Thue W. Schwartz
Professor
Schwartz Group
Blegdamsvej 3B, Mærsk Tårnet, 6. sal, 2200 København N.
Member of:
- 2024
- Published
Molecular dynamics-based identification of binding pathways and two distinct high-affinity sites for succinate in succinate receptor 1/GPR91
Iliyaz, Aslihan Shenol, Lückmann, Michael, Trauelsen, Mette, Lambrughi, M., Tiberti, M., Papaleo, E., Frimurer, Thomas Michael & Schwartz, Thue W., 2024, In: Molecular Cell. 84, 5, p. 955-966.e4 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
Cell selectivity in succinate receptor SUCNR1/GPR91 signaling in skeletal muscle
Abdelmoez, A. M., Dmytriyeva, O., Zurke, Y. X., Trauelsen, Mette, Marica, A. A., Savikj, M., Smith, J. A. B., Monaco, C., Schwartz, Thue W., Krook, A. & Pillon, N. J., 2023, In: American Journal of Physiology - Endocrinology and Metabolism. 324, 4, p. E289-E298 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deciphering specificity and cross-reactivity in tachykinin NK1 and NK2 receptors
Madsen, J. J., Petersen, Jacob Emil, Christensen, D. P., Hansen, J. B., Schwartz, Thue W., Frimurer, Thomas Michael & Olsen, O. H., 2023, In: Journal of Biological Chemistry. 299, 12, 11 p., 105438.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2
Petersen, Jacob Emil, Pedersen, M. H., Dmytriyeva, O., Nellemose, E., Arora, Tulika, Engelstoft, M. S., Asher, W. B., Javitch, J. A., Schwartz, Thue W. & Trauelsen, Mette, 2023, In: Molecular Metabolism. 74, 10 p., 101757.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G-Protein-Coupled Receptor 91-Dependent Signalling Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidaemic Mice
Griepke, S., Trauelsen, Mette, Nilsson, M. D., Hansen, J., Steffensen, L. B., Schwartz, Thue W. & Ketelhuth, D. F. J., 2023, In: Cells. 12, 21, 14 p., 2580.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
Jørgensen, Kathrine Lundø, Dmytriyeva, O., Spøhr, L., Alves, Eliana Carolina Goncalves, Yao, Jiayi, Puig Blasco, Laia, Trauelsen, Mette, Ponniah, M., Severin, M., Sandelin, Albin Gustav, Kveiborg, Marie, Schwartz, Thue W. & Pedersen, Stine Helene Falsig, 2023, In: BMC Cancer. 23, 1, 20 p., 1136.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Paracrine relationship between incretin hormones and endogenous 5-hydroxytryptamine in the small and large intestine
Tough, I. R., Lund, M. L., Patel, B. A., Schwartz, Thue W. & Cox, H. M., 2023, In: Neurogastroenterology and Motility. 35, 8, 14 p., e14589.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk
Forteza, M. J., Berg, M., Edsfeldt, A., Sun, J., Baumgartner, R., Kareinen, I., Casagrande, F. B., Hedin, U., Zhang, S., Vuckovic, I., Dzeja, P. P., Polyzos, K. A., Gisterå, A., Trauelsen, M., Schwartz, T. W., Dib, L., Herrmann, J., Monaco, C., Matic, L., Gonçalves, I. & 1 others, , 2023, In: Cardiovascular Research. 119, 7, p. 1524-1536 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery
Lappa, D., Meijnikman, A. S., Krautkramer, K. A., Olsson, L. M., Aydin, Ö., Van Rijswijk, A. S., Acherman, Y. I. Z., De Brauw, M. L., Tremaroli, V., Olofsson, L. E., Lundqvist, A., Hjorth, Siv Annegrethe, Ji, B., Gerdes, V. E. A., Groen, A. K., Schwartz, Thue W., Nieuwdorp, M., Bäckhed, F. & Nielsen, J., 2023, In: PLoS ONE. 18, 3, 26 p., e0279335.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
A systems biology approach to study non-alcoholic fatty liver (NAFL) in women with obesity
Meijnikman, A. S., Lappa, D., Herrema, H., Aydin, O., Krautkramer, K. A., Tremaroli, V., Olofsson, L. E., Lundqvist, A., Bruin, S., Acherman, Y., Verheij, J., Hjorth, Siv Annegrethe, Gerdes, V. E. A., Schwartz, Thue W., Groen, A. K., Bäckhed, F., Nielsen, J. & Nieuwdorp, M., 2022, In: iScience. 25, 8, 18 p., 104828.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction
Tang, X., Rönnberg, E., Säfholm, J., Thulasingam, M., Trauelsen, Mette, Schwartz, Thue W., Wheelock, C. E., Dahlén, S. E., Nilsson, G. & Haeggström, J. Z., 2022, In: Allergy: European Journal of Allergy and Clinical Immunology. 77, 9, p. 2677-2687Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta-Hydroxybutyrate Suppresses Hepatic Production of the Ghrelin Receptor Antagonist LEAP2
Holm, Stephanie Kjærulff, Husted, Anna Sofie, Skov, Louise Julie, Morville, T. H., Hagemann, C. A., Jorsal, T., Dall, M., Jakobsen, A., Klein, A. B., Treebak, Jonas Thue, Knop, Filip Krag, Schwartz, Thue W., Clemmensen, Christoffer & Holst, Birgitte, 2022, In: Endocrinology. 163, 6, 13 p., bqac038.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts
Meijnikman, A. S., van Olden, C. C., Aydin, Ö., Herrema, H., Kaminska, D., Lappa, D., Männistö, V., Tremaroli, V., Olofsson, L. E., de Brauw, M., van de Laar, A., Verheij, J., Gerdes, V. E. A., Schwartz, T. W., Nielsen, J., Bäckhed, F., Pajukanta, P., Pihlajamäki, J., Tchkonia, T., Kirkland, J. L. & 3 others, , 2022, In: Diabetes. 71, 9, p. 1929-1936 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Jan Fahrenkrug (6/6 1947 – 10/11 2021)
Rehfeld, Jens Frederik, Hannibal, Jens, Holst, Jens Juul, Hökfelt, T., de Muckadell, O. B. S. & Schwartz, Thue W., 2022, In: Peptides. 150, 170771.Research output: Contribution to journal › Editorial › Research
- Published
Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoids
Tang, X., Hou, Y., Schwartz, Thue W. & Haeggström, J. Z., 2022, In: Biochemical Pharmacology. 204, 7 p., 115208.Research output: Contribution to journal › Review › Research › peer-review
- Published
Microbiome-derived ethanol in nonalcoholic fatty liver disease
Meijnikman, A. S., Davids, M., Herrema, H., Aydin, O., Tremaroli, V., Rios-Morales, M., Levels, H., Bruin, S., de Brauw, M., Verheij, J., Kemper, M., Holleboom, A. G., Tushuizen, M. E., Schwartz, T. W., Nielsen, J., Brandjes, D., Dirinck, E., Weyler, J., Verrijken, A., De Block, C. E. M. & 7 others, , 2022, In: Nature Medicine. 28, p. 2100-2106Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Optimization of First-in-Class Dual-Acting FFAR1/FFAR4 Allosteric Modulators with Novel Mode of Action
Lückmann, Michael, Iliyaz, Aslihan Shenol, Nissen, T. A. D., Petersen, Jacob Emil, Kouvchinov, David, Schwartz, Thue W. & Frimurer, Thomas Michael, 2022, In: ACS Medicinal Chemistry Letters. 13, 12, p. 1839-1847Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Outrunning obesity with Lac-Phe?
