Ruth Loos
Professor
Loos Group
Blegdamsvej 3B, Mærsk Tårnet, 7. sal
2200 København N.
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Understanding risk and causal mechanisms for developing obesity in infants and young children: A National Institutes of Health workshop
Aagaard, K. M., Barkin, S. L., Burant, C. F., Carnell, S., Demerath, E., Donovan, S. M., Eneli, I., Francis, L. A., Gilbert-Diamond, D., Hivert, M. F., LeBourgeois, M. K., Loos, R. J. F., Lumeng, J. C., Miller, A. L., Okely, A. D., Osganian, S. K., Ramirez, A. G., Trasande, L., Van Horn, L. V., Wake, M. & 2 others, , 2024, In: Obesity Reviews. 25, 4, 21 p., e13690.Research output: Contribution to journal › Review › Research › peer-review
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The impact of anorexia nervosa and BMI polygenic risk on childhood growth: A 20-year longitudinal population-based study
Abdulkadir, M., Hübel, C., Herle, M., Loos, Ruth, Breen, G., Bulik, C. M. & Micali, N., 2022, In: American Journal of Human Genetics. 109, 7, p. 1242-1254 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Approaches to addressing the rise in obesity levels
Apovian, C. M., Guo, X. R., Hawley, J. A., Karmali, S., Loos, Ruth & Waterlander, W. E., 2023, In: Nature Reviews Endocrinology. 19, p. 76-81Research output: Contribution to journal › Journal article › Research › peer-review
Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program
Armstrong, N. D., Srinivasasainagendra, V., Ammous, F., Assimes, T. L., Beitelshees, A. L., Brody, J., Cade, B. E., Ida Chen, Y-D., Chen, H., de Vries, P. S., Floyd, J. S., Franceschini, N., Guo, X., Hellwege, J. N., House, J. S., Hwu, C-M., Kardia, S. L. R., Lange, E. M., Lange, L. A., McDonough, C. W. & 24 others, , 2023, In: Frontiers in Genetics. 14, 1278215.Research output: Contribution to journal › Journal article › Research › peer-review
Multi-population genome-wide association study implicates immune and non-immune factors in pediatric steroid-sensitive nephrotic syndrome
Barry, A., McNulty, M. T., Jia, X., Gupta, Y., Debiec, H., Luo, Y., Nagano, C., Horinouchi, T., Jung, S., Colucci, M., Ahram, D. F., Mitrotti, A., Sinha, A., Teeninga, N., Jin, G., Shril, S., Caridi, G., Bodria, M., Lim, T. Y., Westland, R. & 50 others, , 2023, In: Nature Communications. 14, 1, 2481.Research output: Contribution to journal › Journal article › Research › peer-review
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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Bentley, A. R., Sung, Y. J., Brown, M. R., Winkler, T. W., Kraja, A. T., Ntalla, I., Schwander, K., Chasman, D. I., Lim, E., Deng, X., Guo, X., Liu, J., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D., Huffman, J. E., Musani, S. K., Li, C., Feitosa, M. F. & 32 others, , Apr 2019, In: Nature Genetics. 51, 4, p. 636-648 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Genetic variance of adolescent growth in stature
Beunen, G., Thomis, M., Maes, H. H., Loos, Ruth, Malina, R. M., Claessens, A. L. & Vlietinck, R., 18 Apr 2000, In: Annals of Human Biology. 27, 2, p. 173-86 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Univariate and multivariate genetic analysis of subcutaneous fatness and fat distribution in early adolescence
Beunen, G., Maes, H. H., Vlietinck, R., Malina, R. M., Thomis, M., Feys, E., Loos, Ruth & Derom, C., Jul 1998, In: Behavior Genetics. 28, 4, p. 279-88 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Clinical Characterization of Copy Number Variants Associated with Neurodevelopmental Disorders in a Large-scale Multiancestry Biobank
Birnbaum, R., Mahjani, B., Loos, Ruth & Sharp, A. J., 2022, In: JAMA Psychiatry. 79, 3, p. 250-259Research output: Contribution to journal › Journal article › Research › peer-review
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Protocol for the combined cardiometabolic deep phenotyping and registry-based 20-year follow-up study of the Inter99 cohort
Bjørnsbo, K. S., Brøns, C., Aadahl, M., Kampmann, F. B., Friis Bryde Nielsen, C., Lundbergh, B., Christensen, R. W., Kårhus, L. L., Madsen, A. L., Hansen, C. S., Nørgaard, K., Jørgensen, N. R., Suetta, C., Kjaer, M., Grarup, N., Kanters, J., Larsen, M., Køber, L., Kofoed, K. F., Loos, R. & 3 others, , 2024, In: BMJ Open. 14, 1, 10 p., e078501.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of individual and environmental factors on dietary or lifestyle interventions to prevent type 2 diabetes development: a systematic review
Bodhini, D., Morton, R. W., Santhakumar, V., Nakabuye, Mariam, Pomares-Millan, H., Clemmensen, Christoffer, Fitzpatrick, S. L., Guasch Ferre, Marta, Pankow, J. S., Ried-Larsen, M., Franks, P. W., Tobias, D. K., Merino, Jordi, Mohan, V., Loos, Ruth & ADA/EASD PMDI, A. P., 2023, In: Communications Medicine. 3, 17 p., 133.Research output: Contribution to journal › Journal article › Research › peer-review
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Role of sociodemographic, clinical, behavioral, and molecular factors in precision prevention of type 2 diabetes: a systematic review
Bodhini, D., Morton, R. W., Santhakumar, V., Nakabuye, Mariam, Pomares-Millan, H., Clemmensen, Christoffer, Fitzpatrick, S. L., Guasch Ferre, Marta, Pankow, J. S., Ried-Larsen, M., Franks, P. W., Tobias, D. K., Merino, Jordi, Mohan, V., Loos, Ruth & ADA/EASD Precision Medicine in Diabetes Initiative, A. P. M. I. D. I., 2023, medRxiv.Research output: Working paper › Preprint
