Kei Sakamoto

Kei Sakamoto

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    1. 5′ Adenosine Monophosphate-Activated Protein Kinase, Metabolism and Exercise

      Aschenbach, W. G., Sakamoto, Kei & Goodyear, L. J., 12 Mar 2004, In: Sports Medicine. 34, 2, p. 91-103 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    2. A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice

      Chen, Q., Xie, B., Zhu, S., Rong, P., Sheng, Y., Ducommun, S., Chen, L., Quan, C., Li, M., Sakamoto, Kei, MacKintosh, C., Chen, S. & Wang, H. Y., 2017, In: Diabetologia. 60, 2, p. 336-345 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition

      Wan, M., Leavens, K. F., Hunter, R. W., Koren, S., Von Wilamowitz-Moellendorff, A., Lu, M., Satapati, S., Chu, Q., Sakamoto, Kei, Burgess, S. C. & Birnbaum, M. J., 2 Jul 2013, In: Cell Metabolism. 18, 1, p. 99-105 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis

      Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, Kei & Hardie, D. G., 15 Nov 2008, In: Biochemical Journal. 416, 1, p. 1-14 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. A small molecule AMPK activator protects the heart against ischemia-reperfusion injury

      Kim, A. S., Miller, E. J., Wright, T. M., Li, J., Qi, D., Atsina, K., Zaha, V., Sakamoto, Kei & Young, L. H., 1 Jul 2011, In: Journal of Molecular and Cellular Cardiology. 51, 1, p. 24-32 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner

      Kopietz, F., Alshuweishi, Y., Bijland, S., Alghamdi, F., Degerman, E., Sakamoto, Kei, Salt, I. P. & Göransson, O., 2021, In: Biochemical Journal. 478, 3, p. 633-646 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake

      Timmermans, A. D., Balteau, M., Gélinas, R., Renguet, E., Ginion, A., de Meester, C., Sakamoto, Kei, Balligand, J. L., Bontemps, F., Vanoverschelde, J. L., Horman, S., Beauloye, C. & Bertrand, L., 15 Jun 2014, In: American Journal of Physiology - Heart and Circulatory Physiology. 306, 12, p. H1619-H1630

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle

      Stoppani, J., Hildebrandt, A. L., Sakamoto, Kei, Cameron-Smith, D., Goodyear, L. J. & Darrell Neufer, P., 1 Dec 2002, In: American Journal of Physiology - Endocrinology and Metabolism. 283, 6 46-6, p. E1239-E1248

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K+ channels

      Sukhodub, A., Jovanović, S., Qingyou, D. U., Budas, G., Clelland, A. K., Shen, M. E. I., Sakamoto, Kei, Tian, R. & Jovanović, A., 1 Jan 2007, In: Journal of Cellular Physiology. 210, 1, p. 224-236 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase

      Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, Kei, Hue, L. & Rider, M. H., 1 Apr 2012, In: Biochemical Journal. 443, 1, p. 193-203 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. AMPK: A key sensor of fuel and energy status in skeletal muscle

      Hardie, D. G. & Sakamoto, Kei, 1 Feb 2006, In: Physiology. 21, 1, p. 48-60 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    12. AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation

      Gélinas, R., Mailleux, F., Dontaine, J., Bultot, L., Demeulder, B., Ginion, A., Daskalopoulos, E. P., Esfahani, H., Dubois-Deruy, E., Lauzier, B., Gauthier, C., Olson, A. K., Bouchard, B., Des Rosiers, C., Viollet, B., Sakamoto, K., Balligand, J. L., Vanoverschelde, J. L., Beauloye, C., Horman, S. & 1 others, Bertrand, L., 1 Dec 2018, In: Nature Communications. 9, 1, 374.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

      Collodet, C., Foretz, M., Deak, M., Bultot, L., Metairon, S., Viollet, B., Lefebvre, G., Raymond, F., Parisi, A., Civiletto, G., Gut, P., Descombes, P. & Sakamoto, Kei, Nov 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 12374-12391 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. AMPK promotes survival of c-Myc-positive melanoma cells by suppressing oxidative stress

