Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts
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Association of current and former smoking with body mass index : A study of smoking discordant twin pairs from 21 twin cohorts. / Piirtola, Maarit; Jelenkovic, Aline; Latvala, Antti; Sund, Reijo; Honda, Chika; Inui, Fujio; Watanabe, Mikio; Tomizawa, Rie; Iwatani, Yoshinori; Ordonana, Juan R.; Sanchez-Romera, Juan F.; Colodro-Conde, Lucia; Tarnoki, Adam D.; Tarnoki, David L.; Martin, Nicholas G.; Montgomery, Grant W.; Medland, Sarah E.; Rasmussen, Finn; Tynelius, Per; Tan, Qihua; Zhang, Dongfeng; Pang, Zengchang; Rebato, Esther; Stazi, Maria A.; Fagnani, Corrado; Brescianini, Sonia; Busjahn, Andreas; Harris, Jennifer R.; Brandt, Ingunn; Nilsen, Thomas Sevenius; Cutler, Tessa L.; Hopper, John L.; Corley, Robin P.; Huibregtse, Brooke M.; Sung, Joohon; Kim, Jina; Lee, Jooyeon; Lee, Sooji; Gatz, Margaret; Butler, David A.; Franz, Carol E.; Kremen, William S.; Lyons, Michael J.; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Aslan, Anna K. Dahl; Oncel, Sevgi Y.; Aliev, Fazil; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J. F.; Silberg, Judy L.; Maes, Hermine H.; Boomsma, Dorret, I; Sorensen, Thorkild I. A.; Korhonen, Tellervo; Kaprio, Jaakko; Silventoinen, Karri.
In: PLoS ONE, Vol. 13, No. 7, e0200140, 12.07.2018.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Association of current and former smoking with body mass index
T2 - A study of smoking discordant twin pairs from 21 twin cohorts
AU - Piirtola, Maarit
AU - Jelenkovic, Aline
AU - Latvala, Antti
AU - Sund, Reijo
AU - Honda, Chika
AU - Inui, Fujio
AU - Watanabe, Mikio
AU - Tomizawa, Rie
AU - Iwatani, Yoshinori
AU - Ordonana, Juan R.
AU - Sanchez-Romera, Juan F.
AU - Colodro-Conde, Lucia
AU - Tarnoki, Adam D.
AU - Tarnoki, David L.
AU - Martin, Nicholas G.
AU - Montgomery, Grant W.
AU - Medland, Sarah E.
AU - Rasmussen, Finn
AU - Tynelius, Per
AU - Tan, Qihua
AU - Zhang, Dongfeng
AU - Pang, Zengchang
AU - Rebato, Esther
AU - Stazi, Maria A.
AU - Fagnani, Corrado
AU - Brescianini, Sonia
AU - Busjahn, Andreas
AU - Harris, Jennifer R.
AU - Brandt, Ingunn
AU - Nilsen, Thomas Sevenius
AU - Cutler, Tessa L.
AU - Hopper, John L.
AU - Corley, Robin P.
AU - Huibregtse, Brooke M.
AU - Sung, Joohon
AU - Kim, Jina
AU - Lee, Jooyeon
AU - Lee, Sooji
AU - Gatz, Margaret
AU - Butler, David A.
AU - Franz, Carol E.
AU - Kremen, William S.
AU - Lyons, Michael J.
AU - Magnusson, Patrik K. E.
AU - Pedersen, Nancy L.
AU - Aslan, Anna K. Dahl
AU - Oncel, Sevgi Y.
AU - Aliev, Fazil
AU - Derom, Catherine A.
AU - Vlietinck, Robert F.
AU - Loos, Ruth J. F.
AU - Silberg, Judy L.
AU - Maes, Hermine H.
AU - Boomsma, Dorret, I
AU - Sorensen, Thorkild I. A.