Anthropometric characteristics of elite male junior rowers
Bourgois, J., Claessens, A. L., Vrijens, J., Philippaerts, R., Van Renterghem, B., Thomis, M., Janssens, M., Loos, Ruth & Lefevre, J., Jun 2000, In: British Journal of Sports Medicine. 34, 3, p. 213-6; discussion 216-7Research output: Contribution to journal › Journal article › Research › peer-review
Anthropometric characteristics of elite female junior rowers
Bourgois, J., Claessens, A. L., Janssens, M., Van Renterghem, B., Loos, Ruth, Thomis, M., Philippaerts, R., Lefevre, J. & Vrijens, J., Mar 2001, In: Journal of Sports Sciences. 19, 3, p. 195-202 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Influence of SNPs in nutrient-sensitive candidate genes and gene-diet interactions on blood lipids: the DiOGenes study
Brahe, L. K., Ängquist, Lars, Larsen, L. H., Vimaleswaran, K. S., Hager, J., Viguerie, N., Loos, Ruth, Handjieva-Darlenska, T., Jebb, S. A., Hlavaty, P., Larsen, T. M., Martinez, J. A., Papadaki, A., Pfeiffer, A. F. H., van Baak, M. A., Sørensen, Thorkild I.A., Holst, C., Langin, D., Astrup, A. & Saris, W. H. M., 2013, In: British Journal of Nutrition. 110, 5, p. 790-796 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Modelling bivariate ordinal responses smoothly with examples from ophthalmology and genetics
Bustami, R., Lesaffre, E., Molenberghs, G., Loos, Ruth, Danckaerts, M. & Vlietinck, R., 30 Jun 2001, In: Statistics in Medicine. 20, 12, p. 1825-42 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
A quantitative genetic study of cephalometric variables in twins
Carels, C., Van Cauwenberghe, N., Savoye, I., Willems, G., Loos, Ruth, Derom, C. & Vlietinck, R., Aug 2001, In: Clinical orthodontics and research. 4, 3, p. 130-40 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease
Carrasquilla, Germán D., Ängquist, Lars, Sørensen, Thorkild I.A., Kilpeläinen, Tuomas O. & Loos, Ruth, 2024, In: Diabetologia. 67, p. 864–873 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Risks of multiple sclerosis in relatives of patients in Flanders, Belgium
Carton, H., Vlietinck, R., Debruyne, J., De Keyser, J., D'Hooghe, M. B., Loos, Ruth, Medaer, R., Truyen, L., Yee, I. M. & Sadovnick, A. D., Apr 1997, In: Journal of neurology, neurosurgery, and psychiatry. 62, 4, p. 329-33 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Utilisation and cost of professional care and assistance according to disability of patients with multiple sclerosis in Flanders (Belgium)
Carton, H., Loos, Ruth, Pacolet, J., Versieck, K. & Vlietinck, R., Apr 1998, In: Journal of neurology, neurosurgery, and psychiatry. 64, 4, p. 444-50 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
A quantitative study of unpaid caregiving in multiple sclerosis
Carton, H., Loos, Ruth, Pacolet, J., Versieck, K. & Vlietinck, R., Aug 2000, In: Multiple Sclerosis Journal. 6, 4, p. 274-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A genomic mutational constraint map using variation in 76,156 human genomes
Chen, S., Francioli, L. C., Goodrich, J. K., Collins, R. L., Kanai, M., Wang, Q., Alföldi, J., Watts, N. A., Vittal, C., Gauthier, L. D., Poterba, T., Wilson, M. W., Tarasova, Y., Phu, W., Grant, R., Yohannes, M. T., Koenig, Z., Farjoun, Y., Banks, E., Donnelly, S. & 18 others, , 2024, In: Nature. 625, 7993, p. 92-100 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Age at menarche in relation to anthropometric characteristics, competition level and boat category in elite junior rowers
Claessens, A. L., Bourgois, J., Beunen, G., Philippaerts, R., Thomis, M., Lefevre, J., Loos, Ruth & Vrijens, J., 15 Mar 2003, In: Annals of Human Biology. 30, 2, p. 148-59 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide association study identifies 48 common genetic variants associated with handedness
Cuellar-Partida, G., Tung, J. Y., Eriksson, N., Albrecht, E., Aliev, F., Andreassen, O. A., Barroso, I., Beckmann, J. S., Boks, M. P., Boomsma, D. I., Boyd, H. A., Breteler, M. M. B., Campbell, H., Chasman, D. I., Cherkas, L. F., Davies, G., de Geus, E. J. C., Deary, I. J., Deloukas, P., Dick, D. M. & 98 others, , 2021, In: Nature Human Behaviour. 5, p. 59-70Research output: Contribution to journal › Journal article › Research › peer-review
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Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity
Dallner, O. S., Marinis, J. M., Lu, Y., Birsoy, K., Werner, E., Fayzikhodjaeva, G., Dill, B. D., Molina, H., Moscati, A., Kutalik, Z., Marques-Vidal, P., Kilpeläinen, Tuomas O., Grarup, Niels, Linneberg, Allan René, Zhang, Y., Vaughan, R., Loos, Ruth, Lazar, M. A. & Friedman, J. M., 2019, In: Nature Medicine. 25, 3, p. 507-530 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Handedness in twins according to zygosity and chorion type: a preliminary report
Derom, C., Thiery, E., Vlietinck, R., Loos, Ruth & Derom, R., Jul 1996, In: Behavior Genetics. 26, 4, p. 407-8 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
Retrospective determination of chorion type in twins using a simple questionnaire
Derom, C., Derom, R., Loos, Ruth, Jacobs, N. & Vlietinck, R., Feb 2003, In: Twin research : the official journal of the International Society for Twin Studies. 6, 1, p. 19-21 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
Gender mix: does it modify birthweight--outcome association?
