Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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Sensing of triacylglycerol in the gut: different mechanisms for fatty acids and 2-monoacylglycerol
Kleberg, K., Jacobsen, A. K., Ferreira, J. G., Windeløv, Johanne Agerlin, Rehfeld, Jens Frederik, Holst, Jens Juul, de Araujo, I. E. & Hansen, Harald S., 16 Jan 2015, In: The Journal of Physiology. 593, 8, p. 2097-109 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals
Kliim-Hansen, V., Gether, I. M., Juel, C. T., Ellegaard, A., Pedersen, M. G., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Lund, Asger Bach, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2024, In: Peptides. 179, 5 p., 171242.Research output: Contribution to journal › Journal article › Research › peer-review
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Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus
Knop, Filip Krag, Vilsbøll, T., Madsbad, Sten, Holst, Jens Juul & Krarup, T., Apr 2007, In: Diabetologia. 50, 4, p. 797-805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucagon suppression during OGTT worsens while suppression during IVGTT sustains alongside development of glucose intolerance in patients with chronic pancreatitis
Knop, Filip Krag, Vilsbøll, Tina, Larsen, S., Madsbad, Sten, Holst, Jens Juul & Krarup, T. M., 24 Sep 2010, In: Regulatory Peptides. 164, 2-3, p. 144-50 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Thirty days of resveratrol supplementation does not affect postprandial incretin hormone responses, but suppresses postprandial glucagon in obese subjects
Knop, Filip Krag, Konings, E., Timmers, S., Schrauwen, P., Holst, Jens Juul & Blaak, E. E., 11 May 2013, In: Diabetic Medicine. 30, 10, p. 1214-1218 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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No reactive hypoglycaemia after subcutaneous administrations of GLP-1 in lean type 2 diabetic patients and in patients with diabeties secondary to chronic pancreatitis
Knop, F., Vilsbøll, T., Larsen, S., Holst, Jens Juul & Krarup, T., 2003, In: Diabetes Care. 26, p. 2581-2587Research output: Contribution to journal › Journal article › Research › peer-review
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Inappropriate suppression of glucagon during OGTT but not during isoglycaemic i.v. glucose infusion contributes to the reduced incretin effect in type 2 diabetes mellitus
Knop, F. K., Vilsbøll, Tina, Madsbad, Sten, Holst, Jens Juul, Krarup, T., Knop, Filip Krag, Vilsbøll, Tina, Madsbad, Sten, Holst, J. M. & Krarup, T., 1 Apr 2007, In: Diabetologia. 50, 4, p. 797-805 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: Challenges and feasibility
Knop, F. K., Holst, Jens Juul & Vilsbøll, Tina, 2008, In: IDrugs. The Investigational Drugs Journal. 11, 7, p. 497-501 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Replacing SUs with incretin-based therapies for type 2 diabetes mellitus: challenges and feasibility
Knop, Filip Krag, Holst, Jens Juul & Vilsbøll, T., Jul 2008, In: I Drugs: the Investigational Drugs Journal. 11, 7, p. 497-501 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Reduced incretin effect in type 2 diabetes: cause or consequence of the diabetic state?
Knop, F. K., Vilsbøll, Tina, Højberg, P. V., Larsen, S., Madsbad, Sten, Vølund, A., Holst, Jens Juul & Krarup, T., 2007, In: Diabetes. 56, 8, p. 1951-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Incretin-based therapy of type 2 diabetes mellitus
Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 2009, In: Current Protein and Peptide Science. 10, 1, p. 46-55 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased postprandial responses of GLP-1 and GIP in patients with chronic pancreatitis and steatorrhea following pancreatic enzyme substitution.
Knop, F. K., Vilsbøll, Tina, Larsen, S., Højberg, P. V., Vølund, A., Madsbad, Sten, Holst, Jens Juul & Krarup, T., 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 292, 1, p. E324-30Research output: Contribution to journal › Journal article › Research › peer-review
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The impact of pancreatic enzyme supplementation on postprandial responses of glucagon-like Peptide-2 in patients with chronic pancreatitis and pancreatic exocrine insufficiency
Knop, Filip Krag, Vilsbøll, Tina, Lund, A., Krarup, T., Holst, Jens Juul & Hornum, Mads, 6 Sep 2010, In: Journal of the Pancreas. 11, 5, p. 489-91 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The insulinotropic effect of GIP is impaired in patients with chronic pancreatitis and secondary diabetes mellitus as compared to patients with chronic pancreatitis and normal glucose tolerance.