Lund, Jens, Clemmensen, Christoffer & Schwartz, Thue W., 2022, In: Cell Metabolism. 34, 8, p. 1085-1087 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration
Mikkelsen, R. B., Arora, Tulika, Trošt, K., Dmytriyeva, O., Jensen, Sune K. , Meijnikman, A. S., Olofsson, L. E., Lappa, D., Aydin, Ö., Nielsen, J., Gerdes, V., Moritz, Thomas, van de Laar, A., de Brauw, M., Nieuwdorp, M., Hjorth, Siv Annegrethe, Schwartz, Thue W. & Bäckhed, F., 2022, In: iScience. 25, 12, 29 p., 105683.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Vagal afferent cholecystokinin receptor activation is required for glucagon-like peptide-1–induced satiation
Vana, V., Lærke, M. K., Rehfeld, Jens Frederik, Arnold, M., Dmytriyeva, O., Langhans, W., Schwartz, Thue W. & Hansen, Harald S., 2022, In: Diabetes, Obesity and Metabolism. 24, 2, p. 268-280Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
A systems biology approach to understand gut microbiota and host metabolism in morbid obesity: design of the BARIA Longitudinal Cohort Study
Van Olden, C. C., Van de Laar, A. W., Meijnikman, A. S., Aydin, O., Van Olst, N., Hoozemans, J. B., De Brauw, L. M., Bruin, S. C., Acherman, Y. I. Z., Verheij, J., Pyykko, J. E., Hagedoorn, M., Sanderman, R., Bosma, N. C., Tremaroli, V., Lundqvist, A., Olofsson, L. E., Herrema, H., Lappa, D., Hjorth, S. & 6 others, , 2021, In: Journal of Internal Medicine. 289, 3, p. 340-354 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells
Grunddal, Kaare Villum, Tonack, S., Egerod, Kristoffer Lihme, Thompson, J. J., Petersen, N., Engelstoft, M. S., Vagne, C., Keinse, C., Gradwohl, G., Offermanns, S. & Schwartz, Thue W., 2021, In: Molecular Metabolism. 51, 17 p., 101231.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms
Modvig, Ida Marie, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Xu, S., Engelstoft, M. S., Egerod, Kristoffer Lihme, Schwartz, Thue W., Ørskov, Cathrine, Rosenkilde, Mette & Holst, Jens Juul, 2021, In: American Journal of Physiology: Endocrinology and Metabolism. 320, p. E874-E885 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disruption of GPR35 Signaling in Bone Marrow-Derived Cells Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice
Baumgartner, R., Casagrande, F. B., Mikkelsen, R. B., Berg, M., Polyzos, K. A., Forteza, M. J., Arora, A., Schwartz, Thue W., Hjorth, Siv Annegrethe & Ketelhuth, D. F. J., 2021, In: Metabolites. 11, 7, 10 p., 411.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evidence that a deviation in the kynurenine pathway aggravates atherosclerotic disease in humans
Baumgartner, R., Berg, M., Matic, L., Polyzos, K. P., Forteza, M. J., Hjorth, Siv Annegrethe, Schwartz, Thue W., Paulson-Berne, G., Hansson, G. K., Hedin, U. & Ketelhuth, D. F. J., 2021, In: Journal of Internal Medicine. 289, 1, p. 53-68 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Extracellular succinate hyperpolarizes M2 macrophages through SUCNR1/GPR91-mediated Gq signaling
Trauelsen, Mette, Hiron, T. K., Lin, D., Petersen, Jacob Emil, Breton, B., Husted, Anna Sofie, Hjorth, Siv Annegrethe, Inoue, A., Frimurer, Thomas Michael, Bouvier, M., O'Callaghan, C. A. & Schwartz, Thue W., 2021, In: Cell Reports. 35, 11, 15 p., 109246.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis
Sveidahl Johansen, O., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., Karavaeva, I., Nielsen, T. S., Kooijman, S., Cero, C., Dmytriyeva, O., Shen, Y., Razzoli, M., O'Brien, S. L., Kuipers, E. N., Nielsen, C. H. & 31 others, , 2021, In: Cell. 184, 13, p. 3502-3518 + 50 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of ligand binding pathways and activation of the succinate receptor
Iliyaz, Aslihan Shenol, Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2021, In: European Biophysics Journal. 50, Suppl. 1, p. 160 1 p., P-234.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Post-oral fat-induced satiation is mediated by endogenous CCK and GLP-1 in a fat self-administration mouse model
Vana, V., Lærke, M. K., Kleberg, K., Mroz, P. A., Lindberg, B. L., Ekberg, J. H., Rehfeld, Jens Frederik, Schwartz, Thue W. & Hansen, Harald S., 2021, In: Physiology and Behavior. 234, 12 p., 113315.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protective succinate-SUCNR1 metabolic stress signaling gone bad
Winther, Sally, Trauelsen, Mette & Schwartz, Thue W., 2021, In: Cell Metabolism. 33, 7, p. 1276-1278 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
L-cell Differentiation Is Induced by Bile Acids Through GPBAR1 and Paracrine GLP-1 and Serotonin Signaling
Lund, M. L., Sorrentino, G., Egerod, Kristoffer Lihme, Kroone, C., Mortensen, B., Knop, Filip Krag, Reimann, F., Gribble, F. M., Drucker, D. J., De Koning, E. J. P., Schoonjans, K., Bäckhed, F., Schwartz, Thue W. & Petersen, N., Apr 2020, In: Diabetes. 69, 4, p. 614-623 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C4
Tang, X., Fuchs, D., Tan, S., Trauelsen, Mette, Schwartz, Thue W., Wheelock, C. E., Li, N. & Haeggstrom, J. Z., 2020, In: Journal of Thrombosis and Haemostasis. 18, 4, p. 976-984 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Autocrine negative feed-back regulation of lipolysis through sensing of NEFAs by FFAR4/GPR120 in WAT
Husted, Anna Sofie, Ekberg, J. H., Tripp, E., Nissen, T. A. D., Meijnikman, S., O'Brien, S. L., Ulven, Trond, Acherman, Y., Bruin, S. C., Nieuwdorp, M., Gerhart-Hines, Zach, Calebiro, D., Dragsted, Lars Ove & Schwartz, Thue W., 2020, In: Molecular Metabolism. 42, 10 p., 101103.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural basis for GPCR signaling by small polar versus large lipid metabolites-discovery of non-metabolite ligands
Lückmann, Michael, Trauelsen, Mette, Frimurer, Thomas Michael & Schwartz, Thue W., 2020, In: Current Opinion in Cell Biology. 63, p. 38-48Research output: Contribution to journal › Review › Research › peer-review
- Published
Synthetic G protein-coupled bile acid receptor agonists and bile acids act via basolateral receptors in ileal and colonic mucosa
Tough, I. R., Schwartz, Thue W. & Cox, H. M., 2020, In: Neurogastroenterology and Motility. 32, 12, 14 p., e13943.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
- Published
snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis
Sun, W., Dong, H., Balaz, M., Slyper, M., Drokhlyansky, E., Colleluori, G., Giordano, A., Kovanicova, Z., Stefanicka, P., Balazova, L., Ding, L., Husted, Anna Sofie, Rudofsky, G., Ukropec, J., Cinti, S., Schwartz, Thue W., Regev, A. & Wolfrum, C., 2020, In: Nature. 587, 31 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Molecular dynamics-guided discovery of an ago-allosteric modulator for GPR40/FFAR1
Lückmann, Michael, Trauelsen, Mette, Bentsen, M. A., Nissen, T. A. D., Martins, J., Fallah, Z., Nygaard, M. M., Papaleo, E., Lindorff-Larsen, Kresten, Schwartz, Thue W. & Frimurer, Thomas Michael, 2 Apr 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 14, p. 7123-7128Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microbial fermentation of flaxseed fibers modulates the transcriptome of GPR41-expressing enteroendocrine cells and protects mice against diet-induced obesity
Arora, Tulika, Rudenko, Olga, Egerod, Kristoffer Lihme, Husted, Anna Sofie, Kovatcheva-Datchary, P., Akrami, R., Kristensen, M., Schwartz, Thue W. & Backhed, F., Mar 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 316, 3, p. E453-E463Research output: Contribution to journal › Journal article › Research › peer-review
- Published
N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis
Grevengoed, Trisha Jean, Trammell, Sam, McKinney, M. K., Petersen, N., Cardone, R. L., Svenningsen, J. S., Ogasawara, D., Nexøe-Larsen, C. C., Knop, Filip Krag, Schwartz, Thue W., Kibbey, R. G., Cravatt, B. F. & Gillum, M. P., 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 49, p. 24770-24778Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide 1 (GLP-1)
Mueller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., Holst, J. J., Langhans, W., Meier, J. J., Nauck, M. A., Perez-Tilve, D., Pocai, A., Reimann, F., Sandoval, D. A., Schwartz, T. W., Seeley, R. J. & 5 others, , 2019, In: Molecular Metabolism. 30, p. 72-130Research output: Contribution to journal › Review › Research › peer-review
- Published
Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography
Chen, S., Lu, M., Liu, D., Yang, L., Yi, C., Ma, L., Zhang, H., Liu, Q., Frimurer, Thomas Michael, Wang, M., Schwartz, Thue W., Stevens, R. C., Wu, B., Wuthrich, K. & Zhao, Q., 2019, In: Nature Communications. 10, 8 p., 638.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular adaptations in human subcutaneous adipose tissue after ten weeks of endurance exercise training in healthy males
Riis, S., Christensen, B., Nellemann, B., Moller, A. R., Husted, Anna Sofie, Pedersen, S. B., Schwartz, Thue W., Jorgensen, J. O. L. & Jessen, N., 2019, In: Journal of Applied Physiology. 126, 3, p. 569-577Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Paracrine Crosstalk between Intestinal L- and D-cells Controls Secretion of Glucagon-Like Peptide-1 in mice
Jepsen, Sara Lind, Grunddal, Kaare Villum, Albrechtsen, Nicolai Jacob Wewer, Engelstoft, M. S., Gabe, M. B. N., Jensen, E. P., Ørskov, Cathrine, Poulsen, Steen Seier, Rosenkilde, M. M., Pedersen, J., Gribble, F. M., Reimann, F., Deacon, Carolyn F., Schwartz, Thue W., Christ, A. D., Martin, R. E. & Holst, Jens Juul, 2019, In: American Journal of Physiology: Endocrinology and Metabolism. 317, 6, p. E1081-E1093Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase
Ulsund, A. H., Dahl, M., Frimurer, Thomas Michael, Manfra, O., Schwartz, Thue W., Levy, F. O. & Andressen, K. W., 2019, In: FASEB Journal. 33, 3, p. 3870-3886Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production
Piccand, J., Vagne, C., Blot, F., Meunier, A., Beucher, A., Strasser, P., Lund, M. L., Ghimire, S., Nivlet, L., Lapp, C., Petersen, N., Engelstoft, M. S., Thibault-Carpentier, C., Keime, C., Correa, S. J., Schreiber, V., Molina, N., Schwartz, Thue W., De Arcangelis, A. & Gradwohl, G., 2019, In: Molecular Metabolism. 29, p. 24-39Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The Molecular Diversity of Vagal Afferents Revealed
Egerod, Kristoffer Lihme, Schwartz, Thue W. & Gautron, L., 2019, In: Trends in Neurosciences. 42, 10, p. 663-666Research output: Contribution to journal › Editorial › Research › peer-review
- Published
The aromatic amino acid sensor GPR142 controls metabolism through balanced regulation of pancreatic and gut hormones
Rudenko, Olga, Shang, J., Munk, A., Ekberg, J. P., Petersen, N., Engelstoft, M. S., Egerod, Kristoffer Lihme, Hjorth, Siv Annegrethe, Wu, M., Feng, Y., Zhou, Y., Mokrosinski, J., Thams, P., Reimann, F., Gribble, F., Rehfeld, Jens Frederik, Holst, Jens Juul, Treebak, Jonas Thue, Howard, A. D. & Schwartz, Thue W., 2019, In: Molecular Metabolism. 19, p. 49-64 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Bidirectional GPR119 agonism requires peptide YY and glucose for activity in mouse and human colon mucosa
Tough, I. R., Forbes, S., Herzog, H., Jones, R. M., Schwartz, Thue W. & Cox, H. M., 1 Apr 2018, In: Endocrinology. 159, 4, p. 1704-1717Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites
Lund, M. L., Egerod, Kristoffer Lihme, Engelstoft, M. S., Dmytriyeva, O., Theodorsson, E., Patel, B. A. & Schwartz, Thue W., 2018, In: Molecular Metabolism. 11, p. 70-83 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibiting RHOA Signaling in Mice Increases Glucose Tolerance and Numbers of Enteroendocrine and Other Secretory Cells in the Intestine
Petersen, N., Frimurer, Thomas Michael, Pedersen, M. T., Egerod, Kristoffer Lihme, Albrechtsen, Nicolai Jacob Wewer, Holst, Jens Juul, Grapin-Botton, A., Jensen, Kim Bak & Schwartz, Thue W., 2018, In: Gastroenterology. 155, 4, p. 1164-1176 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Microbial regulation of the L cell transcriptome
Arora, Tulika, Akrami, R., Pais, R., Bergqvist, L., Johansson, B. R., Schwartz, Thue W., Reimann, F., Gribble, F. M. & Bäckhed, F., 2018, In: Scientific Reports. 8, p. 1-9 1207.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Profiling of G protein-coupled receptors in vagal afferents reveals novel gut-to-brain sensing mechanisms
Egerod, Kristoffer Lihme, Petersen, N., Timshel, P. N., Rekling, Jens Christian, Wang, Y., Liu, Q., Schwartz, Thue W. & Gautron, L., 2018, In: Molecular Metabolism. 12, p. 62-75 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1
Ulven, Elisabeth Rexen, Trauelsen, Mette, Brvar, M., Lückmann, Michael, Bielefeldt, L. Ø., Jensen, L. K. I., Schwartz, Thue W. & Frimurer, Thomas Michael, 2018, In: Scientific Reports. 8, 1, p. 1-18 10010.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The HETE Is on FFAR1 and Pancreatic Islet Cells
Trauelsen, Mette, Lückmann, Michael, Frimurer, Thomas Michael & Schwartz, Thue W., 2018, In: Cell Metabolism. 27, 2, p. 273-275 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Trauelsen, Mette, Ulven, Elisabeth Rexen, Hjorth, Siv Annegrethe, Brvar, M., Monaco, C., Frimurer, Thomas Michael & Schwartz, Thue W., Dec 2017, In: Molecular Metabolism. 6, 12, p. 1585-1596 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gq and Gs signaling acting in synergy to control GLP-1 secretion
Pedersen, M. H., Ekberg, J. H., Engelstoft, M. S., Timshel, P., Madsen, A. N. & Schwartz, Thue W., Jul 2017, In: Molecular and Cellular Endocrinology. 449, p. 64-73Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPCR-Mediated Signaling of Metabolites
Husted, Anna Sofie, Trauelsen, Mette, Rudenko, Olga, Hjorth, Siv Annegrethe & Schwartz, Thue W., 4 Apr 2017, In: Cell Metabolism. 25, 4, p. 777-796 20 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
EBI2 overexpression in mice leads to B1 B cell expansion and chronic lymphocytic leukemia-(CLL)-like B cell malignancies
Niss Arfelt, K., Barington, L., Benned-Jensen, T., Kubale, V., Kovalchuk, A. L., Daugvilaite, V., Christensen, Jan Pravsgaard, Thomsen, Allan Randrup, Egerod, Kristoffer Lihme, Bassi, Maria Rosaria, Spiess, Katja, Schwartz, Thue W., Wang, H., Morse, H. C., Holst, Peter Johannes & Rosenkilde, Mette, 2017, In: Blood. 129, 7, p. 866-878Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions.
