Jens Juul Holst

Jens Juul Holst

Professor

ORCID: 0000-0001-6853-3805

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  1. Published

    Identification, characterization and release of GRP gene-associated peptides from the normal porcine and human gastro-intestinal tract

    Bjørnskov-Bartholdy, L., Bersani, M. & Holst, Jens Juul, 1991, In: Regulatory Peptides. 34, p. 197-209

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Ileal release of glucagonlike peptide-1 (GLP-1): association with inhibition of gastric acid in humans

    Layer, P., Holst, Jens Juul, Grandt, D. & Goebell, H., 1995, In: Digestive Disease Science. 40, p. 1074-82

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Immediate enhancement of first-phase insulin secretion and unchanged glucose effectiveness in patients with type 2 diabetes after Roux-en-Y gastric bypass

    Martinussen, C., Bojsen-Moller, K. N., Dirksen, C., Jacobsen, S. H., Jørgensen, N. B., Kristiansen, V. B., Holst, Jens Juul & Madsbad, Sten, 15 Mar 2015, In: American Journal of Physiology: Endocrinology and Metabolism. 308, 6, p. E535-44 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Immunoassays for the incretin hormones GIP and GLP-1

    Deacon, Carolyn F. & Holst, Jens Juul, 2009, In: Best Practice & Research: Clinical Endocrinology & Metabolism. 23, 4, p. 425-32 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Immunohistochemical detection of ganglia in the rat stomach serosa, containing neurons immunoreactive for gastrin-releasing peptide and vasoactive intestinal peptide

    Poulsen, Steen Seier & Holst, Jens Juul, 1987, In: Histochemistry. 87, 1, p. 47-52 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Immunohistochemical localization of pancreatic spasmolytic polypeptide (PSP) in the pig

    Raaberg, L., Poulsen, Steen Seier, Thim, L. & Holst, Jens Juul, Sep 1992, In: Histochemistry. 98, 2, p. 113-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Immunohistochemical localization of pancreatic spasmolytic polypeptide in the pig

    Rasmussen, T. N., Raaberg, L., Poulsen, S. S., Thim, L. & Holst, Jens Juul, 1992, In: Histochemistry. 98, p. 113-119

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice.

    Sørensen, H., Brand, C. L., Neschen, S., Holst, Jens Juul, Fosgerau, K., Nishimura, E. & Shulman, G. I., 2006, In: Diabetes. 55, 10, p. 2843-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Immunoneutralization of endogenous glucagon with monoclonal glucagon antibody normalizes hyperglycemia in moderately streptozotocin-diabetes rats

    Brand, C. L., Rolin, B., Jørgensen, P. N., Svendsen, J. S. & Holst, Jens Juul, 1994, In: Diabetologia. 37, p. 985-993

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Immunoneutralization of endogenous glucagon-like peptide-2 reduces adaptive intestinal growth in diabetic rats.

    Hartmann, B., Thulesen, J., Hare, K. J., Kissow, Hannelouise, Orskov, C., Poulsen, Steen Seier & Holst, Jens Juul, 2002, In: Regulatory Peptides. 105, 3, p. 173-9 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Impact of Synbiotic Intake on Liver Metabolism in Metabolically Healthy Participants and Its Potential Preventive Effect on Metabolic-Dysfunction-Associated Fatty Liver Disease (MAFLD): A Randomized, Placebo-Controlled, Double-Blinded Clinical Trial

    Mantri, A., Köhlmoos, A., Schelski, D. S., Seel, W., Stoffel-Wagner, B., Krawitz, P., Stehle, P., Holst, Jens Juul, Weber, B., Koban, L., Plassmann, H. & Simon, M. C., 2024, In: Nutrients. 16, 9, 14 p., 1300.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Impact of cereal fibre on glucose regulating factors

    Weickert, M. O., Moehlig, M., Koebnick, C., Holst, Jens Juul, Namsolleck, P., Ristow, M., Osterhoff, M., Rochlitz, H., Rudovich, N., Spranger, J. & Pleiffer, A. F. H., 2005, In: Diabetologia. 48, p. 2343-2353

    Research output: Contribution to journal › Journal article › Research

  13. Published

    Impact of cereal fibre on glucose-regulating factors

    Weickert, M. O., Mohlig, M., Koebnick, C., Holst, Jens Juul, Namsolleck, P., Ristow, M., Osterhoff, M., Rochlitz, H., Rudovich, N., Spranger, J. & Pfeiffer, A. F. H., Nov 2005, In: Diabetologia. 48, 11, p. 2343-53 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Impact of exogenous hyperglucagonemia on postprandial concentrations of gastric inhibitory polypeptide and glucagon-like peptide-1 in humans

