Jens Juul Holst

Jens Juul Holst

Professor

ORCID: 0000-0001-6853-3805

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  1. Published

    Dietary Fiber is Essential to Maintain L Cell Secretion and Intestinal Weight

    Dal, Jenna Elizabeth Hunt, Hartmann, Bolette, Holst, Jens Juul & Kissow, Hannelouise, 1 May 2019, In: Gastroenterology. 156, 6 (S1), p. S-477

    Research output: Contribution to journal › Conference abstract in journal › Research

  2. Published

    Dietary carbohydrate restriction augments weight loss-induced improvements in glycaemic control and liver fat in individuals with type 2 diabetes: A randomised controlled trial

    Thomsen, M. N., Skytte, M. J., Samkani, A., Carl, M. H., Weber, P., Astrup, A., Chabanova, E., Fenger, M., Frystyk, J., Hartmann, Bolette, Holst, Jens Juul, Larsen, T. M., Madsbad, Sten, Magkos, Faidon, Thomsen, Henrik S., Haugaard, Steen Bendix & Krarup, T., 2022, In: Diabetologia. 65, p. 506-517 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Dietary impact on fasting and stimulated GLP-1 secretion in different metabolic conditions - a narrative review

    Huber, H., Schieren, A., Holst, Jens Juul & Simon, M., 2024, In: The American Journal of Clinical Nutrition. 119, 3, p. 599-627

    Research output: Contribution to journal › Review › Research › peer-review

  4. Published

    Difference in postprandial GLP-1 response despite similar glucose kinetics after consumption of wheat breads with different particle size in healthy men

    Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., 2017, In: European Journal of Nutrition. 56, 3, p. 1063-1076 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Different Malabsorptive Obesity Surgery Interventions Result in Distinct Postprandial Amino Acid Metabolomic Signatures

    Pereira, S. S., Jarak, I., Carvalho, R. A., Oliveira, P. F., Alves, M. G., Guimaraes, M., Almeida, R., Pereira, A. M., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Nora, M. & Monteiro, M. P., 2020, In: Obesity Surgery. 30, p. 4019-4028

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Different effects of whole milk and a fermented milk with the same fat and lactose content on gastric emptying and postprandial lipaemia, but not on glycaemic response and appetite

    Sanggaard, K. M., Holst, Jens Juul, Rehfeld, J. F., Sandström, B. & Tholstrup, T., 2004, In: Br.J.Nutr.. 92, 92, p. 447-459

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Differential Effects of Secretin-fragments imply a dual Mechanism of Action for Secretin

    Kofod, H., Thams, P. & Holst, Jens Juul, Feb 1991, In: International Journal of Peptide and Protein Research. 37, 2, p. 134-139 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Differential action of TGR5 agonists on GLP-2 secretion and promotion of intestinal adaptation in a piglet short bowel model

    Lin, S., Stoll, B., Robinson, J., Pastor, J. J., Marini, J. C., Ipharraguerre, I. R., Hartmann, Bolette, Holst, Jens Juul, Cruz, S., Lau, P., Olutoye, O., Fang, Z. & Burrin, D. G., May 2019, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 316, 5, p. G641-G652

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Differential effect of PYY1-36 and PYY3-36 on gastric emptying in man

    Witte, A., Grybäck, P., Holst, Jens Juul, Hilsted, Linda, Hellström, P. M., Jacobsson, H. & Schmidt, P. T., 2009, In: Regulatory Peptides. 158, 1-3, p. 57-62 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Differential effects of bile acids on the postprandial secretion of gut hormones: A randomized crossover study

    McGlone, E. R., Malallah, K., Cuenco, J., Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Vincent, R. P., Ling, C., Khan, O. A., Verma, S., Ahmed, A. R., Walters, J. R. F., Khoo, B., Bloom, S. R. & Tan, T. M. M., 2021, In: American Journal of Physiology - Endocrinology and Metabolism. 320, 4, p. E671-E679

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Differential effects of glucagon-like peptide-1 on microvascular recruitment and glucose metabolism in short- and long-term Insulin resistance

    Sjøberg, K. A., Rattigan, S., Jeppesen, J. F., Lundsgaard, Anne-Marie, Holst, Jens Juul & Kiens, Bente, 2015, In: Journal of Physiology. 593, 9, p. 2185-2198 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Differential effects of protein quality on postprandial lipemia in response to a fat-rich meal in type 2 diabetes: comparison of whey, casein, gluten, and cod protein

