Jens Juul Holst

Jens Juul Holst

Professor


  1. Published

    Liraglutide for Type 2 diabetes and obesity: a 2015 update

    Iepsen, E. P. W., Torekov, Signe Sørensen & Holst, Jens Juul, 2015, In: Expert Review of Cardiovascular Therapy. 13, 7, p. 753-67 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Liraglutide for treating type 1 diabetes

    Dejgaard, T. F., Frandsen, C. S., Holst, Jens Juul & Madsbad, Sten, Apr 2016, In: Expert Opinion on Biological Therapy. 16, 4, p. 579-90 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Liraglutide improves the beta-cell function without increasing insulin secretion during a mixed meal in patients, who exhibit well-controlled type 2 diabetes and coronary artery disease

    Anholm, C., Kumarathurai, P., Jurs, A., Pedersen, L. R., Nielsen, Olav Wendelboe, Kristiansen, O. P., Fenger, M., Holst, Jens Juul, Madsbad, Sten, Sajadieh, Ahmad & Haugaard, Steen Bendix, 2019, In: Diabetology & Metabolic Syndrome. 11, 12 p., 42.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Liraglutide preserved insulin secretion in adults with newly diagnosed type 1 diabetes: the NewLira trial: [Meeting Abstract}

    Dejgaard, T. F., Frandsen, C., Kielgast, U., Andersen, H. U., Thorsteinsson, B., Krarup, T., Holst, Jens Juul & Madsbad, Sten, 2019, In: Diabetologia. 62, Supl. 1/SI, p. S75-S75 145.

    Research output: Contribution to journalConference abstract in journalResearch

  5. Published

    Liraglutide treatment for the prevention of glucose tolerance deterioration in women with prior gestational diabetes mellitus: A 52-week randomized controlled clinical trial

    Foghsgaard, S., Vedtofte, L., Andersen, E. S., Bahne, E., Andreasen, C., Sørensen, A. L., Forman, Julie Lyng, Mathiesen, Elisabeth, Svare, J. A., Clausen, Tine Dalsgaard, Damm, Peter, Holst, Jens Juul, Knop, Filip Krag & Vilsbøll, Tina, 2023, In: Diabetes, Obesity and Metabolism. 26, 1, p. 201-214 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Liraglutide-Induced Weight Loss May be Affected by Autonomic Regulation in Type 1 Diabetes

    Hansen, C. S., Frandsen, C. S., Fleischer, J., Vistisen, D., Holst, Jens Juul, Tarnow, L., Knop, Filip Krag, Madsbad, Sten, Andersen, H. U. & Dejgaard, T. F., 2019, In: Frontiers in Endocrinology. 10, 9 p., 242.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Little enhancement of meal-induced GLP-1 secretion in Japanese: Comparison of type 2 diabetes and healthy controls

    Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., Kurose, T., Deacon, Carolyn F., Holst, Jens Juul, Hirano, T., Inagaki, N. & Seino, Y., Jan 2010, In: Journal of Diabetes Investigation. 1, 1/2, p. 56-59

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Little enhancement of meal-induced glucagon-like peptide 1 secretion in Japanese: Comparison of type 2 diabetes patients and healthy controls

    Yabe, D., Kuroe, A., Lee, S., Watanabe, K., Hyo, T., Hishizawa, M., Kurose, T., Deacon, Carolyn F., Holst, Jens Juul, Hirano, T., Inagaki, N. & Seino, Y., 22 Apr 2010, In: Journal of Diabetes Investigation. 1, 1-2, p. 56-9 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Lixisenatide for type 2 diabetes mellitus

    Christensen, M., Knop, Filip Krag, Vilsbøll, Tina & Holst, Jens Juul, 2011, In: Expert Opinion on Investigational Drugs. 20, 4, p. 549-57 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Lixisenatide in type 1 diabetes: A randomised control trial of the effect of lixisenatide on post-meal glucose excursions and glucagon in type 1 diabetes patients

    Ballav, C., Dhere, A., Kennedy, I., Agbaje, O. F., White, S., Franklin, R., Hartmann, Bolette, Holst, Jens Juul, Holman, R. R. & Owen, K. R., 2020, In: Endocrinology, Diabetes and Metabolism. 3, 3, 9 p., e00130.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Lixisenatide, a novel GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus

    Christensen, M., Knop, Filip Krag, Holst, Jens Juul & Vilsboll, T., 2009, In: IDrugs. The Investigational Drugs Journal. 12, 8, p. 503-13 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Localisation and neural control of the release of calcitonin gene-related peptide (CGRP) from the isolated perfused porcine ileum

