Thomas Svava Nielsen

Thomas Svava Nielsen

Research consultant

ORCID: 0000-0002-9457-8000

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  1. Published

    A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes

    Moltke, I., Grarup, N., Jørgensen, M. E., Bjerregaard, P., Treebak, J. T., Fumagalli, M., Korneliussen, T. S., Andersen, M. A., Nielsen, T. S., Krarup, N. T., Gjesing, A. M. P., Zierath, J. R., Linneberg, A., Wu, X., Sun, G., Jin, X., Al-Aama, J., Wang, J., Borch-Johnsen, K., Pedersen, O. & 3 others, Nielsen, R., Albrechtsen, Anders & Hansen, Torben, 2014, In: Nature. 512, 7513, p. 190-193 4 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  2. Published

    Adipose triglyceride lipase and g0/g1 switch gene 2: approaching proof of concept

    Nielsen, Thomas Svava & Møller, N., Mar 2014, In: Diabetes. 63, 3, p. 847-9 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Aerobic and resistance exercise training reverses age-dependent decline in NAD(+) salvage capacity in human skeletal muscle

    de Guia, R. M., Agerholm, M., Nielsen, Thomas Svava, Consitt, L. A., Sogaard, D., Helge, Jørn Wulff, Larsen, Steen, Brandauer, J., Houmard, J. A. & Treebak, Jonas Thue, 2019, In: Physiological Reports. 7, 12, 15 p., e14139.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Age-dependent transition from islet insulin hypersecretion to hyposecretion in mice with the long QT-syndrome loss-of-function mutation Kcnq1-A340V

    Lubberding, Anniek Frederike, Zhang, J., Lundh, M., Nielsen, Thomas Svava, Søndergaard, M. S., Villadsen, M., Skovhøj, E. Z., Boer, G. A., Hansen, J. B., Thomsen, Morten Bækgaard, Treebak, Jonas Thue, Holst, Jens Juul, Kanters, Jørgen K., Mandrup-Poulsen, Thomas, Jespersen, Thomas, Emanuelli, Brice & Torekov, Signe Sørensen, 2021, In: Scientific Reports. 11, 1, 14 p., 12253.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    An abundant biliary fatty acid metabolite derived from dietary omega-3 polyunsaturated fatty acids regulates triglycerides

    Grevengoed, Trisha Jean, Trammell, Sam, Svenningsen, J. S., Makarov, M., Nielsen, Thomas Svava, Jacobsen, Jens Christian Brings, Calder, P. C., Migaud, M. E., Cravatt, B. & Gillum, M. P., 2021, In: Journal of Clinical Investigation. 131, 6, 12 p., e143861.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Assessment of mouse liver [1-13C]pyruvate metabolism by dynamic hyperpolarized MRS

    Faarkrog Høyer, K., Laustsen, C., Ringgaard, S., Qi, H., Mariager, C. Ø., Nielsen, Thomas Svava, Sundekilde, U. K., Treebak, Jonas Thue, Jessen, N. & Stødkilde-Jørgensen, H., 2019, In: Journal of Endocrinology. 242, 3, p. 251-260 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Combined insulin deficiency and endotoxin exposure stimulate lipid mobilization and alter adipose tissue signaling in an experimental model of ketoacidosis in subjects with type 1 diabetes: A randomized, controlled, cross over trial

    Svart, M., Kampmann, U., Voss, T., Pedersen, S. B., Johannsen, M., Rittig, N., Poulsen, P. L., Nielsen, Thomas Svava, Jessen, N. & Møller, N., May 2016, In: Diabetes. 65, 5, p. 1380-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Dietary fat drives whole-body insulin resistance and promotes intestinal inflammation independent of body weight gain

    Jensen, Benjamin Anderschou Holbech, Nielsen, Thomas Svava, Fritzen, Andreas Mæchel, Holm, J. B., Fjære, E., Serup, A. K. L., Borkowski, K., Risis, S., Pærregaard, S. I., Søgaard, I., Poupeau, A. A. G., Poulsen, M., Ma, Tao, Sina, C., Kiens, Bente, Madsen, L., Kristiansen, Karsten & Treebak, Jonas Thue, 2016, In: Metabolism. 65, 12, p. 1706-1719 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Differential regulation of lipid and protein metabolism in obese vs. lean subjects before and after a 72-h fast

    Bak, A. M., Møller, A. B., Vendelbo, M. H., Nielsen, Thomas Svava, Viggers, R., Rungby, Jørgen, Pedersen, S. B., Jørgensen, J. O. L., Jessen, N. & Møller, N., 1 Jul 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 1, p. E224-35 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Discovery of thymosin β4 as a human exerkine and growth factor

    Gonzalez-Franquesa, A., Stocks, Ben Nicholas, Borg, M. L., Kuefner, M., Kellezi, Emilie Dalbram, Nielsen, Thomas Svava, Agrawal, A., Pankratova, Stanislava, Chibalin, A. V., Karlsson, H. K. R., Gheibi, S., Björnholm, M., Jørgensen, Niklas Rye, Clemmensen, Christoffer, Treebak, Jonas Thue, Hostrup, Morten, Krook, A., Zierath, Juleen R & Deshmukh, Atul Shahaji, 2021, In: American Journal of Physiology: Cell Physiology. 321, 5, p. C770-C778 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease

    Nielsen, Thomas Svava, Jessen, N., Jørgensen, J. O. L., Møller, N. & Lund, S., Jun 2014, In: Journal of Molecular Endocrinology. 52, 3, p. R199-R222 24 p.

