Jonas Thue Treebak

Jonas Thue Treebak

Associate Professor


  1. 2021
  2. Published

    Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965

    Ahwazi, Danial, Neopane, K., Markby, G. R., Kopietz, F., Ovens, A. J., Dall, M., Hassing, Anna Skab, Gräsle, P., Alshuweishi, Y., Treebak, Jonas Thue, Salt, I. P., Göransson, O., Zeqiraj, E., Scott, J. W. & Sakamoto, Kei, 2021, In: Biochemical Journal. 478, 15, p. 2977-2997 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

    Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, Orchard, W., Willemsen, N., Jespersen, N. Z., Lundh, M., Sustarsic, E. G., Hallgren, C. M., Frost, M., McGonigle, S., Isidor, Marie Sophie, Broholm, C., Pedersen, Oluf Borbye, Hansen, Jacob B., Grarup, Niels, Hansen, Torben, Kjær, Andreas, Granneman, J. G., Babu, M. M., Calebiro, D., Nielsen, S., Rydén, M., Soccio, R., Rensen, P. C. N., Treebak, Jonas Thue, Schwartz, Thue W., Emanuelli, Brice, Bartolomucci, A., Pfeifer, A., Zechner, R., Schéele, Camilla Charlotte Nielsen, Mandrup, S. & Gerhart-Hines, Z., 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Lysates of Methylococcus capsulatus Bath induce a lean-like microbiota, intestinal FoxP3+RORγt+IL-17+ Tregs and improve metabolism

    Jensen, B. A. H., Holm, J. B., Larsen, I. S., von Burg, N., Derer, S., Sonne, S. B., Pærregaard, S. I., Damgaard, M. V., Indrelid, S. A., Rivollier, A., Agrinier, A. L., Sulek, K., Arnoldussen, Y. J., Fjære, E., Marette, A., Angell, I. L., Rudi, K., Treebak, J. T., Madsen, L., Åkesson, C. P. & 5 others, Agace, W., Sina, C., Kleiveland, C. R., Kristiansen, Karsten & Lea, T. E., 2021, In: Nature Communications. 12, 19 p., 1093.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Mass-spectrometry-based proteomics reveals mitochondrial supercomplexome plasticity

    Gonzalez-Franquesa, A., Stocks, Ben Nicholas, Chubanava, Sabina, Hattel, H. B., Moreno Justicia, Roger, Peijs, Lone, Treebak, Jonas Thue, Zierath, Juleen R & Deshmukh, Atul Shahaji, 2021, In: Cell Reports. 35, 8, 20 p., 109180.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2022
  7. Published

    A randomized placebo-controlled trial of nicotinamide riboside and pterostilbene supplementation in experimental muscle injury in elderly individuals

    Jensen, J. B., Dollerup, O. L., Møller, A. B., Billeskov, T. B., Kellezi, Emilie Dalbram, Chubanava, Sabina, Damgaard, Mads Vargas, Dellinger, R. W., Trošt, K., Moritz, Thomas, Ringgaard, S., Møller, N., Treebak, Jonas Thue, Farup, J. & Jessen, N., 2022, In: JCI insight. 7, 19, 15 p., e158314.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis

    Sato, S., Dyar, K. A., Treebak, J. T., Jepsen, S. L., Ehrlich, A. M., Ashcroft, S. P., Trost, K., Kunzke, T., Prade, V. M., Small, L., Basse, A. L., Schönke, M., Chen, S., Samad, M., Baldi, P., Barrès, R., Walch, A., Moritz, T., Holst, J. J., Lutter, D. & 2 others, Zierath, Juleen R & Sassone-Corsi, P., 2022, In: Cell Metabolism. 34, 2, p. 329-345.e8 26 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Beta-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2

    Holm, Stephanie Kjærulff, Husted, Anna Sofie, Skov, Louise Julie, Morville, T. H., Hagemann, C. A., Jorsal, T., Dall, M., Jakobsen, A., Klein, A. B., Treebak, Jonas Thue, Knop, Filip Krag, Schwartz, Thue W., Clemmensen, Christoffer & Holst, Birgitte, 2022, In: Endocrinology. 163, 6, 13 p., bqac038.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice

    Small, Lewin Barkla, Ehrlich, Amy M, Iversen, Jo Frøkjær, Ashcroft, Stephen Paul, Trošt, K., Moritz, Thomas, Hartmann, Bolette, Holst, Jens Juul, Treebak, Jonas Thue, Zierath, Juleen R & Barrès, Romain, 2022, In: Molecular Metabolism. 57, 8 p., 101440.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Dietary Protein Restriction Improves Metabolic Dysfunction in Patients with Metabolic Syndrome in a Randomized, Controlled Trial