    Mortensen, L. S., Hartvigsen, M. L., Brader, L. J., Astrup, A., Schrezenmeir, J., Holst, Jens Juul, Thomsen, C. & Hermansen, K., 2009, In: American Journal of Clinical Nutrition. 90, 1, p. 41-8 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Differential effects of saturated and monounsaturated fat on postprandial lipaemia and GIP/GLP-1 response in healthy subjects

    Thomsen, C., Rasmussen, O., Lousen, T., Hermansen, K. & Holst, Jens Juul, 1999, In: Am. J. Clin. Nutri.. 69, p. 1135-1143

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Differential effects of saturated and monounsaturated fat on postprandial lipemia and incretin responses in type 2 diabetic subjects

    Thomsen, C., Storm, H., Holst, Jens Juul & Hermansen, K., 2003, In: Am. J. Clin. Nutr.. 77, p. 605-611

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes

    Thomsen, C., Storm, H., Holst, Jens Juul & Hermansen, K., Mar 2003, In: Uden navn. 77, 3, p. 605-11 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Differential impact of glucose administered intravenously or orally on bone turnover markers in healthy male subjects

    Westberg-Rasmussen, S., Starup-Linde, J., Hermansen, K., Holst, Jens Juul, Hartmann, Bolette, Vestergaard, P. & Gregersen, S., Apr 2017, In: Bone. 97, p. 261-266 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Differential incretin effects of GIP and GLP-1 on gastric emptying, appetite, and insulin-glucose homeostasis

    Edholm, T., Degerblad, M., Grybäck, P., Hilsted, Linda, Holst, Jens Juul, Jacobsson, H., Efendic, S., Schmidt, P. T. & Hellström, P. M., 1 Nov 2010, In: Neurogastroenterology and Motility Online. 22, 11, p. 1191-200, e315 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Differential postprandial lipoprotein responses in type 2 diabetic men with and without clinical evidence of a former myocardial infarction.

    Carstensen, M., Thomsen, C., Gotzsche, O., Holst, Jens Juul, Schrezenmeir, J. & Hermansen, K., 2005, In: The review of diabetic studies : RDS. 1, 4, p. 175-84 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Differential regional metabolism of glucagon in anesthetized pigs.

    Deacon, Carolyn F., Kelstrup, M., Trebbien, R., Klarskov, L., Olesen, M. & Holst, Jens Juul, 2003, In: American Journal of Physiology: Endocrinology and Metabolism. 285, 3, p. E552-60

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Dipeptidyl peptidase IV inhibition as an approach to the treatment and prevention of type 2 diabetes: a historical perspective.

    Deacon, Carolyn F. & Holst, Jens Juul, 2002, In: Biochemical and Biophysical Research Communications. 294, 1, p. 1-4 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Dipeptidyl peptidase IV inhibition enhances the intestinotrophic effect of glucagon-like peptide-2 in rats and mice

    Hartmann, Bolette, Thulesen, J., Kissow, Hannelouise, Thulesen, S., Ørskov, Cathrine, Ropke, C., Poulsen, Steen Seier & Holst, Jens Juul, 2000, In: Endocrinology. 141, 11, p. 4013-20 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Dipeptidyl peptidase IV inhibition potentiates the insulinotropic effect of glucagon-like peptide 1 in the anesthetized pig.

    Deacon, Carolyn F., Hughes, T. E. & Holst, Jens Juul, 1998, In: Diabetes. 47, p. 764-769

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs

    Deacon, Carolyn F., Danielsen, P., Klarskov, L., Holst, Jens Juul & Olesen, M., 2001, In: Diabetes. 50, p. 1588-1597

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes.

