Jens Juul Holst
Professor
Endocrinology and Metabolism
Blegdamsvej 3
2200 København N.
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Liraglutide for Type 2 diabetes and obesity: a 2015 update
Iepsen, E. P. W., Torekov, Signe Sørensen & Holst, Jens Juul, 2015, In: Expert Review of Cardiovascular Therapy. 13, 7, p. 753-67 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide for treating type 1 diabetes
Dejgaard, T. F., Frandsen, C. S., Holst, Jens Juul & Madsbad, Sten, Apr 2016, In: Expert Opinion on Biological Therapy. 16, 4, p. 579-90 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide improves the beta-cell function without increasing insulin secretion during a mixed meal in patients, who exhibit well-controlled type 2 diabetes and coronary artery disease
Anholm, C., Kumarathurai, P., Jurs, A., Pedersen, L. R., Nielsen, Olav Wendelboe, Kristiansen, O. P., Fenger, M., Holst, Jens Juul, Madsbad, Sten, Sajadieh, Ahmad & Haugaard, Steen Bendix, 2019, In: Diabetology & Metabolic Syndrome. 11, 12 p., 42.Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide preserved insulin secretion in adults with newly diagnosed type 1 diabetes: the NewLira trial: [Meeting Abstract}
Dejgaard, T. F., Frandsen, C., Kielgast, U., Andersen, H. U., Thorsteinsson, B., Krarup, T., Holst, Jens Juul & Madsbad, Sten, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S75-S75 145.Research output: Contribution to journal › Conference abstract in journal › Research
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Liraglutide treatment for the prevention of glucose tolerance deterioration in women with prior gestational diabetes mellitus: A 52-week randomized controlled clinical trial
Foghsgaard, S., Vedtofte, L., Andersen, E. S., Bahne, E., Andreasen, C., Sørensen, A. L., Forman, Julie Lyng, Mathiesen, Elisabeth, Svare, J. A., Clausen, Tine Dalsgaard, Damm, Peter, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2023, In: Diabetes, Obesity and Metabolism. 26, 1, p. 201-214 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Liraglutide-Induced Weight Loss May be Affected by Autonomic Regulation in Type 1 Diabetes
Hansen, C. S., Frandsen, C. S., Fleischer, J., Vistisen, D., Holst, Jens Juul, Tarnow, L., Knop, Filip Krag, Madsbad, Sten, Andersen, H. U. & Dejgaard, T. F., 2019, In: Frontiers in Endocrinology. 10, 9 p., 242.Research output: Contribution to journal › Journal article › Research › peer-review
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Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls
Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., Kurose, T., Deacon, Carolyn F., Holst, Jens Juul, Hirano, T., Inagaki, N. & Seino, Y., Jan 2010, In: Journal of Diabetes Investigation. 1, 1/2, p. 56-59Research output: Contribution to journal › Journal article › Research › peer-review
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Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls
Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., Kurose, T., Deacon, Carolyn F., Holst, Jens Juul, Hirano, T., Inagaki, N. & Seino, Y., 22 Apr 2010, In: Journal of Diabetes Investigation. 1, 1-2, p. 56-9 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lixisenatide for type 2 diabetes mellitus
Christensen, M., Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 2011, In: Expert Opinion on Investigational Drugs. 20, 4, p. 549-57 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lixisenatide in type 1 diabetes: A randomised control trial of the effect of lixisenatide on post-meal glucose excursions and glucagon in type 1 diabetes patients
Ballav, C., Dhere, A., Kennedy, I., Agbaje, O. F., White, S., Franklin, R., Hartmann, Bolette, Holst, Jens Juul, Holman, R. R. & Owen, K. R., 2020, In: Endocrinology, Diabetes and Metabolism. 3, 3, 9 p., e00130.Research output: Contribution to journal › Journal article › Research › peer-review
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Lixisenatide, a novel GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus
Christensen, M., Knop, Filip Krag, Holst, Jens Juul & Vilsboll, T., 2009, In: IDrugs. The Investigational Drugs Journal. 12, 8, p. 503-13 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Localisation and neural control of the release of calcitonin gene-related peptide (CGRP) from the isolated perfused porcine ileum
Rasmussen, T. N., Schmidt, P., Poulsen, S. S., Holst, Jens Juul & Poulsen, Steen Seier, 20 Apr 2001, In: Regulatory Peptides. 98, 3, p. 137-143 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Localization in the gastrointestinal tract of immunoreactive prosomatostatin
