Kei Sakamoto

Kei Sakamoto

Professor

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    1. 2008

    2. Silencing Metabolic Disorders by Novel SIRT1 Activators

      Sakamoto, Kei, 9 Jan 2008, In: Cell Metabolism. 7, 1, p. 3-4 2 p.

      Research output: Contribution to journal › Letter › Research › peer-review

    3. Published

      Insulin promotes glycogen synthesis in the absence of GSK3 phosphorylation in skeletal muscle

      Bouskila, M., Hirshman, M. F., Jensen, J., Goodyear, L. J. & Sakamoto, Kei, 1 Jan 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 294, 1, p. E28-E35

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. 2007
    5. Published

      Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase

      Göransson, O., McBride, A., Hawley, S. A., Ross, F. A., Shpiro, N., Foretz, M., Viollet, B., Hardie, D. G. & Sakamoto, Kei, 9 Nov 2007, In: Journal of Biological Chemistry. 282, 45, p. 32549-32560 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle

      Howlett, K. F., Sakamoto, Kei, Garnham, A., Cameron-Smith, D. & Hargreaves, M., 1 Jun 2007, In: Diabetes. 56, 6, p. 1608-1614 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: A time-course and dose-response study

      Sriwijitkamol, A., Coletta, D. K., Wajcberg, E., Balbontin, G. B., Reyna, S. M., Barrientes, J., Eagan, P. A., Jenkinson, C. P., Cersosimo, E., DeFronzo, R. A., Sakamoto, Kei & Musi, N., 1 Mar 2007, In: Diabetes. 56, 3, p. 836-848 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. AMP-activated protein kinase mediates preconditioning in cardiomyocytes by regulating activity and trafficking of sarcolemmal ATP-sensitive K+ channels

      Sukhodub, A., Jovanović, S., Qingyou, D. U., Budas, G., Clelland, A. K., Shen, M. E. I., Sakamoto, Kei, Tian, R. & Jovanović, A., 1 Jan 2007, In: Journal of Cellular Physiology. 210, 1, p. 224-236 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. 2006

    10. Role of Akt2 in contraction-stimulated cell signaling and glucose uptake in skeletal muscle

      Sakamoto, Kei, Arnolds, D. E., Fujii, N., Kramer, H. F., Hirshman, M. F. & Goodyear, L. J., 24 Nov 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 291, 5, p. E1031-E1037

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells

      Dimopoulos, N., Watson, M., Sakamoto, Kei & Hundal, H. S., 1 Nov 2006, In: Biochemical Journal. 399, 3, p. 473-481 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Evaluation of approaches to generation of tissue-specific knock-in mice

      Bayascas, J. R., Sakamoto, Kei, Armit, L., Arthur, J. S. C. & Alessi, D. R., 29 Sep 2006, In: Journal of Biological Chemistry. 281, 39, p. 28772-28781 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Insulin-stimulated insulin receptor substrate-2-associated phosphatidylinositol 3-kinase activity is enhanced in human skeletal muscle after exercise

      Howlett, K. F., Sakamoto, Kei, Yu, H., Goodyear, L. J. & Hargreaves, M., 1 Aug 2006, In: Metabolism: Clinical and Experimental. 55, 8, p. 1046-1052 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. LKB1-dependent signaling pathways

      Alessi, D. R., Sakamoto, Kei & Bayascas, J. R., 31 Jul 2006, In: Annual Review of Biochemistry. 75, p. 137-163 27 p.

      Research output: Contribution to journal › Review › Research › peer-review

    15. Regulation of Dishevelled and β-catenin in rat skeletal muscle: An alternative exercise-induced GSK-3β signaling pathway

      Aschenbach, W. G., Ho, R. C., Sakamoto, Kei, Fujii, N., Li, Y., Kim, Y. B., Hirshman, M. F. & Goodyear, L. J., 17 Jul 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 291, 1, p. E152-E158

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Distinct signals regulate AS160 phosphorylation in response to insulin, AICAR, and contraction in mouse skeletal muscle

      Kramer, H. F., Witczak, C. A., Fujii, N., Jessen, N., Taylor, E. B., Arnolds, D. E., Sakamoto, Kei, Hirshman, M. F. & Goodyear, L. J., 1 Jul 2006, In: Diabetes. 55, 7, p. 2067-2076 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKα2 but not AMPKα1

      Sakamoto, Kei, Zarrinpashneh, E., Budas, G. R., Pouleur, A. C., Dutta, A., Prescott, A. R., Vanoverschelde, J. L., Ashworth, A., Jovanović, A., Alessi, D. R. & Bertrand, L., 1 May 2006, In: American Journal of Physiology - Endocrinology and Metabolism. 290, 5, p. E780-E788

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. AMPK: A key sensor of fuel and energy status in skeletal muscle