Knop, F. K., Vilsbøll, Tina, Højberg, P. V., Larsen, S., Madsbad, Sten, Holst, Jens Juul & Krarup, T., 2007, In: Regulatory Peptides. 144, 1-3, p. 123-30 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Unprecedented high insulin secretion in a healthy human subject after intravenous glucagon-like peptide-1: a case report
Knop, Filip Krag, Lund, Asger Bach, Madsbad, Sten, Holst, Jens Juul, Krarup, T. & Vilsbøll, T., 2014, In: BMC Research Notes. 7, p. 1-6 6 p., 326.Research output: Contribution to journal › Journal article › Research › peer-review
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Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity
Knop, Filip Krag, Aaboe, K., Vilsbøll, Tina, Vølund, A., Holst, Jens Juul, Krarup, T. & Madsbad, Sten, 2012, In: Diabetes, Obesity and Metabolism. 14, 6, p. 500-510 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)
Knorr, S., Bytoft, B., Lohse, Z., Boisen, A. B., Clausen, Tine Dalsgaard, Jensen, R. B., Damm, Peter, Beck-Nielsen, H., Holst, Jens Juul, Hartmann, Bolette, Moller, H. J., Hojlund, K., Gravholt, C. H. & Jensen, D. M., 2019, In: Diabetes Care. 42, 8, p. 1560-1568Research output: Contribution to journal › Journal article › Research › peer-review
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Pancreatic Polypeptide in Parkinson's Disease: A Potential Marker of Parasympathetic Denervation
Knudsen, K., Hartmann, Bolette, Fedorova, T. D., Østergaard, K., Krogh, K., Møller, N., Holst, Jens Juul & Borghammer, P., 2017, In: Journal of Parkinson's Disease. 7, 4, p. 645-652 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 derivatives as novel compounds for the treatment of type 2 diabetes: selection of NN2211 for clinical development
Knudsen, L. B., Agerso, H., Bjenning, C. & Holst, Jens Juul, 2001, In: Drug Future. 26, p. 677-685Research output: Contribution to journal › Journal article › Research › peer-review
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Small-molecule agonists for the glucagon-like peptide 1 receptor
Knudsen, L. B., Kiel, D., Teng, M., Behrens, C., Bhumralkar, D., Kodra, J. T., Holst, J. J., Jeppesen, C. B., Johnson, M. D., de Jong, J. C., Jorgensen, A. S., Kercher, T., Kostrowicki, J., Madsen, P., Olesen, P. H., Petersen, J. S., Poulsen, F., Sidelmann, U. G., Sturis, J., Truesdale, L. & 2 others, , 16 Jan 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 3, p. 937-42 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of acute exercise on pancreatic endocrine function in subjects with type 2 diabetes
Knudsen, S. H., Karstoft, K., Winding, K., Holst, Jens Juul, Pedersen, Bente Klarlund & Solomon, T., Feb 2015, In: Diabetes, Obesity and Metabolism. 17, 2, p. 207-210 4 p.Research output: Contribution to journal › Letter › Research › peer-review
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Differential Effects of Secretin-fragments imply a dual Mechanism of Action for Secretin
Kofod, H., Thams, P. & Holst, Jens Juul, Feb 1991, In: International Journal of Peptide and Protein Research. 37, 2, p. 134-139 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Secretin uncouples glucose inhibition of glucagon-producing cells resulting in a simultaneous stimulation of both glucagon and insulin release
Kofod, H., Holst, Jens Juul & Lernmark, A., Dec 1988, In: Regulatory Peptides. 23, 3, p. 315-22 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Duodenal Anaerobutyricum soehngenii infusion stimulates GLP-1 production, ameliorates glycaemic control and beneficially shapes the duodenal transcriptome in metabolic syndrome subjects: a randomised double-blind placebo-controlled cross-over study
Koopen, A., Witjes, J., Wortelboer, K., Majait, S., Prodan, A., Levin, E., Herrema, H., Winkelmeijer, M., Aalvink, S., Bergman, J. J. G. H. M., Havik, S., Hartmann, B., Levels, H., Bergh, P-O., van Son, J., Balvers, M., Bastos, D. M., Stroes, E., Groen, A. K., Henricsson, M. & 8 others, , 2022, In: Gut. 71, p. 1577-1587 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effect of fecal microbiota transplantation combined with Mediterranean diet on insulin sensitivity in subjects with metabolic syndrome
Koopen, A. M., Almeida, E. L., Attaye, I., Witjes, J. J., Rampanelli, E., Majait, S., Kemper, M., Levels, J. H. M., Schimmel, A. W. M., Herrema, H., Scheithauer, T. P. M., Frei, W., Dragsted, Lars Ove, Hartmann, Bolette, Holst, Jens Juul, O’Toole, P. W., Groen, A. K. & Nieuwdorp, M., 2021, In: Frontiers in Microbiology. 12, 15 p., 662159.Research output: Contribution to journal › Journal article › Research › peer-review
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Incretin responses to oral glucose and mixed meal tests and changes in fasting glucose levels during 7 years of follow-up: The Hoorn Meal Study
Koopman, A. D. M., Rutters, F., Rauh, S. P., Nijpels, G., Holst, Jens Juul, Beulens, J. W., Alssema, M. & Dekker, J. M., 2018, In: PloS one. 13, 1, 13 p., e0191114.Research output: Contribution to journal › Journal article › Research › peer-review
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Exogenous glucagon-like peptide-2 (GLP-2) augments GLP-2 receptor mRNA and maintains proglucagon mRNA levels in resected rats