Holst, Jens Juul & Poulsen, Steen Seier, Nov 1987, In: Regulatory Peptides. 19, 3-4, p. 183-95 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Long-acting agonists of human and rodent GLP-2 receptors for studies of the physiology and pharmacological potential of the GLP-2 system
Gadgaard, S., Windeløv, Johanne Agerlin, Schiellerup, S. P., Holst, Jens Juul, Hartmann, Bolette & Rosenkilde, Mette, 2023, In: Biomedicine and Pharmacotherapy. 160, 13 p., 114383.Research output: Contribution to journal › Journal article › Research › peer-review
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Long-acting glucagon-like peptide-1 receptor agonist-status December 2018
Holst, Jens Juul, 2019, In: Annals of Translational Medicine. 7, 5, 6 p., 83 .Research output: Contribution to journal › Editorial › Research
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Long-term effects of bariatric surgery on meal disposal and β-cell function in diabetic and nondiabetic patients
Camastra, S., Muscelli, E., Gastaldelli, A., Holst, Jens Juul, Astiarraga, B., Baldi, S., Nannipieri, M., Ciociaro, D., Anselmino, M., Mari, A. & Ferrannini, E., Nov 2013, In: Diabetes. 62, 11, p. 3709-17 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Long-term exendin-4 treatment delays natural deterioration of glycaemic control in diabetic Goto-Kakizaki rats
Simonsen, L., Pilgaard, S., Orskov, C., Hartmann, Bolette, Holst, Jens Juul & Deacon, Carolyn F., 2009, In: Diabetes, Obesity and Metabolism. 11, 9, p. 884-90 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice
Reimer, M. K., Holst, Jens Juul & Ahrén, B., 2002, In: European Journal of Endocrinology. 146, p. 717-727Research output: Contribution to journal › Journal article › Research › peer-review
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Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice
Reimer, M. K., Holst, Jens Juul & Ahrén, B., May 2002, In: European Journal of Endocrinology. Supplement. 146, 5, p. 717-27 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Long-term outcomes of dietary carbohydrate restriction for HbA1c reduction in type 2 diabetes mellitus are needed. Reply to Kang J and Ma E [letter]
Thomsen, M. N., Astrup, A., Holst, Jens Juul, Madsbad, Sten, Magkos, Faidon, Haugaard, Steen Bendix & Krarup, T., 2022, In: Diabetologia. 65, 6, p. 1060-1062 3 p.Research output: Contribution to journal › Comment/debate › Research
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Loss of Incretin Effect Is a Specific, Important, and Early Characteristic of Type 2 Diabetes
Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Krarup, T. & Madsbad, Sten, May 2011, In: Diabetes Care. 34, Supplement 2, p. S251-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes
Menge, B. A., Grüber, L., Jørgensen, S. M., Deacon, Carolyn F., Schmidt, W. E., Veldhuis, J. D., Holst, Jens Juul & Meier, J. J., Aug 2011, In: Diabetes. 60, 8, p. 2160-2168 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion and Aggravates Metabolic Alkalosis in Mice during Acute Base-Loading
Berg, P., Jensen, T., Andersen, J. F., Svendsen, S. L., Modvig, Ida Marie, Wang, T., Frische, S., Chow, B. K. C., Malte, H., Holst, Jens Juul, Sørensen, M. V. & Leipziger, J., 2023, In: Journal of the American Society of Nephrology : JASN. 34, 8, p. 1329-1342 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Low-Carbohydrate Diet Impairs the Effect of Glucagon in the Treatment of Insulin-Induced Mild Hypoglycemia: A Randomized Crossover Study
Ranjan, A., Schmidt, S., Damm-Frydenberg, C., Steineck, I., Clausen, T. R., Holst, Jens Juul, Madsbad, Sten & Nørgaard, Kirsten, Jan 2017, In: Diabetes Care. 40, 1, p. 132-135 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lower blood glucose, hyperglucagonemia and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice
Gelling, R. W., Du, X. Q., Dichmann, D. S., Rømer, J., Huan, H., Cui, L., Tang, B. L., Holst, Jens Juul, Fledelius, C., Johansen, P. B., Jelicks, L. A., Serup, P., Nishimura, E. & Charron, M. J., 2003, In: Proc Natl Sci. 100, p. 1438-1443Research output: Contribution to journal › Journal article › Research › peer-review
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Lower glucose-dependent insulinotropic polypeptide (GIP) response but similar glucagon-like peptide 1 (GLP-1), glycaemic, and insulinaemic response to ancient wheat compared to modern wheat depends on processing
Bakhøj, S., Flint, A., Holst, Jens Juul & Tetens, Inge , 2003, In: European Journal of Clinical Nutrition. 57, 10, p. 1254-1261 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Lower-body fat mass as an independent marker of insulin sensitivity - the role of adiponectin?