Frimurer, Thomas Michael, Mende, F., Graae, A., Engelstoft, M. S., Egerod, Kristoffer Lihme, Nygaard, R., Gerlach, L., Hansen, J. B., Schwartz, Thue W. & Holst, Birgitte, 2017, In: Journal of Medicinal Chemistry. 60, 3, p. 886-898 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural biology: Full monty of family B GPCRs
Schwartz, Thue W. & Frimurer, Thomas Michael, 2017, In: Nature Chemical Biology. 13, 8, p. 819-821Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure-based discovery of novel US28 small molecule ligands with different modes of action
Lückmann, Michael, Amarandi, R., Papargyri, N., Jakobsen, M. H., Ulven, Elisabeth Rexen, Jensen, Lars Juhl, Pui, A., Schwartz, Thue W., Rosenkilde, Mette & Frimurer, Thomas Michael, 2017, In: Chemical Biology & Drug Design. 89, 3, p. 289–296Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice
Thieme, V., Jolly, N., Madsen, A. N., Bellmann-Sickert, K., Schwartz, Thue W., Holst, Birgitte, Cox, H. M. & Beck-Sickinger, A. G., Nov 2016, In: British Journal of Pharmacology. 173, 22, p. 3208-3221 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR119 - a major Enteroendocrine Sensor of Dietary Triglyceride Metabolites Co-acting in Synergy with FFA1 (GPR40)
Ekberg, J. H., Pedersen, M. H., Kristensen, L. V., Madsen, A. N., Engelstoft, M. S., Husted, Anna Sofie, Sichlau, R., Egerod, Kristoffer Lihme, Timshel, P., Kowalski, T. J., Gribble, F. M., Reiman, F., Hansen, Harald S., Howard, A. D., Holst, Birgitte & Schwartz, Thue W., 25 Oct 2016, In: Endocrinology. 157, 12, p. 4561-4569 9 p., en20161334.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional and genetic epidemiological characterisation of the FFAR4 (GPR120) p.R270H variant in the Danish population
Vestmar, M. A., Galijatovic, E. A. A., Christensen, C. R., Pedersen, M. H., Glümer, C., Linneberg, Allan René, Witte, D. R., Jørgensen, M. E., Christensen, C., Brandslund, I., Lauritzen, T., Pedersen, Oluf Borbye, Holst, Birgitte, Grarup, Niels, Schwartz, Thue W. & Hansen, Torben, Sep 2016, In: Journal of Medical Genetics. 53, 9, p. 616-23 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Opposite Regulation of Ghrelin and Glucagon-like Peptide-1 by Metabolite G-Protein-Coupled Receptors
Engelstoft, M. S. & Schwartz, Thue W., Sep 2016, In: Trends in Endocrinology and Metabolism. 27, 9, p. 665-675 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Biased signaling of lipids and allosteric actions of synthetic molecules for GPR119
Hassing, H. A., Fares, S., Larsen, Olav, Pad, H., Pedersen, M. H., Jones, R. M., Schwartz, Thue W., Hansen, Harald S. & Rosenkilde, Mette, 26 Aug 2016, In: Biochemical Pharmacology. 119, 1, p. 66-75 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Getting from A to B-exploring the activation motifs of the class B adhesion G protein-coupled receptor subfamily G member 4/GPR112
Cornelia Peeters, M., Mos, I., Lenselink, E. B., Lucchesi, M., IJzerman, A. P. & Schwartz, Thue W., May 2016, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 30, 5, p. 1836-1848 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Neurotensin Is Co-Expressed, Co-Released And Acts Together With Glp-1 And Pyy In Enteroendocrine Control Of Metabolism
Grunddal, Kaare Villum, Ratner, C. F., Svendsen, B., Sommer, F., Engelstoft, M. S., Madsen, A. N., Pedersen, Jens, Nøhr, M. K., Egerod, Kristoffer Lihme, Nawrocki, A. R., Kowalski, T., Howard, A. D., Poulsen, Steen Seier, Offermanns, S., Bäckhed, G. F., Holst, Jens Juul, Holst, Birgitte & Schwartz, Thue W., Jan 2016, In: Endocrinology. 157, 1, p. 176-94 19 p., en20151600.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GLP1- and GIP-producing cells rarely overlap and differ by bombesin receptor-2 expression and responsiveness
Svendsen, B., Pais, R., Engelstoft, M. S., Milev, N. B., Richards, P., Christiansen, Charlotte Bayer, Egerod, Kristoffer Lihme, Jensen, S. M., Habib, A. M., Gribble, F. M., Schwartz, Thue W., Reimann, F. & Holst, Jens Juul, 2016, In: Journal of Endocrinology. 228, 1, p. 39-48 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In Silico Investigation of the Neurotensin Receptor 1 Binding Site: Overlapping Binding Modes for Small Molecule Antagonists and the Endogenous Peptide Agonist
Lückmann, Michael, Holst, Birgitte, Schwartz, Thue W. & Frimurer, Thomas Michael, 2016, In: Molecular Informatics. 35, p. 19-24 6 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Oral 2-oleyl glyceryl ether improves glucose tolerance in mice through the GPR119 receptor
Hassing, H. A., Engelstoft, M. S., Sichlau, R. M., Madsen, A. N., Rehfeld, Jens Frederik, Pedersen, Jens, Jones, R. M., Holst, Jens Juul, Schwartz, Thue W., Rosenkilde, Mette & Hansen, Harald S., 2016, In: BioFactors. 42, 6, p. 665-673Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
- Published
The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration
Cornelia Peeters, M., Fokkelman, M., Boogaard, B., Egerod, Kristoffer Lihme, van de Water, B., IJzerman, A. P. & Schwartz, Thue W., Dec 2015, In: Cellular Signalling. 27, 12, p. 2579-88 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics
Park, M., Sivertsen, B. B., Els-Heindl, S., Huber, T., Holst, Birgitte, Beck-Sickinger, A. G., Schwartz, Thue W. & Sakmar, T. P., 19 Nov 2015, In: Chemistry & Biology. 22, 11, p. 1431-1436 6 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Research Resource: A Chromogranin A Reporter for Serotonin and Histamine Secreting Enteroendocrine Cells
Engelstoft, M. S., Lund, M. L., Grunddal, Kaare Villum, Egerod, Kristoffer Lihme, Osborne-Lawrence, S., Poulsen, Steen Seier, Zigman, J. M. & Schwartz, Thue W., Nov 2015, In: Molecular endocrinology (Baltimore, Md.). 29, 11, p. 1658-71 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The MicroRNA Repertoire in Enteroendocrine Cells: Identification of miR-375 as a Potential Regulator of the Enteroendocrine Lineage
Knudsen, L. A., Petersen, N., Schwartz, Thue W. & Egerod, Kristoffer Lihme, Nov 2015, In: Endocrinology. 156, 11, p. 3971-83 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcriptional and Functional Characterization of the G Protein-Coupled Receptor Repertoire of Gastric Somatostatin Cells
Egerod, Kristoffer Lihme, Engelstoft, M. S., Lund, M. L., Grunddal, Kaare Villum, Zhao, M., Barir-Jensen, D., Nygaard, E. B., Petersen, N., Holst, Jens Juul & Schwartz, Thue W., Nov 2015, In: Endocrinology. 156, 11, p. 3909-23 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Biased Gs Versus Gq Proteins and β-Arrestin Signaling in the NK1 Receptor Determined by Interactions in the Water Hydrogen Bond Network
Valentin-Hansen, L., Frimurer, Thomas Michael, Mokrosinski, J., Holliday, N. D. & Schwartz, Thue W., 2 Oct 2015, In: The Journal of Biological Chemistry. 290, 40, p. 24495-508 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1
Manfra, O., Van Craenenbroeck, K., Skieterska, K., Frimurer, Thomas Michael, Schwartz, Thue W., Levy, F. O. & Andressen, K. W., Jul 2015, In: A C S Chemical Neuroscience. 6, 7, p. 1206–1218 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ghrelin
Mueller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., Casanueva, F. F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P. A., Cowley, M., Cummings, D. E., Dagher, A., Diano, S. & 37 others, , Jun 2015, In: Molecular Metabolism. 4, 6, p. 437-460 24 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia
Nøhr, M. K., Egerod, Kristoffer Lihme, Christiansen, S. H., Gille, A., Offermanns, S., Schwartz, Thue W. & Møller, Morten, 2 Apr 2015, In: Neuroscience. 290, p. 126-37 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease
Ádori, C., Glück, L., Barde, S., Yoshitake, T., Kovacs, G. G., Mulder, J., Maglóczky, Z., Havas, L., Bölcskei, K., Mitsios, N., Uhlén, M., Szolcsányi, J., Kehr, J., Rönnbäck, A., Schwartz, Thue W., Rehfeld, Jens Frederik, Harkany, T., Palkovits, M., Schulz, S. & Hökfelt, T., Apr 2015, In: Acta Neuropathologica. 129, 4, p. 541-63 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors
Hamann, J., Aust, G., Araç, D., Engel, F. B., Formstone, C., Fredriksson, R., Hall, R. A., Harty, B. L., Kirchhoff, C., Knapp, B., Krishnan, A., Liebscher, I., Lin, H-H., Martinelli, D. C., Monk, K. R., Cornelia Peeters, M., Piao, X., Prömel, S., Schöneberg, T., Schwartz, T. W. & 9 others, , Apr 2015, In: Pharmacological Reviews. 67, 2, p. 338-67 30 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR40 (FFAR1) – Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo
Pedersen, M. H., Bentsen, M. A., Husted, Anna Sofie, Ekberg, J. P., Wright, M. J., Di Salvo, J., Weinglass, A. B., Engelstoft, M. S., Madsen, A. N., Lückmann, Michael, Miller, M. W., Trujillo, M. E., Frimurer, Thomas Michael, Holst, Birgitte, Howard, A. D. & Schwartz, Thue W., Jan 2015, In: Molecular Metabolism. 4, 1, p. 3-14 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutation-Guided Unbiased Modeling of the Fat Sensor GPR119 for High-Yield Agonist Screening.