Koopmann, M. C., Nelson, D. W., Murali, S. G., Liu, X. W., Brownfield, M. S., Holst, Jens Juul & Ney, D. M., 2008, In: Journal of Parenteral and Enteral Nutrition. 32, 3, p. 254-265 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exogenous glucagon-like peptide-2 (GLP-2) augments GLP-2 receptor mRNA and maintains proglucagon mRNA levels in resected rats
Koopmann, M. C., Nelson, D. W., Murali, S. G., Liu, X., Brownfield, M. S., Holst, Jens Juul & Ney, D. M., 30 Apr 2008, In: Journal of Parenteral and Enteral Nutrition. 32, 3, p. 254-65 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Colonic GLP-2 is not sufficient to promote jejunal adaptation in a PN-dependent rat model of human short bowel syndrome
Koopmann, M. C., Liu, X., Boehler, C. J., Murali, S. G., Holst, Jens Juul & Ney, D. M., 2009, In: Journal of Parenteral and Enteral Nutrition. 33, 6, p. 629-38; discussion 638-9Research output: Contribution to journal › Journal article › Research › peer-review
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Sustained glucagon-like peptide-2 infusion is required for intestinal adaptation, and cessation reverses increased cellularity in rats with intestinal failure
Koopmann, M. C., Chen, X., Holst, Jens Juul & Ney, D. M., 1 Dec 2010, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 299, 6, p. G1222-30 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition
Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., Knop, F. K., Blaak, E. E., Zhao, J., Smidt, H., Harms, A. C., Hankemeijer, T., Bergman, J. J. G. H. M., Romijn, H. A., Schaap, F. G., Olde Damink, S. W. M. & 8 others, , Oct 2017, In: Cell Metabolism. 26, 4, p. 611-619.e6 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding.
Korner, J., Bessler, M., Inabnet, W., Taveras, C. & Holst, Jens Juul, 2007, In: Surgery for Obesity and Related Diseases. 3, 6, p. 597-601 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes
Kozawa, J., Okita, K., Imagawa, A., Iwahashi, H., Holst, Jens Juul, Yamagata, K. & Shimomura, I., 12 Mar 2010, In: Biochemical and Biophysical Research Communications. 393, 3, p. 410-3 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of a Low-Carbohydrate-High-Protein Pre-Exercise Meal in Type 1 Diabetes—a Randomized Crossover Trial
Kristensen, K. B., Ranjan, A. G., Mccarthy, O. M., Holst, Jens Juul, Bracken, R. M., Nørgaard, Kirsten & Schmidt, S., 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 1, p. 208–216 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia
Kristensen, P. L., Pedersen-Bjergaard, Ulrik, Due-Andersen, R., Høi-Hansen, T., Grimmeshave, L., Lyssenko, V., Groop, L., Holst, Jens Juul, Vaag, Allan & Thorsteinsson, B., 2016, In: Endocrine Connections. 5, 6, p. 53-60 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Influence of erythropoietin on cognitive performance during experimental hypoglycemia in patients with type 1 diabetes mellitus: A Randomized Cross-Over Trial
Kristensen, Peter Lommer, Pedersen-Bjergaard, Ulrik, Kjær, T. W., Olsen, N. V., Dela, Flemming, Holst, Jens Juul, Faber, Jens, Tarnow, L. & Thorsteinsson, B., 5 Apr 2013, In: P L o S One. 8, 4, p. 1-8 8 p., e59672.Research output: Contribution to journal › Journal article › Research › peer-review
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The effects of L-arabinose on intestinal sucrase activity: dose-response studies in vitro and in humans
Krog-Mikkelsen, I., Hels, O., Tetens, Inge , Holst, Jens Juul, Andersen, Jens Rikardt & Bukhave, K., 2011, In: American Journal of Clinical Nutrition. 94, 2, p. 472-478 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A low glycemic index diet does not affect postprandial energy metabolism but decreases postprandial insulinemia and increases fullness ratings in healthy women
Krog-Mikkelsen, I., Sloth, B., Dimitrov, D., Tetens, Inge , Björck, I., Flint, A., Holst, Jens Juul, Astrup, A., Elmstähl, H. & Raben, Anne, 2011, In: Journal of Nutrition. 141, 9, p. 1679-1684 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The naturally occurring GIP(1-30)NH2 is a GIP receptor agonist in humans
Krogh, L. S. L., Henriksen, K., Stensen, S., Skov-Jeppesen, Kirsa, Bergmann, N. C., Størling, Joachim, Rosenkilde, Mette, Hartmann, Bolette, Holst, Jens Juul, Gasbjerg, Lærke Smidt & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 188, 1, lvac015.Research output: Contribution to journal › Journal article › Research › peer-review
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Normal physical activity obliterates the deleterious effects of high-caloric intake
Krogh-Madsen, Rikke, Pedersen, M., Solomon, T., Knudsen, S. H., Hansen, L. S., Karstoft, K., Lehrskov-Schmidt, L., Pedersen, K. K., Thomsen, C., Holst, Jens Juul & Pedersen, Bente Klarlund, 7 Nov 2013, In: Journal of Applied Physiology. 116, 3, p. 231-239 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Repaglinide at a cellular level
Krogsgaard Thomsen, M., Bokvist, K., Høy, M., Buschard, K., Holst, Jens Juul, Lindström, P. & Gromada, J., Dec 2002, In: Diabetes, nutrition & metabolism. 15, 6 Suppl, p. 15-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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No direct effect of SGLT2 activity on glucagon secretion
