Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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Insulintropic actions of intravenous glucagon-like peptide-1 (GLP-1) (7-36 amide) in the fasting state in healthy subjects
Qualmann, C., Nauck, M. A., Holst, Jens Juul, Ørskov, Cathrine & Creutzfeldt, W., 1995, In: Acta Diabetologica. 32, p. 13-16Research output: Contribution to journal › Journal article › Research › peer-review
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Intake of Lactobacillus reuteri Improves Incretin and Insulin Secretion in Glucose-Tolerant Humans: A Proof of Concept
Simon, M., Strassburger, K., Nowotny, B., Kolb, H., Nowotny, P., Burkart, V., Zivehe, F., Hwang, J., Stehle, P., Pacini, G., Hartmann, Bolette, Holst, Jens Juul, MacKenzie, C., Bindels, L. B., Martinez, I., Walter, J., Henrich, B., Schloot, N. C. & Roden, M., 2015, In: Diabetes Care. 38, 10, p. 1827-34 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells
Schmidt, S. F., Madsen, J. G. S., Frafjord, K. Ø., Poulsen, L. L. C., Salö, S., Boergesen, M., Loft, A., Larsen, B. D., Madsen, M. S., Holst, Jens Juul, Maechler, P., Dalgaard, L. T. & Mandrup, S., 30 Aug 2016, In: Cell Reports. 16, 9, p. 2359-72 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition
Feng, Y., Demehri, F. R., Xiao, W., Tsai, Y., Jones, J. C., Brindley, C. D., Threadgill, D. W., Holst, Jens Juul, Hartmann, Bolette, Barrett, T. A., Teitelbaum, D. H. & Dempsey, P. J., May 2017, In: Cellular and Molecular Gastroenterology and Hepatology. 3, 3, p. 447-468 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Interleukin-6 Delays Gastric Emptying in Humans with Direct Effects on Glycemic Control
Lehrskov, L. L., Lyngbaek, M. P., Soederlund, L., Legaard, G. E., Ehses, J. A., Heywood, S. E., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Karstoft, K., Pedersen, Bente Klarlund & Ellingsgaard, H., 2018, In: Cell Metabolism. 27, 6, p. 1201-1211Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal Adaptation upon Chemotherapy-Induced Intestinal Injury in Mice Depends on GLP-2 Receptor Activation
Billeschou, Anna, Dal, Jenna Elizabeth Hunt, Ghimire, A., Holst, Jens Juul & Kissow, Hannelouise, 2021, In: Biomedicines. 9, 1, 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors
Dal, Jenna Elizabeth Hunt, Yassin, M., Olsen, Jørgen, Hartmann, Bolette, Holst, Jens Juul & Kissow, Hannelouise, 2021, In: Frontiers in Endocrinology. 12, 7 p., 695145.Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal Growth in Glucagon Receptor Knockout Mice is Not Associated with the Formation of Aom/DSS-Induced Tumours
Dal, Jenna Elizabeth Hunt, Yassin, M., Olsen, Jørgen, Windeløv, Johanne Agerlin, Galsgaard, Katrine Douglas, Holst, Jens Juul & Kissow, Hannelouise, 1 May 2019, In: Gastroenterology. 156, 6 (S1), 1 p., S-692.Research output: Contribution to journal › Conference abstract in journal › Research
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Intestinal adaptation is stimulated by partial enteral nutrition supplemented with the prebiotic short-chain fructooligosaccharide in a neonatal intestinal failure piglet model
Barnes, J. L., Hartmann, Bolette, Holst, Jens Juul & Tappenden, K. A., Sep 2012, In: Journal of Parenteral and Enteral Nutrition. 36, 5, p. 524-37 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal growth adaptation and glucagon-like peptide 2 in rats with ileal--jejunal transposition or small bowel resection
Thulesen, J., Hartmann, Bolette, Kissow, Hannelouise, Jeppesen, Palle Bekker, Ørskov, Cathrine, Holst, Jens Juul & Poulsen, Steen Seier, 2001, In: Digestive Diseases and Sciences. 46, 2, p. 379-88 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal growth adaptation and glucagon-like peptide 2 in rats with ileal-jejunal transposition or small bowel resection
Thulesen, J., Hartmann, B., Kissow, H., Jeppesen, P. B., Ørskov, Cathrine, Holst, Jens Juul & Poulsen, Steen Seier, 2001, In: Digestive Diseases and Sciences. 46 (2), p. 379-388Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal nutrient absorption in newborn pigs in response to enteral nutrition or treatment with glucagon-like peptide 2