Derom, R., Derom, C., Loos, Ruth, Thiery, E., Vlietinck, R. & Fryns, J., Jan 2005, In: Paediatric and Perinatal Epidemiology. 19 Suppl 1, p. 37-40 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Polygenic Scores Help Reduce Racial Disparities in Predictive Accuracy of Automated Type 1 Diabetes Classification Algorithms
Deutsch, A. J., Stalbow, L., Majarian, T. D., Mercader, J. M., Manning, A. K., Florez, J. C., Loos, Ruth & Udler, M. S., 2023, In: Diabetes Care. 46, 4, p. 794-800 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Influence of chorionicity on the heritability estimates of blood pressure: a study in twins
Fagard, R. H., Loos, Ruth, Beunen, G., Derom, C. & Vlietinck, R., Jul 2003, In: Journal of Hypertension. 21, 7, p. 1313-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Islet autoantibodies as precision diagnostic tools to characterize heterogeneity in type 1 diabetes: a systematic review
ADA/EASD PMDI, A. P., Merino, Jordi, Thuesen, Anne Cathrine Baun, Lepola, Mette Andersen, Clemmensen, Christoffer, Hansen, Torben, Nakabuye, Mariam, Loos, Ruth, Guasch Ferre, Marta & Vilsbøll, Tina, 2024, In: Communications Medicine. 4, 1, 8 p., 66.Research output: Contribution to journal › Journal article › Research › peer-review
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Ancestral diversity improves discovery and fine-mapping of genetic loci for anthropometric traits—The Hispanic/Latino Anthropometry Consortium
Fernández-Rhodes, L., Graff, M., Buchanan, V. L., Justice, A. E., Highland, H. M., Guo, X., Zhu, W., Chen, H. H., Young, K. L., Adhikari, K., Palmer, N. D., Below, J. E., Bradfield, J., Pereira, A. C., Glover, L. S., Kim, D., Lilly, A. G., Shrestha, P., Thomas, A. G., Zhang, X. & 96 others, , 2022, In: Human Genetics and Genomics Advances. 3, 2, 21 p., 100099.Research output: Contribution to journal › Journal article › Research › peer-review
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Early-life residential green spaces and traffic exposure in association with young adult body composition: a longitudinal birth cohort study of twins
Figaroa, M. N. S., Gielen, M., Casas, L., Loos, Ruth, Derom, C., Weyers, S., Nawrot, T. S., Zeegers, M. P. & Bijnens, E. M., 2023, In: Environmental Health. 22, 13 p., 18.Research output: Contribution to journal › Journal article › Research › peer-review
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New insights in the mechanisms of weight-loss maintenance: Summary from a Pennington symposium
Flanagan, E. W., Spann, R., Berry, S. E., Berthoud, H. R., Broyles, S., Foster, G. D., Krakoff, J., Loos, Ruth, Lowe, M. R., Ostendorf, D. M., Powell-Wiley, T. M., Redman, L. M., Rosenbaum, M., Schauer, P. R., Seeley, R. J., Swinburn, B. A., Hall, K. & Ravussin, E., 2023, In: Obesity. 31, 12, p. 2895-2908Research output: Contribution to journal › Journal article › Research › peer-review
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Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., Caulkins, L., Koesterer, R., Ma, C., Moutsianas, L., McCarthy, D. J., Rivas, M. A., Perry, J. R. B., Sim, X., Blackwell, T. W., Robertson, N. R., Rayner, N. W., Cingolani, P., Locke, A. E., Tajes, J. F. & 281 others, , 19 Dec 2017, In: Scientific Data. 4, p. 1-20 20 p., 170179.Research output: Contribution to journal › Journal article › Research › peer-review
Population-Based Penetrance of Deleterious Clinical Variants
Forrest, I. S., Chaudhary, K., Vy, H. M. T., Petrazzini, B. O., Bafna, S., Jordan, D. M., Rocheleau, G., Loos, Ruth, Nadkarni, G. N., Cho, J. H. & Do, R., 2022, In: JAMA. 327, 4, p. 350-359 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Physical activity energy expenditure may mediate the relationship between plasma leptin levels and worsening insulin resistance independently of adiposity
Franks, P. W., Loos, Ruth, Brage, S., O'Rahilly, S., Wareham, N. J. & Ekelund, U., May 2007, In: Journal of applied physiology (Bethesda, Md. : 1985). 102, 5, p. 1921-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., Shields, B., Harries, L. W., Barrett, J. C., Ellard, S., Groves, C. J., Knight, B., Patch, A-M., Ness, A. R., Ebrahim, S., Lawlor, D. A. & 21 others, , 11 May 2007, In: Science (New York, N.Y.). 316, 5826, p. 889-94 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Growth in peak aerobic power during adolescence
Geithner, C. A., Thomis, M. A., Vanden Eynde, B., Maes, H. H. M., Loos, Ruth, Peeters, M., Claessens, A. L. M., Vlietinck, R., Malina, R. M. & Beunen, G. P., Sep 2004, In: Medicine and Science in Sports and Exercise. 36, 9, p. 1616-24 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Editorial overview: Fat tissue in focus: Assembled deeply insightful perspectives on state-of-the-art explorations