Norn, C., Pedersen, M. H., Engelstoft, M. S., Kim, S. H., Lehmann, J., Jones, R. M., Schwartz, Thue W. & Frimurer, Thomas Michael, 2015, In: Structure. 23, 12, p. 2377-2386 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo
Panaro, B. L., Tough, I. R., Engelstoft, M. S., Matthews, R. T., Digby, G. J., Møller, C. L., Svendsen, B., Gribble, F., Reimann, F., Holst, Jens Juul, Holst, Birgitte, Schwartz, Thue W., Cox, H. M. & Cone, R. D., 2 Dec 2014, In: Cell Metabolism. 20, 6, p. 1018-29 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural basis for constitutive activity and agonist-induced activation of the enteroendocrine fat sensor GPR119
Engelstoft, M. S., Norn, C., Pedersen, M. H., Holliday, N. D., Elster, L., Lehmann, J., Jones, R. M., Frimurer, Thomas Michael & Schwartz, Thue W., Dec 2014, In: British Journal of Pharmacology. 171, 24, p. 5774-89 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors
Tian, H., Naganathan, S., Kazmi, M. A., Schwartz, Thue W., Sakmar, T. P. & Huber, T., 18 Aug 2014, In: ChemBioChem. 15, 12, p. 1820-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mapping Substance P Binding Sites on the Neurokinin-1 Receptor Using Genetic Incorporation of a Photoreactive Amino Acid
Valentin-Hansen, L., Park, M., Huber, T., Grunbeck, A., Naganathan, S., Schwartz, Thue W. & Sakmar, T. P., 27 Jun 2014, In: The Journal of Biological Chemistry. 289, 26, p. 18045-54 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of PYY3-36 and GLP-1 on energy intake, energy expenditure and appetite in overweight men
Schmidt, J. B., Gregersen, N. T., Pedersen, S. D., Arentoft, J. L., Ritz, C., Schwartz, Thue W., Holst, Jens Juul, Astrup, A. & Sjödin, Anders Mikael, 2014, In: American Journal of Physiology: Endocrinology and Metabolism. 306, 11, p. E1248-E1256 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Enteroendocrine cell types revisited
Engelstoft, M. S., Egerod, Kristoffer Lihme, Lund, M. L. & Schwartz, Thue W., Dec 2013, In: Current Opinion in Pharmacology. 13, 6, p. 912-21 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Seven transmembrane G protein-coupled receptor repertoire of gastric ghrelin cells
Engelstoft, M. S., Park, W-M., Sakata, I., Kristensen, L. V., Husted, A. S., Osborne-Lawrence, S., Piper, P. K., Walker, A. K., Pedersen, M. H., Nøhr, M. K., Pan, J., Sinz, C. J., Carrington, P. E., Akiyama, T. E., Jones, R. M., Tang, C., Ahmed, K., Offermanns, S., Egerod, K. L., Zigman, J. M. & 1 others, , Nov 2013, In: Molecular Metabolism. 2, 4, p. 376-92 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes
Nøhr, M. K., Pedersen, M. H., Gille, A., Egerod, Kristoffer Lihme, Engelstoft, M. S., Husted, Anna Sofie, Sichlau, R. M., Grunddal, Kaare Villum, Poulsen, Steen Seier, Han, S., Jones, R. M., Offermanns, S. & Schwartz, Thue W., 24 Jul 2013, In: Endocrinology.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose metabolism is altered after loss of L cells and α-cells but not influenced by loss of K cells
Pedersen, J., Ugleholdt, Randi Kjærsgaard, Jørgensen, S. M., Windeløv, Johanne Agerlin, Grunddal, Kaare Villum, Schwartz, Thue W., Füchtbauer, E., Poulsen, Steen Seier, Holst, Peter Johannes & Holst, Jens Juul, 1 Jan 2013, In: American Journal of Physiology: Endocrinology and Metabolism. 304, 1, p. E60-73 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
Albrechtsen, A., Grarup, N., Li, Y., Sparsø, T. H., Tian, G., Cao, H., Jiang, T., Kim, S. Y., Korneliussen, T. S., Li, Q., Nie, C., Wu, R., Skotte, L., Morris, A. P., Ladenvall, C., Cauchi, S., Stancáková, A., Andersen, G., Astrup, A., Banasik, K. & 86 others, , 2013, In: Diabetologia. 56, 2, p. 298-310 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions
Møller, T. C., Wirth, V. F., Roberts, N. I., Bender, J., Bach, Anders, Jacky, B. P. S., Strømgaard, Kristian, Deussing, J. M., Schwartz, Thue W. & Martinez, Karen Laurence, 2013, In: PLOS ONE. 8, 5, e63352.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation
Valentin-Hansen, L., Holst, Birgitte, Frimurer, Thomas Michael, Schwartz, Thue W. & Hansen, L. V., 21 Dec 2012, In: Journal of Biological Chemistry. 287, 52, p. 43516-43526 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A Major Lineage of Enteroendocrine Cells Coexpress CCK, Secretin, GIP, GLP-1, PYY, and Neurotensin but Not Somatostatin
Egerod, Kristoffer Lihme, Engelstoft, M. S., Grunddal, Kaare Villum, Nøhr, M. K., Secher, A., Sakata, I., Pedersen, Jens, Windeløv, Johanne Agerlin, Füchtbauer, E., Olsen, Jørgen, Sundler, F., Christensen, Jan Pravsgaard, Wierup, N., Olsen, Jesper Velgaard, Holst, Jens Juul, Zigman, J. M., Poulsen, Steen Seier & Schwartz, Thue W., 1 Dec 2012, In: Endocrinology. 153, 12, p. 5782-95 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dissecting signaling and functions of adhesion G protein-coupled receptors
Araç, D., Aust, G., Calebiro, D., Engel, F. B., Formstone, C., Goffinet, A., Hamann, J., Kittel, R. J., Liebscher, I., Lin, H-H., Monk, K. R., Petrenko, A., Piao, X., Prömel, S., Schiöth, H. B., Schwartz, T. W., Stacey, M., Ushkaryov, Y. A., Wobus, M., Wolfrum, U. & 2 others, , Dec 2012, In: Annals of the New York Academy of Sciences. 1276, p. 1-25 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The arginine of the DRY motif in transmembrane segment III functions as a balancing micro-switch in the activation of the β2-adrenergic receptor
Hansen, L. V., Groenen, M., Nygaard, R., Frimurer, Thomas Michael, Holliday, N. D. & Schwartz, Thue W., 14 Sep 2012, In: Journal of Biological Chemistry. 287, 38, p. 31973-82 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor
Els, S., Schild, E., Petersen, P. S., Kilian, T., Mokrosinski, J., Frimurer, Thomas Michael, Chollet, C., Schwartz, Thue W., Holst, Birgitte & Beck-Sickinger, A. G., 13 Sep 2012, In: Journal of Medicinal Chemistry. 55, 17, p. 7437-49 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop
Mokrosinski, J., Frimurer, Thomas Michael, Sivertsen, B., Schwartz, Thue W. & Holst, Birgitte, Sep 2012, In: Journal of Biological Chemistry. 287, p. 33488-33502 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of intravenous infusions of PYY3-36 and GLP-1, as monoinfusion and in combination, on ad libitum energy intake in healthy obese subjects
Schmidt, J. B., Gregersen, N. T., Pedersen, S. D., Holst, Jens Juul, Schwartz, Thue W., Astrup, A. & Sjödin, Anders Mikael, 10 Aug 2012, In: Regulatory Peptides. 177, Supplement, p. S32 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
GPR119 as a fat sensor
Hansen, Harald S., Rosenkilde, Mette, Holst, Jens Juul & Schwartz, Thue W., Jul 2012, In: Trends in Pharmacological Sciences. 33, 7, p. 374-81 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Structural biology: snapshot of a signalling complex.