Elnif, J., Buddington, R. K., Petersen, Y. M., Hartmann, B., Holst, Jens Juul, Schmidt, M., Burrin, D. G. & Sangild, Per Torp, 2001, Ikke angivet. Lindberg, J. E., Ogle & B. (eds.). CABI Publishing, p. 37-39 3 p.Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research
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Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study
Robertson, M. A., Sigalet, D. L., Holst, Jens Juul, Meddings, J. B., Wood, J. & Sharkey, K. A., Jul 2008, In: Journal of Autism and Developmental Disorders. 38, 6, p. 1066-71 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study
Robertson, M. A., Sigalet, D. L., Holst, Jens Juul, Meddings, J. B., Wood, J. & Sharkey, K. A., 2008, In: Journal of Autism and Developmental Disorders. 38, 6, p. 1066-1071 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Intestinal sensing and handling of dietary lipids in gastric bypass-operated patients and matched controls
Martinussen, C., Dirksen, C., Bojsen-Møller, K. N., Svane, M. S., Carlsson, E. R., Hartmann, Bolette, Clausen, T. R., Veedfald, Simon, Kristiansen, V. B., Rehfeld, Jens Frederik, Hansen, Harald S., Holst, Jens Juul & Madsbad, Sten, 2020, In: American Journal of Clinical Nutrition. 111, 1, p. 28-41Research output: Contribution to journal › Journal article › Research › peer-review
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Intravenous glucagon-like peptide 1 (GLP-1) normalizes blood glucose after major surgery in patients with type 2 diabetes
Meier, J. J., Weyhe, D., Michaely, M., Senkal, M., Zumtobel, V., Nauck, M. A., Holst, Jens Juul, Schmidt, W. E. & Gallwitz, B., 2004, In: Critical Care Medicine. 32, p. 848-851Research output: Contribution to journal › Journal article › Research › peer-review
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Intravenous glucagon-like peptide 1 normalizes blood glucose after major surgery in patients with type 2 diabetes
Meier, J. J., Weyhe, D., Michaely, M., Senkal, M., Zumtobel, V., Nauck, M. A., Holst, Jens Juul, Schmidt, W. E. & Gallwitz, B., Mar 2004, In: New Horizons (Baltimore). 32, 3, p. 848-51 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development
Petersen, Y. M., Hartmann, Bolette, Holst, Jens Juul, Le Huerou-Luron, I., Bjørnvad, Charlotte Reinhard & Sangild, Per Torp, Jun 2003, In: Journal of Nutrition. 133, 6, p. 1781-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Introduction of enteral food increases plasma GLP-2 and decreases GLP-2 receptor mRNA abundance during pig development
Petersen, Y. M., Hartmann, B., Holst, Jens Juul, Le Huërou-Luron, I., Bjørnvad, Charlotte Reinhard & Sangild, Per Torp, 2003, In: Journal of Nutrition. 133, 6, p. 1781-1786 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Investigating Intestinal Glucagon after Roux-en-Y Gastric Bypass Surgery
Jorsal, T., Wewer Albrechtsen, N. J., Christensen, M. M., Mortensen, B., Wandall, E., Langholz, E., Friis, S., Worm, D., Ørskov, C., Støving, R. K., Andries, A., Juhl, C. B., Sørensen, F., Forman, J. L., Falkenhahn, M., Musholt, P. B., Theis, S., Larsen, P. J., Holst, J. J., Vrang, N. & 3 others, , 2019, In: Journal of Clinical Endocrinology and Metabolism. 104, 12, p. 6403–6416 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Investigating the roles of hyperglycaemia, hyperinsulinaemia and elevated free fatty acids in cardiac function in patients with type 2 diabetes via treatment with insulin compared with empagliflozin: Protocol for the HyperCarD2 randomised, crossover trial
Thirumathyam, R., Richter, Erik A., Goetze, Jens P. , Fenger, M., van Hall, Gerrit, Dixen, Ulrik, Holst, Jens Juul, Madsbad, Sten, Vejlstrup, N., Madsen, Per & Jørgensen, N. B., 2022, In: B M J Open. 12, 8, 10 p., e054100.Research output: Contribution to journal › Journal article › Research › peer-review
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Involvement of endogenous glucagon-like peptide-1 in regulation of gastric motility and pancreatic endocrine secretion
Witte, A., Grybäck, P., Jacobsson, H., Näslund, E., Hellström, P. M., Holst, Jens Juul, Hilsted, Linda & Schmidt, P. T., 2011, In: Scandinavian Journal of Gastroenterology. Supplement. 46, 4, p. 428-35 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Is glucagon‐like peptide‐1 fully protected by the dipeptidyl peptidase 4 inhibitor sitagliptin when administered to patients with type 2 diabetes?