Buemann, B., Black, E., Sørensen, Thorkild I.A., Holst, C., Toubro, S., Pedersen, O., Holst, Jens Juul, Rasmussen, C. & Astrup, A., 2005, In: International Journal of Obesity. 29, p. 624-631Research output: Contribution to journal › Journal article › Research › peer-review
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MODERATE EXERCISE DOES NOT IMPAIR THE EFFECT OF GLUCAGON IN INSULIN PUMP TREATED INDIVIDUALS WITH TYPE 1 DIABETES: A RANDOMIZED CROSSOVER STUDY: [Meeting Abstract}
Steineck, I., Ranjan, A., Schmidt, S., Holst, Jens Juul & Norgaard, K., 2018, In: Diabetes Technology & Therapeutics. 20, p. A35-A35 072.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Major rapid weight loss induces changes in cardiac repolarization
Vedel-Larsen, E., Iepsen, E. P. W., Lundgren, J., Graff, C., Struijk, J. J., Hansen, Torben, Holst, Jens Juul, Madsbad, Sten, Torekov, Signe Sørensen & Kanters, Jørgen K., 10 Feb 2016, In: Journal of Electrocardiology. 49, 3, p. 467-472 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Markers of Glucagon Resistance Improve With Reductions in Hepatic Steatosis and Body Weight in Type 2 Diabetes
Kjeldsen, Sasha Alexandra Sampson, Thomsen, M. N., Skytte, M. J., Samkani, A., Richter, Michael Martin, Frystyk, J., Magkos, Faidon, Hansen, E., Thomsen, Henrik S., Holst, Jens Juul, Madsbad, Sten, Haugaard, Steen Bendix, Krarup, T. & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Journal of the Endocrine Society. 7, 11, 11 p., bvad122.Research output: Contribution to journal › Journal article › Research › peer-review
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Mathematical Modelling of Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 following Ingestion of Glucose
Røge, R. M., Bagger, J. I., Alskär, O., Kristensen, N. R., Klim, S., Holst, Jens Juul, Ingwersen, S. H., Karlsson, M. O., Knop, Filip Krag, Vilsbøll, Tina & Kjellsson, M. C., Oct 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 4, p. 290-297 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
Lund, M. T., Taudorf, L., Hartmann, Bolette, Helge, Jørn Wulff, Holst, Jens Juul & Dela, Flemming, 1 Nov 2013, In: European Journal of Applied Physiology. 113, 11, p. 2737-47 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meal-induced compositional changes in blood and saliva in persons with bulimia nervosa
Dynesen, A. W., Jensen, A. B., Astrup, A., Petersson, B., Holst, Jens Juul & Nauntofte, B., 2008, In: American Journal of Clinical Nutrition. 87, 1, p. 12-22 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes
Porksen, S., Nielsen, L. B., Kaas, A., Kocova, M., Chiarelli, F., Orskov, C., Holst, Jens Juul, Ploug, K. B., Hougaard, P. P., Hansen, L. & Mortensen, H. B., 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 8, p. 2910-2916 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes
Pörksen, S., Nielsen, L. B., Kaas, A., Kocova, M., Chiarelli, F., Ørskov, Cathrine, Holst, Jens Juul, Ploug, K. B., Hougaard, P., Hansen, L. & Mortensen, H. B., Aug 2007, In: The Journal of clinical endocrinology and metabolism. 92, 8, p. 2910-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meals with similar energy densities but rich in protein, fat, carbohydrate, or alcohol have different effects on energy expenditure and substrate metabolism but not on appetite and energy intake
Raben, A. B., Agerholm-Larsen, L., Flint, A., Holst, Jens Juul & Astrup, A., 2003, In: American Journal of Clinical Nutrition. 77, 1, p. 91-100 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Measurement of plasma glucagon in humans: A shift in the performance of a current commercially available radioimmunoassay kit
Wu, T., Rayner, C. K., Jones, K. L., Horowitz, M., Feinle-Bisset, C., Standfield, S. D., Xie, C., Deacon, Carolyn F., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Diabetes, Obesity and Metabolism. 24, 6, p. 1182-1184Research output: Contribution to journal › Letter › Research › peer-review
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Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide
Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, Apr 2015, In: Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Measurements Inhibition of DPP-4 evokes pancreatic and extra-pancreatic mechanisms that improve glucose homeostasis in type 2 diabetes mellitus.