    Deacon, Carolyn F. & Holst, Jens Juul, 2005, In: International Journal of Biochemistry & Cell Biology. 38, 5-6, p. 831-44 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activity

    Deacon, Carolyn F., Knudsen, L. B., Madsen, K., Wiberg, F. C., Jacobsen, O. & Holst, Jens Juul, 1998, In: Diabetologia. 41, p. 271-278

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Dipeptidyl peptidase expression during experimental colitis in mice

    Yazbeck, R., Sulda, M. L., Howarth, G. S., Bleich, A., Raber, K., von Hörsten, S., Holst, Jens Juul & Abbott, C. A., 1 Aug 2010, In: Inflammatory Bowel Diseases. 16, 8, p. 1340-1351 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Dipeptidyl peptidase-4 inhibition increases portal concentrations of intact glucagon-like peptide-1 (GLP-1) to a greater extent than peripheral concentrations in anaesthetised pigs

    Hjøllund, K. R., Deacon, Carolyn F. & Holst, Jens Juul, 2011, In: Diabetologia. 54, 8, p. 2206-8 3 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  28. Published

    Dipeptidyl peptidase-4 inhibitors administered in combination with metformin result in an additive increase in the plasma concentration of active GLP-1

    Migoya, E. M., Bergeron, R., Miller, J. L., Snyder, R. N. K., Tanen, M., Hilliard, D., Weiss, B., Larson, P., Gutierrez, M., Jiang, G., Liu, F., Pryor, K. A., Yao, J., Zhu, L., Holst, J. J., Deacon, C., Herman, G., Thornberry, N., Amatruda, J., Williams-Herman, D. & 2 others, Wagner, J. A. & SinhaRoy, R., 1 Dec 2010, In: Clinical Pharmacology and Therapeutics. 88, 6, p. 801-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety

    Deacon, Carolyn F. & Holst, Jens Juul, Oct 2013, In: Expert Opinion on Pharmacotherapy. 14, 15, p. 2047-58 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Disassociation of bone resorption and formation by GLP-2: a 14-day study in healthy postmenopausal women

    Henriksen, D. B., Alexandersen, P., Hartmann, Bolette, Adrian, C. L., Byrjalsen, I., Bone, H. G., Holst, Jens Juul & Christiansen, C., Mar 2007, In: Bone. 40, 3, p. 723-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Disassociation of bone resorption and formation by GLP-2 - A 14-day study in healthy postmenopausal women

    Henriksen, D. B., Alexandersen, P., Hartmann, B., Adrian, C. L., Byrjalsen, I., Bone, H. G., Holst, Jens Juul & Christiansen, C., 2007, In: Bone. 40, 3, p. 723-729 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Discovery of amino acid variants in the human glucose-dependent insulinotropic polypeptide (GIP) receptor: the impact on the pancreatic beta cell responses and functional expression studies in CHL cells

    Almind, K., Ambye, L., Urhammer, S. A., Hansen, T., Echwald, S. M., Holst, Jens Juul, Gromada, J. L., Thorens, B. & Pedersen, O., 1998, In: Diabetologia. 41, p. 1194-1198

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Discovery of the GI Effects of GLP-1: An Historical Perspective

    Holst, Jens Juul, 2022, In: Digestive Diseases and Sciences. 67, p. 2716-2720

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    Discovery, characterization, and clinical development of the glucagon-like peptides

    Drucker, D. J., Habener, J. F. & Holst, Jens Juul, 1 Dec 2017, In: The Journal of Clinical Investigation. 127, 12, p. 4217-4227 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  35. Published

    Disruption of PC1/3 expression in mice causes dwarfism and multiple neuroendocrine peptide processing defects

    Zhu, X., Zhou, A., Dey, A., Norrbom, C., Carroll, R., Zhang, C., Laurent, V., Lindberg, I., Ugleholdt, Randi Kjærsgaard, Holst, Jens Juul & Steiner, D. F., 6 Aug 2002, In: Proceedings of the National Academy of Sciences of the United States of America. 99, 16, p. 10293-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis

    Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Ørskov, Cathrine, Kissow, Hannelouise, Poulsen, Steen Seier, Vilstrup, H., Prehn, C., Adamski, J., Jepsen, Sara Lind, Hartmann, Bolette, Dal, Jenna Elizabeth Hunt, Charron, M. J., Pedersen, Jens, Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2018, In: American Journal of Physiology: Endocrinology and Metabolism. 314, 1, p. E93-E103

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Dissociated incretin hormone response to protein versus fat ingestion in obese subjects

    Lindgren, O., Carr, R., Holst, Jens Juul, Deacon, Carolyn F. & Ahren, B., Jul 2011, In: Diabetes, Obesity and Metabolism Online. 13, 9, p. 863-865 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Dissociated incretin response to oral glucose at 1 year after restrictive vs. malabsorptive bariatric surgery