Andersen, E. S., Lund, A., Bagger, J. I., Andreasen, C., Grøndahl, M., Deacon, Carolyn F., Hartmann, Bolette, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, Aug 2018, In: Diabetes, Obesity and Metabolism. 20, 8, p. 1937-1943Research output: Contribution to journal › Journal article › Research › peer-review
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Is there a place for incretin therapies in obesity and prediabetes?
Holst, Jens Juul & Deacon, Carolyn F., 13 Feb 2013, In: Trends in Endocrinology and Metabolism. 24, 3, p. 145-152 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Islet-cell dysfunction induced by glucocorticoid treatment: potential role for altered sympathovagal balance?
van Raalte, D. H., Kwa, K. A. A., van Genugten, R. E., Tushuizen, M. E., Holst, Jens Juul, Deacon, Carolyn F., Karemaker, J. M., Heine, R. J., Mari, A. & Diamant, M., 2013, In: Metabolism. 62, 4, p. 568-577 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Isolated organs as replacements for vertebrate animals
Holst, Jens Juul, 1994, Handbook of Laboratory Animal Science. USA: CRC Press, p. 397-408Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Isolation and molecular characterization of porcine calcitonin gene-related peptide (CGRP) and its endocrine effects in the porcine pancreas
Rasmussen, T. N., Bersani, M., Schmidt, P., Thim, L., Kofod, H., Jørgensen, P. N., Poulsen, Steen Seier & Holst, Jens Juul, Mar 1998, In: Pancreas. 16, 2, p. 195-204 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Jan Fahrenkrug (6/6 1947 – 10/11 2021)
Rehfeld, Jens Frederik, Hannibal, Jens, Holst, Jens Juul, Hökfelt, T., de Muckadell, O. B. S. & Schwartz, Thue W., 2022, In: Peptides. 150, 170771.Research output: Contribution to journal › Editorial › Research
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Jejunal feeding is followed by a greater rise in plasma cholecystokinin, peptide YY, glucagon-like peptide 1, and glucagon-like peptide 2 concentrations compared with gastric feeding in vivo in humans: a randomized trial
Luttikhold, J., van Norren, K., Rijna, H., Buijs, N., Ankersmit, M., Heijboer, A. C., Gootjes, J., Hartmann, Bolette, Holst, Jens Juul, van Loon, L. J. & van Leeuwen, P. A., Feb 2016, In: The American Journal of Clinical Nutrition. 103, 2, p. 435-43 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide (GIP) in patients with type 2 diabetes
Aaboe, K., Knop, Filip Krag, Vilsbøll, Tina, Vølund, A., Simonsen, U., Deacon, Carolyn F., Madsbad, Sten, Holst, Jens Juul & Krarup, T., 2009, In: Journal of Clinical Endocrinology and Metabolism. 94, 2, p. 603-608Research output: Contribution to journal › Journal article › Research › peer-review
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KATP channel closure ameliorates the impaired insulinotropic effect of glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
Aaboe, K., Knop, Filip Krag, Vilsboll, T., Vølund, A., Simonsen, U., Deacon, Carolyn F., Madsbad, Sten, Holst, Jens Juul & Krarup, T., 2008, In: Journal of Clinical Endocrinology and Metabolism. 94, 2, p. 603-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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KCNQ1 Long QT syndrome patients have hyperinsulinemia and symptomatic hypoglycemia
Torekov, Signe Sørensen, Iepsen, E., Christiansen, M., Linneberg, Allan René, Pedersen, Oluf Borbye, Holst, Jens Juul, Kanters, Jørgen K. & Hansen, Torben, Apr 2014, In: Diabetes. 63, 4, p. 1315-1325 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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KU bestemmer selv over sin forskning
Wewer, Ulla M., Holst, Jens Juul, Schwartz, Thue W. & Quistorff, B., 2 Jun 2011, In: Universitetsavisen.Research output: Contribution to journal › Contribution to newspaper - Comment/debate › Communication