    Meier, J. J., Ritter, P. R., Jacob, A., Menge, B. A., Deacon, Carolyn F., Schmidt, W. E., Nauck, M. A. & Holst, Jens Juul, 1 Aug 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 8, p. 4061-5 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance

    Muscelli, E., Mari, A., Natali, A., Astiarraga, B. D., Camastra, S., Frascerra, S., Holst, Jens Juul & Ferrannini, E., 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 6, p. E1144-E1150

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Impact of incretin hormones on beta-cell function in subjects with normal or impaired glucose tolerance

    Muscelli, E., Mari, A., Natali, A., Astiarraga, B. D., Camastra, S., Frascerra, S., Holst, Jens Juul & Ferrannini, E., Dec 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 291, 6, p. E1144-50

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity

    Vrieze, A., Out, C., Fuentes, S., Jonker, L., Reuling, I., Kootte, R. S., van Nood, E., Holleman, F., Knaapen, M., Romijn, J. A., Soeters, M. R., Blaak, E. E., Dallinga-Thie, G. M., Reijnders, D., Ackermans, M. T., Serlie, M. J., Knop, F. K., Holst, J. J., van der Ley, C., Kema, I. P. & 6 others, Zoetendal, E. G., de Vos, W. M., Hoekstra, J. B. L., Stroes, E. S., Groen, A. K. & Nieuwdorp, M., Apr 2014, In: Journal of Hepatology. 60, 4, p. 824-31 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Impact of polymorphism in the β₂-receptor gene on metabolic responses to repeated hypoglycaemia in healthy humans

    Rokamp, K. Z., Holst, Jens Juul, Olsen, N. V., Dela, Flemming, Secher, Niels H., Juul, Anders, Faber, Jens, Wiberg, S., Thorsteinsson, B. & Pedersen-Bjergaard, Ulrik, 2022, In: Journal of Clinical Endocrinology and Metabolism. 107, 8, p. e3194–e3205 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Impact of postprandial glycaemia on health and prevention of disease

    Blaak, E. E., Antoine, J., Benton, D., Björck, I., Bozzetto, L., Brouns, F., Diamant, M., Dye, L., Hulshof, T., Holst, Jens Juul, Lamport, D. J., Laville, M., Lawton, C. L., Meheust, A., Nilson, A., Normand, S., Rivellese, A. A., Theis, S., Torekov, Signe Sørensen & Vinoy, S., 2012, In: Obesity Reviews. 13, 10, p. 923-984

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Impact of the TCF7L2 genotype on risk of hypoglycaemia and glucagon secretion during hypoglycaemia

    Kristensen, P. L., Pedersen-Bjergaard, Ulrik, Due-Andersen, R., Høi-Hansen, T., Grimmeshave, L., Lyssenko, V., Groop, L., Holst, Jens Juul, Vaag, Allan & Thorsteinsson, B., 2016, In: Endocrine Connections. 5, 6, p. 53-60 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Impact of the reconstruction method on delayed gastric emptying after pylorus-preserving pancreaticoduodenectomy: a prospective randomized study

    Tamandl, D., Sahora, K., Prucker, J., Schmid, R., Holst, J., Miholic, J., Goetzinger, P., Gnant, M. & Holst, Jens Juul, Feb 2014, In: World Journal of Surgery. 38, 2, p. 465-75 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Impact of weight loss achieved through a multidisciplinary intervention on appetite in patients with severe obesity

    Coutinho, S. R., Rehfeld, Jens Frederik, Holst, Jens Juul, Kulseng, B. & Martins, C., Jul 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 315, 1, p. E91-E98

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Impaired beta cell sensitivity to incretins in type 2 diabetes is insufficiently compensated by higher incretin response

    Tura, A., Bagger, J. I., Ferrannini, E., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina & Mari, A., Dec 2017, In: Nutrition, Metabolism and Cardiovascular Diseases. 27, 12, p. 1123-1129 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Impaired crosstalk between pulsatile insulin and glucagon secretion in prediabetic individuals

    Rohrer, S., Menge, B. A., Grüber, L., Deacon, Carolyn F., Schmidt, W. E., Veldhuis, J. D., Holst, Jens Juul & Meier, J. J., 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 5, p. E791-E795

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Impaired fasting glycaemia vs impaired glucose tolerance: similar impairment of pancreatic alpha and beta cell function but differential roles of incretin hormones and insulin action

    Faerch, K., Vaag, Allan, Holst, Jens Juul, Glümer, C., Pedersen, Oluf Borbye & Borch-Johnsen, K., 2008, In: Diabetologia. 51, 5, p. 853-61 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