Gerhart-Hines, Zach & Loos, Ruth, 2023, In: Current Opinion in Genetics and Development. 83, 102117.Research output: Contribution to journal › Editorial › Research
Twin-specific intrauterine 'growth' charts based on cross-sectional birthweight data
Gielen, M., Lindsey, P. J., Derom, C., Loos, Ruth, Souren, N. Y., Paulussen, A. D. C., Zeegers, M. P., Derom, R., Vlietinck, R. & Nijhuis, J. G., Apr 2008, In: Twin Research and Human Genetics. 11, 2, p. 224-35 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Twin birth weight standards
Gielen, M., Lindsey, P. J., Derom, C., Loos, Ruth, Derom, R., Nijhuis, J. G. & Vlietinck, R., 2007, In: Neonatology. 92, 3, p. 164-73 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meta-analysis uncovers genome-wide significant variants for rapid kidney function decline
Gorski, M., Jung, B., Li, Y., Matias-Garcia, P. R., Wuttke, M., Coassin, S., Thio, C. H. L., Kleber, M. E., Winkler, T. W., Wanner, V., Chai, J-F., Chu, A. Y., Cocca, M., Feitosa, M. F., Ghasemi, S., Hoppmann, A., Horn, K., Li, M., Nutile, T., Scholz, M. & 31 others, , 2021, In: Kidney International. 99, 4, p. 926-939Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Graff, M., Scott, R. A., Justice, A. E., Young, K. L., Feitosa, M. F., Barata, L., Winkler, T. W., Chu, A. Y., Mahajan, A., Hadley, D., Xue, L., Workalemahu, T., Heard-Costa, N. L., den Hoed, M., Ahluwalia, T. S., Qi, Q., Ngwa, J. S., Renström, F., Quaye, L., Eicher, J. D. & 34 others, , 1 Apr 2017, In: PLOS Genetics. 13, 4, e1006528.Research output: Contribution to journal › Journal article › Research › peer-review
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Strong protective effect of the APOL1 p.N264K variant against G2-associated focal segmental glomerulosclerosis and kidney disease
Gupta, Y., Friedman, D. J., McNulty, M. T., Khan, A., Lane, B., Wang, C., Ke, J., Jin, G., Wooden, B., Knob, A. L., Lim, T. Y., Appel, G. B., Huggins, K., Liu, L., Mitrotti, A., Stangl, M. C., Bomback, A., Westland, R., Bodria, M., Marasa, M. & 60 others, , 2023, In: Nature Communications. 14, 8 p., 7836.Research output: Contribution to journal › Journal article › Research › peer-review
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The energy balance model of obesity: beyond calories in, calories out
Hall, K. D., Farooqi, I. S., Friedman, J. M., Klein, S., Loos, Ruth, Mangelsdorf, D. J., O'Rahilly, S., Ravussin, E., Redman, L. M., Ryan, D. H., Speakman, J. R. & Tobias, D. K., 2022, In: American Journal of Clinical Nutrition. 115, 5, p. 1243-1254 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- E-pub ahead of print
An integrative framework to prioritize genes in more than 500 loci associated with body mass index
Hemerich, D., Svenstrup, Victor, Díez Obrero, Virginia, Preuss, M. H., Moscati, A., Hirschhorn, J. N. & Loos, Ruth, 9 May 2024, (E-pub ahead of print) In: American Journal of Human Genetics.Research output: Contribution to journal › Journal article › Research › peer-review
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Machine learning models for blood pressure phenotypes combining multiple polygenic risk scores
Hrytsenko, Y., Shea, B., Elgart, M., Kurniansyah, N., Lyons, G., Morrison, A. C., Carson, A. P., Haring, B., Mitchel, B. D., Psaty, B. M., Jaeger, B. C., Gu, C. C., Kooperberg, C., Levy, D., Lloyd-Jones, D., Choi, E., Brody, J. A., Smith, J. A., Rotter, J. I., Moll, M. & 18 others, , 2023, medRxiv, 41 p.Research output: Working paper › Preprint
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Genomics and phenomics of body mass index reveals a complex disease network
Huang, J., Huffman, J. E., Huang, Y., Do Valle, Í., Assimes, T. L., Raghavan, S., Voight, B. F., Liu, C., Barabási, A. L., Huang, R. D. L., Hui, Q., Nguyen, X. M. T., Ho, Y. L., Djousse, L., Lynch, J. A., Vujkovic, M., Tcheandjieu, C., Tang, H., Damrauer, S. M., Reaven, P. D. & 19 others, , 2022, In: Nature Communications. 13, 1, 10 p., 7973.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic loci that increase obesity risk but protect against cardiometabolic comorbidities are embedded in regulatory regions of adipocyte function: P19.049.B
Huang, L. O., Rauch, A., Mazzaferro, E., Bayrak, C. S., Carribio, S., Preuss, M., Chami, N., Wang, Z., Schnick, U., Yang, N., Itan, Y., Vidal-Puig, A., den Hoed, M., Mandrup, S., Kilpelainen, T. O. & Loos, Ruth, 2020, In: European Journal of Human Genetics. 28, Suppl. 1, p. 716-717 2 p.Research output: Contribution to journal › Conference abstract in journal › Research