      Kfoury, A., Armaro, M., Collodet, C., Sordet-Dessimoz, J., Giner, M. P., Christen, S., Moco, S., Leleu, M., de Leval, L., Koch, U., Trumpp, A., Sakamoto, Kei, Beermann, F. & Radtke, F., 1 Mar 2018, In: EMBO Journal. 37, 5, e97673.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy

      Dohmen, M., Krieg, S., Agalaridis, G., Zhu, X., Shehata, S. N., Pfeiffenberger, E., Amelang, J., Bütepage, M., Buerova, E., Pfaff, C. M., Chanda, D., Geley, S., Preisinger, C., Sakamoto, Kei, Lüscher, B., Neumann, D. & Vervoorts, J., 2020, In: Nature Communications. 11, 1, 18 p., 1032.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration

      Mounier, R., Théret, M., Arnold, L., Cuvellier, S., Bultot, L., Göransson, O., Sanz, N., Ferry, A., Sakamoto, Kei, Foretz, M., Viollet, B. & Chazaud, B., 6 Aug 2013, In: Cell Metabolism. 18, 2, p. 251-264 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis

      Theret, M., Gsaier, L., Schaffer, B., Juban, G., Ben Larbi, S., Weiss-Gayet, M., Bultot, L., Collodet, C., Foretz, M., Desplanches, D., Sanz, P., Zang, Z., Yang, Lin, Vial, G., Viollet, B., Sakamoto, Kei, Brunet, A., Chazaud, B. & Mounier, R., 3 Jul 2017, In: EMBO Journal. 36, 13, p. 1946-1962 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      AMPKα2 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion

      Kneppers, A., Ben Larbi, S., Theret, M., Saugues, A., Dabadie, C., Gsaier, L., Ferry, A., Rhein, P., Gondin, J., Sakamoto, Kei & Mounier, R., 2023, In: iScience. 26, 12, 17 p., 108343.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues

      Wang, H. Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, Kei, Mackintosh, C. & Chen, S., 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 479-489 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Activity of LKB1 and AMPK-related kinases in skeletal muscle: Effects of contraction, phenformin, and AICAR

      Sakamoto, Kei, Göransson, O., Hardie, D. G. & Alessi, D. R., 1 Aug 2004, In: American Journal of Physiology - Endocrinology and Metabolism. 287, 2 50-2, p. E310-E317

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Akt signaling in skeletal muscle: Regulation by exercise and passive stretch

      Sakamoto, Kei, Aschenbach, W. G., Hirshman, M. F. & Goodyear, L. J., 1 Nov 2003, In: American Journal of Physiology - Endocrinology and Metabolism. 285, 5 48-5, p. E1081-E1088

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle

      Bouskila, M., Hunter, R. W., Ibrahim, A. F. M., Delattre, L., Peggie, M., Van Diepen, J. A., Voshol, P. J., Jensen, J. & Sakamoto, Kei, 3 Nov 2010, In: Cell Metabolism. 12, 5, p. 456-466 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Amino acid homeostasis is a target of metformin therapy

      Forteath, C., Mordi, I., Nisr, R., Gutierrez-Lara, E. J., Alqurashi, N., Phair, I. R., Cameron, A. R., Beall, C., Bahr, I., Mohan, M., Wong, A. K. F., Dihoum, A., Mohammad, A., Palmer, C. N. A., Lamont, D., Sakamoto, Kei, Viollet, B., Foretz, M., Lang, C. C. & Rena, G., 2023, In: Molecular Metabolism. 74, 16 p., 101750.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Ampk activation by a-769662 and 991 does not affect catecholamine-induced lipolysis in human adipocytes

      Kopietz, F., Berggreen, C., Larsson, S., Säll, J., Ekelund, M., Sakamoto, Kei, Degerman, E., Holm, C. & Göransson, O., Nov 2018, In: American Journal of Physiology - Endocrinology and Metabolism. 315, 5, p. E1075-E1085

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase

      Shehata, S. N., Hunter, R. W., Ohta, E., Peggie, M. W., Lou, H. J., Sicheri, F., Zeqiraj, E., Turk, B. E. & Sakamoto, Kei, 1 Nov 2012, In: Cellular Signalling. 24, 11, p. 2085-2094 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status

