Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day

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Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. / Orskov, C; Wettergren, A; Holst, J J.

In: Scandinavian Journal of Gastroenterology, Vol. 31, No. 7, 07.1996, p. 665-70.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Orskov, C, Wettergren, A & Holst, JJ 1996, 'Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day', Scandinavian Journal of Gastroenterology, vol. 31, no. 7, pp. 665-70. https://doi.org/10.3109/00365529609009147

APA

Orskov, C., Wettergren, A., & Holst, J. J. (1996). Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. Scandinavian Journal of Gastroenterology, 31(7), 665-70. https://doi.org/10.3109/00365529609009147

Vancouver

Orskov C, Wettergren A, Holst JJ. Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. Scandinavian Journal of Gastroenterology. 1996 Jul;31(7):665-70. https://doi.org/10.3109/00365529609009147

Author

Orskov, C ; Wettergren, A ; Holst, J J. / Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day. In: Scandinavian Journal of Gastroenterology. 1996 ; Vol. 31, No. 7. pp. 665-70.

Bibtex

@article{7d472c11c33342c9b1e07bf5e49a5758,
title = "Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day",
abstract = "BACKGROUND: The insulinotropic hormones gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), secreted from the K-cells of the upper small intestine and from the L-cells of the lower small intestine, respectively, are thought to be responsible for intestinal stimulation of insulin secretion. If true, their plasma concentrations should parallel the meal-related diurnal changes in plasma insulin concentrations.METHODS: Using COOH-terminal assays, thought to reflect accurately their rates of secretion, we measured circulating levels of GIP and GLP-1 in six normal subjects for 15 h of a day, during which they ate three mixed meals.RESULTS: Both GIP and GLP-1 concentrations increased significantly and in parallel with insulin in response to all three meals. The plasma insulin concentrations correlated significantly with both GIP and GLP-1 values throughout the study period (correlation coefficients, 0.49 +/- 0.07 and 0.56 +/- 0.05; p < 0.001).CONCLUSIONS: These results support the notion that GLP-1 and GIP are important incretin hormones.",
keywords = "Adult, Circadian Rhythm, Female, Gastric Inhibitory Polypeptide/secretion, Gastrointestinal Hormones/secretion, Glucagon/secretion, Glucagon-Like Peptide 1, Glucagon-Like Peptides, Humans, Insulin/secretion, Intestine, Small/secretion, Male, Peptide Fragments/secretion",
author = "C Orskov and A Wettergren and Holst, {J J}",
year = "1996",
month = jul,
doi = "10.3109/00365529609009147",
language = "English",
volume = "31",
pages = "665--70",
journal = "Scandinavian Journal of Gastroenterology. Supplement",
issn = "0085-5928",
publisher = "Taylor & Francis",
number = "7",

}

RIS

TY - JOUR

T1 - Secretion of the incretin hormones glucagon-like peptide-1 and gastric inhibitory polypeptide correlates with insulin secretion in normal man throughout the day

AU - Orskov, C

AU - Wettergren, A

AU - Holst, J J

PY - 1996/7

Y1 - 1996/7

N2 - BACKGROUND: The insulinotropic hormones gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), secreted from the K-cells of the upper small intestine and from the L-cells of the lower small intestine, respectively, are thought to be responsible for intestinal stimulation of insulin secretion. If true, their plasma concentrations should parallel the meal-related diurnal changes in plasma insulin concentrations.METHODS: Using COOH-terminal assays, thought to reflect accurately their rates of secretion, we measured circulating levels of GIP and GLP-1 in six normal subjects for 15 h of a day, during which they ate three mixed meals.RESULTS: Both GIP and GLP-1 concentrations increased significantly and in parallel with insulin in response to all three meals. The plasma insulin concentrations correlated significantly with both GIP and GLP-1 values throughout the study period (correlation coefficients, 0.49 +/- 0.07 and 0.56 +/- 0.05; p < 0.001).CONCLUSIONS: These results support the notion that GLP-1 and GIP are important incretin hormones.

AB - BACKGROUND: The insulinotropic hormones gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), secreted from the K-cells of the upper small intestine and from the L-cells of the lower small intestine, respectively, are thought to be responsible for intestinal stimulation of insulin secretion. If true, their plasma concentrations should parallel the meal-related diurnal changes in plasma insulin concentrations.METHODS: Using COOH-terminal assays, thought to reflect accurately their rates of secretion, we measured circulating levels of GIP and GLP-1 in six normal subjects for 15 h of a day, during which they ate three mixed meals.RESULTS: Both GIP and GLP-1 concentrations increased significantly and in parallel with insulin in response to all three meals. The plasma insulin concentrations correlated significantly with both GIP and GLP-1 values throughout the study period (correlation coefficients, 0.49 +/- 0.07 and 0.56 +/- 0.05; p < 0.001).CONCLUSIONS: These results support the notion that GLP-1 and GIP are important incretin hormones.

KW - Adult

KW - Circadian Rhythm

KW - Female

KW - Gastric Inhibitory Polypeptide/secretion

KW - Gastrointestinal Hormones/secretion

KW - Glucagon/secretion

KW - Glucagon-Like Peptide 1

KW - Glucagon-Like Peptides

KW - Humans

KW - Insulin/secretion

KW - Intestine, Small/secretion

KW - Male

KW - Peptide Fragments/secretion

U2 - 10.3109/00365529609009147

DO - 10.3109/00365529609009147

M3 - Journal article

C2 - 8819215

VL - 31

SP - 665

EP - 670

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

SN - 0085-5928

IS - 7

ER -

ID: 194815515