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Evidence of genetic predisposition for metabolically healthy obesity and metabolically obese normal weight
Huang, L. O., Loos, Ruth & Kilpeläinen, Tuomas O., 2018, In: Physiological Genomics. 50, 3, p. 169-178 10 p.Research output: Contribution to journal › Review › Research › peer-review
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TOP-LD: A tool to explore linkage disequilibrium with TOPMed whole-genome sequence data
Huang, L., Rosen, J. D., Sun, Q., Chen, J., Wheeler, M. M., Zhou, Y., Min, Y. I., Kooperberg, C., Conomos, M. P., Stilp, A. M., Rich, S. S., Rotter, J. I., Manichaikul, A., Loos, R. J. F., Kenny, E. E., Blackwell, T. W., Smith, A. V., Jun, G., Sedlazeck, F. J., Metcalf, G. & 6 others, , 2022, In: American Journal of Human Genetics. 109, 6, p. 1175-1181 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes
Huerta-Chagoya, A., Schroeder, P., Mandla, R., Deutsch, A. J., Zhu, W., Petty, L., Yi, X., Cole, J. B., Udler, M. S., Dornbos, P., Porneala, B., DiCorpo, D., Liu, C. T., Li, J. H., Szczerbiński, L., Kaur, V., Kim, J., Lu, Y., Martin, A., Eizirik, D. L. & 31 others, , 2023, In: Diabetologia. 66, p. 1273-1288 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas
Hughes, O., Bentley, A. R., Breeze, C. E., Aguet, F., Xu, X., Nadkarni, G., Sun, Q., Lin, B. M., Gilliland, T., Meyer, M. C., Du, J., Raffield, L. M., Kramer, H., Morton, R. W., Gouveia, M. H., Atkinson, E. G., Valladares-Salgado, A., Wacher-Rodarte, N., Dueker, N. D., Guo, X. & 54 others, , 2024, In: Cell Genomics. 4, 1, 13 p., 100468.Research output: Contribution to journal › Journal article › Research › peer-review
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Body composition estimations by BIA versus anthropometric equations in body builders and other power athletes
Huygens, W., Claessens, A. L., Thomis, M., Loos, Ruth, Van Langendonck, L., Peeters, M., Philippaerts, R., Meynaerts, E., Vlietinck, R. & Beunen, G., Mar 2002, In: The Journal of Sports Medicine and Physical Fitness. 42, 1, p. 45-55 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity
Hägg, S., Ganna, A., Van Der Laan, S. W., Esko, T., Pers, Tune H, Locke, A. E., Berndt, S. I., Justice, A. E., Kahali, B., Siemelink, M. A., Pasterkamp, G., Strachan, D. P., Speliotes, E. K., North, K. E., Loos, Ruth, Hirschhorn, J. N., Pawitan, Y., Ingelsson, E. & GIANT Consortium, G. C., 1 Dec 2015, In: Human Molecular Genetics. 24, 23, p. 6849-60 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Persistent thinness and anorexia nervosa differ on a genomic level
Hübel, C., Abdulkadir, M., Herle, M., Palmos, A. B., Loos, Ruth, Breen, G., Micali, Nadia & Bulik, C. M., 2024, In: European Journal of Human Genetics. 32, 1, p. 117-124Research output: Contribution to journal › Journal article › Research › peer-review
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PFAS Exposures and the Human Metabolome: A Systematic Review of Epidemiological Studies
India-Aldana, S., Yao, M., Midya, V., Colicino, E., Chatzi, L., Chu, J., Gennings, C., Jones, D. P., Loos, Ruth, Setiawan, V. W., Smith, M. R., Walker, R. W., Barupal, D., Walker, D. I. & Valvi, D., 2023, In: Current Pollution Reports. 9, p. 510-568Research output: Contribution to journal › Review › Research › peer-review
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Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing
Jakubek, Y. A., Zhou, Y., Stilp, A., Bacon, J., Wong, J. W., Ozcan, Z., Arnett, D., Barnes, K., Bis, J. C., Boerwinkle, E., Brody, J. A., Carson, A. P., Chasman, D. I., Chen, J., Cho, M., Conomos, M. P., Cox, N., Doyle, M. F., Fornage, M., Guo, X. & 31 others, , 2023, In: Nature Genetics. 55, 11, p. 1912-1919 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Birth size and gestational age in opposite-sex twins as compared to same-sex twins: An individual-based pooled analysis of 21 cohorts
Jelenkovic, A., Sund, R., Yokoyama, Y., Hur, Y-M., Ullemar, V., Almqvist, C., Magnusson, P. K. E., Willemsen, G., Bartels, M., van Beijsterveldt, C. E. M., Bogl, L. H., Pietilainen, K. H., Vuoksimaa, E., Ji, F., Ning, F., Pang, Z., Nelson, T. L., Whitfield, K. E., Rebato, E., Llewellyn, C. H. & 38 others, , 1 Dec 2018, In: Scientific Reports. 8, 1, p. 1-8 8 p., 6300.Research output: Contribution to journal › Journal article › Research › peer-review
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Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts
