Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people. / Grarup, N.; Albrechtsen, A.; Ek, J.; Borch-Johnsen, K; Jørgensen, T.; Schmitz, O.; Hansen, T.; Pedersen, O.

In: Diabetologia, Vol. 50, No. 6, 2007, p. 1201-1208.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Grarup, N, Albrechtsen, A, Ek, J, Borch-Johnsen, K, Jørgensen, T, Schmitz, O, Hansen, T & Pedersen, O 2007, 'Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people', Diabetologia, vol. 50, no. 6, pp. 1201-1208. https://doi.org/10.1007/s00125-007-0668-2

APA

Grarup, N., Albrechtsen, A., Ek, J., Borch-Johnsen, K., Jørgensen, T., Schmitz, O., Hansen, T., & Pedersen, O. (2007). Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people. Diabetologia, 50(6), 1201-1208. https://doi.org/10.1007/s00125-007-0668-2

Vancouver

Grarup N, Albrechtsen A, Ek J, Borch-Johnsen K, Jørgensen T, Schmitz O et al. Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people. Diabetologia. 2007;50(6):1201-1208. https://doi.org/10.1007/s00125-007-0668-2

Author

Grarup, N. ; Albrechtsen, A. ; Ek, J. ; Borch-Johnsen, K ; Jørgensen, T. ; Schmitz, O. ; Hansen, T. ; Pedersen, O. / Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people. In: Diabetologia. 2007 ; Vol. 50, No. 6. pp. 1201-1208.

Bibtex

@article{49dae63e877a4f42a66080393709b60a,
title = "Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people",
abstract = "Studies in animals reveal that peroxisome proliferator-activated receptor delta (PPARdelta) regulates glucose metabolism and insulin sensitivity in both the liver and skeletal muscles. Moreover, PPARdelta augments physical endurance and increases oxidative metabolism, thereby averting obesity. Thus, we hypothesised that common variation in the PPARD gene is associated with insulin resistance and metabolic traits.",
keywords = "Adult, DNA Mutational Analysis, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Genetic Variation, Genome, Glucose, Humans, Lipids, Liver, Male, Middle Aged, Muscle, Skeletal, PPAR delta, Polymorphism, Genetic",
author = "N. Grarup and A. Albrechtsen and J. Ek and K Borch-Johnsen and T. J{\o}rgensen and O. Schmitz and T. Hansen and O. Pedersen",
year = "2007",
doi = "10.1007/s00125-007-0668-2",
language = "English",
volume = "50",
pages = "1201--1208",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "6",

}

RIS

TY - JOUR

T1 - Variation in the peroxisome proliferator-activated receptor δ gene in relation to common metabolic traits in 7,495 middle-aged white people

AU - Grarup, N.

AU - Albrechtsen, A.

AU - Ek, J.

AU - Borch-Johnsen, K

AU - Jørgensen, T.

AU - Schmitz, O.

AU - Hansen, T.

AU - Pedersen, O.

PY - 2007

Y1 - 2007

N2 - Studies in animals reveal that peroxisome proliferator-activated receptor delta (PPARdelta) regulates glucose metabolism and insulin sensitivity in both the liver and skeletal muscles. Moreover, PPARdelta augments physical endurance and increases oxidative metabolism, thereby averting obesity. Thus, we hypothesised that common variation in the PPARD gene is associated with insulin resistance and metabolic traits.

AB - Studies in animals reveal that peroxisome proliferator-activated receptor delta (PPARdelta) regulates glucose metabolism and insulin sensitivity in both the liver and skeletal muscles. Moreover, PPARdelta augments physical endurance and increases oxidative metabolism, thereby averting obesity. Thus, we hypothesised that common variation in the PPARD gene is associated with insulin resistance and metabolic traits.

KW - Adult

KW - DNA Mutational Analysis

KW - Diabetes Mellitus, Type 2

KW - European Continental Ancestry Group

KW - Female

KW - Genetic Variation

KW - Genome

KW - Glucose

KW - Humans

KW - Lipids

KW - Liver

KW - Male

KW - Middle Aged

KW - Muscle, Skeletal

KW - PPAR delta

KW - Polymorphism, Genetic

U2 - 10.1007/s00125-007-0668-2

DO - 10.1007/s00125-007-0668-2

M3 - Journal article

C2 - 17431579

VL - 50

SP - 1201

EP - 1208

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 6

ER -

ID: 45426246