Kuhre, Rune Ehrenreich, Ghiasi, S. M., Adriaenssens, A. E., Albrechtsen, Nicolai Jacob Wewer, Andersen, Daniel Bjørklund, Aivazidis, A., Chen, L., Mandrup-Poulsen, Thomas, Ørskov, Cathrine, Gribble, F. M., Reimann, F., Wierup, N., Tyrberg, B. & Holst, Jens Juul, 2019, In: Diabetologia. 62, 6, p. 1011-1023Research output: Contribution to journal › Journal article › Research › peer-review
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Do sodium-glucose transporter-2 inhibitors increase plasma glucagon by direct actions on the alpha-cell? - and does the increase matter for the associated increase in endogenous glucose production?
Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2021, In: Diabetes, Obesity and Metabolism. 23, 9, p. 2009-2019Research output: Contribution to journal › Review › Research › peer-review
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Molecular Mechanisms of Glucose-Stimulated GLP-1 Secretion From Perfused Rat Small Intestine
Kuhre, Rune Ehrenreich, Frost, C. R., Svendsen, B. & Holst, Jens Juul, Feb 2015, In: Diabetes. 64, 2, p. 370-382 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion
Kuhre, Rune Ehrenreich, Modvig, Ida Marie, Jepsen, Sara Lind, Kizilkaya, Hüsün Sheyma, Bæch-Laursen, C., Smith, C. A., Reimann, F., Gribble, F. M., Rosenkilde, Mette & Holst, Jens Juul, 2021, In: Frontiers in Endocrinology. 12, 12 p., 690387.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: Journal of Visualized Experiments. 144, e58533.Research output: Contribution to journal › Journal article › Research › peer-review
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What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?
Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Holst, Jens Juul & Petersen, N., 2021, In: Frontiers in Endocrinology. 12, 19 p., 694284.Research output: Contribution to journal › Review › Research › peer-review
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Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, Apr 2015, In: Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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GLP-1 Amidation Efficiency Along the Length of the Intestine in Mice, Rats and Pigs and in GLP-1 Secreting Cell Lines
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Windeløv, Johanne Agerlin, Svendsen, B., Hartmann, Bolette & Holst, Jens Juul, 31 Jan 2014, In: Peptides. 55, p. 52-57 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fructose stimulates GLP-1 but not GIP secretion in mice, rats, and humans
Kuhre, Rune Ehrenreich, Gribble, F. M., Hartmann, Bolette, Reimann, F., Windeløv, Johanne Agerlin, Rehfeld, Jens Frederik & Holst, Jens Juul, 1 Apr 2014, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 306, 7, p. G622-30 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pancreatic effects of GLP-1
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 22 Dec 2014, Diapedia: The Living Textbook of Diabetes. European Association for the Study of Diabetes (EASD)Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Communication
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Neuromedin U Does Not Act as a Decretin in Rats
Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Ghiasi, S. M., Gabe, M. B. N., Skat-Rørdam, P. A., Modvig, Ida Marie, Mandrup-Poulsen, Thomas, Albrechtsen, Reidar, Rosenkilde, Mette, Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2019, In: Cell Metabolism. 29, 3, p. 719-726.e1-e5 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Bile acids are important direct and indirect regulators of the secretion of appetite- and metabolism-regulating hormones from the gut and pancreas.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Larsen, Olav, Jepsen, Sara Lind, Balk-Møller, E., Andersen, Daniel Bjørklund, Deacon, Carolyn F., Schoonjans, K., Reimann, F., Gribble, F. M., Albrechtsen, Reidar, Hartmann, Bolette, Rosenkilde, Mette & Holst, Jens Juul, 2018, In: Molecular Metabolism. 11, p. 84-95 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Glucose Stimulates GLP-1 Secretion from Isolated Perfused Rat Small Intestine by SGLT1 and GLUT2 Mediated Uptake, Causing V-gated Calcium Channel Activation
Kuhre, Rune Ehrenreich, Frost, C. R., Svendsen, B. & Holst, Jens Juul, Jun 2014, In: Diabetes. 63, suppl 1, p. A491 1 p., Abstract no 1915-P.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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On the relationship between glucose absorption and glucose‐stimulated secretion of GLP‐1, neurotensin, and PYY from different intestinal segments in the rat
Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Saltiel, M. Y., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 3 Dec 2017, In: Physiological Reports. 5, 23, 13 p., e13507.Research output: Contribution to journal › Journal article › Research › peer-review
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The regulation of function, growth and survival of GLP-1-producing L-cells.