Jelenkovic, A., Sund, R., Hur, Y-M., Yokoyama, Y., Hjelmborg, J. V. B., Möller, S., Honda, C., Magnusson, P. K. E., Pedersen, N. L., Ooki, S., Aaltonen, S., Stazi, M. A., Fagnani, C., D'Ippolito, C., Freitas, D. L., Maia, J. A., Ji, F., Ning, F., Pang, Z., Rebato, E. & 83 others, , 23 Jun 2016, In: Scientific Reports. 6, p. 1-13 13 p., 28496.Research output: Contribution to journal › Journal article › Research › peer-review
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Precision medicine in complex diseases - Molecular subgrouping for improved prediction and treatment stratification
Johansson, Å., Andreassen, O. A., Brunak, Søren, Franks, P. W., Hedman, H., Loos, Ruth, Meder, B., Melén, E., Wheelock, C. E. & Jacobsson, B., 2023, In: Journal of Internal Medicine. 294, 4, p. 378-396 19 p.Research output: Contribution to journal › Review › Research › peer-review
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Whole Genome Sequencing Identifies CRISPLD2 as a Lung Function Gene in Children With Asthma
Kachroo, P., Hecker, J., Chawes, B. L., Ahluwalia, T. S., Cho, M. H., Qiao, D., Kelly, R. S., Chu, S. H., Virkud, Y. V., Huang, M., Barnes, K. C., Burchard, E. G., Eng, C., Hu, D., Celedón, J. C., Daya, M., Levin, A. M., Gui, H., Williams, L. K., Forno, E. & 31 others, , 2019, In: Chest. 156, 6, p. 1068-1079 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., Xue, C. & 519 others, , 2022, In: Genome Biology. 23, 1, 42 p., 268.Research output: Contribution to journal › Journal article › Research › peer-review
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Disentangling the genetics of lean mass
Karasik, D., Zillikens, M. C., Hsu, Y. H., Aghdassi, A., Akesson, K., Amin, N., Barroso, I., Bennett, D. A., Bertram, L., Bochud, M., Borecki, I. B., Broer, L., Buchman, A. S., Byberg, L., Campbell, H., Campos-Obando, N., Cauley, J. A., Cawthon, P. M., Chambers, J. C., Chen, Z. & 137 others, , 2019, In: American Journal of Clinical Nutrition. 109, 2, p. 276-287Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Million Veteran Program, M. V. P., LifeLines Cohort Study, L. C. S., CHARGE Consortium, C. C. & ICBP Consortium, I. C., 2024, In: Nature Genetics. 56, 5, p. 778-791Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Kilpeläinen, T. O., Carli, J. F. M., Skowronski, A. A., Sun, Q., Kriebel, J., Feitosa, M. F., Hedman, Å. K., Drong, A. W., Hayes, J. E., Zhao, J., Pers, T. H., Schick, U., Grarup, N., Kutalik, Z., Trompet, S., Mangino, M., Kristiansson, K., Beekman, M., Lyytikäinen, L-P., Eriksson, J. & 157 others, , 2016, In: Nature Communications. 7, 14 p., 10494.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Kilpeläinen, T. O., Bentley, A. R., Noordam, R., Sung, Y. J., Schwander, K., Winkler, T. W., Jakupović, H., Chasman, D. I., Manning, A., Ntalla, I., Aschard, H., Brown, M. R., de las Fuentes, L., Franceschini, N., Guo, X., Vojinovic, D., Aslibekyan, S., Feitosa, M. F., Kho, M., Musani, S. K. & 32 others, , 2019, In: Nature Communications. 10, 11 p., 376.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genome-wide association analyses define pathogenic signaling pathways and prioritize drug targets for IgA nephropathy
Kiryluk, K., Sanchez-Rodriguez, E., Zhou, X. J., Zanoni, F., Liu, L., Mladkova, N., Khan, A., Marasa, M., Zhang, J. Y., Balderes, O., Sanna-Cherchi, S., Bomback, A. S., Canetta, P. A., Appel, G. B., Radhakrishnan, J., Trimarchi, H., Sprangers, B., Cattran, D. C., Reich, H., Pei, Y. & 168 others, , 2023, In: Nature Genetics. 55, 7, p. 1091-1105 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Discrepancy between predicted and measured exercise intensity for eliciting the maximal rate of lipid oxidation
Kittrell, H. D., DiMenna, F. J., Arad, A. D., Oh, W., Hofer, I., Walker, R. W., Loos, Ruth, Albu, J. B. & Nadkarni, G. N., 2023, In: Nutrition, Metabolism and Cardiovascular Diseases. 33, 11, p. 2189-2198Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals
Kraja, A. T., Cook, J. P., Warren, H. R., Surendran, P., Liu, C., Evangelou, E., Manning, A. K., Grarup, N., Drenos, F., Sim, X., Smith, A. V., Amin, N., Blakemore, A. I. F., Bork-Jensen, J., Brandslund, I., Farmaki, A-E., Fava, C., Ferreira, T., Herzig, K-H., Giri, A. & 122 others, , Oct 2017, In: Circulation: Cardiovascular Genetics. 10, 5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits
Kraja, A. T., Liu, C., Fetterman, J. L., Graff, M., Have, C. T., Gu, C., Yanek, L. R., Feitosa, M. F., Arking, D. E., Chasman, D. I., Young, K., Ligthart, S., Hill, W. D., Weiss, S., Luan, J., Giulianini, F., Li-Gao, R., Hartwig, F. P., Lin, S. J., Wang, L. & 132 others, , 2019, In: American Journal of Human Genetics. 104, 1, p. 112-138 27 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
