Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity

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Insulin resistance induced by growth hormone (GH) is linked to promotion of lipolysis by unknown mechanisms. We hypothesized that suppression of the activity of pyruvate dehydrogenase in the active form (PDHa) underlies GH-induced insulin resistance similar to what is observed during fasting.
Original languageEnglish
JournalActa Physiologica
Issue number2
Pages (from-to)392-402
Number of pages11
Publication statusPublished - 2014

ID: 63535152