Kei Sakamoto

Kei Sakamoto

Professor

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    1. Published

      Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site

      Sanders, M. J., Ratinaud, Y., Neopane, K., Bonhoure, N., Day, E. A., Ciclet, O., Lassueur, S., Pinta, M. N., Deak, M., Brinon, B., Christen, S., Steinberg, G. R., Barron, D. & Sakamoto, Kei, 2022, In: Journal of Biological Chemistry. 298, 5, 15 p., 101852.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase

      Nguyen-Tu, M., Harris, J., Martinez-Sanchez, A., Chabosseau, P., Hu, M., Georgiadou, E., Pollard, A., Otero, P., Lopez-Noriega, L., Leclerc, I., Sakamoto, Kei, Schmoll, D., Smith, D. M., Carling, D. & Rutter, G. A., 2022, In: Diabetologia. 65, p. 997-1011 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity

      Fujii, N., Boppart, M. D., Dufresne, S. D., Crowley, P. F., Jozsi, A. C., Sakamoto, Kei, Yu, H., Aschenbach, W. G., Kim, S., Miyazaki, H., Rui, L., White, M. F., Hirshman, M. F. & Goodyear, L. J., 1 Jul 2004, In: American Journal of Physiology - Cell Physiology. 287, 1 56-1, p. C200-C208

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      PEN2: Metformin’s new partner at lysosome

      Sakamoto, Kei & Jessen, N., 2022, In: Cell Research. 32, p. 507-508

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Protor-1 is required for efticient mT0RC2-mediated activation of SGK1 in the kidney

      Pearce, L. R., Sommer, E. M., Sakamoto, Kei, Wullschleger, S. & Alessi, D. R., 15 May 2011, In: Biochemical Journal. 436, 1, p. 169-179 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise

      Li, M., Verdijk, L. B., Sakamoto, Kei, Ely, B., van Loon, L. J. C. & Musi, N., 1 Nov 2012, In: Mechanisms of Ageing and Development. 133, 11-12, p. 655-664 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

      Mauvais-Jarvis, F., Ueki, K., Fruman, D. A., Hirshman, M. F., Sakamoto, Kei, Goodyear, L. J., Iannacone, M., Accili, D., Cantley, L. C. & Ronald Kahn, C., 1 Jan 2002, In: Journal of Clinical Investigation. 109, 1, p. 141-149 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Regulating the Motor for GLUT4 Vesicle Traffic

      Holman, G. D. & Sakamoto, Kei, 5 Nov 2008, In: Cell Metabolism. 8, 5, p. 344-346 3 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    9. Published

      Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes

      Gormand, A., Henriksson, E., Ström, K., Jensen, Thomas Elbenhardt, Sakamoto, Kei & Göransson, O., 2011, In: Journal of Cellular Biochemistry. 112, 5, p. 1364-1375 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Regulation of Dishevelled and β-catenin in rat skeletal muscle: An alternative exercise-induced GSK-3β signaling pathway

      Aschenbach, W. G., Ho, R. C., Sakamoto, Kei, Fujii, N., Li, Y., Kim, Y. B., Hirshman, M. F. & Goodyear, L. J., 17 Jul 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 291, 1, p. E152-E158

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

      Richardson, C., Sakamoto, Kei, De Los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R., 1 Mar 2011, In: Journal of Cell Science. 124, 5, p. 789-800 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle

      Howlett, K. F., Sakamoto, Kei, Garnham, A., Cameron-Smith, D. & Hargreaves, M., 1 Jun 2007, In: Diabetes. 56, 6, p. 1608-1614 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells

      De Meester, C., Timmermans, A. D., Balteau, M., Ginion, A., Roelants, V., Noppe, G., Porporato, P. E., Sonveaux, P., Viollet, B., Sakamoto, Kei, Feron, O., Horman, S., Vanoverschelde, J. L., Beauloye, C. & Bertrand, L., 1 Jan 2014, In: Cardiovascular Research. 101, 1, p. 20-29 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle

      Sakamoto, Kei, Arnolds, D. E., Fujii, N., Kramer, H. F., Hirshman, M. F. & Goodyear, L. J., 24 Nov 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 291, 5, p. E1031-E1037

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P2 in regulating insulin sensitivity defined by knock-in analysis

      Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, Kei & Alessi, D. R., 1 Mar 2011, In: Biochemical Journal. 434, 2, p. 265-274 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart

      Mora, A., Sakamoto, Kei, McManus, E. J. & Alessi, D. R., 27 Jul 2005, In: FEBS Letters. 579, 17, p. 3632-3638 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

      McManus, E. J., Sakamoto, Kei, Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R. & Alessi, D. R., 20 Apr 2005, In: EMBO Journal. 24, 8, p. 1571-1583 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes

      Henriksson, E., Säll, J., Gormand, A., Wasserstrom, S., Morrice, N. A., Fritzen, Andreas Mæchel, Foretz, M., Campbell, D. G., Sakamoto, Kei, Ekelund, M., Degerman, E., Stenkula, K. G. & Göransson, O., 2015, In: Journal of Cell Science. 128, 3, p. 472-486 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. SIKs control osteocyte responses to parathyroid hormone

      Wein, M. N., Liang, Y., Goransson, O., Sundberg, T. B., Wang, J., Williams, E. A., O'Meara, M. J., Govea, N., Beqo, B., Nishimori, S., Nagano, K., Brooks, D. J., Martins, J. S., Corbin, B., Anselmo, A., Sadreyev, R., Wu, J. Y., Sakamoto, K., Foretz, M., Xavier, R. J. & 6 others, Baron, R., Bouxsein, M. L., Gardella, T. J., Divieti-Pajevic, P., Gray, N. S. & Kronenberg, H. M., 19 Oct 2016, In: Nature Communications. 7, 13176.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Salicylic acid: old and new implications for the treatment of type 2 diabetes?

      Rena, G. & Sakamoto, Kei, 1 Jan 2014, In: Diabetology International. 5, 4, p. 212-218 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Silencing Metabolic Disorders by Novel SIRT1 Activators

      Sakamoto, Kei, 9 Jan 2008, In: Cell Metabolism. 7, 1, p. 3-4 2 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    22. Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle

      Sakakibara, I., Wurmser, M., Dos Santos, M., Santolini, M., Ducommun, S., Davaze, R., Guernec, A., Sakamoto, Kei & Maire, P., 5 Sep 2016, In: Skeletal Muscle. 6, 1, 30.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Skeletal muscle

      Markby, G. R. & Sakamoto, Kei, 1 Jan 2021, Autophagy in Health and Disease. Elsevier, p. 213-225 13 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    24. Standardized LC×LC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural Extracts

      Coulerie, P., Ratinaud, Y., Moco, S., Merminod, L., Naranjo Pinta, M., Boccard, J., Bultot, L., Deak, M., Sakamoto, Kei, Queiroz, E. F., Wolfender, J. L. & Barron, D., 23 Nov 2016, In: Journal of Natural Products. 79, 11, p. 2856-2864 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Static stretch increases c-Jun NH 2-terminal kinase activity and p38 phosphorylation in rat skeletal muscle

      Boppart, M. D., Hirshman, M. F., Sakamoto, Kei, Fielding, R. A. & Goodyear, L. J., 9 Jun 2001, In: American Journal of Physiology - Cell Physiology. 280, 2 49-2, p. C352-C358

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Structural basis for the recruitment of glycogen synthase by glycogenin

      Zeqiraj, E., Tang, X., Hunter, R. W., García-Rocha, M., Judd, A., Deak, M., Von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., Sakamoto, Kei & Sicheri, F., 15 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. E2831-E2840

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

      Langendorf, C. G., Ngoei, K. R. W., Scott, J. W., Ling, N. X. Y., Issa, S. M. A., Gorman, M. A., Parker, M. W., Sakamoto, Kei, Oakhill, J. S. & Kemp, B. E., 8 Mar 2016, In: Nature Communications. 7, 10912.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16

      Dixon-Clarke, S. E., Shehata, S. N., Krojer, T., Sharpe, T. D., Von Delft, F., Sakamoto, Kei & Bullock, A. N., 1 Mar 2017, In: Biochemical Journal. 474, 5, p. 699-713 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions

      Lanfranchi, M., Yandiev, S., Meyer-Dilhet, G., Ellouze, S., Kerkhofs, M., Dos Reis, R., Garcia, A., Blondet, C., Amar, A., Kneppers, A., Polvèche, H., Plassard, D., Foretz, M., Viollet, B., Sakamoto, Kei, Mounier, R., Bourgeois, C. F., Raineteau, O., Goillot, E. & Courchet, J., 2024, In: Nature Communications. 15, 17 p., 2487.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser 358 in adipocytes

      Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, Kei & Göransson, O., 15 Jun 2012, In: Biochemical Journal. 444, 3, p. 503-514 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. The Ca2+/calmodulin-dependent kinase kinase β-AMP-activated protein kinase-α1 pathway regulates phosphorylation of cytoskeletal targets in thrombin-stimulated human platelets