      Cameron, A. R., Morrison, V. L., Levin, D., Mohan, M., Forteath, C., Beall, C., McNeilly, A. D., Balfour, D. J. K., Savinko, T., Wong, A. K. F., Viollet, B., Sakamoto, Kei, Fagerholm, S. C., Foretz, M., Lang, C. C. & Rena, G., 19 Aug 2016, In: Circulation Research. 119, 5, p. 652-665 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells

      Din, F. V. N., Valanciute, A., Houde, V. P., Zibrova, D., Green, K. A., Sakamoto, Kei, Alessi, D. R. & Dunlop, M. G., Jun 2012, In: Gastroenterology. 142, 7, p. 1504-1515.e3

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle

      Bultot, L., Jensen, Thomas Elbenhardt, Lai, Y., Madsen, A. L. B., Collodet, C., Kviklyte, S., Deak, M., Yavari, A., Foretz, M., Ghaffari, S., Bellahcene, M., Ashrafian, H., Rider, M. H., Richter, Erik A. & Sakamoto, Kei, 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 4, p. E706-E719 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Beyond AICA riboside: In search of new specific AMP-activated protein kinase activators

      Guigas, B., Sakamoto, Kei, Taleux, N., Reyna, S. M., Musi, N., Viollet, B. & Hue, L., 1 Dec 2009, In: IUBMB Life. 61, 1, p. 18-26 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    30. Published

      Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

      Neopane, K., Kozlov, N., Negoita, F., Murray-Segal, L., Brink, R., Hoque, A., Ovens, A. J., Tjin, G., McAloon, L. M., Yu, D., Ling, N. X. Y., Sanders, M. J., Oakhill, J. S., Scott, J. W., Steinberg, G. R., Loh, K., Kemp, B. E., Sakamoto, Kei & Galic, S., 2022, In: Cell Reports. 41, 12, 26 p., 111862.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle

      Negoita, F., Addinsall, A. B., Hellberg, K., Bringas, C. F., Hafen, P. S., Sermersheim, T. J., Agerholm, M., Lewis, C. T. A., Ahwazi, D., Ling, N. X. Y., Larsen, J. K., Deshmukh, A. S., Hossain, M. A., Oakhill, J. S., Ochala, J., Brault, J. J., Sankar, U., Drewry, D. H., Scott, J. W., Witczak, C. A. & 1 others, Sakamoto, Kei, 2023, In: Molecular Metabolism. 75, 14 p., 101761.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Cellular responses to the metal-binding properties of metformin

      Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H. H., Xue, L., Jiang, H., Sakamoto, Kei, Prescott, A. R. & Rena, G., 1 Jun 2012, In: Diabetes. 61, 6, p. 1423-1433 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Changes in Leukocytes after Eccentric Exerclse ot the Elbow Flexors

      Nosaka, K. & Sakamoto, Kei, 25 May 2000, In: Advances in Exercise and Sports Physiology. 6, 2, p. 59-65 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Changes in plasma enzyme activity after intramuscular injection of bupivacaine into the human biceps brachii

      Nosaka, K. & Sakamoto, Kei, 1 Dec 1999, In: Acta Physiologica Scandinavica. 167, 3, p. 259-265 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis

      Banko, M. R., Allen, J. J., Schaffer, B. E., Wilker, E. W., Tsou, P. P., White, J. L., Villén, J., Wang, B., Kim, S. R., Sakamoto, Kei, Gygi, S. P., Cantley, L. C., Yaffe, M. B., Shokat, K. M. & Brunet, A., 23 Dec 2011, In: Molecular Cell. 44, 6, p. 878-892 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates

      Ducommun, S., Deak, M., Zeigerer, A., Göransson, O., Seitz, S., Collodet, C., Madsen, A. B., Jensen, Thomas Elbenhardt, Viollet, B., Foretz, M., Gut, P., Sumpton, D. & Sakamoto, Kei, 2019, In: Cellular Signalling. 57, p. 45-57 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle

      Rhein, P., Desjardins, E. M., Rong, P., Ahwazi, D., Bonhoure, N., Stolte, J., Santos, M. D., Ovens, A. J., Ehrlich, A. M., Sanchez Garcia, J. L., Ouyang, Q., Yabut, J. M., Kjolby, M., Membrez, M., Jessen, N., Oakhill, J. S., Treebak, J. T., Maire, P., Scott, J. W., Sanders, M. J. & 4 others, Descombes, P., Chen, S., Steinberg, G. R. & Sakamoto, Kei, 2021, In: Molecular Metabolism. 51, 18 p., 101228.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Contraction regulation of Akt in rat skeletal muscle

      Sakamoto, Kei, Hirshman, M. F., Aschenbach, W. G. & Goodyear, L. J., 5 Apr 2002, In: Journal of Biological Chemistry. 277, 14, p. 11910-11917 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Corrigendum: SIKs control osteocyte responses to parathyroid hormone

      Wein, M. N., Liang, Y., Goransson, O., Sundberg, T. B., Wang, J., Williams, E. A., O'Meara, M. J., Govea, N., Beqo, B., Nishimori, S., Nagano, K., Brooks, D. J., Martins, J. S., Corbin, B., Anselmo, A., Sadreyev, R., Wu, J. Y., Sakamoto, K., Foretz, M., Xavier, R. J. & 6 others, Baron, R., Bouxsein, M. L., Gardella, T. J., Divieti-Pajevic, P., Gray, N. S. & Kronenberg, H. M., 22 Feb 2017, In: Nature Communications. 8, 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase

      Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, Kei & Hundal, H. S., 15 Apr 2011, In: Biochemical Journal. 435, 2, p. 463-474 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Creatine kinase release from regenerated muscles after eccentric contractions in rats

      Sakamoto, Kei, Nosaka, K., Shimegi, S., Ohmori, H. & Katsuta , S., 1 Jan 1996, In: European Journal of Applied Physiology and Occupational Physiology. 73, 6, p. 516-520 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16

      Shehata, S. N., Deak, M., Morrice, N. A., Ohta, E., Hunter, R. W., Kalscheuer, V. M. & Sakamoto, Kei, 1 Aug 2015, In: Biochemical Journal. 469, 3, p. 409-420 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1

      Sakamoto, Kei, Zarrinpashneh, E., Budas, G. R., Pouleur, A. C., Dutta, A., Prescott, A. R., Vanoverschelde, J. L., Ashworth, A., Jovanović, A., Alessi, D. R. & Bertrand, L., 1 May 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 290, 5, p. E780-E788

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

      Sakamoto, Kei, McCarthy, A., Smith, D., Green, K. A., Hardie, D. G., Ashworth, A. & Alessi, D. R., 18 May 2005, In: EMBO Journal. 24, 10, p. 1810-1820 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: An immunohistochemical study

      Sakuma, K., Watanabe, K., Totsuka, T., Uramoto, I., Sano, M. & Sakamoto, Kei, 1 Jan 1998, In: Acta Neuropathologica. 95, 2, p. 123-130 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells

      Dimopoulos, N., Watson, M., Sakamoto, Kei & Hundal, H. S., 1 Nov 2006, In: Biochemical Journal. 399, 3, p. 473-481 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion

      Chen, L., Chen, Q., Xie, B., Quan, C., Sheng, Y., Zhu, S., Rong, P., Zhou, S., Sakamoto, Kei, MacKintosh, C., Wang, H. Y. & Chen, S., 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. 7219-7224 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle

      Kramer, H. F., Witczak, C. A., Fujii, N., Jessen, N., Taylor, E. B., Arnolds, D. E., Sakamoto, Kei, Hirshman, M. F. & Goodyear, L. J., 1 Jul 2006, In: Diabetes. 55, 7, p. 2067-2076 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin α∥bβ3 activation and granule secretion in platelets

      Moore, S. F., Van Den Bosch, M. T. J., Hunter, R. W., Sakamoto, Kei, Poole, A. W. & Hers, I., 8 Feb 2013, In: Journal of Biological Chemistry. 288, 6, p. 3918-3928 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Effect of AICAR treatment on glycogen metabolism in skeletal muscle

      Aschenbach, W. G., Hirshman, M. F., Fujii, N., Sakamoto, Kei, Howlett, K. F. & Goodyear, L. J., 1 Jan 2002, In: Diabetes. 51, 3, p. 567-573 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: A time-course and dose-response study