Kuhre, Rune Ehrenreich, Holst, Jens Juul & Kappe, C., 1 Jan 2016, In: Clinical Science. 130, 2, p. 79-91 13 p.Research output: Contribution to journal › Review › Research › peer-review
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Glucose stimulates neurotensin secretion from the rat small intestine by mechanisms involving SGLT1 and GLUT2 leading to cell depolarization and calcium influx
Kuhre, Rune Ehrenreich, Bechmann, L. E., Hartmann, Bolette, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 21 Apr 2015, In: American Journal of Physiology: Endocrinology and Metabolism. 308, 12, p. E1123–E1130 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Peptide production and secretion in GLUTag, NCI-H716 and STC-1 cells: a comparison to native L-cells.
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Deacon, Carolyn F., Balk-Møller, E., Rehfeld, Jens Frederik, Relman, F., Gribble, F. M. & Holst, Jens Juul, 2016, In: Journal of Molecular Endocrinology. 56, p. 201-211Research output: Contribution to journal › Journal article › Research › peer-review
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Enterohepatic, gluco-metabolic, and gut microbial characterization of individuals with bile acid malabsorption
Kårhus, M. L., Sonne, David Peick, Thomasen, M., Ellegaard, A., Holst, Jens Juul, Rehfeld, Jens Frederik, Chávez-Talavera, O., Tailleux, A., Staels, B., Nielsen, Dennis Sandris, Dragsted, Lars Ove, Vilsbøll, Tina, Brønden, A. & Knop, Filip Krag, 2022, In: Gastro Hep Advances. 1, 3, p. 299-312 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Insulin sensitivity, insulin release and glucagon-like peptide-1 levels in persons with impaired fasting glucose and/or impaired glucose tolerance in the EUGENE2 study
Laakso, M., Zilinskaite, J., Hansen, Torben, Boesgaard, T. W., Vänttinen, M., Stancáková, A., Jansson, P., Pellmé, F., Kuulasmaa, T., Hribal, M. L., Sesti, G., Stefan, N., Fritsche, A., Häring, H., Pedersen, Oluf Borbye, Smith, U., EUGENE2 Consortium, E. C. & Holst, Jens Juul, 2008, In: Diabetologia. 51, 3, p. 502-11 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pancreas and gut hormone responses to oral glucose and intravenous glucagon in cystic fibrosis patients with normal, impaired and diabetic glucose tolerance
Laang, S., Thorsteinsson, B., Røder, M. E., Ørskov, Cathrine, Holst, Jens Juul, Nerup, J. & Koch, C., 1993, In: Acta Endoctrinologica. 128, p. 207-214Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of exogenous glucagon-like peptide-2 and distal bowel resection on intestinal and systemic adaptive responses in rats
Lai, S. W., de Heuvel, E., Wallace, L. E., Hartmann, Bolette, Holst, Jens Juul, Brindle, M. E., Chelikani, P. K. & Sigalet, D. L., 2017, In: PloS one. 12, 7, 20 p., e0181453.Research output: Contribution to journal › Journal article › Research › peer-review
- Accepted/In press
Exogenous glucagon-like peptide 2 counteracts exogenous cholecystokinin-induced gallbladder contraction in healthy men
Lange, A. H., Hansen, N. L., Pedersen, M. G., Nerild, H. H., Rehfeld, Jens Frederik, Hartmann, Bolette, Holst, Jens Juul, Ellegaard, A. & Knop, Filip Krag, 2024, (Accepted/In press) In: The Journal of clinical endocrinology and metabolism.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Afferent Endocrine Control of Eating
Langhans, W. & Holst, Jens Juul, 22 Aug 2016, Neuroendocrinology of Appetite. Dickson, S. L. & Mercer, J. G. (eds.). Wiley-Blackwell, p. 24-54 31 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Gluco-metabolic effects of oral and intravenous alcohol administration in men
Lanng, A. R., Gasbjerg, Lærke Smidt, Bergmann, N. C., Bergmann, S., Heisted, M. M., Gillum, M. P., Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2019, In: Endocrine Connections. 8, 10, p. 1372-1382Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men
Lapauw, B., Ouwens, M., 't Hart, L. M., Wuyts, B., Holst, Jens Juul, T'Sjoen, G., Kaufman, J. & Ruige, J. B., 1 Aug 2010, In: Diabetes Care. 33, 8, p. 1831-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pancreatic α-cell hyperplasia and hyperglucagonemia due to a mutation of the glucagon