    Research output: Contribution to journal › Review › Research › peer-review

  12. Published

    Dynamic changes in DICER levels in adipose tissue control metabolic adaptations to exercise

    Brandão, B. B., Madsen, S., Rabiee, A., Oliverio, M., Ruiz, G. P., Ferrucci, D. L., Branquinho, J. L., Razolli, D., Pinto, S., Nielsen, T. S., Festuccia, W. T., Martins, A. S., Guerra, B. A., Knittel, T. L., Søgaard, D., Larsen, S., Helge, J. W., Brandauer, J., Velloso, L. A., Emanuelli, B. & 6 others, Kornfeld, J., Kahn, C. R., Vienberg, S. G., Zierath, Juleen R, Treebak, Jonas Thue & Mori, M. A., 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 38, p. 23932-23941

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Dynamic interplay between Afadin S1795 phosphorylation and diet regulates glucose homeostasis in obese mice

    Tozzi, M., Brown, E. L., Petersen, P. S., Lundh, M., Isidor, Marie Sophie, Plucinska, Kaja, Nielsen, Thomas Svava, Agueda Oyarzabal, Marina, Small, Lewin Barkla, Treebak, Jonas Thue & Emanuelli, Brice, 2022, In: The Journal of Physiology. 600, 4, p. 885-902

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Effects of GH in human muscle and fat

    Jørgensen, J. O. L., Rubeck, K. Z., Nielsen, Thomas Svava, Clasen, B. F. F., Vendelboe, M., Hafstrøm, T. K., Madsen, M. & Lund, S., Apr 2010, In: Pediatric nephrology (Berlin, Germany). 25, 4, p. 705-9 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Effects of insulin-induced hypoglycaemia on lipolysis rate, lipid oxidation and adipose tissue signalling in human volunteers: a randomised clinical study

    Voss, T. S., Vendelbo, M. H., Kampmann, U., Pedersen, S. B., Nielsen, Thomas Svava, Johannsen, M., Svart, M. V., Jessen, N. & Møller, N., Jan 2017, In: Diabetologia. 60, 1, p. 143-52 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Effects of short-term prednisolone treatment on indices of lipolysis and lipase signaling in abdominal adipose tissue in healthy humans

    Ramshanker, N., Jessen, N., Voss, T. S., Pedersen, S. B., Jørgensen, J. O. L., Nielsen, Thomas Svava, Frystyk, J. & Møller, N., 2019, In: Metabolism: Clinical and Experimental. 99, p. 1-10

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Electrical pulse stimulation induces differential responses in insulin action in myotubes from severely obese individuals

    Park, S., Turner, K. D., Zheng, D., Brault, J. J., Zou, K., Chaves, A. B., Nielsen, Thomas Svava, Tanner, C. J., Treebak, Jonas Thue & Houmard, J. A., 2019, In: The Journal of Physiology. 597, 2, p. 449-466

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects

    Christensen, B., Lundby, C., Jessen, N., Nielsen, Thomas Svava, Vestergaard, P. F., Møller, N., Pilegaard, Henriette, Pedersen, S. B., Kopchick, J. J. & Jørgensen, J. O. L., 2012, In: P L o S One. 7, 2, 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Fasting, but not exercise, increases adipose triglyceride lipase (ATGL) protein and reduces G(0)/G(1) switch gene 2 (G0S2) protein and mRNA content in human adipose tissue

    Nielsen, Thomas Svava, Vendelbo, M., Jessen, N., Pedersen, S. B., Jørgensen, J. O. L., Lund, S. & Møller, N., Aug 2011, In: The Journal of clinical endocrinology and metabolism. 96, 8, p. E1293-7

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    From trainee to trainer: lessons Learned through implementation of a dual-catheter model in mice

    Nielsen, Thomas Svava & Treebak, Jonas Thue, 2022, In: Laboratory Animals. 56, S1, p. 105 1 p., S5C1.2.

    Research output: Contribution to journal › Conference abstract in journal › Research

  21. GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance

    Kampmann, U., Christensen, B., Nielsen, Thomas Svava, Pedersen, S. B., Ørskov, L., Lund, S., Møller, N. & Jessen, N., 2011, In: PLOS ONE. 6, 11, p. e27854

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Growth hormone acts along the PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes

    Sharma, V. M., Vestergaard, E. T., Jessen, N., Kolind-Thomsen, P., Nellemann, B., Nielsen, Thomas Svava, Vendelbo, M. H., Møller, N., Sharma, R., Lee, K. Y., Kopchick, J. J., Jørgensen, J. O. L. & Puri, V., 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 1, p. E34-E42

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity

    Nellemann, B., Vendelbo, M. H., Nielsen, Thomas Svava, Bak, A. M., Høgild, M., Pedersen, S. B., Biensø, R. S., Pilegaard, Henriette, Møller, N., Jessen, N. & Jørgensen, J. O. L., 2014, In: Acta Physiologica. 210, 2, p. 392-402 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes

    Dall, M., Hassing, Anna Skab, Niu, Lili, Nielsen, Thomas Svava, Ingerslev, L. R., Sulek, K., Trammell, Sam, Gillum, M. P., Barrès, Romain, Larsen, Steen, Poulsen, Steen Seier, Mann, Matthias, Ørskov, Cathrine & Treebak, Jonas Thue, 2021, In: Journal of Biological Chemistry. 297, 6, 26 p., 101388.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle

    Vendelbo, M., Clasen, B. F. F., Treebak, Jonas Thue, Møller, L., Krusenstjerna-Hafstrøm, T., Madsen, M., Nielsen, Thomas Svava, Stødkilde-Jørgensen, H., Pedersen, S. B., Jørgensen, J. O. L., Goodyear, L. J., Wojtaszewski, Jørgen F P, Møller, N. & Jessen, N., 2012, In: American Journal of Physiology: Endocrinology and Metabolism. 302, 2, p. E190-E200 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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