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Kardiale virkninger af glukagonlignende peptid 1
Holst, Jens Juul, 11 Oct 2010, In: Ugeskrift for Laeger. 172, 41, p. 2821 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Kirurgisk behandling af type 2-diabetes
Olesen, S. C., Hansen, D. L., Almdal, Thomas Peter, Bendtsen, Flemming, Nordgaard, I., Hvolris, L. E., Holst, Jens Juul, Naver, L. & Madsbad, Sten, 2009, In: Ugeskrift for læger. 171, 8, p. 615-7 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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L cell secretory responses after gastric bypass surgery can be imitated in un-operated individuals by modulating carbohydrate digestion
Martinussen, C., Bojsen-Moller, K. N., Dirksen, C., Svane, M. S., Holst, Jens Juul & Madsbad, Sten, 2018, In: Diabetologia. 61, S1, p. S124-S125 244.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion
Kuhre, Rune Ehrenreich, Modvig, Ida Marie, Jepsen, Sara Lind, Kizilkaya, Hüsün Sheyma, Bæch-Laursen, C., Smith, C. A., Reimann, F., Gribble, F. M., Rosenkilde, Mette & Holst, Jens Juul, 2021, In: Frontiers in Endocrinology. 12, 12 p., 690387.Research output: Contribution to journal › Journal article › Research › peer-review
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L-glutamine and whole protein restore first-phase insulin response and increase glucagon-like Peptide-1 in type 2 diabetes patients
Samocha-Bonet, D., Chisholm, D. J., Holst, Jens Juul & Greenfield, J. R., 2015, In: Nutrients. 7, 4, p. 2101-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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LEAP2 reduces postprandial glucose excursions and ad libitum food intake in healthy men
Hagemann, C. A., Jensen, M. S., Holm, Stephanie Kjærulff, Gasbjerg, Lærke Smidt, Byberg, Sarah, Skov-Jeppesen, Kirsa, Hartmann, Bolette, Holst, Jens Juul, Dela, Flemming, Vilsbøll, Tina, Christensen, Mikkel Bring, Holst, Birgitte & Knop, Filip Krag, 2022, In: Cell Reports Medicine. 3, 4, 100582.Research output: Contribution to journal › Journal article › Research › peer-review
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Lactobacillus paracasei subsp paracasei L. casei W8 suppresses energy intake acutely
Bjerg, A. T., Kristensen, M. B., Ritz, C., Holst, Jens Juul, Rasmussen, C., Leser, T. D., Wellejus, A. & Astrup, A., 2014, In: Appetite. 82, p. 111-118 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Leptin Serum Levels are Associated With GLP-1 Receptor Agonist-Mediated Effects on Glucose Metabolism in Clozapine-or Olanzapine-Treated, Prediabetic, Schizophrenia Patients
Tomasik, J., Rustogi, N., Larsen, J. R., Jakobsen, M. I., Svensson, C. K., Vedtofte, L., Jakobsen, M. S. L., Jespersen, H. R., Koyuncu, K., Schjerning, O., Nielsen, Jimmi, Ekstrøm, Claus Thorn, Correll, C. U., Holst, Jens Juul, Vilsbøll, Tina, Bahn, S. & Fink-Jensen, Anders, 2020, In: Schizophrenia Bulletin Open. 1, 1, 11 p., sgaa044.Research output: Contribution to journal › Journal article › Research › peer-review
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Leptin og dens betydning for vægtvedligeholdelse
Iepsen, E. P. W., Torekov, Signe Sørensen & Holst, Jens Juul, 2012, In: Klinisk biokemi i Norden. 24, 4, p. 8-15 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus
Rauch, T., Graefe-Mody, U., Deacon, Carolyn F., Ring, A., Holst, Jens Juul, Woerle, H., Dugi, K. A. & Heise, T., Nov 2012, In: Diabetes Therapy. 3, 1, p. 10Research output: Contribution to journal › Journal article › Research › peer-review
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Linagliptin, a selective DPP-4 inhibitor, inhibits DPP-4, increases incretin levels, lowers glucagon, and improves glycaemic control in patients with Type 2 diabetes.