    Rasmussen, T. N., Schmidt, P., Poulsen, S. S., Holst, Jens Juul & Poulsen, Steen Seier, 20 Apr 2001, In: Regulatory Peptides. 98, 3, p. 137-143 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Localization in the gastrointestinal tract of immunoreactive prosomatostatin

    Holst, Jens Juul & Poulsen, Steen Seier, Nov 1987, In: Regulatory Peptides. 19, 3-4, p. 183-95 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Long-acting agonists of human and rodent GLP-2 receptors for studies of the physiology and pharmacological potential of the GLP-2 system

    Gadgaard, S., Windeløv, Johanne Agerlin, Schiellerup, S. P., Holst, Jens Juul, Hartmann, Bolette & Rosenkilde, Mette, 2023, In: Biomedicine and Pharmacotherapy. 160, 13 p., 114383.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Long-acting glucagon-like peptide-1 receptor agonist-status December 2018

    Holst, Jens Juul, 2019, In: Annals of Translational Medicine. 7, 5, 6 p., 83 .

    Research output: Contribution to journalEditorialResearch

  16. Published

    Long-term effects of bariatric surgery on meal disposal and β-cell function in diabetic and nondiabetic patients

    Camastra, S., Muscelli, E., Gastaldelli, A., Holst, Jens Juul, Astiarraga, B., Baldi, S., Nannipieri, M., Ciociaro, D., Anselmino, M., Mari, A. & Ferrannini, E., Nov 2013, In: Diabetes. 62, 11, p. 3709-17 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Long-term exendin-4 treatment delays natural deterioration of glycaemic control in diabetic Goto-Kakizaki rats

    Simonsen, L., Pilgaard, S., Orskov, C., Hartmann, Bolette, Holst, Jens Juul & Deacon, Carolyn F., 2009, In: Diabetes, Obesity and Metabolism. 11, 9, p. 884-90 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice

    Reimer, M. K., Holst, Jens Juul & Ahrén, B., 2002, In: European Journal of Endocrinology. 146, p. 717-727

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice

    Reimer, M. K., Holst, Jens Juul & Ahrén, B., May 2002, In: European Journal of Endocrinology. Supplement. 146, 5, p. 717-27 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Long-term outcomes of dietary carbohydrate restriction for HbA1c reduction in type 2 diabetes mellitus are needed. Reply to Kang J and Ma E [letter]

    Thomsen, M. N., Astrup, A., Holst, Jens Juul, Madsbad, Sten, Magkos, Faidon, Haugaard, Steen Bendix & Krarup, T., 2022, In: Diabetologia. 65, 6, p. 1060-1062 3 p.

    Research output: Contribution to journalComment/debateResearch

  21. Published

    Loss of Incretin Effect Is a Specific, Important, and Early Characteristic of Type 2 Diabetes

    Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Krarup, T. & Madsbad, Sten, May 2011, In: Diabetes Care. 34, Supplement 2, p. S251-7 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Loss of inverse relationship between pulsatile insulin and glucagon secretion in patients with type 2 diabetes

    Menge, B. A., Grüber, L., Jørgensen, S. M., Deacon, Carolyn F., Schmidt, W. E., Veldhuis, J. D., Holst, Jens Juul & Meier, J. J., Aug 2011, In: Diabetes. 60, 8, p. 2160-2168 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Loss of the Secretin Receptor Impairs Renal Bicarbonate Excretion and Aggravates Metabolic Alkalosis in Mice during Acute Base-Loading

    Berg, P., Jensen, T., Andersen, J. F., Svendsen, S. L., Modvig, Ida Marie, Wang, T., Frische, S., Chow, B. K. C., Malte, H., Holst, Jens Juul, Sørensen, M. V. & Leipziger, J., 2023, In: Journal of the American Society of Nephrology : JASN. 34, 8, p. 1329-1342 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Low-Carbohydrate Diet Impairs the Effect of Glucagon in the Treatment of Insulin-Induced Mild Hypoglycemia: A Randomized Crossover Study

    Ranjan, A., Schmidt, S., Damm-Frydenberg, C., Steineck, I., Clausen, T. R., Holst, Jens Juul, Madsbad, Sten & Nørgaard, Kirsten, Jan 2017, In: Diabetes Care. 40, 1, p. 132-135 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Lower blood glucose, hyperglucagonemia and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice

    Gelling, R. W., Du, X. Q., Dichmann, D. S., Rømer, J., Huan, H., Cui, L., Tang, B. L., Holst, Jens Juul, Fledelius, C., Johansen, P. B., Jelicks, L. A., Serup, P., Nishimura, E. & Charron, M. J., 2003, In: Proc Natl Sci. 100, p. 1438-1443

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Lower glucose-dependent insulinotropic polypeptide (GIP) response but similar glucagon-like peptide 1 (GLP-1), glycaemic, and insulinaemic response to ancient wheat compared to modern wheat depends on processing

    Bakhøj, S., Flint, A., Holst, Jens Juul & Tetens, Inge , 2003, In: European Journal of Clinical Nutrition. 57, 10, p. 1254-1261 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Lower-body fat mass as an independent marker of insulin sensitivity - the role of adiponectin?