      Sriwijitkamol, A., Coletta, D. K., Wajcberg, E., Balbontin, G. B., Reyna, S. M., Barrientes, J., Eagan, P. A., Jenkinson, C. P., Cersosimo, E., DeFronzo, R. A., Sakamoto, Kei & Musi, N., 1 Mar 2007, In: Diabetes. 56, 3, p. 836-848 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. Published

      Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects

      Jensen, J., Tantiwong, P., Stuenæs, J. T., Molina-Carrion, M., de Fronzo, R. A., Sakamoto, Kei & Musi, N., 1 Jul 2012, In: American Journal of Physiology - Endocrinology and Metabolism. 303, 1, p. E82-E89

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Effect of elbow joint angle on the magnitude of muscle damage to the elbow flexors

      Nosaka, K. & Sakamoto, Kei, 1 Jan 2001, In: Medicine and Science in Sports and Exercise. 33, 1, p. 22-29 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Effect of high-intensity intermittent swimming on postexercise insulin sensitivity in rat epitrochlearis muscle

      Koshinaka, K., Sano, A., Howlett, K. F., Yamazaki, T., Sasaki, M., Sakamoto, Kei & Kawanaka, K., 1 Jun 2008, In: Metabolism: Clinical and Experimental. 57, 6, p. 749-756 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

      Sakamoto, Kei & Holman, G. D., 1 Jul 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 295, 1, p. E29-E37

      Research output: Contribution to journal › Review › Research › peer-review

    56. Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662

      Ducommun, S., Ford, R. J., Bultot, L., Deak, M., Bertrand, L., Kemp, B. E., Steinberg, G. R. & Sakamoto, Kei, 15 Mar 2014, In: American Journal of Physiology - Endocrinology and Metabolism. 306, 6, p. E688-E696

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Evaluation of approaches to generation of tissue-specific knock-in mice

      Bayascas, J. R., Sakamoto, Kei, Armit, L., Arthur, J. S. C. & Alessi, D. R., 29 Sep 2006, In: Journal of Biological Chemistry. 281, 39, p. 28772-28781 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. Exercise regulates Akt and glycogen synthase kinase-3 activities in human skeletal muscle

      Sakamoto, Kei, Arnolds, D. E. W., Ekberg, I., Thorell, A. & Goodyear, L. J., 25 Jun 2004, In: Biochemical and Biophysical Research Communications. 319, 2, p. 419-425 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    59. Published

      Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

      Hingst, J. R., Bruhn, L., Hansen, M. B., Rosschou, M. F., Birk, Jesper Bratz, Fentz, J., Foretz, M., Viollet, B., Sakamoto, Kei, Færgeman, N. J., Havelund, J. F., Parker, B. L., James, D. E., Kiens, Bente, Richter, Erik A., Jensen, J. & Wojtaszewski, Jørgen F P, 2018, In: Molecular Metabolism. 16, p. 24-34 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    60. Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells

      Hunter, R. W., Zeqiraj, E., Morrice, N., Sicheri, F. & Sakamoto, Kei, Apr 2015, In: Protein Expression and Purification. 108, p. 23-29 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    61. GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis

      Zibrova, D., Vandermoere, F., Göransson, O., Peggie, M., Mariño, K. V., Knierim, A., Spengler, K., Weigert, C., Viollet, B., Morrice, N. A., Sakamoto, Kei & Heller, R., 15 Mar 2017, In: Biochemical Journal. 474, 6, p. 983-1001 19 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis

      Von Wilamowitz-Moellendorff, A., Hunter, R. W., García-Rocha, M., Kang, L., López-Soldado, I., Lantier, L., Patel, K., Peggie, M. W., Martínez-Pons, C., Voss, M., Calbó, J., Cohen, P. T. W., Wasserman, D. H., Guinovart, J. J. & Sakamoto, Kei, 1 Dec 2013, In: Diabetes. 62, 12, p. 4070-4082 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function

      Cheung, R., Pizza, G., Chabosseau, P., Rolando, D., Tomas, A., Burgoyne, T., Wu, Z., Salowka, A., Thapa, A., Macklin, A., Cao, Y., Nguyen-Tu, M. S., Dickerson, M. T., Jacobson, D. A., Marchetti, P., Shapiro, J., Piemonti, L., de Koning, E., Leclerc, I., Bouzakri, K. & 4 others, Sakamoto, Kei, Smith, D. M., Rutter, G. A. & Martinez-Sanchez, A., 2022, In: Diabetes. 71, 7, p. 1525-1545 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    64. How long does the protective effect on eccentric exercise-induced muscle damage last?

      Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Jan 2001, In: Medicine and Science in Sports and Exercise. 33, 9, p. 1490-1495 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    65. How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

      Wullschleger, S., Sakamoto, Kei, Johnstone, L., Duce, S., Fleming, S. & Alessi, D. R., 1 Jan 2011, In: DMM Disease Models and Mechanisms. 4, 1, p. 95-103 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    66. Identification of novel PCTAIRE-1/CDK16 substrates using a chemical genetic screen

      Shehata, S. N., Deak, M., Collodet, C., Spiegl, S., Geley, S., Sumpton, D. & Sakamoto, Kei, Jul 2019, In: Cellular Signalling. 59, p. 53-61 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    67. Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle

      Joanne, P., Hourdé, C., Ochala, J., Caudéran, Y., Medja, F., Vignaud, A., Mouisel, E., Hadj-Said, W., Arandel, L., Garcia, L., Goyenvalle, A., Mounier, R., Zibroba, D., Sakamoto, Kei, Sakamato, K., Butler-Browne, G., Agbulut, O. & Ferry, A., 2012, In: PLoS ONE. 7, 4, p. e35346

      Research output: Contribution to journal › Journal article › Research › peer-review

    68. Published

      Important role for AMPKα1 in limiting skeletal muscle cell hypertrophy

      Mounier, R., Lantier, L., Leclerc, J., Sotiropoulos, A., Pende, M., Daegelen, D., Sakamoto, Kei, Foretz, M. & Viollet, B., Jul 2009, In: FASEB Journal. 23, 7, p. 2264-2273 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    69. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

      Huang, X., Wullschleger, S., Shpiro, M., McGuire, V. A., Sakamoto, Kei, Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R., 1 Jun 2008, In: Biochemical Journal. 412, 2, p. 211-221 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    70. Published

      In Vitro Screening for Probiotic Properties of Lactobacillus and Bifidobacterium Strains in Assays Relevant for Non-Alcoholic Fatty Liver Disease Prevention

      Lopez-Escalera, S., Lund, M. L., Hermes, G. D. A., Choi, Beatrice So-Yun, Sakamoto, Kei & Wellejus, A., 2023, In: Nutrients. 15, 10, 23 p., 2361.

      Research output: Contribution to journal › Journal article › Research › peer-review

    71. Influence of Arm-cranking on Changes in Plasma CK Activity after High Force Eccentric Exercise of the Elbow Flexors

      Nosaka, K., Sakamoto, Kei & Newton, M., 25 Mar 2002, In: Advances in Exercise and Sports Physiology. 8, 2, p. 45-50 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    72. Influence of pre-exercise muscle temperature on responses to eccentric exercise

      Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Apr 2004, In: Journal of Athletic Training. 39, 2, p. 132-137 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    73. Published

      Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle

      Bouskila, M., Hirshman, M. F., Jensen, J., Goodyear, L. J. & Sakamoto, Kei, 1 Jan 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 294, 1, p. E28-E35

      Research output: Contribution to journal › Journal article › Research › peer-review

    74. Insulin signaling after exercise in insulin receptor substrate-2-deficient mice

      Hewlett, K. F., Sakamoto, Kei, Hirshman, M. F., Aschenbach, W. G., Dow, M., White, M. F. & Goodyear, L. J., 24 Jul 2002, In: Diabetes. 51, 2, p. 479-483 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    75. Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle

      Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, Kei, Hajduch, E., Arthur, J. S. C. & Hundal, H. S., 1 Nov 2005, In: Diabetes. 54, 11, p. 3161-3168 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    76. Insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise

      Howlett, K. F., Sakamoto, Kei, Yu, H., Goodyear, L. J. & Hargreaves, M., 1 Aug 2006, In: Metabolism: Clinical and Experimental. 55, 8, p. 1046-1052 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    77. Investigation of LKB1 Ser431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