Larger, E., Albrechtsen, Nicolai Jacob Wewer, Hansen, L. H., Gelling, R. W., Capeau, J., Deacon, Carolyn F., Madsen, O. D., Yakushiji, F., Meyts, P. D., Holst, Jens Juul & Nishimura, E., 2016, In: Endocrinology, Diabetes & Metabolism Case Reports. 2016, 6 p., EDM160081.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of growth in infancy on body composition, insulin resistance, and concentration of appetite hormones in adolescence
Larnkjær, Anni, Schack-Nielsen, L., Mølgaard, Christian, Ingstrup, H. K., Holst, Jens Juul & Michaelsen, Kim F., 1 Jun 2010, In: American Journal of Clinical Nutrition. 91, 6, p. 1675-83 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulinets vej ind i det danske samfund
Larsen, Erik Hviid & Holst, Jens Juul, 2010, Det fremmede som historisk drivkraft. Danmark efter 1742: Et festskrift til Hendes Majestæt Dronning Margrethe II ved 70-års-fødselsdagen den 16. april 2010. Nielsen, M. A. (ed.). København: Det Kongelige Danske Videnskabernes Selskab, p. 85-94Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
- Published
Effect of Liraglutide Treatment on Prediabetes and Overweight or Obesity in Clozapine- or Olanzapine-Treated Patients With Schizophrenia Spectrum Disorder: A Randomized Clinical Trial
Larsen, J. R., Vedtofte, L., Jakobsen, M. S. L., Jespersen, H. R., Jakobsen, M. I., Svensson, C. K., Koyuncu, K., Schjerning, O., Oturai, P. S., Kjær, Andreas, Nielsen, J., Holst, Jens Juul, Ekstrøm, Claus Thorn, Correll, C. U., Vilsbøll, Tina & Fink-Jensen, Anders, 1 Jul 2017, In: J A M A Psychiatry. 74, 7, p. 719-728 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High prevalence of prediabetes and metabolic abnormalities in overweight or obese schizophrenia patients treated with clozapine or olanzapine
Larsen, J. R., Svensson, C. K., Vedtofte, L., Jakobsen, M. L., Jespersen, H. S., Jakobsen, M. I., Koyuncu, K., Schjerning, O., Nielsen, J., Ekstrøm, Claus Thorn, Holst, Jens Juul, Correll, C. U., Vilsbøll, Tina & Fink-Jensen, Anders, 2019, In: CNS Spectrums. 24, 4, p. 441-452 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Does a GLP-1 receptor agonist change glucose tolerance in patients treated with antipsychotic medications? Design of a randomised, double-blinded, placebo-controlled clinical trial
Larsen, J. R., Vedtofte, L., Holst, Jens Juul, Oturai, P., Kjær, Andreas, Corell, C. U., Vilsbøll, T. & Fink-Jensen, Anders, 2014, In: B M J Open. 4, 3, p. 1-9 9 p., e004227.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduction of beta cell mass: partial insulin secretory compensation from the residual beta cell population in the nicotinamide-streptozotocin Göttingen minipig after oral glucose in vivo and in the perfused pancreas
Larsen, M. O., Rolin, B., Gotfredsen, C. F., Carr, R. D. & Holst, Jens Juul, 2004, In: Diabetologia. 47, p. 1873-1878Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Appetite regulation in overweight, sedentary men after different amounts of endurance exercise: a randomized controlled trial
Larsen, M. R., Reichkendler, M. H., Auerbach, P., Toräng, S., Gram, A. S., Ploug, Thorkil, Holst, Jens Juul, Sjödin, Anders Mikael & Stallknecht, Bente Merete, Dec 2013, In: Journal of Applied Physiology. 115, 11, p. 1599-1609 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cocaine- and amphetamine-regulated transcript is present in hypothalamic neuroendocrine neurones and is released to the hypothalamic-pituitary portal circuit
Larsen, P. J., Seier, V., Fink-Jensen, Anders, Holst, Jens Juul, Warberg, J. & Vrang, N., Mar 2003, In: Journal of Neuroendocrinology. 15, 3, p. 219-26 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Et æble om dagen
Larsen, P. J., Holst, Jens Juul & Astrup, A., 2003, In: Politiken. 29, 2 p.Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication
- Published
Cocaine and amphetamine-regulated transcript (CART) is present in hypothalamic neuroendocrine neurons and is related to the hypothalamo-pituitary portal circuit
Larsen, P. J., Seier, V., Fink-Jensen, A., Holst, Jens Juul, Warberg, J. & Vrang, N., 2003, In: Journal of Neuroendocrinology. 15, p. 219-226Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-related peptide 1 (GLP-1): hormone and neurotransmitter.