Lagou, V., Jiang, L., Ulrich, A., Zudina, L., González, K. S. G., Balkhiyarova, Z., Faggian, A., Maina, J. G., Chen, S., Todorov, P. V., Sharapov, S., David, A., Marullo, L., Mägi, R., Rujan, R. M., Ahlqvist, E., Thorleifsson, G., Gao, Η., Εvangelou, Ε., Benyamin, B. & 78 others, , 2023, In: Nature Genetics. 55, 9, p. 1448-1461 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: the DIOGENES study
Larsen, L. H., Ängquist, Lars, Vimaleswaran, K. S., Hager, J., Viguerie, N., Loos, Ruth, Handjieva-Darlenska, T., Jebb, S. A., Kunesova, M., Larsen, T. M., Martinez, J. A., Papadaki, A., Pfeiffer, A. F. H., van Baak, M. A., Sørensen, Thorkild I.A., Holst, C., Langin, D., Astrup, A. & Saris, W. H. M., 2012, In: American Journal of Clinical Nutrition. 95, 5, p. 1254-1260 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ancestral diversity in lipoprotein(a) studies helps address evidence gaps
Lee, M. P., Dimos, S. F., Raffield, L. M., Wang, Z., Ballou, A. F., Downie, C. G., Arehart, C. H., Correa, A., De Vries, P. S., Du, Z., Gignoux, C. R., Gordon-Larsen, P., Guo, X., Haessler, J., Howard, A. G., Hu, Y., Kassahun, H., Kent, S. T., Lopez, J. A. G., Monda, K. L. & 14 others, , 2023, In: Open Heart. 10, 2, 11 p., e002382.Research output: Contribution to journal › Journal article › Research › peer-review
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Selection, optimization and validation of ten chronic disease polygenic risk scores for clinical implementation in diverse US populations
Lennon, N. J., Kottyan, L. C., Kachulis, C., Abul-Husn, N. S., Arias, J., Belbin, G., Below, J. E., Berndt, S. I., Chung, W. K., Cimino, J. J., Clayton, E. W., Connolly, J. J., Crosslin, D. R., Dikilitas, O., Velez Edwards, D. R., Feng, Q. P., Fisher, M., Freimuth, R. R., Ge, T., Glessner, J. T. & 59 others, , 2024, In: Nature Medicine. 30, 2, p. 480-487 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Testing the role of predicted gene knockouts in human anthropometric trait variation
NHLBI GO Exome Sequence Project, N. G. E. S. P., GOT2D, G., T2D-GENES, T. & GIANT Consortium, G. C., 15 May 2016, In: Human Molecular Genetics. 25, 10, p. 2082-2092 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population
Li, H., Wu, Y., Loos, Ruth, Hu, F. B., Liu, Y., Wang, J., Yu, Z. & Lin, X., Jan 2008, In: Diabetes. 57, 1, p. 264-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Progress in the genetics of common obesity: size matters
Li, S. & Loos, Ruth, Apr 2008, In: Current Opinion in Lipidology. 19, 2, p. 113-21 9 p.Research output: Contribution to journal › Review › Research › peer-review
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A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies
Li, X., Chen, H., Selvaraj, M. S., Van Buren, E., Zhou, H., Wang, Y., Sun, R., McCaw, Z. R., Yu, Z., Arnett, D. K., Bis, J. C., Blangero, J., Boerwinkle, E., Bowden, D. W., Brody, J. A., Cade, B. E., Carson, A. P., Carlson, J. C., Chami, N., Chen, Y-D. I. & 31 others, , 2023, bioRxiv, 71 p.Research output: Working paper › Preprint
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Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
Ligthart, S., Vaez, A., Vosa, U., Stathopoulou, M. G., de Vries, P. S., Prins, B. P., Van der Most, P. J., Tanaka, T., Naderi, E., Rose, L. M., Wu, Y., Karlsson, R., Barbalic, M., Lin, H., Pool, R., Zhu, G., Mace, A., Sidore, C., Trompet, S., Mangino, M. & 266 others, , 1 Nov 2018, In: American Journal of Human Genetics. 103, 5, p. 691-706Research output: Contribution to journal › Journal article › Research › peer-review
Gender-specific regional changes in genetic structure of muscularity in early adolescence
Loos, Ruth, Thomis, M., Maes, H. H., Beunen, G., Claessens, A. L., Derom, C., Legius, E., Derom, R. & Vlietinck, R., Jun 1997, In: Journal of applied physiology (Bethesda, Md. : 1985). 82, 6, p. 1802-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
The East Flanders Prospective Twin Survey (Belgium): a population-based register
Loos, Ruth, Derom, C., Vlietinck, R. & Derom, R., Dec 1998, In: Twin research : the official journal of the International Society for Twin Studies. 1, 4, p. 167-75 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Birth weight and body composition in young adult men--a prospective twin study
