-ACC and mTOR pathways in muscle. In addition, prolonged resistance type exercise training induces an isoform-selective up regulation of AMPK activity.

AB - AMP-activated protein kinase (AMPK) is a key energy-sensitive enzyme that controls numerous metabolic and cellular processes. Mammalian target of rapamycin (mTOR) is another energy/nutrient-sensitive kinase that controls protein synthesis and cell growth. In this study we determined whether older versus younger men have alterations in the AMPK and mTOR pathways in skeletal muscle, and examined the effect of a long term resistance type exercise training program on these signaling intermediaries. Older men had decreased AMPKα2 activity and lower phosphorylation of AMPK and its downstream signaling substrate acetyl-CoA carboxylase (ACC). mTOR phosphylation also was reduced in muscle from older men. Exercise training increased AMPKα1 activity in older men, however, AMPKα2 activity, and the phosphorylation of AMPK, ACC and mTOR, were not affected. In conclusion, older men have alterations in the AMPK-ACC and mTOR pathways in muscle. In addition, prolonged resistance type exercise training induces an isoform-selective up regulation of AMPK activity.

KW - Aging

KW - AMPK

KW - MTOR

KW - Resistance exercise

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=84870756683&partnerID=8YFLogxK

U2 - 10.1016/j.mad.2012.09.001

DO - 10.1016/j.mad.2012.09.001

M3 - Journal article

C2 - 23000302

AN - SCOPUS:84870756683

VL - 133

SP - 655

EP - 664

JO - Mechanisms of Ageing and Development

JF - Mechanisms of Ageing and Development

SN - 0047-6374

IS - 11-12

ER -

ID: 239566310