      Houde, V. P., Ritorto, M. S., Gourlay, R., Varghese, J., Davies, P., Shpiro, N., Sakamoto, Kei & Alessi, D. R., 15 Jan 2014, In: Biochemical Journal. 458, 1, p. 41-56 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    78. Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug

      Cameron, A. R., Logie, L., Patel, K., Bacon, S., Forteath, C., Harthill, J., Roberts, A., Sutherland, C., Stewart, D., Viollet, B., Sakamoto, Kei, McDougall, G., Foretz, M. & Rena, G., 1 Aug 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 8, p. 1412-1422 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    79. Published

      Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965

      Ahwazi, Danial, Neopane, K., Markby, G. R., Kopietz, F., Ovens, A. J., Dall, M., Hassing, Anna Skab, Gräsle, P., Alshuweishi, Y., Treebak, Jonas Thue, Salt, I. P., Göransson, O., Zeqiraj, E., Scott, J. W. & Sakamoto, Kei, 2021, In: Biochemical Journal. 478, 15, p. 2977-2997 21 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    80. Invited review: Intracellular signaling in contracting skeletal muscle

      Sakamoto, Kei & Goodyear, L. J., 1 Jan 2002, In: Journal of Applied Physiology. 93, 1, p. 369-383 15 p.

      Research output: Contribution to journal › Review › Research › peer-review

    81. Published

      LKB1 regulates lipid oxidation during exercise independently of AMPK

      Jeppesen, J. F., Maarbjerg, S. J., Jordy, A. B., Fritzen, Andreas Mæchel, Pehmøller, C., Sylow, Lykke, Serup, A. K. L., Jessen, N., Thorsen, K., Prats Gavalda, Clara, Qvortrup, Klaus, Dyck, J. R. B., Hunter, R. W., Sakamoto, Kei, Thomson, D. M., Schjerling, Peter, Wojtaszewski, Jørgen F P, Richter, Erik A. & Kiens, Bente, 2013, In: Diabetes. 62, 5, p. 1490-1499 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    82. LKB1-dependent signaling pathways

      Alessi, D. R., Sakamoto, Kei & Bayascas, J. R., 31 Jul 2006, In: Annual Review of Biochemistry. 75, p. 137-163 27 p.

      Research output: Contribution to journal › Review › Research › peer-review

    83. Published

      Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function

      Mottillo, E. P., Desjardins, E. M., Crane, J. D., Smith, B. K., Green, A. E., Ducommun, S., Henriksen, T. I., Rebalka, I. A., Razi, A., Sakamoto, Kei, Schéele, Camilla Charlotte Nielsen, Kemp, B. E., Hawke, T. J., Ortega, J., Granneman, J. G. & Steinberg, G. R., 12 Jul 2016, In: Cell Metabolism. 24, 1, p. 118-129 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    84. Loss of sarcoplasmic reticulum membrane integrity after eccentric contractions

      Yasuda, T., Sakamoto, Kei, Nosaka, K., Wada, M. & Katsuta, S., 1 Jan 1997, p. 581-582. 2 p.

      Research output: Contribution to conference › Conference abstract for conference › Research

    85. Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line

      Habinowski, S. A., Hirshman, M., Sakamoto, Kei, Kemp, B. E., Gould, S. J., Goodyear, L. J. & Witters, L. A., 1 Dec 2001, In: Archives of Biochemistry and Biophysics. 396, 1, p. 71-79 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    86. Published

      Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase

      Göransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. & Sakamoto, Kei, 9 Nov 2007, In: Journal of Biological Chemistry. 282, 45, p. 32549-32560 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    87. Mechanism of action of compound-13: An α1-selective small molecule activator of AMPK

      Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, Kei, 17 Jul 2014, In: Chemistry and Biology. 21, 7, p. 866-879 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    88. Published

      Mechanism of glycogen synthase inactivation and interaction with glycogenin

      Marr, L., Biswas, Dipsikha, Daly, L. A., Browning, C., Vial, S. C. M., Maskell, D. P., Hudson, C., Bertrand, J. A., Pollard, J., Ranson, N. A., Khatter, H., Eyers, C. E., Sakamoto, Kei & Zeqiraj, E., 2022, In: Nature Communications. 13, 1, 14 p., 3372.