    Buemann, B., Black, E., Sørensen, Thorkild I.A., Holst, C., Toubro, S., Pedersen, O., Holst, Jens Juul, Rasmussen, C. & Astrup, A., 2005, In: International Journal of Obesity. 29, p. 624-631

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    MODERATE EXERCISE DOES NOT IMPAIR THE EFFECT OF GLUCAGON IN INSULIN PUMP TREATED INDIVIDUALS WITH TYPE 1 DIABETES: A RANDOMIZED CROSSOVER STUDY: [Meeting Abstract}

    Steineck, I., Ranjan, A., Schmidt, S., Holst, Jens Juul & Norgaard, K., 2018, In: Diabetes Technology & Therapeutics. 20, p. A35-A35 072.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  29. Published

    Major rapid weight loss induces changes in cardiac repolarization

    Vedel-Larsen, E., Iepsen, E. P. W., Lundgren, J., Graff, C., Struijk, J. J., Hansen, Torben, Holst, Jens Juul, Madsbad, Sten, Torekov, Signe Sørensen & Kanters, Jørgen K., 10 Feb 2016, In: Journal of Electrocardiology. 49, 3, p. 467-472 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Markers of Glucagon Resistance Improve With Reductions in Hepatic Steatosis and Body Weight in Type 2 Diabetes

    Kjeldsen, Sasha Alexandra Sampson, Thomsen, M. N., Skytte, M. J., Samkani, A., Richter, Michael Martin, Frystyk, J., Magkos, Faidon, Hansen, E., Thomsen, Henrik S., Holst, Jens Juul, Madsbad, Sten, Haugaard, Steen Bendix, Krarup, T. & Albrechtsen, Nicolai Jacob Wewer, 2023, In: Journal of the Endocrine Society. 7, 11, 11 p., bvad122.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Mathematical Modelling of Glucose-Dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 following Ingestion of Glucose

    Røge, R. M., Bagger, J. I., Alskär, O., Kristensen, N. R., Klim, S., Holst, Jens Juul, Ingwersen, S. H., Karlsson, M. O., Knop, Filip Krag, Vilsbøll, Tina & Kjellsson, M. C., Oct 2017, In: Basic & Clinical Pharmacology & Toxicology. 121, 4, p. 290-297 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Meal induced gut hormone secretion is altered in aerobically trained compared to sedentary young healthy males

    Lund, M. T., Taudorf, L., Hartmann, Bolette, Helge, Jørn Wulff, Holst, Jens Juul & Dela, Flemming, 1 Nov 2013, In: European Journal of Applied Physiology. 113, 11, p. 2737-47 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Meal-induced compositional changes in blood and saliva in persons with bulimia nervosa

    Dynesen, A. W., Jensen, A. B., Astrup, A., Petersson, B., Holst, Jens Juul & Nauntofte, B., 2008, In: American Journal of Clinical Nutrition. 87, 1, p. 12-22 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes

    Porksen, S., Nielsen, L. B., Kaas, A., Kocova, M., Chiarelli, F., Orskov, C., Holst, Jens Juul, Ploug, K. B., Hougaard, P. P., Hansen, L. & Mortensen, H. B., 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 8, p. 2910-2916 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Meal-stimulated glucagon release is associated with postprandial blood glucose level and does not interfere with glycemic control in children and adolescents with new-onset type 1 diabetes

    Pörksen, S., Nielsen, L. B., Kaas, A., Kocova, M., Chiarelli, F., Ørskov, Cathrine, Holst, Jens Juul, Ploug, K. B., Hougaard, P., Hansen, L. & Mortensen, H. B., Aug 2007, In: The Journal of clinical endocrinology and metabolism. 92, 8, p. 2910-6 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Meals with similar energy densities but rich in protein, fat, carbohydrate, or alcohol have different effects on energy expenditure and substrate metabolism but not on appetite and energy intake

    Raben, A. B., Agerholm-Larsen, L., Flint, A., Holst, Jens Juul & Astrup, A., 2003, In: American Journal of Clinical Nutrition. 77, 1, p. 91-100 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Measurement of plasma glucagon in humans: A shift in the performance of a current commercially available radioimmunoassay kit

    Wu, T., Rayner, C. K., Jones, K. L., Horowitz, M., Feinle-Bisset, C., Standfield, S. D., Xie, C., Deacon, Carolyn F., Holst, Jens Juul & Albrechtsen, Nicolai Jacob Wewer, 2022, In: Diabetes, Obesity and Metabolism. 24, 6, p. 1182-1184

    Research output: Contribution to journalLetterResearchpeer-review

  38. Published

    Measurement of the incretin hormones: glucagon-like peptide-1 and glucose-dependent insulinotropic peptide

    Kuhre, Rune Ehrenreich, Albrechtsen, Nicolai Jacob Wewer, Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, Apr 2015, In: Journal of Diabetes and its Complications. 29, 3, p. 445-450 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Measurements Inhibition of DPP-4 evokes pancreatic and extra-pancreatic mechanisms that improve glucose homeostasis in type 2 diabetes mellitus.