Schwartz, Thue W. & Sakmar, T., Sep 2011, In: Nature.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand Modulation of the Epstein-Barr Virus-induced Seven-transmembrane Receptor EBI2: IDENTIFICATION OF A POTENT AND EFFICACIOUS INVERSE AGONIST
Benned-Jensen, T., Smethurst, C., Holst, Peter Johannes, Page, K. R., Sauls, H., Sivertsen, B. B., Schwartz, Thue W., Blanchard, A., Jepras, R. & Rosenkilde, Mette, 19 Aug 2011, In: Journal of Biological Chemistry. 286, p. 29292-29302 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Deficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism
Petersen, P. S., Jin, C., Madsen, A. N., Rasmussen, M., Kuhre, Rune Ehrenreich, Egerod, Kristoffer Lihme, Nielsen, L. B., Schwartz, Thue W. & Holst, Birgitte, 22 Jul 2011, In: FASEB Journal. p. 3803-3814 12 p., 4.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Unique interaction pattern for a functionally biased ghrelin receptor agonist
Sivertsen, B. B., Lang, M., Frimurer, T. M., Holliday, N. D., Bach, Anders, Els, S., Engelstoft, M. S., Petersen, P. S., Madsen, A. N., Schwartz, Thue W., Beck-Sickinger, A. G. & Holst, Birgitte, 10 Jun 2011, In: The Journal of Biological Chemistry. 286, 23, p. 20845-20860 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
KU bestemmer selv over sin forskning
Wewer, Ulla M., Holst, Jens Juul, Schwartz, Thue W. & Quistorff, B., 2 Jun 2011, In: Universitetsavisen.Research output: Contribution to journal › Contribution to newspaper - Comment/debate › Communication
- Published
Reversible switching of ultrastrong light-molecule coupling
Schwartz, Thue W., Hutchison, J. A., Genet, C. & Ebbesen, T. W., 13 May 2011, In: Physical Review - Index. 106, p. 196405 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor modulation with pepducins: moving closer to the clinic
Dimond, P., Carlson, K., Bouvier, M., Gerard, C., Xu, L., Covic, L., Agarwal, A., Ernst, O. P., Janz, J. M., Schwartz, Thue W., Gardella, T. J., Milligan, G., Kuliopulos, A., Sakmar, T. P. & Hunt III, S. W., May 2011, In: New York Academy of Sciences. Annals. 1226, p. 34-49 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor modulation with pepducins: moving closer to the clinic
Dimond, P., Carlson, K., Bouvier, M., Gerard, C., Xu, L., Covic, L., Agarwal, A., Ernst, O. P., Janz, J. M., Schwartz, Thue W., Gardella, T. J., Milligan, G., Kuliopulos, A., Sakmar, T. P. & Hunt, S. W., 2011, In: Annals of the New York Academy of Sciences. 1226, p. 34-49 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Long-acting lipidated analogue of human pancreatic polypeptide is slowly released into circulation
Bellmann-Sickert, K., Elling, C. E., Madsen, A. N., Little, P. B., Lundgren, K., Gerlach, L., Bergmann, R., Holst, Birgitte, Schwartz, Thue W. & Beck-Sickinger, A. G., 2011, In: Journal of Medicinal Chemistry. 54, 8, p. 2658-67 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
ß-Cell Specific Overexpression of GPR39 Protects against Streptozotocin-Induced Hyperglycemia
Egerod, Kristoffer Lihme, Jin, C., Petersen, P. S., Wierup, N., Sundler, F., Holst, Birgitte & Schwartz, Thue W., 2011, In: International Journal of Endocrinology. 2011, p. 401258Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
A conserved aromatic lock for the tryptophan rotameric switch in TM-VI of seven-transmembrane receptors
Holst, Birgitte, Nygaard, R., Hansen, L. V., Bach, Anders, Engelstoft, M. S., Petersen, P. S., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Journal of Biological Chemistry. 285, 6, p. 3973-85 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An enteroendocrine full package solution
Schwartz, Thue W. & Holst, Birgitte, 2010, In: Cell Metabolism. 11, 6, p. 445-7 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conserved water-mediated hydrogen bond network between TM-I, -II, -VI, and -VII in 7TM receptor activation
Nygaard, R., Hansen, L. V., Mokrosinski, J., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Journal of Biological Chemistry. 285, 25, p. 19625-36 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
Gjesing, A. P., Larsen, L. H., Torekov, S. S., Hainerová, I. A., Kapur, R., Johansen, A., Albrechtsen, A., Boj, S., Holst, B., Harper, A., Urhammer, S. A., Borch-Johnsen, K., Pisinger, C. H., Echwald, S. M., Eiberg, H. R. L., Astrup, A., Lebl, J., Ferrer, J., Schwartz, T. W., Hansen, T. & 1 others, , 2010, In: P L o S One. 5, 4, 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MTNR1B G24E variant associates With BMI and fasting plasma glucose in the general population in studies of 22,142 Europeans
Andersson, E. A., Holst, Birgitte, Sparsø, T., Grarup, Niels, Banasik, Karina, Holmkvist, J., Jørgensen, T., Borch-Johnsen, K., Egerod, Kristoffer Lihme, Lauritzen, T., Sørensen, Thorkild I.A., Bonnefond, A., Meyre, D., Froguel, P., Schwartz, Thue W., Pedersen, Oluf Borbye & Hansen, Torben, 2010, In: Diabetes. 59, 6, p. 1539-48 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular basis for agonism in the BB3 receptor: an epitope located on the interface of transmembrane-III, -VI, and -VII
Gbahou, F., Holst, Birgitte & Schwartz, Thue W., 2010, In: Journal of Pharmacology and Experimental Therapeutics. 333, 1, p. 51-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Resequencing of 200 human exomes identifies an excess of low-frequency non-synonymous coding variants
Li, Y., Vinckenbosch, N., Tian, G., Huerta-Sanchez, E., Jiang, T., Jiang, H., Albrechtsen, A., Andersen, G., Cao, H., Korneliussen, T. S., Grarup, N., Guo, Y., Hellman, I., Jin, X., Li, Q., Liu, J., Liu, X., Sparsø, T., Tang, M., Wu, H. & 18 others, , 2010, In: Nature Genetics. 42, 11, p. 969-72 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Targeting CXCR4 in HIV Cell-Entry Inhibition
Steen, A., Schwartz, Thue W. & Rosenkilde, Mette, 2010, In: Mini reviews in medicinal chemistry. 9, 14, p. 1605-21 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The minor binding pocket: a major player in 7TM receptor activation
Rosenkilde, Mette, Benned-Jensen, T., Frimurer, T. M. & Schwartz, Thue W., 2010, In: Trends in Pharmacological Sciences. 31, 12, p. 567-574 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Construction of covalently coupled, concatameric dimers of 7TM receptors
Terpager, M., Scholl, D. J., Kubale, V., Martini, L., Elling, C. E. & Schwartz, Thue W., 2009, In: Journal of Receptors and Signal Transduction. 29, 5, p. 235-45 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction
Holst, Birgitte, Egerod, Kristoffer Lihme, Jin, C., Petersen, P. S., Østergaard, M. V., Hald, J., Sprinkel, A. M. E., Størling, J., Mandrup-Poulsen, Thomas, Holst, Jens Juul, Thams, P., Orskov, C., Wierup, N., Sundler, F., Madsen, O. D. & Schwartz, Thue W., 2009, In: Endocrinology. 150, 6, p. 2577-85 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ligand binding and micro-switches in 7TM receptor structures
Nygaard, R., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Schwartz, Thue W., 2009, In: TIPS - Trends in Pharmacological Sciences. 30, 5, p. 249-59 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
[Fine needle aspiration cytology of mammography screening]
Engvad, B., Laenkholm, A. V., Schwartz, Thue W. & Bak, M., 2009, In: Ugeskrift for læger. 171, 34, p. 2379-2382 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding
Jensen, P. C., Thiele, S., Ulven, Trond, Schwartz, Thue W. & Rosenkilde, Mette, 17 Jun 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-23128 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A gut feeling for obesity: 7TM sensors on enteroendocrine cells
Engelstoft, M. S., Egerod, Kristoffer Lihme, Holst, Birgitte & Schwartz, Thue W., 2008, In: Cell Metabolism. 8, 6, p. 447-9 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A second disulfide bridge from the N-terminal domain to extracellular loop 2 dampens receptor activity in GPR39
Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: Biochemistry. 47, 35, p. 9198-207 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of G-protein coupled receptor kinase interaction with the NK-1 receptor using BRET
Joergensen, R., Holliday, N. D., Hansen, J. L., Vrecl, M., Heding, A., Elling, C. E. & Schwartz, Thue W., 2008, In: Molecular Pharmaceutics. 73, 2, p. 349-358 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39
Storjohann, L., Holst, Birgitte & Schwartz, Thue W., 2008, In: FEBS Letters. 582, 17, p. 2583-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor
Holst, Birgitte, Frimurer, T. M., Mokrosinski, J., Halkjaer, T., Cullberg, K. B., Underwood, C. R. & Schwartz, Thue W., 2008, In: Molecular Pharmacology. 75, 1, p. 44-59 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Positive versus negative modulation of different endogenous chemokines for CC-chemokine receptor 1 by small molecule agonists through allosteric versus orthosteric binding
Jensen, P. C., Thiele, S., Ulven, T., Schwartz, Thue W. & Rosenkilde, Mette, 2008, In: Journal of Biological Chemistry. 283, 34, p. 23121-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Receptorji s sedmimi transmembranskimi območji (7TM) v luči dimerizacije ter eksperimentalni pristopi za proučevanje njihove dimerizacije in medsebojnih vplivov
Kubale, V., Pogačnik, A., Schwartz, Thue W. & Vrecl, M., 2008, In: Slovenian Veterinary Research. 45, 3, p. 89-102 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Structural biology: A moving story of receptors
Schwartz, Thue W. & Hubbell, W. L., 2008, In: Nature. 455, 7212, p. 473-4 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Allosteric enhancers, allosteric agonists and ago-allosteric modulators: where do they bind and how do they act?
Schwartz, Thue W. & Holst, Birgitte, 2007, In: TIPS - Trends in Pharmacological Sciences. 28, 8, p. 366-73 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer
Jorgensen, R., Holliday, N. D., Hansen, J. L., Vrecl, M., Heding, A., Schwartz, Thue W. & Elling, C. E., 2007, In: Molecular Pharmacology. 73, 2, p. 349-58 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue.