Rauch, T., Graefe-Mody, U., Deacon, Carolyn F., Ring, A., Holst, Jens Juul, Woerle, H., Dugi, K. & Heise, T., 2012, In: Diabetes Therapy. 3, 1, p. 10Research output: Contribution to journal › Journal article › Research › peer-review
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Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes
Deacon, Carolyn F. & Holst, Jens Juul, 2010, In: Expert Opinion on Investigational Drugs. 19, 1, p. 133-140 8 p.Research output: Contribution to journal › Review › Research › peer-review
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Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes
Deacon, Carolyn F. & Holst, Jens Juul, Jan 2010, In: Expert Opinion on Investigational Drugs. 19, 1, p. 133-40 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide Treatment Is Associated with a Low Frequency and Magnitude of Antibody Formation with No Apparent Impact on Glycemic Response or Increased Frequency of Adverse Events: Results from the Liraglutide Effect and Action in Diabetes (LEAD) trials
Buse, J. B., Garber, A., Rosenstock, J., Schmidt, W. E., Brett, J. H., Videbæk, N., Holst, Jens Juul & Nauck, M., 2011, In: Journal of Clinical Endocrinology and Metabolism. 96, 6, p. 1695-702 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide as adjunct to insulin treatment in type 1 diabetes does not interfere with glycaemic recovery or gastric emptying rate during hypoglycaemia: a randomised, placebo-controlled, double-blind, parallel-group study
Frandsen, C. S., Dejgaard, T. F., Andersen, H. U., Holst, Jens Juul, Hartmann, Bolette, Thorsteinsson, B. & Madsbad, Sten, 17 Mar 2017, In: Diabetes, Obesity and Metabolism. 19, 6, p. 773-782 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide changes postprandial responses of gut hormones involved in the regulation of gallbladder motility
Nerild, H. H., Brønden, Andreas, Gether, I. M., Hellmann, P. H., Baekdal, M., Gillum, M. P., Svenningsen, J. S., Hartmann, Bolette, Rathor, N., Kudiyanur Muniraju, H. A., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina, Sonne, David Peick & Knop, Filip Krag, 2023, In: Diabetes, Obesity and Metabolism. 25, 6, p. 1632-1637Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide decreases postprandial fibroblast growth factor 19 and glucagon-like peptide 2, and increases postprandial cholecystokinin in individuals with obesity
Bronden, A., Nerild, H. H., Nexoe-Larsen, C. C., Hellmann, P. H., Baekdal, M., Gether, I. M., Gillum, M. P., Hartmann, Bolette, Knudsen, L. B., Jacobsen, L. V., Rehfeld, Jens Frederik, Holst, Jens Juul, Vilsbøll, Tina, Sonne, D. P. & Knop, Filip Krag, 2021, In: Diabetologia. 64, SUPPL 1, p. 94-94 177.Research output: Contribution to journal › Conference abstract in journal › Research
ID: 4207
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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