    Ferraz-Bannitz, R., Beraldo, R. A., Peluso, A., Dall, M., Babaei, P., Foglietti, R. C., Martins, L. M., Gomes, P. M., Marchini, J. S., Miguel Suen, V. M., Conti de Freitas, L. C., Navegantes, L. C., Pretti, M. A. M., Boroni, M., Treebak, Jonas Thue, Mori, M. A., Foss, M. C. & Foss-Freitas, M. C., 2022, In: Nutrients. 14, 13, 18 p., 2670.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Dynamic interplay between Afadin S1795 phosphorylation and diet regulates glucose homeostasis in obese mice

    Tozzi, M., Brown, E. L., Petersen, P. S., Lundh, M., Isidor, Marie Sophie, Plucinska, Kaja, Nielsen, Thomas Svava, Agueda Oyarzabal, Marina, Small, Lewin Barkla, Treebak, Jonas Thue & Emanuelli, Brice, 2022, In: The Journal of Physiology. 600, 4, p. 885-902

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Ellagic acid prevents myocardial infarction-induced left ventricular diastolic dysfunction in ovariectomized rats

    Costa, B. M., Mengal, V., Brasil, G. A., Peluso, A. A., Treebak, Jonas Thue, Endlich, P. W., de Almeida, S. A. & de Abreu, G. R., 2022, In: Journal of Nutritional Biochemistry. 105, 9 p., 108990.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Exercise effects on γ3-AMPK activity, Akt substrate of 160 kDa phosphorylation, and glucose uptake in muscle of normal and insulin-resistant female rats

    Wang, H., Arias, E. B., Treebak, Jonas Thue & Cartee, G. D., 2022, In: Journal of Applied Physiology. 132, 1, p. 140-153 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Fasting potentiates insulin-mediated glucose uptake in rested and prior-contracted rat skeletal muscle

    Kido, K., Egawa, T., Watanabe, S., Kawanaka, K., Treebak, Jonas Thue & Hayashi, T., 2022, In: American Journal of Physiology - Endocrinology and Metabolism. 322, 5, p. E425-E435

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    From trainee to trainer: lessons Learned through implementation of a dual-catheter model in mice

    Nielsen, Thomas Svava & Treebak, Jonas Thue, 2022, In: Laboratory Animals. 56, S1, p. 105 1 p., S5C1.2.

    Research output: Contribution to journalConference abstract in journalResearch

  17. Published

    Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes

    Dollet, L., Kuefner, M., Caria, E., Rizo-Roca, D., Pendergrast, L., Abdelmoez, A. M., Karlsson, H. K., Kellezi, Emilie Dalbram, Treebak, Jonas Thue, Harada, J., Näslund, E., Rydén, M., Zierath, Juleen R, Pillon, N. J. & Krook, A., 2022, In: Diabetes. 71, 4, p. 624-636

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Intravenous nicotinamide riboside elevates mouse skeletal muscle NAD+ without impacting respiratory capacity or insulin sensitivity

    Damgaard, Mads Vargas, Nielsen, Thomas Svava, Basse, A. L., Chubanava, Sabina, Trost, K., Moritz, Thomas, Dellinger, R. W., Larsen, Steen & Treebak, Jonas Thue, 2022, In: iScience. 25, 2, 21 p., 103863.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives

    Hochreuter, Mette Yde, Dall, M., Treebak, Jonas Thue & Barrès, Romain, 2022, In: Molecular Metabolism. 65, 17 p., 101581.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    NAD+ and NAFLD - Caution, Causality, and Careful Optimism

    Dall, M., Hassing, Anna Skab & Treebak, Jonas Thue, 2022, In: The Journal of Physiology. 600, 5, p. 1135-1154

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Protocol for qPCR analysis that corrects for cDNA amplification efficiency

    Damgaard, Mads Vargas & Treebak, Jonas Thue, 2022, In: STAR Protocols. 3, 3, 11 p., 101515.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Pterostilbene Fails to Rescue Insulin Secretion and Sensitivity in Multiple Murine Models of Diabetes

    Damgaard, Mads Vargas, Jepsen, Sara Lind, Ashcroft, Stephen Paul, Holst, Jens Juul & Treebak, Jonas Thue, 2022, In: Nutrients. 14, 18, 11 p., 3741.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2023
  24. Published

    NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner

    Basse, A. L., Nielsen, K. N., Karavaeva, Iuliia, Ingerslev, L. R., Ma, Tao, Havelund, J. F., Nielsen, Thomas Svava, Frost, M., Peics, J., Kellezi, Emilie Dalbram, Dall, M., Zierath, Juleen R, Barrès, Romain, Færgeman, N. J., Treebak, Jonas Thue & Gerhart-Hines, Zach, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 14, e2220102120.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans

    Peluso, A. A., Lundgaard, A. T., Babaei, P., Mousovich-Neto, F., Rocha, A. L., Damgaard, M. V., Bak, E. G., Gnanasekaran, T., Dollerup, O. L., Trammell, S. A. J., Nielsen, T. S., Kern, T., Abild, C. B., Sulek, K., Ma, T., Gerhart-Hines, Z., Gillum, M. P., Arumugam, M., Ørskov, C., McCloskey, D. & 4 others, Jessen, N., Herrgård, M. J., Mori, M. A. S. & Treebak, Jonas Thue, 2023, In: npj Aging. 9, 21 p., 7.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity

    Backe, M. B., Andersen, Rita Chan, Jensen, M., Jin, C., Hundahl, C., Dmytriyeva, O., Treebak, Jonas Thue, Hansen, J. B., Gerhart-Hines, Zach, Madsen, Kenneth Lindegaard & Holst, Birgitte, 2023, In: Journal of the endocrine society. 7, 6, p. 1-13 bvad057.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published
  28. Published

    ROS-induced ribosome impairment underlies ZAKα-mediated metabolic decline in obesity and aging

    Snieckute, G., Ryder, L., Vind, A. C., Wu, Z., Arendrup, F. S., Stoneley, M., Chamois, S., Martinez-Val, A., Leleu, M., Dreos, R., Russell, A., Gay, D. M., Genzor, A. V., Choi, B. S-Y., Basse, A. L., Sass, F., Dall, M., Dollet, L. C. M., Blasius, M., Willis, A. E. & 10 others, Lund, Anders H., Treebak, Jonas Thue, Olsen, Jesper Velgaard, Poulsen, Steen Seier, Pownall, M. E., Jensen, Benjamin Anderschou Holbech, Clemmensen, Christoffer, Gerhart-Hines, Zach, Gatfield, D. & Bekker-Jensen, Simon Holst, 2023, In: Science (New York, N.Y.). 382, 6675, 14 p., eadf3208.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Regular exercise effectively protects against the aging-associated decline in skeletal muscle NAD content

    Chubanava, Sabina & Treebak, Jonas Thue, 2023, In: Experimental Gerontology. 173, 112109.

    Research output: Contribution to journalReviewResearchpeer-review

  30. Published

    Seasonal light hours modulate peripheral clocks and energy metabolism in mice

    Small, Lewin Barkla, Lundell, L. S., Iversen, Jo Frøkjær, Ehrlich, Amy M, Dall, M., Basse, A. L., Kellezi, Emilie Dalbram, Hansen, Ann Normann, Treebak, Jonas Thue, Barrès, Romain & Zierath, Juleen R, 2023, In: Cell Metabolism. 35, 10, p. 1722-1735.e5 20 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Sleep-Time eating boosts exercise endurance

    Treebak, Jonas Thue, 2023, In: Life Metabolism. 2, 5, 2 p., load029.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published
  33. Published

    Time of day determines postexercise metabolism in mouse adipose tissue

    Pendergrast, L. A., Lundell, L. S., Ehrlich, Amy M, Ashcroft, Stephen Paul, Schönke, M., Basse, A. L., Krook, A., Treebak, Jonas Thue, Dollet, L. & Zierath, Juleen R, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 8, e2218510120.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    What is really known about the effects of nicotinamide riboside supplementation in humans

    Damgaard, Mads Vargas & Treebak, Jonas Thue, 2023, In: Science Advances. 9, 29, 12 p., eadi4862.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2024
  36. Published

    Effect of resveratrol on insulin action in primary myotubes from lean individuals and individuals with severe obesity

    Park, S., Jevtovic, F., Krassovskaia, P. M., Chaves, A. B., Zheng, D., Treebak, Jonas Thue & Houmard, J. A., 2024, In: American Journal of Physiology - Endocrinology and Metabolism. 326, 3, p. E398-E406 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Metabolic plasticity and obesity-associated changes in diurnal postexercise metabolism in mice

    Pendergrast, L. A., Ashcroft, Stephen Paul, Ehrlich, Amy M, Treebak, Jonas Thue, Krook, A., Dollet, L. & Zierath, Juleen R, 2024, In: Metabolism: Clinical and Experimental. 155, 12 p., 155834.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia

    Membrez, M., Migliavacca, E., Christen, S., Yaku, K., Trieu, J., Lee, A. K., Morandini, F., Giner, M. P., Stiner, J., Makarov, M. V., Garratt, E. S., Vasiloglou, M. F., Chanvillard, L., Dalbram, E., Ehrlich, A. M., Sanchez-Garcia, J. L., Canto, C., Karagounis, L. G., Treebak, J. T., Migaud, M. E. & 15 others, Heshmat, R., Razi, F., Karnani, N., Ostovar, A., Farzadfar, F., Tay, S. K. H., Sanders, M. J., Lillycrop, K. A., Godfrey, K. M., Nakagawa, T., Moco, S., Koopman, R., Lynch, G. S., Sorrentino, V. & Feige, J. N., 2024, In: Nature Metabolism. 6, 3, p. 433–447

    Research output: Contribution to journalLetterResearchpeer-review

  39. E-pub ahead of print

    Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments

    Espino Gonzalez, Ever, Dalbram, E., Mounier, R., Gondin, J., Farup, J., Jessen, N. & Treebak, Jonas Thue, 7 Mar 2024, (E-pub ahead of print) In: Cell Metabolism.

    Research output: Contribution to journalReviewResearchpeer-review

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