    Azuma, K., Radikova, Z., Mancino, J., Toledo, F., Thomas, E., Kangani, C., Dalla Man, C., Cobelli, C., Holst, Jens Juul, Deacon, Carolyn F., He, Y., Ligueros-Saylan, M., Serra, D. & Kelley, D., 2008, In: Journal of Clinical Endocrinology and Metabolism. 93, p. 459-463

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Measurements of islet function and glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes

    Azuma, K., Rádiková, Z., Mancino, J., Toledo, F. G. S., Thomas, E., Kangani, C., Dalla Man, C., Cobelli, C., Holst, Jens Juul, Deacon, Carolyn F., He, Y., Ligueros-Saylan, M., Serra, D., Foley, J. E. & Kelley, D. E., 2007, In: Journal of Clinical Endocrinology and Metabolism. 93, 2, p. 459-464 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Mechanism-based population modelling for assessment of L-cell function based on total GLP-1 response following an oral glucose tolerance test

    Møller, J. B., Jusko, W. J., Gao, W., Hansen, Torben, Pedersen, Oluf Borbye, Holst, Jens Juul, Overgaard, R. V., Madsen, H. & Ingwersen, S. H., 2011, In: Journal of Pharmacokinetics and Pharmacodynamics. 38, 6, p. 713-25 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Mechanisms Underlying Gut Hormone Secretion Using the Isolated Perfused Rat Small Intestine

    Kuhre, Rune Ehrenreich & Holst, Jens Juul, 2019, In: Journal of Visualized Experiments. 144, e58533.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Mechanisms behind the superior effects of interval vs continuous training on glycaemic control in individuals with type 2 diabetes: a randomised controlled trial

    Karstoft, K., Winding, K., Knudsen, S. H., James, N. G., Scheel, M. M., Olesen, J., Holst, Jens Juul, Pedersen, Bente Klarlund & Solomon, T., 2014, In: Diabetologia. 57, 10, p. 2081-2093 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes

    Muscelli, E., Casolaro, A., Gastaldelli, A., Mari, A., Seghieri, G., Astiarraga, B., Chen, Y., Alba, M., Holst, Jens Juul & Ferrannini, E., Aug 2012, In: Journal of Clinical Endocrinology and Metabolism. 97, 8, p. 2818-26 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Mechanisms in bariatric surgery: Gut hormones, diabetes resolution, and weight loss

    Holst, Jens Juul, Madsbad, Sten, Bojsen-Møller, K. N., Svane, M. S., Jørgensen, N. B., Dirksen, C. & Martinussen, C., May 2018, In: Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 14, 5, p. 708-714 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Mechanisms of Gastric Emptying Disturbances in Chronic and Acute Inflammation of the Distal Gastrointestinal Tract

    Keller, J., Beglinger, C., Holst, Jens Juul, Andresen, V. & Layer, P., 2009, In: American Journal of Physiology: Gastrointestinal and Liver Physiology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Mechanisms of action of a carbohydrate-reduced, high-protein diet in reducing the risk of postprandial hypoglycemia after Roux-en-Y gastric bypass surgery

    Kandel, D., Bojsen-Møller, K. N., Svane, M. S., Samkani, A., Astrup, A., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2019, In: American Journal of Clinical Nutrition. 110, 2, p. 296-304 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Mechanisms of changes in glucose metabolism and bodyweight after bariatric surgery

    Madsbad, Sten, Dirksen, C. & Holst, Jens Juul, Feb 2014, In: The Lancet Diabetes & Endocrinology. 2, 2, p. 152-64 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Mechanisms of gastric emptying disturbances in chronic and acute inflammation of the distal gastrointestinal tract

    Keller, J., Beglinger, C., Holst, Jens Juul, Andresen, V. & Layer, P., Nov 2009, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 297, 5, p. G861-8

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass

    Dirksen, C., Jørgensen, N. B., Bojsen-Møller, K. N., Jacobsen, S. H., Hansen, D. L., Worm, Dorte, Holst, Jens Juul & Madsbad, Sten, 2012, In: Diabetologia. 55, 7, p. 1890-901 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 4207