Egerod, Kristoffer Lihme, Holst, Birgitte, Petersen, P. S., Hansen, Jacob B., Mulder, J., Hökfelt, T. & Schwartz, Thue W., 2007, In: Molecular Endocrinology. 21, 7, p. 1685-98 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism
Holst, Birgitte, Mokrosinski, J., Lang, M., Brandt, E., Nygaard, R., Frimurer, T. M., Beck-Sickinger, A. G. & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 21, p. 15799-811 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Importance of constitutive activity and arrestin-independent mechanisms for intracellular trafficking of the ghrelin receptor
Holliday, N. D., Holst, Birgitte, Rodionova, E. A., Schwartz, Thue W. & Cox, H. M., 2007, In: Molecular Endocrinology. 21, 12, p. 3100-12 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Kaposi sarcoma-associated herpes virus targets the lymphotactin receptor with both a broad spectrum antagonist vCCL2 and a highly selective and potent agonist vCCL3
Lüttichau, H. R., Johnsen, A. H., Jurlander, J., Rosenkilde, Mette & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 24, p. 17794-805 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Modest human immunodeficiency virus coreceptor function of CXCR3 is strongly enhanced by mimicking the CXCR4 ligand binding pocket in the CXCR3 receptor
Hatse, S., Huskens, D., Princen, K., Vermeire, K., Bridger, G. J., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W. & Schols, D., 2007, In: Journal of Virology. 81, 7, p. 3632-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8
Jensen, P. C., Nygaard, R., Thiele, S., Elder, A., Zhu, G., Kolbeck, R., Ghosh, S., Schwartz, Thue W. & Rosenkilde, Mette, 2007, In: Molecular Pharmacology. 72, 2, p. 327-40 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor
Rosenkilde, Mette, Gerlach, L., Hatse, S., Skerlj, R. T., Schols, D., Bridger, G. J. & Schwartz, Thue W., 2007, In: Journal of Biological Chemistry. 282, 37, p. 27354-65 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s)
Jorgensen, R., Kubale, V., Vrecl, M., Schwartz, Thue W. & Elling, C. E., 2007, In: Journal of Pharmacology and Experimental Therapeutics. 322, 1, p. 148-54 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI
Rosenkilde, Mette, Andersen, Michael Brun, Nygaard, R., Frimurer, T. M. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 71, 3, p. 930-41 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ago-allosteric modulation and other types of allostery in dimeric 7TM receptors
Schwartz, Thue W. & Holst, Birgitte, 2006, In: Journal of Receptors and Signal Transduction. 26, 1-2, p. 107-28 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conformational constraining of inactive and active States of a seven transmembrane receptor by metal ion site engineering in the extracellular end of transmembrane segment V
Rosenkilde, Mette, David, R., Oerlecke, I., Benned-Jensen, T., Geumann, U., Beck-Sickinger, A. G. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 6, p. 1892-901 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GPR39 signaling is stimulated by zinc ions but not by obestatin
Holst, Birgitte, Egerod, Kristoffer Lihme, Schild, E., Vickers, S. P., Cheetham, S., Gerlach, L., Storjohann, L., Stidsen, C. E., Jones, R., Beck-Sickinger, A. G. & Schwartz, Thue W., 2006, In: Endocrinology. 148, 1, p. 13-20 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ghrelin receptor inverse agonists: identification of an active peptide core and its interaction epitopes on the receptor
Holst, Birgitte, Lang, M., Brandt, E., Bach, Anders, Howard, A., Frimurer, T. M., Beck-Sickinger, A. & Schwartz, Thue W., 2006, In: Molecular Pharmacology. 70, 3, p. 936-46 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ghrelin receptor mutations--too little height and too much hunger
Holst, Birgitte & Schwartz, Thue W., 2006, In: Journal of Clinical Investigation. 116, 3, p. 637-41 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GluVII : 06 - a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors
Rosenkilde, Mette & Schwartz, Thue W., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1319-1333 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptors
Rosenkilde, Mette & Schwartz, Thue W., 2006, In: Current Topics in Medicinal Chemistry. 6, 13, p. 1319-33 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation
Elling, C. E., Frimurer, T. M., Gerlach, L., Jorgensen, R., Holst, Birgitte & Schwartz, Thue W., 2006, In: Journal of Biological Chemistry. 281, 25, p. 17337-46 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of 7TM receptor activation--a global toggle switch model
Schwartz, Thue W., Frimurer, T. M., Holst, Birgitte, Rosenkilde, Mette & Elling, C. E., 2006, In: Annual Review of Pharmacology and Toxicology. 46, p. 481-519 38 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity
Rosenkilde, Mette, Benned-Jensen, T., Holst, Peter Johannes, Kledal, T. N., Lüttichau, H. R., Larsen, J. K., Christensen, Jan Pravsgaard, Schwartz, Thue W. & Andersen, H., 2006, In: Journal of Biological Chemistry. 281, 19, p. 13199-208 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR
Nygaard, R., Nielbo, S., Schwartz, Thue W. & Poulsen, F. M., 2006, In: Biochemistry. 45, 27, p. 8350-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma.
Jensen, K., Manfra, D., Grisotto, M., Martin, A., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S., Mar 2005, In: Journal of immunology (Baltimore, Md. : 1950).Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor
Hatse, S., Princen, K., De Clercq, E., Rosenkilde, Mette, Schwartz, Thue W., Hernandez-Abad, P. E., Skerlj, R. T., Bridger, G. J. & Schols, D., 2005, In: Biochemical Pharmacology. 70, 5, p. 752-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor
Casarosa, P., Waldhoer, M., LiWang, P. J., Vischer, H. F., Kledal, T., Timmerman, H., Schwartz, Thue W., Smit, M. J. & Leurs, R., 2005, In: Journal of Biological Chemistry. 280, 5, p. 3275-3285 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype
Jorgensen, R., Martini, L., Schwartz, Thue W. & Elling, C. E., 2005, In: Molecular Endocrinology. 19, 3, p. 812-23 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterizaton of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotype
Jorgensen, R., Martini, L., Schwartz, Thue W. & Elling, C. E., 2005, In: Molecular Endocrinology. Vol. 19, no.3, p. 812-23Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High constitutive activity of a virus-encoded seven transmembrane receptor in the absence of the conserved DRY motif (Asp-Arg-Tyr) in transmembrane helix 3
Rosenkilde, Mette, Kledal, T. N. & Schwartz, Thue W., 2005, In: Molecular Pharmacology. 68, 1, p. 11-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling
Holst, Birgitte, Brandt, E., Bach, Anders, Heding, A. & Schwartz, Thue W., 2005, In: Molecular Endocrinology. 19, 9, p. 2400-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Studies of relationships between variation of the human G protein-coupled receptor 40 Gene and Type 2 diabetes and insulin release
Hamid, Y. H., Vissing, H., Holst, Birgitte, Urhammer, S. A., Pyke, C., Hansen, S. K., Glümer, C., Borch-Johnsen, K., Jørgensen, T., Schwartz, Thue W., Pedersen, O. & Hansen, Torben, 2005, In: Diabetic Medicine. 22, 1, p. 74-80 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposi's sarcoma
Jensen, K. K., Manfra, D. J., Grisotto, M. G., Martin, A. P., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S. A., 2005, In: Journal of Immunology. 174, 6, p. 3686-94 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The human herpes virus 8-encoded chemokine receptor is required for angioproliferation in a murine model of Kaposis sarcoma
Jensen, K. K., Manfra, D. J., Grisotto, M. G., Martin, A. P., Vassileva, G., Kelley, K., Schwartz, Thue W. & Lira, S. A., 2005, In: Journal of Immunology. Vol. 174, no. 6, p. 3686-94Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP)
Heydorn, A., Søndergaard, B. P., Ersbøll, B., Holst, Birgitte, Nielsen, Finn Cilius, Haft, C. R., Whistler, J. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 52, p. 54291-303 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Common structural basis for constitutive activity of the ghrelin receptor family
Holst, Birgitte, Holliday, N. D., Bach, Anders, Elling, C. E., Cox, H. M. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 51, p. 53806-17 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Constitutive and regulated activities of virus-encoded 7TM receptors
Rosenkilde, Mette & Schwartz, Thue W., 2004, Handbook of Cellular Signalling. Chapter 29 ed. p. 173-76Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
- Published
Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation
Holst, Birgitte & Schwartz, Thue W., 2004, In: TIPS - Trends in Pharmacological Sciences. 25, 3, p. 113-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Det chemokine system - en vigtig regulator af angiogenese i sundhed og sygdom
Rosenkilde, Mette & Schwartz, Thue W., 2004, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 112, 7-8, p. 481-95 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinct in vitro interaction pattern of dopamine receptor subtypes with adaptor proteins involved in post-endocytotic receptor targeting
Heydorn, A., Søndergaard, B. P., Hadrup, N., Holst, Birgitte, Haft, C. R. & Schwartz, Thue W., 2004, In: FEBS Letters. 556, 1-3, p. 276-80 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist
Princen, K., Hatse, S., Vermeire, K., Aquaro, S., De Clercq, E., Gerlach, L., Rosenkilde, Mette, Schwartz, Thue W., Skerlj, R., Bridger, G. & Schols, D., 2004, In: Journal of Virology. 78, 23, p. 12996-3006 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor
Rosenkilde, Mette, Gerlach, L., Jakobsen, J. S., Skerlj, R. T., Bridger, G. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. VOl. 279, no. 4, p. 3033-41Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of AMD3100 antagonism in the CXCR4 receptor: transfer of binding site to the CXCR3 receptor
Rosenkilde, Mette, Gerlach, L., Jakobsen, J. S., Skerlj, R. T., Bridger, G. J. & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 4, p. 3033-41 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Similar activation of signal transduction pathways by the herpesvirus-encoded chemokine receptors US28 and ORF74
McLean, K. A., Holst, Peter Johannes, Martini, L., Schwartz, Thue W. & Rosenkilde, Mette, 2004, In: Virology. 325, 2, p. 241-51 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The CXC chemokine receptor encoded by herpesvirus saimiri, ECRF3, shows ligand-regulated signaling through Gi, Gq, and G12/13 proteins but constitutive signaling only through Gi and G12/13 proteins
Rosenkilde, Mette, McLean, K. A., Holst, Peter Johannes & Schwartz, Thue W., 2004, In: Journal of Biological Chemistry. 279, 31, p. 32524-33 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The chemokine system - a major regulator of angiogenesis in health and disease
Rosenkilde, Mette & Schwartz, Thue W., 2004, In: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum. Vol. 112, 7-8, p. 481-95Research output: Contribution to journal › Journal article › Research › peer-review
