Repaglinide at a cellular level

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Repaglinide at a cellular level. / Krogsgaard Thomsen, M; Bokvist, K; Høy, M; Buschard, K; Holst, Jens Juul; Lindström, P; Gromada, J.

In: Diabetes, nutrition & metabolism, Vol. 15, No. 6 Suppl, 12.2002, p. 15-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Krogsgaard Thomsen, M, Bokvist, K, Høy, M, Buschard, K, Holst, JJ, Lindström, P & Gromada, J 2002, 'Repaglinide at a cellular level', Diabetes, nutrition & metabolism, vol. 15, no. 6 Suppl, pp. 15-8.

APA

Krogsgaard Thomsen, M., Bokvist, K., Høy, M., Buschard, K., Holst, J. J., Lindström, P., & Gromada, J. (2002). Repaglinide at a cellular level. Diabetes, nutrition & metabolism, 15(6 Suppl), 15-8.

Vancouver

Krogsgaard Thomsen M, Bokvist K, Høy M, Buschard K, Holst JJ, Lindström P et al. Repaglinide at a cellular level. Diabetes, nutrition & metabolism. 2002 Dec;15(6 Suppl):15-8.

Author

Krogsgaard Thomsen, M ; Bokvist, K ; Høy, M ; Buschard, K ; Holst, Jens Juul ; Lindström, P ; Gromada, J. / Repaglinide at a cellular level. In: Diabetes, nutrition & metabolism. 2002 ; Vol. 15, No. 6 Suppl. pp. 15-8.

Bibtex

@article{6fab28d68ad4438590ce51313791323f,
title = "Repaglinide at a cellular level",
abstract = "To investigate the hormonal and cellular selectivity of the prandial glucose regulators, we have undertaken a series of experiments, in which we characterised the effects of repaglinide and nateglinide on ATP-sensitive potassium ion (KATP) channel activity, membrane potential and exocytosis in rat pancreatic alpha-cells and somatotrophs. We found a pharmacological dissociation between the actions on KATP channels and exocytosis and suggest that compounds that, unlike repaglinide, have direct stimulatory effects on exocytosis in somatotrophs and alpha- and beta-cells, such as sulphonylureas and nateglinide, may have a clinically undesirable general stimulatory effect on cells within the endocrine system.",
keywords = "Animals, Carbamates, Cyclohexanes, Electrophysiology, Exocytosis, Hypoglycemic Agents, Islets of Langerhans, Membrane Potentials, Phenylalanine, Piperidines, Postprandial Period, Potassium Channels, Rats",
author = "{Krogsgaard Thomsen}, M and K Bokvist and M H{\o}y and K Buschard and Holst, {Jens Juul} and P Lindstr{\"o}m and J Gromada",
year = "2002",
month = dec,
language = "English",
volume = "15",
pages = "15--8",
journal = "Diabetes, Nutrition and Metabolism - Clinical and Experimental",
issn = "0394-3402",
publisher = "EditriceKurtis s.r.l.",
number = "6 Suppl",

}

RIS

TY - JOUR

T1 - Repaglinide at a cellular level

AU - Krogsgaard Thomsen, M

AU - Bokvist, K

AU - Høy, M

AU - Buschard, K

AU - Holst, Jens Juul

AU - Lindström, P

AU - Gromada, J

PY - 2002/12

Y1 - 2002/12

N2 - To investigate the hormonal and cellular selectivity of the prandial glucose regulators, we have undertaken a series of experiments, in which we characterised the effects of repaglinide and nateglinide on ATP-sensitive potassium ion (KATP) channel activity, membrane potential and exocytosis in rat pancreatic alpha-cells and somatotrophs. We found a pharmacological dissociation between the actions on KATP channels and exocytosis and suggest that compounds that, unlike repaglinide, have direct stimulatory effects on exocytosis in somatotrophs and alpha- and beta-cells, such as sulphonylureas and nateglinide, may have a clinically undesirable general stimulatory effect on cells within the endocrine system.

AB - To investigate the hormonal and cellular selectivity of the prandial glucose regulators, we have undertaken a series of experiments, in which we characterised the effects of repaglinide and nateglinide on ATP-sensitive potassium ion (KATP) channel activity, membrane potential and exocytosis in rat pancreatic alpha-cells and somatotrophs. We found a pharmacological dissociation between the actions on KATP channels and exocytosis and suggest that compounds that, unlike repaglinide, have direct stimulatory effects on exocytosis in somatotrophs and alpha- and beta-cells, such as sulphonylureas and nateglinide, may have a clinically undesirable general stimulatory effect on cells within the endocrine system.

KW - Animals

KW - Carbamates

KW - Cyclohexanes

KW - Electrophysiology

KW - Exocytosis

KW - Hypoglycemic Agents

KW - Islets of Langerhans

KW - Membrane Potentials

KW - Phenylalanine

KW - Piperidines

KW - Postprandial Period

KW - Potassium Channels

KW - Rats

M3 - Journal article

C2 - 12702003

VL - 15

SP - 15

EP - 18

JO - Diabetes, Nutrition and Metabolism - Clinical and Experimental

JF - Diabetes, Nutrition and Metabolism - Clinical and Experimental

SN - 0394-3402

IS - 6 Suppl

ER -

ID: 132056158