Thue W. Schwartz

Thue W. Schwartz

Professor

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    ORCID: 0000-0002-0261-6904

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    1. Published

      GPR119 - a major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Co-acting in Synergy with FFA1 (GPR40)

      Ekberg, J. H., Pedersen, M. H., Kristensen, L. V., Madsen, A. N., Engelstoft, M. S., Husted, Anna Sofie, Sichlau, R., Egerod, Kristoffer Lihme, Timshel, P., Kowalski, T. J., Gribble, F. M., Reiman, F., Hansen, Harald S., Howard, A. D., Holst, Birgitte & Schwartz, Thue W., 25 Oct 2016, In: Endocrinology. 157, 12, p. 4561-4569 9 p., en20161334.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      GPCR-Mediated Signaling of Metabolites

      Husted, Anna Sofie, Trauelsen, Mette, Rudenko, Olga, Hjorth, Siv Annegrethe & Schwartz, Thue W., 4 Apr 2017, In: Cell Metabolism. 25, 4, p. 777-796 20 p.

      Research output: Contribution to journal › Review › Research › peer-review

    3. Published

      GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness

      Svendsen, B., Pais, R., Engelstoft, M. S., Milev, N. B., Richards, P., Christiansen, Charlotte Bayer, Egerod, Kristoffer Lihme, Jensen, S. M., Habib, A. M., Gribble, F. M., Schwartz, Thue W., Reimann, F. & Holst, Jens Juul, 2016, In: Journal of Endocrinology. 228, 1, p. 39-48 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      GLP-1-directed NMDA receptor antagonism for obesity treatment

      Petersen, J., Ludwig, M. Q., Juozaityte, V., Ranea-Robles, P., Svendsen, C., Hwang, E., Kristensen, A. W., Fadahunsi, N., Lund, J., Breum, A. W., Mathiesen, C. V., Sachs, L., Moreno-Justicia, R., Rohlfs, R., Ford, J. C., Douros, J. D., Finan, B., Portillo, B., Grose, K., Petersen, J. E. & 13 others, Trauelsen, Mette, Feuchtinger, A., DiMarchi, R. D., Schwartz, Thue W., Deshmukh, Atul Shahaji, Thomsen, Morten Bækgaard, Kohlmeier, Kristi Anne, Williams, K. W., Pers, Tune H, Frølund, Bente, Strømgaard, Kristian, Klein, A. B. & Clemmensen, Christoffer, 2024, In: Nature. 629, 8014, p. 1133–1141

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      G-Protein-Coupled Receptor 91-Dependent Signalling Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidaemic Mice

      Griepke, S., Trauelsen, Mette, Nilsson, M. D., Hansen, J., Steffensen, L. B., Schwartz, Thue W. & Ketelhuth, D. F. J., 2023, In: Cells. 12, 21, 14 p., 2580.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      G protein-coupled receptor modulation with pepducins: moving closer to the clinic

      Dimond, P., Carlson, K., Bouvier, M., Gerard, C., Xu, L., Covic, L., Agarwal, A., Ernst, O. P., Janz, J. M., Schwartz, Thue W., Gardella, T. J., Milligan, G., Kuliopulos, A., Sakmar, T. P. & Hunt III, S. W., May 2011, In: New York Academy of Sciences. Annals. 1226, p. 34-49 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      G protein-coupled receptor modulation with pepducins: moving closer to the clinic

      Dimond, P., Carlson, K., Bouvier, M., Gerard, C., Xu, L., Covic, L., Agarwal, A., Ernst, O. P., Janz, J. M., Schwartz, Thue W., Gardella, T. J., Milligan, G., Kuliopulos, A., Sakmar, T. P. & Hunt, S. W., 2011, In: Annals of the New York Academy of Sciences. 1226, p. 34-49 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction

      Holst, Birgitte, Egerod, Kristoffer Lihme, Jin, C., Petersen, P. S., Østergaard, M. V., Hald, J., Sprinkel, A. M. E., Størling, J., Mandrup-Poulsen, Thomas, Holst, Jens Juul, Thams, P., Orskov, C., Wierup, N., Sundler, F., Madsen, O. D. & Schwartz, Thue W., 2009, In: Endocrinology. 150, 6, p. 2577-85 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population