    Guldstrand, M., Ahrén, B., Näslund, E., Holst, Jens Juul & Adamson, U., 2009, In: Diabetes, Obesity and Metabolism. 11, 11, p. 1027-33 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Distal gastrectomy in pancreaticoduodenectomy is associated with accelerated gastric emptying, enhanced postprandial release of GLP-1, and improved insulin sensitivity

    Harmuth, S., Wewalka, M., Holst, Jens Juul, Nemecek, R., Thalhammer, S., Schmid, R., Sahora, K., Gnant, M. & Miholić, J., Jan 2014, In: Journal of Gastrointestinal Surgery. 18, 1, p. 52-9 8 p.

    Research output: Contribution to journal › Conference article › Research › peer-review

  40. Published

    Distal small bowel hormones: Correlation with fasting antroduodenal motility and gastric emptying

    Naslund, E., Gryback, P., Backman, L., Jacobsson, H., Holst, Jens Juul, Theodorsson, E. & Hellstrom, P. M., 1998, In: Dig. Dis. Sci.. 43, p. 945-952

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Distal, not proximal, colonic acetate infusions promote fat oxidation and improve metabolic markers in overweight/obese men

    van der Beek, C. M., Canfora, E. E., Lenaerts, K., Troost, F. J., Damink, S. W. M. O., Holst, Jens Juul, Masclee, A. A. M., Dejong, C. H. C. & Blaak, E. E., 11 Oct 2016, In: Clinical Science. 130, 22, p. 2073-2082 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility.

    Miki, T., Minami, K., Shinozaki, H., Matsumura, K., Saraya, A., Ikeda, H., Yamada, Y., Holst, Jens Juul & Seino, S., 2005, In: Diabetes. 54, 4, p. 1056-63 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Distribution and characterization of different molecular products of Pro-somatostatin in the hypothalmus and posterior pituitary lobe of the mongolian gerbil (Meriones unguiculatus)

    Larsen, P. J., Bersani, M., Holst, Jens Juul, Møller, M. & Mikkelsen, J. D., 1992, In: Journal of Neuroscience. 12, hæfte 3, p. 946-961

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem

    Larsen, P. J., Tang-Christensen, M., Holst, Jens Juul & Ørskov, Cathrine, 1997, In: Neuroscience. Vol. 77, No. 1, p. 257-270

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Disturbed postprandial glucose metabolism and gut hormone responses in non-diabetic patients with psoriasis

    Gyldenløve, M., Vilsbøll, Tina, Holst, Jens Juul, Zachariae, Claus, Skov, L. & Knop, Filip Krag, Nov 2016, In: British Journal of Dermatology. 175, 5, p. 1085–1088

    Research output: Contribution to journal › Letter › Research › peer-review

  46. Published

    Diurnal metabolic profiles after 14 d of an ad libitum high-starch, high-sucrose, or high-fat diet in normal-weight never-obese and postobese women

    Raben, A., Holst, Jens Juul, Madsen, J. & Astrup, A., 2001, In: American Journal of Clinical Nutrition. 73, p. 177-89 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Do glucagonomas always produce glucagon?

    Albrechtsen, Nicolai Jacob Wewer, Challis, B., Damjanov, I. & Holst, Jens Juul, 1 Feb 2016, In: Bosnian Journal of Basic Medical Sciences. 16, 1, p. 1-7 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

  48. Published

    Do sodium-glucose transporter-2 inhibitors increase plasma glucagon by direct actions on the alpha-cell? - and does the increase matter for the associated increase in endogenous glucose production?

    Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 2021, In: Diabetes, Obesity and Metabolism. 23, 9, p. 2009-2019

    Research output: Contribution to journal › Review › Research › peer-review

  49. Published

    Do the actions of glucagon-like peptide-1 on gastric emptying, appetite, and food intake involve release of amylin in humans?

    Asmar, M., Bache, M., Knop, Filip Krag, Madsbad, Sten & Holst, Jens Juul, 1 May 2010, In: The Journal of clinical endocrinology and metabolism. 95, 5, p. 2367-75 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Do we know the true mechanism of action of the DPP-4 inhibitors?

    Andersen, E. S., Deacon, Carolyn F. & Holst, Jens Juul, 2018, In: Diabetes, Obesity and Metabolism. 20, 1, p. 34-41 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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