Loos, Ruth, Beunen, G., Fagard, R., Derom, C. & Vlietinck, R., Oct 2001, In: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity. 25, 10, p. 1537-45 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Birth weight and blood pressure in young adults: a prospective twin study
Loos, Ruth, Fagard, R., Beunen, G., Derom, C. & Vlietinck, R., 2 Oct 2001, In: Circulation. 104, 14, p. 1633-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Twin studies and estimates of heritability
Loos, Ruth, Beunen, G., Fagard, R., Derom, C., Vlietinck, R. & Phillips, D. I., 5 May 2001, In: Lancet. 357, 9266, p. 1445Research output: Contribution to journal › Journal article › Research › peer-review
The influence of zygosity and chorion type on fat distribution in young adult twins consequences for twin studies
Loos, Ruth, Beunen, G., Fagard, R., Derom, C. & Vlietinck, R., Oct 2001, In: Twin research : the official journal of the International Society for Twin Studies. 4, 5, p. 356-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Length of gestation and birthweight in dizygotic twins
Loos, Ruth, Derom, C., Eeckels, R., Derom, R. & Vlietinck, R., 18 Aug 2001, In: Lancet. 358, 9281, p. 560-1 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
Birthweight in liveborn twins: the influence of the umbilical cord insertion and fusion of placentas
Loos, Ruth, Derom, C., Derom, R. & Vlietinck, R., Sep 2001, In: BJOG : an international journal of obstetrics and gynaecology. 108, 9, p. 943-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Melanocortin-4 receptor gene and physical activity in the Québec Family Study
Loos, Ruth, Rankinen, T., Tremblay, A., Pérusse, L., Chagnon, Y. & Bouchard, C., Apr 2005, In: International journal of obesity (2005). 29, 4, p. 420-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Markers for cardiovascular disease in monozygotic twins discordant for the use of third-generation oral contraceptives
Loos, Ruth, Verhaeghe, J., De Zegher, F., Beunen, G., Derom, C., Fagard, R., Mathieu, C. & Vlietinck, R., Jul 2003, In: Journal of Human Hypertension. 17, 7, p. 481-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
FTO: the first gene contributing to common forms of human obesity
Loos, Ruth & Bouchard, C., May 2008, In: Obesity reviews : an official journal of the International Association for the Study of Obesity. 9, 3, p. 246-50 5 p.Research output: Contribution to journal › Review › Research › peer-review
Obesity--is it a genetic disorder?
Loos, Ruth & Bouchard, C., Nov 2003, In: Journal of Internal Medicine. 254, 5, p. 401-25 25 p.Research output: Contribution to journal › Review › Research › peer-review
Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study
HERITAGE Family Study, H. F. S., Dec 2003, In: The Journal of clinical endocrinology and metabolism. 88, 12, p. 5935-43 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family Study
Loos, Ruth, Rankinen, T., Leon, A. S., Skinner, J. S., Wilmore, J. H., Rao, D. C. & Bouchard, C., Jul 2004, In: The Journal of Nutrition. 134, 7, p. 1772-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study
Loos, Ruth, Ruchat, S., Rankinen, T., Tremblay, A., Pérusse, L. & Bouchard, C., Jan 2007, In: The American Journal of Clinical Nutrition. 85, 1, p. 26-34 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
The influence of maternal BMI and age in twin pregnancies on insulin resistance in the offspring
Loos, Ruth, Phillips, D. I. W., Fagard, R., Beunen, G., Derom, C., Mathieu, C., Verhaeghe, J. & Vlietinck, R., Dec 2002, In: Diabetes Care. Supplement. 25, 12, p. 2191-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
Determinants of birthweight and intrauterine growth in liveborn twins
Loos, Ruth, Derom, C., Derom, R. & Vlietinck, R., Jan 2005, In: Paediatric and Perinatal Epidemiology. 19 Suppl 1, p. 15-22 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Association of lipin 1 gene polymorphisms with measures of energy and glucose metabolism
Loos, Ruth, Rankinen, T., Pérusse, L., Tremblay, A., Després, J. & Bouchard, C., Nov 2007, In: Obesity. 15, 11, p. 2723-32 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Birth weight and body composition in young women: a prospective twin study
Loos, Ruth, Beunen, G., Fagard, R., Derom, C. & Vlietinck, R., Apr 2002, In: The American Journal of Clinical Nutrition. 75, 4, p. 676-82 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
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A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
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Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
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