      Hardie, D. G. & Sakamoto, Kei, 1 Feb 2006, In: Physiology. 21, 1, p. 48-60 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    19. 2005

    20. Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle

      Turban, S., Beardmore, V. A., Carr, J. M., Sakamoto, Kei, Hajduch, E., Arthur, J. S. C. & Hundal, H. S., 1 Nov 2005, In: Diabetes. 54, 11, p. 3161-3168 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart

      Mora, A., Sakamoto, Kei, McManus, E. J. & Alessi, D. R., 27 Jul 2005, In: FEBS Letters. 579, 17, p. 3632-3638 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

      Sakamoto, Kei, McCarthy, A., Smith, D., Green, K. A., Hardie, D. G., Ashworth, A. & Alessi, D. R., 18 May 2005, In: EMBO Journal. 24, 10, p. 1810-1820 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

      McManus, E. J., Sakamoto, Kei, Armit, L. J., Ronaldson, L., Shpiro, N., Marquez, R. & Alessi, D. R., 20 Apr 2005, In: EMBO Journal. 24, 8, p. 1571-1583 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. 2004

    25. Activity of LKB1 and AMPK-related kinases in skeletal muscle: Effects of contraction, phenformin, and AICAR

      Sakamoto, Kei, Göransson, O., Hardie, D. G. & Alessi, D. R., 1 Aug 2004, In: American Journal of Physiology - Endocrinology and Metabolism. 287, 2 50-2, p. E310-E317

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity

      Fujii, N., Boppart, M. D., Dufresne, S. D., Crowley, P. F., Jozsi, A. C., Sakamoto, Kei, Yu, H., Aschenbach, W. G., Kim, S., Miyazaki, H., Rui, L., White, M. F., Hirshman, M. F. & Goodyear, L. J., 1 Jul 2004, In: American Journal of Physiology - Cell Physiology. 287, 1 56-1, p. C200-C208

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Exercise regulates Akt and glycogen synthase kinase-3 activities in human skeletal muscle

      Sakamoto, Kei, Arnolds, D. E. W., Ekberg, I., Thorell, A. & Goodyear, L. J., 25 Jun 2004, In: Biochemical and Biophysical Research Communications. 319, 2, p. 419-425 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Influence of pre-exercise muscle temperature on responses to eccentric exercise

      Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Apr 2004, In: Journal of Athletic Training. 39, 2, p. 132-137 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. 5′ Adenosine Monophosphate-Activated Protein Kinase, Metabolism and Exercise

      Aschenbach, W. G., Sakamoto, Kei & Goodyear, L. J., 12 Mar 2004, In: Sports Medicine. 34, 2, p. 91-103 13 p.

      Research output: Contribution to journal › Review › Research › peer-review

    30. 2003

    31. Akt signaling in skeletal muscle: Regulation by exercise and passive stretch

      Sakamoto, Kei, Aschenbach, W. G., Hirshman, M. F. & Goodyear, L. J., 1 Nov 2003, In: American Journal of Physiology - Endocrinology and Metabolism. 285, 5 48-5, p. E1081-E1088

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. 2002

    33. AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle

      Stoppani, J., Hildebrandt, A. L., Sakamoto, Kei, Cameron-Smith, D., Goodyear, L. J. & Darrell Neufer, P., 1 Dec 2002, In: American Journal of Physiology - Endocrinology and Metabolism. 283, 6 46-6, p. E1239-E1248

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Insulin signaling after exercise in insulin receptor substrate-2-deficient mice

      Hewlett, K. F., Sakamoto, Kei, Hirshman, M. F., Aschenbach, W. G., Dow, M., White, M. F. & Goodyear, L. J., 24 Jul 2002, In: Diabetes. 51, 2, p. 479-483 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Contraction regulation of Akt in rat skeletal muscle

      Sakamoto, Kei, Hirshman, M. F., Aschenbach, W. G. & Goodyear, L. J., 5 Apr 2002, In: Journal of Biological Chemistry. 277, 14, p. 11910-11917 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Influence of Arm-cranking on Changes in Plasma CK Activity after High Force Eccentric Exercise of the Elbow Flexors

      Nosaka, K., Sakamoto, Kei & Newton, M., 25 Mar 2002, In: Advances in Exercise and Sports Physiology. 8, 2, p. 45-50 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Effect of AICAR treatment on glycogen metabolism in skeletal muscle

      Aschenbach, W. G., Hirshman, M. F., Fujii, N., Sakamoto, Kei, Howlett, K. F. & Goodyear, L. J., 1 Jan 2002, In: Diabetes. 51, 3, p. 567-573 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Invited review: Intracellular signaling in contracting skeletal muscle

      Sakamoto, Kei & Goodyear, L. J., 1 Jan 2002, In: Journal of Applied Physiology. 93, 1, p. 369-383 15 p.