      Research output: Contribution to journal › Journal article › Research › peer-review

    89. Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems

      Thevenet, J., De Marchi, U., Domingo, J. S., Christinat, N., Bultot, L., Lefebvre, G., Sakamoto, Kei, Descombes, P., Masoodi, M. & Wiederkehr, A., May 2016, In: FASEB Journal. 30, 5, p. 1913-1926 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    90. Published

      Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

      Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, Kei, Andreelli, F. & Viollet, B., 1 Jul 2010, In: Journal of Clinical Investigation. 120, 7, p. 2355-2369 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    91. Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase

      Hunter, R. W., Hughey, C. C., Lantier, L., Sundelin, E. I., Peggie, M., Zeqiraj, E., Sicheri, F., Jessen, N., Wasserman, D. H. & Sakamoto, Kei, 1 Sep 2018, In: Nature Medicine. 24, 9, p. 1395-1406 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    92. Metformin selectively targets redox control of complex I energy transduction

      Cameron, A. R., Logie, L., Patel, K., Erhardt, S., Bacon, S., Middleton, P., Harthill, J., Forteath, C., Coats, J. T., Kerr, C., Curry, H., Stewart, D., Sakamoto, Kei, Repiščák, P., Paterson, M. J., Hassinen, I., McDougall, G. & Rena, G., Apr 2018, In: Redox Biology. 14, p. 187-197 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    93. MiR-184 expression is regulated by AMPK in pancreatic islets

      Martinez-Sanchez, A., Nguyen-Tu, M. S., Cebola, I., Yavari, A., Marchetti, P., Piemonti, L., De Koning, E., Shapiro, A. M. J., Johnson, P., Sakamoto, Kei, Smith, D. M., Leclerc, I., Ashrafian, H., Ferrer, J. & Rutter, G. A., May 2018, In: FASEB Journal. 32, 5, p. 2587-2600 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    94. Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking

      Chen, S., Wasserman, D. H., MacKintosh, C. & Sakamoto, Kei, 5 Jan 2011, In: Cell Metabolism. 13, 1, p. 68-79 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    95. Published

      Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle

      Hunter, R. W., Treebak, Jonas Thue, Wojtaszewski, Jørgen F P & Sakamoto, Kei, 2011, In: Diabetes. 60, 3, p. 766-774 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    96. Molecular mechanism of action of metformin: Old or new insights?

      Rena, G., Pearson, E. R. & Sakamoto, Kei, 1 Sep 2013, In: Diabetologia. 56, 9, p. 1898-1906 9 p.

      Research output: Contribution to journal › Review › Research › peer-review

    97. Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate

      Ducommun, S., Deak, M., Sumpton, D., Ford, R. J., Núñez Galindo, A., Kussmann, M., Viollet, B., Steinberg, G. R., Foretz, M., Dayon, L., Morrice, N. A. & Sakamoto, Kei, 1 May 2015, In: Cellular Signalling. 27, 5, p. 978-988 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    98. Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

      Patra, K. C., Kato, Y., Mizukami, Y., Widholz, S., Boukhali, M., Revenco, I., Grossman, E. A., Ji, F., Sadreyev, R. I., Liss, A. S., Screaton, R. A., Sakamoto, Kei, Ryan, D. P., Mino-Kenudson, M., Castillo, C. F. D., Nomura, D. K., Haas, W. & Bardeesy, N., 1 Jul 2018, In: Nature Cell Biology. 20, 7, p. 811-822 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    99. Mutation in the γ2-Subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage

      Kim, M., Hunter, R. W., Garcia-Menendez, L., Gong, G., Yang, Y. Y., Kolwicz, S. C., Xu, J., Sakamoto, Kei, Wang, W. & Tian, R., 14 Mar 2014, In: Circulation Research. 114, 6, p. 966-975 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    100. Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance

      Bayascas, J. R., Wullschleger, S., Sakamoto, Kei, García-Martínez, J. M., Clacher, C., Komander, D., Van Aalten, D. M. F., Boini, K. M., Lang, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., Van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R., May 2008, In: Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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