      Vestmar, M. A., Galijatovic, E. A. A., Christensen, C. R., Pedersen, M. H., Glümer, C., Linneberg, Allan René, Witte, D. R., Jørgensen, M. E., Christensen, C., Brandslund, I., Lauritzen, T., Pedersen, Oluf Borbye, Holst, Birgitte, Grarup, Niels, Schwartz, Thue W. & Hansen, Torben, Sep 2016, In: Journal of Medical Genetics. 53, 9, p. 616-23 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2

      Petersen, Jacob Emil, Pedersen, M. H., Dmytriyeva, O., Nellemose, E., Arora, Tulika, Engelstoft, M. S., Asher, W. B., Javitch, J. A., Schwartz, Thue W. & Trauelsen, Mette, 2023, In: Molecular Metabolism. 74, 10 p., 101757.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity

      Gjesing, A. P., Larsen, L. H., Torekov, S. S., Hainerová, I. A., Kapur, R., Johansen, A., Albrechtsen, A., Boj, S., Holst, B., Harper, A., Urhammer, S. A., Borch-Johnsen, K., Pisinger, C. H., Echwald, S. M., Eiberg, H. R. L., Astrup, A., Lebl, J., Ferrer, J., Schwartz, T. W., Hansen, T. & 1 others, Pedersen, Oluf Borbye, 2010, In: P L o S One. 5, 4, 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling

      Trauelsen, Mette, Hiron, T. K., Lin, D., Petersen, Jacob Emil, Breton, B., Husted, Anna Sofie, Hjorth, Siv Annegrethe, Inoue, A., Frimurer, Thomas Michael, Bouvier, M., O'Callaghan, C. A. & Schwartz, Thue W., 2021, In: Cell Reports. 35, 11, 15 p., 109246.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia

      Nøhr, M. K., Egerod, Kristoffer Lihme, Christiansen, S. H., Gille, A., Offermanns, S., Schwartz, Thue W. & Møller, Morten, 2 Apr 2015, In: Neuroscience. 290, p. 126-37 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes

      Albrechtsen, A., Grarup, N., Li, Y., Sparsø, T. H., Tian, G., Cao, H., Jiang, T., Kim, S. Y., Korneliussen, T. S., Li, Q., Nie, C., Wu, R., Skotte, L., Morris, A. P., Ladenvall, C., Cauchi, S., Stancáková, A., Andersen, G., Astrup, A., Banasik, K. & 86 others, Bennett, A. J., Bolund, L., Charpentier, G., Chen, Y., Dekker, J. M., Doney, A. S. F., Dorkhan, M., Forsen, T., Frayling, T. M., Groves, C. J., Gui, Y., Hallmans, G., Hattersley, A. T., He, K., Hitman, G. A., Holmkvist, J., Huang, S., Jiang, H., Jin, X., Justesen, Johanne Marie, Kristiansen, Karsten, Kuusisto, J., Lajer, M., Lantieri, O., Li, W., Liang, H., Liao, Q., Liu, X., Ma, T., Ma, X., Manijak, M. P., Marre, M., Mokrosinski, J., Morris, A. D., Mu, B., Nielsen, A. A., Nijpels, G., Nilsson, P., Palmer, C. N. A., Rayner, N. W., Renström, F., Ribel-Madsen, R., Robertson, N., Rolandsson, O., Rossing, P., Schwartz, Thue W., Slagboom, P. E., Sterner, M., Tang, M., Tarnow, L., Tuomi, T., Van't Riet, E., van Leeuwen, N., V Varga, Tibor, Vestmar, M. A., Walker, M., Wang, B., Wang, Y., Wu, H., Xi, F., Yengo, L., Yu, C., Zhang, X., Zhang, J., Zhang, Q., Zhang, W., Zheng, H., Zhou, Y., Altshuler, D., 't Hart, L. M., Franks, P. W., Balkau, B., Froguel, P., McCarthy, M. I., Laakso, M., Groop, L., Christensen, C., Brandslund, I., Lauritzen, T., Witte, D. R., Linneberg, A., Jørgensen, T., Hansen, Torben, Wang, J., Nielsen, Rasmus & Pedersen, Oluf Borbye, 2013, In: Diabetologia. 56, 2, p. 298-310 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans

      Baumgartner, R., Berg, M., Matic, L., Polyzos, K. P., Forteza, M. J., Hjorth, Siv Annegrethe, Schwartz, Thue W., Paulson-Berne, G., Hansson, G. K., Hedin, U. & Ketelhuth, D. F. J., 2021, In: Journal of Internal Medicine. 289, 1, p. 53-68 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Enteroendocrine cell types revisited

      Engelstoft, M. S., Egerod, Kristoffer Lihme, Lund, M. L. & Schwartz, Thue W., Dec 2013, In: Current Opinion in Pharmacology. 13, 6, p. 912-21 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites

      Lund, M. L., Egerod, Kristoffer Lihme, Engelstoft, M. S., Dmytriyeva, O., Theodorsson, E., Patel, B. A. & Schwartz, Thue W., 2018, In: Molecular Metabolism. 11, p. 70-83 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Enhanced fluorescence resonance energy transfer between spectral variants of green fluorescent protein through zinc-site engineering

      Jensen, K. K., Martini, L. & Schwartz, Thue W., 2001, In: Biochemistry. 40 (4), p. 938-945

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Engineering of metal-ion sites as distance constraints in structural and functional analysis of 7TM receptors

      Elling, C. E., Thirstrup, K., Nielsen, S. M., Hjorth, S. A. & Schwartz, Thue W., 1997, In: Structure. 2, no. 4, p. 76-80

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Effects of intravenous infusions of PYY3-36 and GLP-1, as monoinfusion and in combination, on ad libitum energy intake in healthy obese subjects

      Schmidt, J. B., Gregersen, N. T., Pedersen, S. D., Holst, Jens Juul, Schwartz, Thue W., Astrup, A. & Sjödin, Anders Mikael, 10 Aug 2012, In: Regulatory Peptides. 177, Supplement, p. S32 1 p.

      Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

    21. Published

      Effects of PYY3-36 and GLP-1 on energy intake, energy expenditure and appetite in overweight men

      Schmidt, J. B., Gregersen, N. T., Pedersen, S. D., Arentoft, J. L., Ritz, C., Schwartz, Thue W., Holst, Jens Juul, Astrup, A. & Sjödin, Anders Mikael, 2014, In: American Journal of Physiology: Endocrinology and Metabolism. 306, 11, p. E1248-E1256 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      EBI2 overexpression in mice leads to B1 B cell expansion and chronic lymphocytic leukemia-(CLL)-like B cell malignancies

      Niss Arfelt, K., Barington, L., Benned-Jensen, T., Kubale, V., Kovalchuk, A. L., Daugvilaite, V., Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Egerod, Kristoffer Lihme, Bassi, Maria Rosaria, Spiess, Katja, Schwartz, Thue W., Wang, H., Morse, H. C., Holst, Peter Johannes & Rosenkilde, Mette, 2017, In: Blood. 129, 7, p. 866-878

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Dual agonistic and antagonistic proberty of non-peptide angiotensin AT1 ligands: Susceptibility to receptor mutations

      Perlman, S., Costa-Neto, C. M., Miyakawa, A. A., Schambye, H. T., Hjorth, S. A., Paiva, A. C., Rivero, R. A., Greenlee, W. J. & Schwartz, Thue W., 1997, In: Molecular Pharmaceutics. 51, no. 2, p. 301-311

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1

      Manfra, O., Van Craenenbroeck, K., Skieterska, K., Frimurer, Thomas Michael, Schwartz, Thue W., Levy, F. O. & Andressen, K. W., Jul 2015, In: A C S Chemical Neuroscience. 6, 7, p. 1206–1218 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Disulfide bridge engineering in the tachykinen NK1 receptor

      Elling, C. E., Raffetseder, U., Nielsen, S. M. & Schwartz, Thue W., 2000, In: Biochemistry. 39, no. 4, p. 667-75

      Research output: Contribution to journal › Journal article › Research › peer-review

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