A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control
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A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control. / Schmidt, P T; Näslund, E; Grybäck, P; Jacobsson, H; Holst, Jens Juul; Hilsted, L; Hellström, P M.
In: The Journal of clinical endocrinology and metabolism, Vol. 90, No. 9, 09.2005, p. 5241-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control
AU - Schmidt, P T
AU - Näslund, E
AU - Grybäck, P
AU - Jacobsson, H
AU - Holst, Jens Juul
AU - Hilsted, L
AU - Hellström, P M
PY - 2005/9
Y1 - 2005/9
N2 - CONTEXT: Previous studies using pancreatic polypeptide (PP) infusions in humans have failed to show an effect on gastric emptying, glucose metabolism, and insulin secretion. This might be due to the use of nonhuman sequences of the peptide.OBJECTIVE: The objective of this study was to use synthetic human PP to study gastric emptying rates of a solid meal and postprandial hormone secretion and glucose disposal as well as the gastric emptying rate of water.DESIGN: This was a single-blind study.SETTING: The study was performed at a university hospital.PARTICIPANTS: Fourteen healthy adult subjects were studied.INTERVENTIONS: Infusion of saline or PP at 0.75 or 2.25 pmol/kg.min was given to eight subjects (gastric emptying of solid food), and infusion of saline or PP at 2.25 pmol/kg.min was given to six subjects (gastric emptying of water).MAIN OUTCOME MEASURES: The main outcome measures were gastric emptying of solids (scintigraphy), hunger ratings (visual analog scale), and plasma concentrations of PP, insulin, glucagon, somatostatin, glucagon-like peptide 1, glucose, and gastric emptying of plain water (scintigraphy).RESULTS: PP prolonged the lag phase and the half-time of emptying of the solid meal. The change in hunger rating, satiety, desire to eat after the meal, or prospective consumption was not affected. The postprandial rise in plasma glucose was prolonged by PP. The postprandial rise in insulin was also delayed by PP. PP had no significant effect on the emptying of water.CONCLUSIONS: PP inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. PP is suggested to have a physiological role in the pancreatic postprandial counterregulation of gastric emptying and insulin secretion.
AB - CONTEXT: Previous studies using pancreatic polypeptide (PP) infusions in humans have failed to show an effect on gastric emptying, glucose metabolism, and insulin secretion. This might be due to the use of nonhuman sequences of the peptide.OBJECTIVE: The objective of this study was to use synthetic human PP to study gastric emptying rates of a solid meal and postprandial hormone secretion and glucose disposal as well as the gastric emptying rate of water.DESIGN: This was a single-blind study.SETTING: The study was performed at a university hospital.PARTICIPANTS: Fourteen healthy adult subjects were studied.INTERVENTIONS: Infusion of saline or PP at 0.75 or 2.25 pmol/kg.min was given to eight subjects (gastric emptying of solid food), and infusion of saline or PP at 2.25 pmol/kg.min was given to six subjects (gastric emptying of water).MAIN OUTCOME MEASURES: The main outcome measures were gastric emptying of solids (scintigraphy), hunger ratings (visual analog scale), and plasma concentrations of PP, insulin, glucagon, somatostatin, glucagon-like peptide 1, glucose, and gastric emptying of plain water (scintigraphy).RESULTS: PP prolonged the lag phase and the half-time of emptying of the solid meal. The change in hunger rating, satiety, desire to eat after the meal, or prospective consumption was not affected. The postprandial rise in plasma glucose was prolonged by PP. The postprandial rise in insulin was also delayed by PP. PP had no significant effect on the emptying of water.CONCLUSIONS: PP inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. PP is suggested to have a physiological role in the pancreatic postprandial counterregulation of gastric emptying and insulin secretion.
KW - Adult
KW - Appetite
KW - Blood Glucose
KW - Cross-Over Studies
KW - Eating
KW - Female
KW - Food
KW - Gastric Emptying
KW - Glucagon
KW - Hormones
KW - Humans
KW - Insulin
KW - Male
KW - Pain Measurement
KW - Pancreatic Polypeptide
KW - Postprandial Period
KW - Reference Values
KW - Satiation
KW - Single-Blind Method
KW - Water
U2 - 10.1210/jc.2004-2089
DO - 10.1210/jc.2004-2089
M3 - Journal article
C2 - 15998783
VL - 90
SP - 5241
EP - 5246
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 9
ER -
ID: 132053647