Kei Sakamoto

Kei Sakamoto

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    1. Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells

      Dimopoulos, N., Watson, M., Sakamoto, Kei & Hundal, H. S., 1 Nov 2006, In: Biochemical Journal. 399, 3, p. 473-481 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells

      Din, F. V. N., Valanciute, A., Houde, V. P., Zibrova, D., Green, K. A., Sakamoto, Kei, Alessi, D. R. & Dunlop, M. G., Jun 2012, In: Gastroenterology. 142, 7, p. 1504-1515.e3

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

      Dite, T. A., Ling, N. X. Y., Scott, J. W., Hoque, A., Galic, S., Parker, B. L., Ngoei, K. R. W., Langendorf, C. G., O'Brien, M. T., Kundu, M., Viollet, B., Steinberg, G. R., Sakamoto, Kei, Kemp, B. E. & Oakhill, J. S., 1 Dec 2017, In: Nature Communications. 8, 1, 571.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16

      Dixon-Clarke, S. E., Shehata, S. N., Krojer, T., Sharpe, T. D., Von Delft, F., Sakamoto, Kei & Bullock, A. N., 1 Mar 2017, In: Biochemical Journal. 474, 5, p. 699-713 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

      Dohmen, M., Krieg, S., Agalaridis, G., Zhu, X., Shehata, S. N., Pfeiffenberger, E., Amelang, J., Bütepage, M., Buerova, E., Pfaff, C. M., Chanda, D., Geley, S., Preisinger, C., Sakamoto, Kei, Lüscher, B., Neumann, D. & Vervoorts, J., 2020, In: Nature Communications. 11, 1, 18 p., 1032.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates

      Ducommun, S., Deak, M., Zeigerer, A., Göransson, O., Seitz, S., Collodet, C., Madsen, A. B., Jensen, Thomas Elbenhardt, Viollet, B., Foretz, M., Gut, P., Sumpton, D. & Sakamoto, Kei, 2019, In: Cellular Signalling. 57, p. 45-57 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

      Ducommun, S., Ford, R. J., Bultot, L., Deak, M., Bertrand, L., Kemp, B. E., Steinberg, G. R. & Sakamoto, Kei, 15 Mar 2014, In: American Journal of Physiology - Endocrinology and Metabolism. 306, 6, p. E688-E696

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

      Ducommun, S., Deak, M., Sumpton, D., Ford, R. J., Núñez Galindo, A., Kussmann, M., Viollet, B., Steinberg, G. R., Foretz, M., Dayon, L., Morrice, N. A. & Sakamoto, Kei, 1 May 2015, In: Cellular Signalling. 27, 5, p. 978-988 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Thr 649 Ala-AS160 knock-in mutation does not impair contraction/ AICAR-induced glucose transport in mouse muscle

      Ducommun, S., Wang, H. Y., Sakamoto, Kei, MacKintosh, C. & Chen, S., 1 May 2012, In: American Journal of Physiology - Endocrinology and Metabolism. 302, 9, p. E1036-E1043

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

      Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, Kei, Andreelli, F. & Viollet, B., 1 Jul 2010, In: Journal of Clinical Investigation. 120, 7, p. 2355-2369 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Amino acid homeostasis is a target of metformin therapy

      Forteath, C., Mordi, I., Nisr, R., Gutierrez-Lara, E. J., Alqurashi, N., Phair, I. R., Cameron, A. R., Beall, C., Bahr, I., Mohan, M., Wong, A. K. F., Dihoum, A., Mohammad, A., Palmer, C. N. A., Lamont, D., Sakamoto, Kei, Viollet, B., Foretz, M., Lang, C. C. & Rena, G., 2023, In: Molecular Metabolism. 74, 16 p., 101750.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity

      Fujii, N., Boppart, M. D., Dufresne, S. D., Crowley, P. F., Jozsi, A. C., Sakamoto, Kei, Yu, H., Aschenbach, W. G., Kim, S., Miyazaki, H., Rui, L., White, M. F., Hirshman, M. F. & Goodyear, L. J., 1 Jul 2004, In: American Journal of Physiology - Cell Physiology. 287, 1 56-1, p. C200-C208

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes

      Gormand, A., Henriksson, E., Ström, K., Jensen, Thomas Elbenhardt, Sakamoto, Kei & Göransson, O., 2011, In: Journal of Cellular Biochemistry. 112, 5, p. 1364-1375 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

      Green, C. J., Göransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, Kei & Hundal, H. S., 10 Oct 2008, In: Journal of Biological Chemistry. 283, 41, p. 27653-27667 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

      Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, Kei & Hundal, H. S., 15 Apr 2011, In: Biochemical Journal. 435, 2, p. 463-474 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Beyond AICA riboside: In search of new specific AMP-activated protein kinase activators

      Guigas, B., Sakamoto, Kei, Taleux, N., Reyna, S. M., Musi, N., Viollet, B. & Hue, L., 1 Dec 2009, In: IUBMB Life. 61, 1, p. 18-26 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    17. AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

      Gélinas, R., Mailleux, F., Dontaine, J., Bultot, L., Demeulder, B., Ginion, A., Daskalopoulos, E. P., Esfahani, H., Dubois-Deruy, E., Lauzier, B., Gauthier, C., Olson, A. K., Bouchard, B., Des Rosiers, C., Viollet, B., Sakamoto, K., Balligand, J. L., Vanoverschelde, J. L., Beauloye, C., Horman, S. & 1 others, Bertrand, L., 1 Dec 2018, In: Nature Communications. 9, 1, 374.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase

      Göransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. & Sakamoto, Kei, 9 Nov 2007, In: Journal of Biological Chemistry. 282, 45, p. 32549-32560 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line

      Habinowski, S. A., Hirshman, M., Sakamoto, Kei, Kemp, B. E., Gould, S. J., Goodyear, L. J. & Witters, L. A., 1 Dec 2001, In: Archives of Biochemistry and Biophysics. 396, 1, p. 71-79 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. AMPK: A key sensor of fuel and energy status in skeletal muscle

      Hardie, D. G. & Sakamoto, Kei, 1 Feb 2006, In: Physiology. 21, 1, p. 48-60 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    21. The ancient drug salicylate directly activates AMP-activated protein kinase

      Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, Kei, Steinberg, G. R. & Hardie, D. G., 18 May 2012, In: Science. 336, 6083, p. 918-922 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes

      Henriksson, E., Säll, J., Gormand, A., Wasserstrom, S., Morrice, N. A., Fritzen, Andreas Mæchel, Foretz, M., Campbell, D. G., Sakamoto, Kei, Ekelund, M., Degerman, E., Stenkula, K. G. & Göransson, O., 2015, In: Journal of Cell Science. 128, 3, p. 472-486 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser 358 in adipocytes

      Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, Kei & Göransson, O., 15 Jun 2012, In: Biochemical Journal. 444, 3, p. 503-514 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Insulin signaling after exercise in insulin receptor substrate-2-deficient mice

      Hewlett, K. F., Sakamoto, Kei, Hirshman, M. F., Aschenbach, W. G., Dow, M., White, M. F. & Goodyear, L. J., 24 Jul 2002, In: Diabetes. 51, 2, p. 479-483 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

      Hingst, J. R., Bruhn, L., Hansen, M. B., Rosschou, M. F., Birk, Jesper Bratz, Fentz, J., Foretz, M., Viollet, B., Sakamoto, Kei, Færgeman, N. J., Havelund, J. F., Parker, B. L., James, D. E., Kiens, Bente, Richter, Erik A., Jensen, J. & Wojtaszewski, Jørgen F P, 2018, In: Molecular Metabolism. 16, p. 24-34 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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