      Research output: Contribution to journal › Review › Research › peer-review

    39. Reduced expression of the murine p85α subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes

      Mauvais-Jarvis, F., Ueki, K., Fruman, D. A., Hirshman, M. F., Sakamoto, Kei, Goodyear, L. J., Iannacone, M., Accili, D., Cantley, L. C. & Ronald Kahn, C., 1 Jan 2002, In: Journal of Clinical Investigation. 109, 1, p. 141-149 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. 2001

    41. Malonyl-CoA decarboxylase is not a substrate of AMP-activated protein kinase in rat fast-twitch skeletal muscle or an islet cell line

      Habinowski, S. A., Hirshman, M., Sakamoto, Kei, Kemp, B. E., Gould, S. J., Goodyear, L. J. & Witters, L. A., 1 Dec 2001, In: Archives of Biochemistry and Biophysics. 396, 1, p. 71-79 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Static stretch increases c-Jun NH 2-terminal kinase activity and p38 phosphorylation in rat skeletal muscle

      Boppart, M. D., Hirshman, M. F., Sakamoto, Kei, Fielding, R. A. & Goodyear, L. J., 9 Jun 2001, In: American Journal of Physiology - Cell Physiology. 280, 2 49-2, p. C352-C358

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Effect of elbow joint angle on the magnitude of muscle damage to the elbow flexors

      Nosaka, K. & Sakamoto, Kei, 1 Jan 2001, In: Medicine and Science in Sports and Exercise. 33, 1, p. 22-29 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. How long does the protective effect on eccentric exercise-induced muscle damage last?

      Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Jan 2001, In: Medicine and Science in Sports and Exercise. 33, 9, p. 1490-1495 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. The repeated bout effect of reduced-load eccentric exercise on elbow flexor muscle damage

      Nosaka, K., Sakamoto, Kei, Newton, M. & Sacco, P., 1 Jan 2001, In: European Journal of Applied Physiology. 85, 1-2, p. 34-40 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      The muscle-specific protein phosphatase PP1G/R(GL)(G(M))is essential for activation of glycogen synthase by exercise

      Aschenbach, W. G., Suzuki, Y., Breeden, K., Prats Gavalda, Clara, Hirshman, M. F., Dufresne, S. D., Sakamoto, Kei, Vilardo, P. G., Steele, M., Kim, J. H., Jing, S. L., Goodyear, L. J. & DePaoli-Roach, A. A., 2001, In: Journal of Biological Chemistry. 276, 43, p. 39959-67 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. 2000

    48. Changes in Leukocytes after Eccentric Exerclse ot the Elbow Flexors

      Nosaka, K. & Sakamoto, Kei, 25 May 2000, In: Advances in Exercise and Sports Physiology. 6, 2, p. 59-65 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. The adaptive response of transforming growth factor-β2 and -βRII in the overloaded, regenerating and denervated muscles of rats

      Sakuma, K., Watanabe, K., Sano, M., Kitajima, S., Sakamoto, Kei, Uramoto, I. & Totsuka, T., Feb 2000, In: Acta Neuropathologica. 99, 2, p. 177-185 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. 1999

    51. Changes in plasma enzyme activity after intramuscular injection of bupivacaine into the human biceps brachii

      Nosaka, K. & Sakamoto, Kei, 1 Dec 1999, In: Acta Physiologica Scandinavica. 167, 3, p. 259-265 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    52. The adaptive response of MyoD family proteins in overloaded, regenerating and denervated rat muscles

      Sakuma, K., Watanabe, K., Sano, M., Uramoto, I., Sakamoto, Kei & Totsuka, T., 5 Aug 1999, In: Biochimica et Biophysica Acta - General Subjects. 1428, 2-3, p. 284-292 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. 1998

    54. Differential adaptations of insulin-like growth factor-I, basic fibroblast growth factor, and leukemia inhibitory factor in the plantaris muscle of rats by mechanical overloading: An immunohistochemical study

      Sakuma, K., Watanabe, K., Totsuka, T., Uramoto, I., Sano, M. & Sakamoto, Kei, 1 Jan 1998, In: Acta Neuropathologica. 95, 2, p. 123-130 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. 1997

    56. Loss of sarcoplasmic reticulum membrane integrity after eccentric contractions

      Yasuda, T., Sakamoto, Kei, Nosaka, K., Wada, M. & Katsuta, S., 1 Jan 1997, p. 581-582. 2 p.

      Research output: Contribution to conference › Conference abstract for conference › Research

    57. 1996

    58. Creatine kinase release from regenerated muscles after eccentric contractions in rats

      Sakamoto, Kei, Nosaka, K., Shimegi, S., Ohmori, H. & Katsuta , S., 1 Jan 1996, In: European Journal of Applied Physiology and Occupational Physiology. 73, 6, p. 516-520 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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