Azuma, K., Radikova, Z., Mancino, J., Toledo, F., Thomas, E., Kangani, C., Dalla Man, C., Cobelli, C., Holst, Jens Juul, Deacon, Carolyn F., He, Y., Ligueros-Saylan, M., Serra, D. & Kelley, D., 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, p. 459-463Research output: Contribution to journal › Journal article › Research › peer-review
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Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes
Azuma, K., Rádiková, Z., Mancino, J., Toledo, F. G. S., Thomas, E., Kangani, C., Dalla Man, C., Cobelli, C., Holst, Jens Juul, Deacon, Carolyn F., He, Y., Ligueros-Saylan, M., Serra, D., Foley, J. E. & Kelley, D. E., 2007, In: Journal of Clinical Endocrinology and Metabolism. 93, 2, p. 459-464 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test
Møller, J. B., Jusko, W. J., Gao, W., Hansen, Torben, Pedersen, Oluf Borbye, Holst, Jens Juul, Overgaard, R. V., Madsen, H. & Ingwersen, S. H., 2011, In: Journal of Pharmacokinetics and Pharmacodynamics. 38, 6, p. 713-25 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine
Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: Journal of Visualized Experiments. 144, e58533.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms behind the superior effects of interval vs continuous training on glycaemic control in individuals with type 2 diabetes: a randomised controlled trial
Karstoft, K., Winding, K., Knudsen, S. H., James, N. G., Scheel, M. M., Olesen, J., Holst, Jens Juul, Pedersen, Bente Klarlund & Solomon, T., 2014, In: Diabetologia. 57, 10, p. 2081-2093 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes
Muscelli, E., Casolaro, A., Gastaldelli, A., Mari, A., Seghieri, G., Astiarraga, B., Chen, Y., Alba, M., Holst, Jens Juul & Ferrannini, E., Aug 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 8, p. 2818-26 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms in bariatric surgery: Gut hormones, diabetes resolution, and weight loss
Holst, Jens Juul, Madsbad, Sten, Bojsen-Møller, K. N., Svane, M. S., Jørgensen, N. B., Dirksen, C. & Martinussen, C., May 2018, In: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 14, 5, p. 708-714 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of Gastric Emptying Disturbances in Chronic and Acute Inflammation of the Distal Gastrointestinal Tract
Keller, J., Beglinger, C., Holst, Jens Juul, Andresen, V. & Layer, P., 2009, In: American Journal of Physiology: Gastrointestinal and Liver Physiology.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of action of a carbohydrate-reduced, high-protein diet in reducing the risk of postprandial hypoglycemia after Roux-en-Y gastric bypass surgery
Kandel, D., Bojsen-Møller, K. N., Svane, M. S., Samkani, A., Astrup, A., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2019, In: American Journal of Clinical Nutrition. 110, 2, p. 296-304 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of changes in glucose metabolism and bodyweight after bariatric surgery
Madsbad, Sten, Dirksen, C. & Holst, Jens Juul, Feb 2014, In: The Lancet Diabetes & Endocrinology. 2, 2, p. 152-64 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of gastric emptying disturbances in chronic and acute inflammation of the distal gastrointestinal tract
Keller, J., Beglinger, C., Holst, Jens Juul, Andresen, V. & Layer, P., Nov 2009, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 297, 5, p. G861-8Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass
Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Jacobsen, S. H., Hansen, D. L., Worm, Dorte, Holst, Jens Juul & Madsbad, Sten, 2012, In: Diabetologia. 55, 7, p. 1890-901 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4207
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Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males
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Copenhagen study of overweight patients with coronary artery disease undergoing low energy diet or interval training: the randomized CUT-IT trial protocol
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Whole grain-rich diet reduces body weight and systemic low-grade inflammation without inducing major changes of the gut microbiome: a randomised cross-over trial
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