- 2003
- Published
A highly selective CCR2 chemokine agonist encoded by human herpesvirus 6
Lüttichau, H. R., Clark-Lewis, I., Jensen, Peter Østrup, Moser, C., Gerstoft, Jan & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, Vol. 278 (13), p. 10928-33 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High constitutive signaling of the ghrelin receptor--identification of a potent inverse agonist
Holst, Birgitte, Cygankiewicz, A., Jensen, T. H., Ankersen, M. & Schwartz, Thue W., 2003, In: Molecular Endocrinology. 17, 11, p. 2201-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metal ion enhanced binding of AMD3100 to Asp262 in the CXCR4 receptor
Gerlach, L. O., Jakobsen, J. S., Jensen, K. P., Rosenkilde, Mette, Skerlj, R. T., Ryde, U., Bridger, G. J. & Schwartz, Thue W., 2003, In: Biochemistry. 42, 3, p. 710-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism of agonism and inverse agonism in the melanocortin receptors: Zn(2+) as a structural and functional probe
Holst, Birgitte & Schwartz, Thue W., 2003, In: Annals of the New York Academy of Sciences. 994, p. 1-11 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry
Hatse, S., Princen, K., Vermeire, K., Gerlach, L., Rosenkilde, Mette, Schwartz, Thue W., Bridger, G., De Clercq, E. & Schols, D., 2003, In: FEBS Letters. 546, 2-3, p. 300-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis
Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. 278, 21, p. 19473-82 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endoytosis
Waldhoer, M., Casarosa, P., Rosenkilde, Mette, Smit, M. J., Leurs, R., Whistler, J. L. & Schwartz, Thue W., 2003, In: Journal of Biological Chemistry. Vol. 278 (21), p. 19473-82Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The virus-encoded chemokine vMIP-II inhibits virus-induced Tc1-driven inflammation
Lindow, M., Nansen, A., Bartholdy, C., Stryhn, A., Hansen, N. J. V., Boesen, T. P., Wells, T. N. C., Schwartz, Thue W. & Thomsen, Allan Randrup, 2003, In: Journal of Virology. 77, 13, p. 7393-400 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Viral leads for chemokine-modulatory drugs
Lindow, M., Lüttichau, H. R. & Schwartz, Thue W., 2003, In: TIPS - Trends in Pharmacological Sciences. 24, 3, p. 126-30 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Virally encoded chemokines and chemokine receptors in the role of viral infections
Holst, Peter Johannes, Lüttichau, H. R., Schwartz, Thue W. & Rosenkilde, Mette, 2003, In: Contributions to Microbiology. 10, p. 232-52 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2002
- Published
Interaction of a non-peptide agonist with angiotensin II AT1 receptor mutants
Costa-Neto, C. M., Miyakawa, A. A., Pesquero, J. B., Oliveira, L., Hjorth, S. A., Schwartz, Thue W. & Paiva, A. C. M., 2002, In: Canadian Journal of Physiology and Pharmacology. 80, 5, p. 413-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Localization of HCMV UL33 and US27 in endocytic compartments and viral membranes
Fraile-Ramos, A., Pelchen-Matthews, A., Kledal, T. N., Browne, H., Schwartz, Thue W. & Marsh, M., 2002, In: Traffic - International Journal of Intracellular Transport. 3, 3, p. 218-32 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metal ion-mediated agonism and agonist enhancement in melanocortin MC1 and MC4 receptors
Holst, Birgitte, Elling, C. E. & Schwartz, Thue W., 2002, In: Journal of Biological Chemistry. 277, 49, p. 47662-70 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular structure and function of 7TM/G-protein coupled receptors
Schwartz, Thue W. & Holst, Birgitte, 2002, Textbook of receptor Pharmacology. p. 65-84Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
- Published
Murine cytomegalovirus (CMV) M33 and human CMV US28 receptors exhibit similar constitutive signaling activities
Waldhoer, M., Kledal, T. N., Farrell, H. & Schwartz, Thue W., 2002, In: Journal of Virology. 76, 16, p. 8161-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype
Martini, L., Hastrup, H., Holst, Birgitte, Fraile-Ramos, A., Marsh, M. & Schwartz, Thue W., 2002, In: Molecular Pharmacology. 62, 1, p. 30-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel method for the study of receptor Ca2+ signalling exemplified by the NK1 receptor
Heding, A., Elling, C. E. & Schwartz, Thue W., 2002, In: Journal of Receptors and Signal Transduction. 22, 1-4, p. 241-52 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Single-chain vascular endothelial growth factor variant with antagonist activity
Boesen, T. P., Soni, B., Schwartz, Thue W. & Halkier, T., 2002, In: Journal of Biological Chemistry. 277, 43, p. 40335-41 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Enhanced fluorescence resonance energy transfer between spectral variants of green fluorescent protein through zinc-site engineering
Jensen, K. K., Martini, L. & Schwartz, Thue W., 2001, In: Biochemistry. 40 (4), p. 938-945Research output: Contribution to journal › Journal article › Research › peer-review
- Published
MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8
Lüttichau, H. R., Gerstoft, Jan & Schwartz, Thue W., 2001, In: Journal of Leukocyte Biology. 70, 2, p. 277-82 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine
Mizoue, L. S., Sullivan, S. K., King, D. S., Kledal, T. N., Schwartz, Thue W., Bacon, K. B. & Handel, T. M., 2001, In: Journal of Biological Chemistry. 276, 36, p. 33906-14 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor
Gerlach, L., Skerlj, R. T., Bridger, G. J. & Schwartz, Thue W., 2001, In: Journal of Biological Chemistry. 276 (17), p. 14153-14160Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutation of Asp (171) and Asp (262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100
Hatse, S., Princen, K., Gerlach, L., Bridger, G., Henson, G., De Clercq, E., Schwartz, Thue W. & Schols, D., 2001, In: Molecular Pharmacology. 60 (1), p. 164-173Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100
Hatse, S., Princen, K., Gerlach, L. O., Bridger, G., Henson, G., De Clercq, E., Schwartz, Thue W. & Schols, D., 2001, In: Molecular Pharmacology. 60, 1, p. 164-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The first PP supper - Camelot at Bispebjerg
Schwartz, Thue W. & Verlaege, O., 2001, In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement. vol. 234, p. 109-21Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The first PP supper--Camelot at Bispebjerg
Schwartz, Thue W. & Verlaege, O., 2001, In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement. 234, p. 109-21 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus encoded chemokine MC148, inhibits the CCR10 receptor
Lüttichau, H. R., Lewis, I. C., Gerstoft, J. & Schwartz, Thue W., 2001, In: European Journal of Immunology. 31 (4), p. 1217-1220Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The herpesvirus 8-encoded chemokine vMIP-II, but not the poxvirus-encoded chemokine MC148, inhibits the CCR10 receptor
Lüttichau, H. R., Lewis, I. C., Gerstoft, Jan & Schwartz, Thue W., 2001, In: European Journal of Immunology. 31, 4, p. 1217-20 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling
Fraile-Ramos, A., Kledal, T. N., Pelchen-Matthews, A., Bowers, K., Schwartz, Thue W. & Marsh, M., 2001, In: Molecular Biology of the Cell. 12, 6, p. 1737-49 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity
Holst, Peter Johannes, Rosenkilde, Mette, Manfra, D., Chen, S. C., Wiekowski, M. T., Holst, Birgitte, Cifire, F., Lipp, M., Schwartz, Thue W. & Lira, S. A., 2001, In: Journal of Clinical Investigation. 108, 12, p. 1789-96 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Two active molecular phenotypes of the tachykinin NK1 receptor revealed by G-protein fusions and mutagenesis
Holst, Birgitte, Hastrup, H., Raffetseder, U., Martini, L. & Schwartz, Thue W., 2001, In: Journal of Biological Chemistry. 276, 23, p. 19793-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Virally encoded 7TM receptors
Rosenkilde, Mette, Waldhoer, M., Lüttichau, H. R. & Schwartz, Thue W., 2001, In: Oncogene. 20, 13, p. 1582-93 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2000
- Published
A highly selective CC chemokine receptor (CCR)8 antagonist encoded by the poxvirus molluscum contagiosum
Lüttichau, H. R., J., S., Boesen, T. P., Johnsen, A. H., Chantry, D., Gerstoft, J. & Schwartz, Thue W., 2000, In: Journal of Experimental Medicine. 191, no. 1, p. 171-80Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Binding of norbinaltorphimine (norBNI) congeners to wild-type and mutant mu and kappa opioid receptors: molecular recognition loci for the pharmacophore and address components of kappa antagonists
Larson, D. L., Jones, R. M., Hjorth, S. A., Schwartz, Thue W. & Portoghese, P. S., 2000, In: Journal of Medicinal Chemistry. 43, no. 8, p. 1573-6Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Disulfide bridge engineering in the tachykinen NK1 receptor
Elling, C. E., Raffetseder, U., Nielsen, S. M. & Schwartz, Thue W., 2000, In: Biochemistry. 39, no. 4, p. 667-75Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutational analysis of the interaction of the N- and C-terminal ends of angiotensin II with the rat AT(1A) receptor
Costa-Neto, C. M., Miyakawa, A. A., Oliveira, L., Hjorth, S. A., Schwartz, Thue W. & Paiva, A. C., 2000, In: British Journal of Pharmacology. 130, no. 6, p. 1263-8Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Partial agonism through a zinc-Ion switch constructed between transmembrane domains III and VII in the tachykinin NK(1) receptor
Holst, Birgitte, Elling, C. E. & Schwartz, Thue W., 2000, In: Molecular Pharmacology. 58, 2, p. 263-70 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Potency of ligands correlates with affinity measured against agonist and inverse agonists but not against neutral ligand in constitutively active chemokine receptor
Rosenkilde, Mette & Schwartz, Thue W., 2000, In: Molecular Pharmacology. 57, no. 3, p. 602-9Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective elimination of high constitutive activity or chemokine binding in the human herpesvirus 8 encoded seven transmembrane oncogene ORF74
Rosenkilde, Mette, Kledal, T. N., Holst, Peter Johannes & Schwartz, Thue W., 2000, In: Journal of Biological Chemistry. 275, 34, p. 26309-15 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Validation of chemokine receptors as drug targets
Lüttichau, H. R. & Schwartz, Thue W., 2000, In: Current Opinion in Drug Discovery & Development. 3, no. 5, p. 610-623Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Agonists and inverse agonists for the herpesvirus 8-encoded constitutively active seven-transmembrane oncogene product, ORF-74
Rosenkilde, Mette, Kledal, T. N., Bräuner, Hans & Schwartz, Thue W., 8 Jan 1999, In: Journal of Biological Chemistry. 274, 2, p. 956-961Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CD4-chemokine receptor hybrids in human immunodeficiency virus type 1 infection