Larsen, P. J. & Holst, Jens Juul, 2005, In: Regulatory Peptides. 128, 2, p. 97-107 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem
Larsen, P. J., Tang-Christensen, M., Holst, Jens Juul & Ørskov, Cathrine, 1997, In: Neuroscience. Vol. 77, No. 1, p. 257-270Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distribution and characterization of different molecular products of Pro-somatostatin in the hypothalmus and posterior pituitary lobe of the mongolian gerbil (Meriones unguiculatus)
Larsen, P. J., Bersani, M., Holst, Jens Juul, Møller, M. & Mikkelsen, J. D., 1992, In: Journal of Neuroscience. 12, hæfte 3, p. 946-961Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-1 (GLP-17-36amide) reduces hepatic glucose production indirectly through changes in insulin and glucagon secretion.
Larsson, H., Holst, Jens Juul & Ahrén, B., 1997, In: Acta Phys. Scand.. 160, p. 413-422Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP-1 secretion in acute ischemic stroke: association with functional outcome and comparison with healthy individuals
Larsson, M., Patrone, C., von Euler, M., Holst, Jens Juul & Nathanson, D., 2019, In: Cardiovascular Diabetology. 18, 8 p., 91.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of preceding glucose decline rate on low-dose glucagon efficacy in individuals with type 1 diabetes: A randomized crossover trial
Laugesen, C., Schmidt, S., Holst, Jens Juul, Nørgaard, Kirsten & Ranjan, A. G., 2021, In: Diabetes, Obesity and Metabolism. 23, 4, p. 1057-1062 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oral glucose has little or no effect on appetite and satiety sensations despite a significant gastrointestinal response
Lauritsen, J. V., Bergmann, N., Junker, A. E., Gyldenløve, Mette, Skov, Lone, Gluud, Lise Lotte, Hartmann, Bolette, Holst, Jens Juul, Vilsbøll, Tina & Knop, Filip Krag, 2023, In: European Journal of Endocrinology. 189, 6, p. 619-626 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effect of melatonin on incretin hormones: results from experimental and randomized clinical studies
Lauritzen, E. S., Støy, J., Bæch-Laursen, C., Grarup, Niels, Jessen, N., Hansen, Torben, Møller, N., Hartmann, Bolette, Holst, Jens Juul & Kampmann, U., 2021, In: Journal of Clinical Endocrinology and Metabolism. 106, 12, p. e5109-e5123 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adaptive changes in pancreas post Roux-en-Y gastric bypass induced weight loss
Lautenbach, A., Wernecke, M., Riedel, N., Veigel, J., Yamamura, J., Keller, S., Jung, R., Busch, P., Mann, O., Knop, Filip Krag, Holst, Jens Juul, Meier, J. J. & Aberle, J., Oct 2018, In: Diabetes - Metabolism: Research and Reviews (Print Edition). 34, 7, p. 1-8 e3025.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Altered postprandial motility in chronic pancreatitis: role of malabsorption.
Layer, P., v.d. Ohe, M. R., Grandt, D., Holst, Jens Juul, Jansen, J. B. M. J., Holtmann, G., Keller, J. & Goebell, H., 1997, In: Today in Medicine. Gastroenterology. 112, p. 1624-1634Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Postprandial glucagon-like peptide-1 (GLP-1) release in states of normal and disturbed luminal nutrient digestion.