    Schäfer, S. A., Tschritter, O., Machicao, F., Thamer, C., Stefan, N., Gallwitz, B., Holst, Jens Juul, Dekker, J. M., 't Hart, L. M., t'Hart, L. M., Nijpels, G., van Haeften, T. W., Häring, H. U. & Fritsche, A., Dec 2007, In: Diabetologia. 50, 12, p. 2443-50 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms

    Schafer, S. A., Tschritter, O., Machicao, F., Thamer, C., Stefan, N., Gallwitz, B., Holst, Jens Juul, Dekker, J. M., t'Hart, L. M., Nijpels, G., Haeften, T. W. V., Haring, H. U. & Fritsche, A., 2007, In: Diabetologia. 50, 12, p. 2443-2450 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Impaired glucose-induced glucagon suppression after partial pancreatectomy

    Schrader, H., Menge, B. A., Breuer, T. G. K., Ritter, P. R., Uhl, W., Schmidt, W. E., Holst, Jens Juul & Meier, J. J., 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 8, p. 2857-63 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity

    Knop, Filip Krag, Aaboe, K., Vilsbøll, Tina, Vølund, A., Holst, Jens Juul, Krarup, T. & Madsbad, Sten, 2012, In: Diabetes, Obesity and Metabolism. 14, 6, p. 500-510 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Impaired incretin effect is an early sign of glucose dysmetabolism in nondiabetic patients with psoriasis

    Gyldenløve, M., Vilsbøll, Tina, Zachariae, Claus, Holst, Jens Juul, Knop, Filip Krag & Skov, Lone, 11 Nov 2015, In: Journal of Internal Medicine. 278, 6, p. 660-70 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Impaired incretin response after a mixed meal is associated with insulin resistance in nondiabetic men

    Rask, E., Olsson, T., Soderberg, S. & Holst, Jens Juul, 2001, In: Diabetes Care. 24, p. 1640-1645

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects

    Hansen, K. B., Vilsbøll, Tina, Bagger, J. I., Holst, Jens Juul & Knop, Filip Krag, 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 4, p. 1363-70 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Impaired insulin-stimulated nonoxidative glucose metabolism in pancreas-kidney transplant recipients: dose-response effects of insulin on glucose turnover

    Christiansen, E., drb459, drb459, Tibell, A., Hother-Nielsen, O., Holst, Jens Juul, Pedersen, O. & Madsbad, Sten, 1996, In: Diabetes. 45, 9, p. 1267-75 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Impaired intestinal proglucagon processing in mice lacking prohormone convertase 1.

    Ugleholdt, Randi Kjærsgaard, Zhu, X., Deacon, Carolyn F., Ørskov, Cathrine, Steiner, D. F. & Holst, Jens Juul, 2003, In: Endocrinology. 145, 3, p. 1349-55 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Impaired meal-stimulated glucagon-like peptide-2 responses in short bowel patients with intestinal failure

    Jeppesen, P. B., Hansen, B. S., Hartmann, B., Holst, Jens Juul & Mortensen, P. B., 1999, In: Gut. 45, p. 559-563

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Impaired regulation of the incretin effect in patients with type 2 diabetes

    Bagger, J. I., Knop, Filip Krag, Lund, Asger Bach, drb459, drb459, Holst, Jens Juul & Vilsbøll, Tina, 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 3, p. 737-45 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism

    Belda, E., Voland, L., Tremaroli, V., Falony, G., Adriouch, S., Assmann, K. E., Prifiti, E., Aron-Wisnewsky, J., Debedat, J., Le Roy, T., Nielsen, T., Amouyal, C., Andre, S., Andreelli, F., Blueher, M., Chakaroun, R., Chilloux, J., Coelho, L. P., Dao, M. C., Das, P. & 42 others, Fellahi, S., Forslund, S., Galleron, N., Hansen, T. H., Holmes, B., Ji, B., Pedersen, H. K., Phuong Le, Le Chatelier, E., Lewinter, C., Manneras-Holm, L., Marquet, F., Myridakis, A., Pelloux, V., Pons, N., Quinquis, B., Rouault, C., Roume, H., Salem, J., Sokolovska, N., Søndertoft, N. B., Touch, S., Vieira-Silva, S., Galan, P., Holst, Jens Juul, Gøtze, J. P., Køber, Lars Valeur, drb459, drb459, Hansen, Torben, Hercberg, S., Oppert, J., Nielsen, J., Letunic, I., Dumas, M., Stumvoll, M., Pedersen, Oluf Borbye, Bork, P., Ehrlich, S. D., Zucker, J., Baeckhed, F., Raes, J. & Clement, K., 2022, In: Gut. 71, 12, p. 2463-2480 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Implementation of GLP-1 based therapy of type 2 diabetes mellitus using DPP-IV inhibitors.