      Onselaer, M. B., Oury, C., Hunter, R. W., Eeckhoudt, S., Barile, N., Lecut, C., Morel, N., Viollet, B., Jacquet, L. M., Bertrand, L., Sakamoto, Kei, Vanoverschelde, J. L., Beauloye, C. & Horman, S., Jun 2014, In: Journal of Thrombosis and Haemostasis. 12, 6, p. 973-986 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

      Patel, K., Foretz, M., Marion, A., Campbell, D. G., Gourlay, R., Boudaba, N., Tournier, E., Titchenell, P., Peggie, M., Deak, M., Wan, M., Kaestner, K. H., Göransson, O., Viollet, B., Gray, N. S., Birnbaum, M. J., Sutherland, C. & Sakamoto, Kei, 4 Aug 2014, In: Nature Communications. 5, 4535.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. The Salt-Inducible Kinases: Emerging Metabolic Regulators

      Sakamoto, Kei, Bultot, L. & Göransson, O., Dec 2018, In: Trends in Endocrinology and Metabolism. 29, 12, p. 827-840 14 p.

      Research output: Contribution to journal › Review › Research › peer-review

    34. The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles

      Sakuma, K., Watanabe, K., Sano, M., Uramoto, I., Sakamoto, Kei & Totsuka, T., 5 Aug 1999, In: Biochimica et Biophysica Acta - General Subjects. 1428, 2-3, p. 284-292 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. The adaptive response of transforming growth factor-β2 and -βRII in the overloaded, regenerating and denervated muscles of rats

      Sakuma, K., Watanabe, K., Sano, M., Kitajima, S., Sakamoto, Kei, Uramoto, I. & Totsuka, T., Feb 2000, In: Acta Neuropathologica. 99, 2, p. 177-185 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. The ancient drug salicylate directly activates AMP-activated protein kinase

      Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, Kei, Steinberg, G. R. & Hardie, D. G., 18 May 2012, In: Science. 336, 6083, p. 918-922 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

      Dite, T. A., Ling, N. X. Y., Scott, J. W., Hoque, A., Galic, S., Parker, B. L., Ngoei, K. R. W., Langendorf, C. G., O'Brien, M. T., Kundu, M., Viollet, B., Steinberg, G. R., Sakamoto, Kei, Kemp, B. E. & Oakhill, J. S., 1 Dec 2017, In: Nature Communications. 8, 1, 571.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle

      Howlett, K. F., Mathews, A., Garnham, A. & Sakamoto, Kei, 1 Feb 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 294, 2, p. E401-E407

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise

      Aschenbach, W. G., Suzuki, Y., Breeden, K., Prats Gavalda, Clara, Hirshman, M. F., Dufresne, S. D., Sakamoto, Kei, Vilardo, P. G., Steele, M., Kim, J. H., Jing, S. L., Goodyear, L. J. & DePaoli-Roach, A. A., 2001, In: Journal of Biological Chemistry. 276, 43, p. 39959-67 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

      Desjardins, E. M., Smith, B. K., Day, E. A., Ducommun, S., Sanders, M. J., Nederveen, J. P., Ford, R. J., Pinkosky, S. L., Townsend, L. K., Gutgesell, R. M., Lu, R., Sakamoto, Kei & Steinberg, G. R., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 48, 8 p., e2119824119.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. The repeated bout effect of reduced-load eccentric exercise on elbow flexor muscle damage

      Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Jan 2001, In: European Journal of Applied Physiology. 85, 1-2, p. 34-40 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Thr 649 Ala-AS160 knock-in mutation does not impair contraction/ AICAR-induced glucose transport in mouse muscle

      Ducommun, S., Wang, H. Y., Sakamoto, Kei, MacKintosh, C. & Chen, S., 1 May 2012, In: American Journal of Physiology - Endocrinology and Metabolism. 302, 9, p. E1036-E1043

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Transcription factor EB and TFE3: new metabolic coordinators mediating adaptive responses to exercise in skeletal muscle?

      Markby, G. R. & Sakamoto, Kei, 2020, In: American Journal of Physiology: Endocrinology and Metabolism. 319, 4, p. E763-E768 6 p.

      Research output: Contribution to journal › Review › Research › peer-review

    44. Published

      Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

      Green, C. J., Göransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, Kei & Hundal, H. S., 10 Oct 2008, In: Journal of Biological Chemistry. 283, 41, p. 27653-27667 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b

      Uehara, K., Lee, W. D., Stefkovich, M., Biswas, Dipsikha, Santoleri, D., Whitlock, A. G., Quinn, W., Coopersmith, T., Creasy, K. T., Rader, D. J., Sakamoto, Kei, Rabinowitz, J. D. & Titchenell, P. M., 2024, In: Journal of Clinical Investigation. 134, 7, 13 p., e173782.

      Research output: Contribution to journal › Journal article › Research › peer-review

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