Layer, P., v d Ohe, M. & Holst, Jens Juul, 1995, Gastrointestinal Tract and Endocrine System. Dordrecht/Boston/London: Kluwer Academic Publishers, p. 547-550Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- Published
Ileal release of glucagonlike peptide-1 (GLP-1): association with inhibition of gastric acid in humans
Layer, P., Holst, Jens Juul, Grandt, D. & Goebell, H., 1995, In: Digestive Disease Science. 40, p. 1074-82Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative effect of orally administered sodium butyrate before or after weaning on growth and several indices of gastrointestinal biology of piglets
Le Gall, M., Gallois, M., Sève, B., Louveau, I., Holst, Jens Juul, Oswald, I. P., Lallès, J. & Guilloteau, P., 2009, In: British Journal of Nutrition. 102, 9, p. 1285-96 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of different doses of exercise and diet-induced weight loss on beta-cell function in type 2 diabetes (DOSE-EX): a randomized clinical trial
Legaard, G. E., Lyngbæk, M. P. P., Almdal, T. P., Karstoft, K., Bennetsen, S. L., Feineis, C. S., Nielsen, N. S., Durrer, C. G., Liebetrau, B., Nystrup, U., Østergaard, M., Thomsen, K., Trinh, B., Solomon, T. P. J., Van Hall, G., Brønd, J. C., Holst, J. J., Hartmann, B., Christensen, R., Pedersen, B. K. & 1 others, , 2023, In: Nature Metabolism. 5, p. 880–895Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control
Lehrskov, L. L., Lyngbaek, M. P., Soederlund, L., Legaard, G. E., Ehses, J. A., Heywood, S. E., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Karstoft, K., Pedersen, Bente Klarlund & Ellingsgaard, H., 2018, In: Cell Metabolism. 27, 6, p. 1201-1211Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial
Lehrskov, L. L., Christensen, R. H., Wedell-Neergaard, A-S., Legaard, G. E., Dorph, E., Larsen, M. K., Henneberg, M., Launbo, N., Fagerlind, S. R., Seide, S. K., Nymand, S., Ball, M., Vinum, N., Dahl, C., Albrechtsen, N. J. W., Holst, J. J., Ried-Larsen, M., Rosenmeier, J. B., Krogh-Madsen, R., Karstoft, K. & 2 others, , 2019, In: Frontiers in Physiology. 10, 11 p., 1249 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The effects of TNF-α on GLP-1-stimulated plasma glucose kinetics
Lehrskov-Schmidt, L., Lehrskov-Schmidt, L., Nielsen, S. T., Holst, Jens Juul, Møller, K. & Solomon, T. P. J., Apr 2015, In: The Journal of clinical endocrinology and metabolism. 100, 4, p. E616-E622 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide-1 inhibits blood-brain glucose transfer in humans
Lerche, S., Brock, B., Rungby, J., Bøtker, H. E., Møller, N., Rodell, A., Bibby, B. M., Holst, Jens Juul, Schmitz, O. & Gjedde, Albert, 2008, In: Diabetes. 57, 2, p. 325-31 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
No increased risk of hypoglycaemic episodes during 48 h of subcutaneous glucagon-like-peptide-1 administration in fasting healthy subjects
Lerche, S., Soendergaard, L., Rungby, J., Moeller, N., Holst, Jens Juul, Schmitz, O. E. & Brock, B., 2008, In: Clinical Endocrinology. 71, 4, p. 500-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ghrelin stimulates gastric emptying and hunger in normal-weight humans
Levin, F., Edholm, T., Schmidt, P. T., Grybäck, P., Jacobsson, H., Degerblad, M., Höybye, C., Holst, Jens Juul, Rehfeld, Jens Frederik, Hellström, P. M. & Näslund, E., Sep 2006, In: The Journal of clinical endocrinology and metabolism. 91, 9, p. 3296-302 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ghrelin stimulates gastric emptying and hunger in normal-weight humans
Levin, F., Edholm, T., Schmidt, P. T., Gryback, P., Jacobsson, H., Degerblad, M., Hoybye, C., Holst, Jens Juul, Rehfeld, J. F., Hellstrom, P. M. & Naslund, E., 2006, In: Journal of Clinical Endocrinology and Metabolism. 91, 9, p. 3296-3302 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Systems signatures reveal unique remission-path of Type 2 diabetes following Roux-en-Y gastric bypass surgery
Li, Q-R., Wang, Z-M., Albrechtsen, N. J. W., Wang, D-D., Su, Z-D., Gao, X-F., Wu, Q-Q., Zhang, H-P., Zhu, L., Li, R-X., Jacobsen, S., Jørgensen, N. B., Dirksen, C., Bojsen-Møller, K. N., Petersen, J. S., Madsbad, S., Clausen, T. R., Diderichsen, B., Chen, L-N., Holst, J. J. & 2 others, , 2018, In: EBioMedicine. 28, p. 234-240 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential action of TGR5 agonists on GLP-2 secretion and promotion of intestinal adaptation in a piglet short bowel model
Lin, S., Stoll, B., Robinson, J., Pastor, J. J., Marini, J. C., Ipharraguerre, I. R., Hartmann, Bolette, Holst, Jens Juul, Cruz, S., Lau, P., Olutoye, O., Fang, Z. & Burrin, D. G., May 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 5, p. G641-G652Research output: Contribution to journal › Journal article › Research › peer-review
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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