Thomas Michael Frimurer
Associate Professor
Platforms
Blegdamsvej 3B, Mærsk Tårnet, 6-7-8. sal, 2200 København N.
Member of:
Introductory remarks on publicationslist
Publications: Author or co-author on > 40 papers in peer-reviewed, medium to high profile scientific journals. Involved in innovation and commercialization activities. Patents: Author or co-author on > 15 patents on chemical leads and drug candidates for the treatment of obesity, type-2 diabetes, asthma inflammation and pain. Most recently (Mar. 2014) we patented a strong chemical package on oral available small molecule GPR39 agonists – a potential obesity and type-2 diabetes target. Invited talks: Participated in multiple oral presentations at international and national scientific meetings.
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Biased Signaling of CCL21 and CCL19 Does Not Rely on N-Terminal Differences, but Markedly on the Chemokine Core Domains and Extracellular Loop 2 of CCR7
Jørgensen, Astrid Sissel, Larsen, Olav, Uetz-von Allmen, E., Lückmann, Michael, Legler, D. F., Frimurer, Thomas Michael, Veldkamp, C. T., Hjortø, Gertrud Malene & Rosenkilde, Mette, 2019, In: Frontiers in Immunology. 10, 14 p., 2156.Research output: Contribution to journal › Journal article › Research › peer-review
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Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2
Jensen, P. C., Thiele, S., Steen, A., Elder, A., Kolbeck, R., Ghosh, S., Frimurer, Thomas Michael & Rosenkilde, Mette, May 2012, In: British Journal of Pharmacology. 166, 1, p. 258-75 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Molecular mechanism of ligand binding pathways and activation of the succinate receptor
Iliyaz, Aslihan Shenol, Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2021, In: European Biophysics Journal. 50, Suppl. 1, p. 160 1 p., P-234.Research output: Contribution to journal › Conference abstract in journal › Research
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Melanin concentrating hormone receptor 1 (MCHR1) antagonists - Still a viable approach for obesity treatment?
Högberg, T., Frimurer, Thomas Michael & Sasmal, P. K., 1 Oct 2012, In: Bioorganic & Medicinal Chemistry Letters. 22, 19, p. 6039-6047 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor
Hansen, L. V., Groenen, M., Nygaard, R., Frimurer, Thomas Michael, Holliday, N. D. & Schwartz, Thue W., 14 Sep 2012, In: Journal of Biological Chemistry. 287, 38, p. 31973-82 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist
Grunddal, K. V., Diep, T. A., Petersen, N., Tough, I. R., Skov, Louise Julie, Liu, L., Buijink, J. A., Mende, F., Jin, C., Jepsen, Sara Lind, Sørensen, L. M. E., Achiam, Michael Patrick, Strandby, R. B., Bach, Anders, Hartmann, Bolette, Frimurer, Thomas Michael, Hjorth, Siv Annegrethe, Bouvier, M., Cox, H. & Holst, Birgitte, 2021, In: Molecular Metabolism. 49, 14 p., 101207.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel selective thiazoleacetic acids as CRTH2 antagonists developed from in silico derived hits. Part 2
Grimstrup, M., Rist, Ø., Receveur, J., Frimurer, Thomas Michael, Ulven, Trond, Mathiesen, Jesper M., Kostenis, E. & Högberg, T., 1 Feb 2010, In: Bioorganic & Medicinal Chemistry Letters. 20, 3, p. 1181-1185 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exploration of SAR features by modifications of thiazoleacetic acids as CRTH2 antagonists
Grimstrup, M., Receveur, J. M., Rist, Ø., Frimurer, Thomas Michael, Nielsen, P. A., Mathiesen, Jesper M. & Högberg, T., 1 Mar 2010, In: Bioorganic and Medicinal Chemistry Letters. 20, 5, p. 1638-1641 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions.
Frimurer, Thomas Michael, Mende, F., Graae, A., Engelstoft, M. S., Egerod, Kristoffer Lihme, Nygaard, R., Gerlach, L., Hansen, J. B., Schwartz, Thue W. & Holst, Birgitte, 2017, In: Journal of Medicinal Chemistry. 60, 3, p. 886-898 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A pseudo-sequence method for comparing 7TM receptors with respect to the physicochemical properties of their binding sites
Frimurer, Thomas Michael, Ulven, Trond, Högberg, T. & Elling, C. E., 2004, Patent No. WO 2004/079625Research output: Patent
ID: 34520257
Most downloads
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609
downloads
Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
143
downloads
Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
132
downloads
Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
Research output: Contribution to journal › Journal article › Research › peer-review
Published