AU - Korhonen, Tellervo
AU - Kaprio, Jaakko
AU - Silventoinen, Karri
PY - 2018/7/12
Y1 - 2018/7/12
N2 - BACKGROUND: Smokers tend to weigh less than never smokers, while successful quitting leads to an increase in body weight. Because smokers and non-smokers may differ in genetic and environmental family background, we analysed data from twin pairs in which the co-twins differed by their smoking behaviour to evaluate if the association between smoking and body mass index (BMI) remains after controlling for family background.METHODS AND FINDINGS: The international CODATwins database includes information on smoking and BMI measured between 1960 and 2012 from 156,593 twin individuals 18-69 years of age. Individual-based data (230,378 measurements) and data of smoking discordant twin pairs (altogether 30,014 pairwise measurements, 36% from monozygotic [MZ] pairs) were analysed with linear fixed-effects regression models by 10-year periods. In MZ pairs, the smoking co-twin had, on average, 0.57 kg/m2 lower BMI in men (95% confidence interval (CI): 0.49, 0.70) and 0.65 kg/m2 lower BMI in women (95% CI: 0.52, 0.79) than the never smoking co-twin. Former smokers had 0.70 kg/m2 higher BMI among men (95% CI: 0.63, 0.78) and 0.62 kg/m2 higher BMI among women (95% CI: 0.51, 0.73) than their currently smoking MZ co-twins. Little difference in BMI was observed when comparing former smoking co-twins with their never smoking MZ co-twins (0.13 kg/m2, 95% CI 0.04, 0.23 among men; -0.04 kg/m2, 95% CI -0.16, 0.09 among women). The associations were similar within dizygotic pairs and when analysing twins as individuals. The observed series of cross-sectional associations were independent of sex, age, and measurement decade.CONCLUSIONS: Smoking is associated with lower BMI and smoking cessation with higher BMI. However, the net effect of smoking and subsequent cessation on weight development appears to be minimal, i.e. never more than an average of 0.7 kg/m2.
AB - BACKGROUND: Smokers tend to weigh less than never smokers, while successful quitting leads to an increase in body weight. Because smokers and non-smokers may differ in genetic and environmental family background, we analysed data from twin pairs in which the co-twins differed by their smoking behaviour to evaluate if the association between smoking and body mass index (BMI) remains after controlling for family background.METHODS AND FINDINGS: The international CODATwins database includes information on smoking and BMI measured between 1960 and 2012 from 156,593 twin individuals 18-69 years of age. Individual-based data (230,378 measurements) and data of smoking discordant twin pairs (altogether 30,014 pairwise measurements, 36% from monozygotic [MZ] pairs) were analysed with linear fixed-effects regression models by 10-year periods. In MZ pairs, the smoking co-twin had, on average, 0.57 kg/m2 lower BMI in men (95% confidence interval (CI): 0.49, 0.70) and 0.65 kg/m2 lower BMI in women (95% CI: 0.52, 0.79) than the never smoking co-twin. Former smokers had 0.70 kg/m2 higher BMI among men (95% CI: 0.63, 0.78) and 0.62 kg/m2 higher BMI among women (95% CI: 0.51, 0.73) than their currently smoking MZ co-twins. Little difference in BMI was observed when comparing former smoking co-twins with their never smoking MZ co-twins (0.13 kg/m2, 95% CI 0.04, 0.23 among men; -0.04 kg/m2, 95% CI -0.16, 0.09 among women). The associations were similar within dizygotic pairs and when analysing twins as individuals. The observed series of cross-sectional associations were independent of sex, age, and measurement decade.CONCLUSIONS: Smoking is associated with lower BMI and smoking cessation with higher BMI. However, the net effect of smoking and subsequent cessation on weight development appears to be minimal, i.e. never more than an average of 0.7 kg/m2.
U2 - 10.1371/journal.pone.0200140
DO - 10.1371/journal.pone.0200140
M3 - Journal article
C2 - 30001359
VL - 13
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 7
M1 - e0200140
ER -
ID: 209463884