Klasse, P. J., Rosenkilde, Mette, Signoret, N., Pelchen-Matthews, A., Schwartz, Thue W. & Marsh, M., 1999, In: Journal of Virology. 73, no. 9, p. 7453-7466Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conversion of agonist site to metal-ion chelator site in the beta(2)-adrenergic receptor
Elling, C. E., Thirstrup, K., Holst, Birgitte & Schwartz, Thue W., 1999, In: Proceedings of the National Academy of Sciences of the United States of America. 96, 22, p. 12322-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Conversion of agonist site to metal-ion chelator site in the ¿2-adrenergic receptor
Elling, C. E., Thirstrup, K., Holst, Birgitte & Schwartz, Thue W., 1999, In: Proceedings of the National Academy of Science of the United States of America. 96, no. 22, p. 12322-12327Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
Constitutive activity of glucagon receptor mutants
Hjorth, S. A., Ørskov, Cathrine & Schwartz, Thue W., 1998, In: Molecular Endocrinology. 12, no. 1, p. 78-86Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Differential regulation of CXCR4 and CCR5 endocytosis
Signoret, N., Rosenkilde, Mette, Klasse, P. J., Schwartz, Thue W., Malim, M. H., Hoxie, J. A. & Marsh, M., 1998, In: Journal of Cell Science. 111, no. 18, p. 2819-2830Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors
Jones, R. M., Hjorth, S. A., Schwartz, Thue W. & Portoghese, P. S., 1998, In: Journal of Medicinal Chemistry. 41, p. 4911-4914Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Natural agonist enhancing bis-His zinc-site in transmembrane segment V of the tachykinin NK3 receptor
Rosenkilde, Mette, Lucibello, M., Holst, Birgitte & Schwartz, Thue W., 1998, In: FEBS Letters. 439, 1-2, p. 35-40 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Principles of Agonism - Undressing Efficacy
Schwartz, Thue W. & Ijzermann, A. P., 1998, In: TIPS - Trends in Pharmacological Sciences. 19, no. 11, p. 433-436Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selective recognition of the membrane-bound CXC3 chemokine, fractal by the human cytomegalovirus-encoded broad-spectrum receptor US28
Kledal, T. N., Rosenkilde, Mette & Schwartz, Thue W., 1998, In: FEBS Letters. 441, p. 209-214Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Split-receptors in the tachykinin NK-1 system - mutational analysis of intracellular loop 3
Nielsen, S. M., Elling, C. E. & Schwartz, Thue W., 1998, In: European Journal of Biochemistry. 251, p. 217-226Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Steric hindrance mutagenesis versus alanine scan in mapping of ligand binding sites in the tachykinin NK1 receptor
Holst, Birgitte, Jensen, S. Z., Elling, C. E., Hjorth, S. A. & Schwartz, Thue W., 1998, In: Molecular Pharmacology. 53, no. 1, p. 166-175Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The CCR5 receptor acts as an alloantigen in CCR5¿32 homozygous individuals: Identification of chemokine- and HIV-1 blocking human antibodies
Ditzel, H. J., Rosenkilde, Mette, Garred, P., Wang, M., Pedersen, C., Burton, D. R. & Schwartz, Thue W., 1998, In: Proceedings of the National Academy of Science of the United States of America. 95, no. 9, p. 5241-5245Research output: Contribution to journal › Journal article › Research › peer-review
- Published
XVI: International Union of Pharmacology Recommendations for the nomenclature of neuropeptide Y, peptide YY and pancreatic polypeptide receptors
Michel, M. C., Beck-Sickinger, A., Cox, H., Doods, H. N., Herzog, H., Larhammer, D., Quirion, R., Schwartz, Thue W. & Westfall, T., 1998, In: Pharmacological Reviews. 50, no. 1, p. 143-150Research output: Contribution to journal › Journal article › Research › peer-review
- 1997
- Published
Den normale hjerne: Ny viden på flere fronter
Pakkenberg, B., Gundersen, H. J. G., Mortensen, Erik Lykke, Lauritzen, Martin, Jeune, B., Regeur, L., West, M. J. & Schwartz, Thue W., 1 Dec 1997, In: Ugeskrift for Laeger. 159, 6, p. 723-727 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
7TM receptorer - fra lugtesans og nye hormoner til HIV-infektion
Schwartz, Thue W., 1997, In: Ugeskrift for læger. 159, p. 1239-1245Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A broadspectrum chemokine antagonist encoded by Karposis sarcoma associated herpes virus
Kledal, T. N., Rosenkilde, Mette, Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Schwartz, Thue W., Poucer, C. A., Lüttichau, H. R., Gerstoft, J., Clapham, P. R., Clark-Lewis, I. & Wells, T. N. C., 1997, In: Kexue (Shanghai). 277, p. 1656-1659Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of non-peptide antagonist and peptide agonist binding sites of the NK1 receptor with fluorescent ligands
Turcatti, G., Drozda, S. E., Chassaing, G., Schwartz, Thue W., Chollet, A., Jensen, S. Z. & Lowe III, J. A., 1997, In: Journal of Biological Chemistry. 272, no. 34, p. 21167-21175Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dual agonistic and antagonistic proberty of non-peptide angiotensin AT1 ligands: Susceptibility to receptor mutations
Perlman, S., Costa-Neto, C. M., Miyakawa, A. A., Schambye, H. T., Hjorth, S. A., Paiva, A. C., Rivero, R. A., Greenlee, W. J. & Schwartz, Thue W., 1997, In: Molecular Pharmaceutics. 51, no. 2, p. 301-311Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Engineering of metal-ion sites as distance constraints in structural and functional analysis of 7TM receptors
Elling, C. E., Thirstrup, K., Nielsen, S. M., Hjorth, S. A. & Schwartz, Thue W., 1997, In: Structure. 2, no. 4, p. 76-80Research output: Contribution to journal › Journal article › Research › peer-review
- Published
How receptor mutagenesis may confirm or confuse receptor classification
Schwartz, Thue W., Perlman, S., Rosenkilde, Mette & Hjorth, S. A., 1997, In: Annals of the New York Academy of Sciences. 817, p. 71-84Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metal-ion sites as structural and functional probes of helix-helix interactions in 7TM receptors
Elling, C. E., Thirstrup, K., Nielsen, S. M., Hjorth, S. A. & Schwartz, Thue W., 1997, In: Annals of the New York Academy of Sciences. 814, p. 142-151Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Phorbol esters and SDF-1 induce rapid endocytosis and down-modulation of the chemokine receptor CXCR4
Signoret, N., Oldridge, J., Pelchen-Matthews, A., Klasse, P. J., Tran, T., Brass, L. F., Rosenkilde, Mette, Schwartz, Thue W., Luther, M. A., Wells, T. N. C., Hoxie, J. A. & March, M., 1997, In: Journal of Cell Biology. 139, no. 3, p. 651-664Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Plagiarism of the host immune system - lessons about chemokine immunology from viruses
Wells, T. N. C. & Schwartz, Thue W., 1997, In: Current Opinion in Biotechnology. 8, no. 6, p. 741-748Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist
Simmons, G., Clapham, P. R., Picard, L., Offord, R. E., Rosenkilde, Mette, Schwartz, Thue W., Buser, R., Weels, T. N. C. & Proudfoot, A., 1997, In: Kexue (Shanghai). 276, p. 276-279Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The dual nature of the NK-1 receptor
Maggi, C. & Schwartz, Thue W., 1997, In: TIPS - Trends in Pharmacological Sciences. 18, no. 10, p. 351-355Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
- Published
Molecular mechanism of action of non-peptide ligands for peptide receptors
Schwartz, Thue W., Gether, Ulrik, Schambye, H. T. & Hjorth, Siv Annegrethe, Oct 1995, In: Current Pharmaceutical Design. 1, 3, p. 325-342 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1993
- Published
Conservation of a helix-stabilizing dipole moment in the PP-fold family of regulatory peptides
Bjørnholm, B., Jørgensen, Flemming Steen & Schwartz, Thue W., 1993, In: Biochemistry. 32, 12, p. 2954-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Immunohistochemical and chromatographic Identification of Peptides derived from Proneuropeptide Y in the human frontal Cortex
Mikkelsen, J. D., Larsen, P. J., Kruse-Larsen, C., O'Hare, M. M. T. & Schwartz, Thue W., 1993, In: Brain Research Bulletin. 31, p. 415-425Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regional distribution of putative NPY Y*U1 receptors and neurons expressing Y*U1 mRNA in forebrain areas of the rat central nervous system
Larsen, P. J., Sheikh, S. P., Jakobsen, C. R., Schwartz, Thue W. & Mikkelsen, J. D., 1993, In: European Journal of Neuroscience. Vol 5, p. 1622-37Research output: Contribution to journal › Journal article › Research › peer-review
- 1991
- Published
Processing of pro-CGRP in a rat medullary thyroid carcinoma cell line transfected with protease inhibitors
Johansen, T. E., Schifter, S., Vogel, Lotte, Tolstoy, S. & Schwartz, Thue W., 1991, In: Molecular and Cellular Endocrinology. 82, 1, p. 51-60 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1990
- Published
C-terminal KDEL-modified cystatin C is retained in transfected CHO cells
Johansen, T. E., Vogel, Lotte & Schwartz, Thue W., 1990, In: Biochemical and Biophysical Research Communications. 172, 3, p. 1384-91 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Y1 receptors for neuropeptide Y are coupled to mobilization of intracellular calcium and inhibition of adenylate cyclase
Aakerlund, L., Gether, Ulrik, Fuhlendorff, J., Schwartz, Thue W. & Thastrup, Ole, 1990, In: F E B S Letters. 260, 1, p. 73-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
[Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist
Fuhlendorff, J., Gether, Ulrik, Aakerlund, L., Langeland-Johansen, N., Thøgersen, H., Melberg, S. G., Olsen, U. B., Thastrup, Ole & Schwartz, Thue W., 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 1, p. 182-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1989
- Published
Release of PYY from pig intestinal mucosa; luminal and neural regulation
Sheikh, S. P., Holst, Jens Juul, Ørskov, Cathrine, Ekman, R. & Schwartz, Thue W., Dec 1989, In: Regulatory Peptides. 26, 3, p. 253-66 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1987
- Published
High-performance liquid chromatography of phenylthiocarbamyl derivatives of amino acids and side-chain derivatized amino acids.
O'Hare, M., Tortora, O., Gether, Ulrik, Nielsen, Henrik & Schwartz, Thue W., Mar 1987, In: Journal of Chromatography.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
Holst, Jens Juul, Ørskov, Cathrine, Nielsen, Olaf & Schwartz, Thue W., 1987, In: F E B S Letters. 211, 2, p. 169-74 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1986
- Published
Kredsløbsregulation ved hypovolaemisk shock
Sander Jensen, K., Secher, Niels H., Rørsgaard, S., Warberg, J., Astrup, A., Christensen, N. J., Giese, J., Schwartz, Thue W. & Bie, P., 1986, In: Ugeskrift for læger. 148, 38, p. 2383-2387 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 11601
Most downloads
-
4515
downloads
Family and population-based studies of variation within the ghrelin receptor locus in relation to measures of obesity
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
2785
downloads
PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
606
downloads
Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91
Research output: Contribution to journal › Journal article › Research › peer-review
Published