    Holst, Jens Juul, 2003, In: Advances in Experimental Medicine and Biology. 524, p. 263-79 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Importance of colonic fermentation in short bowel patients. Small intestinal malabsorption of easily digestible carbohydrate

    Olesen, M., Gudmand-Høyer, E., Holst, Jens Juul & Jørgensen, S., 1999, In: Dig. Dis. Sci.. 44, p. 1914-1923

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Importance of endogenous GLP-1 and GIP for postprandial glucose tolerance after Roux-en-Y gastric bypass and sleeve gastrectomy surgery

    Hindso, M., Hedback, N., Moller, A., Svane, M. S., Martinussen, C., Jorgensen, N. B., Dirksen, C., Gasbjerg, Lærke Smidt, Kristiansen, V. B., Hartmann, Bolette, Rosenkilde, Mette, Holst, Jens Juul, Madsbad, Sten & Bojsen-Moller, K. N., 2021, In: Diabetologia. 64, SUPPL 1, p. 200-201 387.

    Research output: Contribution to journal › Conference abstract in journal › Research

  41. Published

    Importance of small bowel peptides for the improved glucose metabolism 20 years after jejunoileal bypass for obesity

    Naslund, E., Backman, L., Holst, Jens Juul, Theodorsson, E. & Hellstrom, P. M., 1998, In: Obes. Surg.. 8, p. 253-260

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Important species differences regarding lymph contribution to gut hormone responses

    Hansen, M., Hjøllund, K. R., Hartmann, Bolette, Plamboeck, A., Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, Sep 2015, In: Peptides. 71, p. 28-31 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Improved glucagon tolerance and insulin secretion by inhibition of dipeptidyl peptidase IV in mice

    Ahrén, B., Holst, Jens Juul, Mårtensson, H. & Balkan, B., 2000, In: Eur. J. Pharmacol.. 404, p. 239-245

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Improved tolerance to sequential glucose loading (Staub-Traugott effect): size and mechanisms

    Bonuccelli, S., Muscelli, E., Gastaldelli, A., Barsotti, E., Astiarraga, B. D., Holst, Jens Juul, Mari, A. & Ferrannini, E., 2009, In: American Journal of Physiology: Endocrinology and Metabolism. 297, 2, p. E532-7

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

    Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., Knop, F. K., Blaak, E. E., Zhao, J., Smidt, H., Harms, A. C., Hankemeijer, T., Bergman, J. J. G. H. M., Romijn, H. A., Schaap, F. G., Olde Damink, S. W. M. & 8 others, Ackermans, M. T., Dallinga-Thie, G. M., Zoetendal, E., de Vos, W. M., Serlie, M. J., Stroes, E. S. G., Groen, A. K. & Nieuwdorp, M., Oct 2017, In: Cell Metabolism. 26, 4, p. 611-619.e6 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Improvements in glucose metabolism early after gastric bypass surgery are not explained by increases in total bile acids and fibroblast growth factor 19 concentrations

    Jørgensen, N. B., Dirksen, C., Bojsen-Møller, K. N., Kristiansen, V. B., Wulff, B. S., Rainteau, D., Humbert, L., Rehfeld, Jens Frederik, Holst, Jens Juul, Madsbad, Sten & Clausen, T. R., Mar 2015, In: The Journal of clinical endocrinology and metabolism. 100, 3, p. E396-406 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    In Vivo Inhibition of Dipeptidyl Peptidase 4 Allows Measurement of GLP-1 Secretion in Mice

    Smits, Mark, Galsgaard, Katrine Douglas, Jepsen, Sara Lind, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette & Holst, Jens Juul, 2024, In: Diabetes. 73, 5, p. 671-681

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    In patients with controlled acromegaly, indices of glucose homeostasis correlate with IGF-1 levels rather than with type of treatment

    Decock, A., Verroken, C., Van de Velde, F., Vilsbøll, Tina, Holst, Jens Juul, T’Sjoen, G. & Lapauw, B., 2021, In: Clinical Endocrinology. 95, 1, p. 65-73

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    In the rat pancreas, somatostatin tonically inhibits glucagon secretion and is required for glucose-induced inhibition of glucagon secretion

    Xu, S. F. S., Andersen, Daniel Bjørklund, Izarzugaza, J. M. G., Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2020, In: Acta Physiologica. 229, 3, 15 p., e13464.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    In vivo and in vitro degradation of glucagon-like peptide-2 in humans

    Hartmann, B., Harr, M. B., Jeppesen, P. B., Wojdemann, M., Deacon, Carolyn F., Mortensen, P. B. & Holst, Jens Juul, 2000, In: Journal of Clinical Endocrinology and Metabolism. 85, p. 2884-2888

    Research output: Contribution to journal › Journal article › Research › peer-review

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