Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day
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Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. / Orskov, C; Wettergren, A; Holst, J J.
In: Scandinavian Journal of Gastroenterology, Vol. 31, No. 7, 07.1996, p. 665-70.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day
AU - Orskov, C
AU - Wettergren, A
AU - Holst, J J
PY - 1996/7
Y1 - 1996/7
N2 - BACKGROUND: The insulinotropic hormones gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), secreted from the K-cells of the upper small intestine and from the L-cells of the lower small intestine, respectively, are thought to be responsible for intestinal stimulation of insulin secretion. If true, their plasma concentrations should parallel the meal-related diurnal changes in plasma insulin concentrations.METHODS: Using COOH-terminal assays, thought to reflect accurately their rates of secretion, we measured circulating levels of GIP and GLP-1 in six normal subjects for 15 h of a day, during which they ate three mixed meals.RESULTS: Both GIP and GLP-1 concentrations increased significantly and in parallel with insulin in response to all three meals. The plasma insulin concentrations correlated significantly with both GIP and GLP-1 values throughout the study period (correlation coefficients, 0.49 +/- 0.07 and 0.56 +/- 0.05; p < 0.001).CONCLUSIONS: These results support the notion that GLP-1 and GIP are important incretin hormones.
AB - BACKGROUND: The insulinotropic hormones gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), secreted from the K-cells of the upper small intestine and from the L-cells of the lower small intestine, respectively, are thought to be responsible for intestinal stimulation of insulin secretion. If true, their plasma concentrations should parallel the meal-related diurnal changes in plasma insulin concentrations.METHODS: Using COOH-terminal assays, thought to reflect accurately their rates of secretion, we measured circulating levels of GIP and GLP-1 in six normal subjects for 15 h of a day, during which they ate three mixed meals.RESULTS: Both GIP and GLP-1 concentrations increased significantly and in parallel with insulin in response to all three meals. The plasma insulin concentrations correlated significantly with both GIP and GLP-1 values throughout the study period (correlation coefficients, 0.49 +/- 0.07 and 0.56 +/- 0.05; p < 0.001).CONCLUSIONS: These results support the notion that GLP-1 and GIP are important incretin hormones.
KW - Adult
KW - Circadian Rhythm
KW - Female
KW - Gastric Inhibitory Polypeptide/secretion
KW - Gastrointestinal Hormones/secretion
KW - Glucagon/secretion
KW - Glucagon-Like Peptide 1
KW - Glucagon-Like Peptides
KW - Humans
KW - Insulin/secretion
KW - Intestine, Small/secretion
KW - Male
KW - Peptide Fragments/secretion
U2 - 10.3109/00365529609009147
DO - 10.3109/00365529609009147
M3 - Journal article
C2 - 8819215
VL - 31
SP - 665
EP - 670
JO - Scandinavian Journal of Gastroenterology. Supplement
JF - Scandinavian Journal of Gastroenterology. Supplement
SN - 0085-5928
IS - 7
ER -
ID: 194815515