Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians

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Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. / Li, H; Oskari Kilpeläinen, Tuomas; Liu, C; Zhu, Jie; Liu, Y; Hu, C; Yang, Z; Zhang, W; Bao, W; Cha, Seung-Tae; Wu, Y; Yang, T; Sekine, A; Choi, B Y; Yajnik, C S; Zhou, Dao; Takeuchi, F; Yamamoto, K; Chan, J C; Mani, K R; Been, L F; Imamura, M; Nakashima, E; Lee, N; Fujisawa, T; Karasawa, S; Wen, Wan; Joglekar, C V; Lu, W; Chang, Y; Xiang, Y; Gao, Y; Liu, S; Song, Y; Kwak, S H; Shin, H D; Park, Kiwoo; Fall, C H D; Kim, J Y; Sham, P C; Lam, K S L; Zheng, W; Shu, X; Deng, Hong; Ikegami, H; Krishnaveni, G V; Sanghera, D K; Chuang, L; Liu, L; Hu, R; Kim, Y; Daimon, M; Hotta, K; Jia, W; Kooner, J S; Chambers, J C; Chandak, G R; Ma, R C; Maeda, S; Dorajoo, R; Yokota, M; Takayanagi, R; Kato, N; Lin, Xue; Loos, R J F.

In: Diabetologia, Vol. 55, No. 4, 04.2012, p. 981-95.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Li, H, Oskari Kilpeläinen, T, Liu, C, Zhu, J, Liu, Y, Hu, C, Yang, Z, Zhang, W, Bao, W, Cha, S-T, Wu, Y, Yang, T, Sekine, A, Choi, BY, Yajnik, CS, Zhou, D, Takeuchi, F, Yamamoto, K, Chan, JC, Mani, KR, Been, LF, Imamura, M, Nakashima, E, Lee, N, Fujisawa, T, Karasawa, S, Wen, W, Joglekar, CV, Lu, W, Chang, Y, Xiang, Y, Gao, Y, Liu, S, Song, Y, Kwak, SH, Shin, HD, Park, K, Fall, CHD, Kim, JY, Sham, PC, Lam, KSL, Zheng, W, Shu, X, Deng, H, Ikegami, H, Krishnaveni, GV, Sanghera, DK, Chuang, L, Liu, L, Hu, R, Kim, Y, Daimon, M, Hotta, K, Jia, W, Kooner, JS, Chambers, JC, Chandak, GR, Ma, RC, Maeda, S, Dorajoo, R, Yokota, M, Takayanagi, R, Kato, N, Lin, X & Loos, RJF 2012, 'Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians', Diabetologia, vol. 55, no. 4, pp. 981-95. https://doi.org/10.1007/s00125-011-2370-7

APA

Li, H., Oskari Kilpeläinen, T., Liu, C., Zhu, J., Liu, Y., Hu, C., Yang, Z., Zhang, W., Bao, W., Cha, S-T., Wu, Y., Yang, T., Sekine, A., Choi, B. Y., Yajnik, C. S., Zhou, D., Takeuchi, F., Yamamoto, K., Chan, J. C., ... Loos, R. J. F. (2012). Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia, 55(4), 981-95. https://doi.org/10.1007/s00125-011-2370-7

Vancouver

Li H, Oskari Kilpeläinen T, Liu C, Zhu J, Liu Y, Hu C et al. Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. Diabetologia. 2012 Apr;55(4):981-95. https://doi.org/10.1007/s00125-011-2370-7

Author

Li, H ; Oskari Kilpeläinen, Tuomas ; Liu, C ; Zhu, Jie ; Liu, Y ; Hu, C ; Yang, Z ; Zhang, W ; Bao, W ; Cha, Seung-Tae ; Wu, Y ; Yang, T ; Sekine, A ; Choi, B Y ; Yajnik, C S ; Zhou, Dao ; Takeuchi, F ; Yamamoto, K ; Chan, J C ; Mani, K R ; Been, L F ; Imamura, M ; Nakashima, E ; Lee, N ; Fujisawa, T ; Karasawa, S ; Wen, Wan ; Joglekar, C V ; Lu, W ; Chang, Y ; Xiang, Y ; Gao, Y ; Liu, S ; Song, Y ; Kwak, S H ; Shin, H D ; Park, Kiwoo ; Fall, C H D ; Kim, J Y ; Sham, P C ; Lam, K S L ; Zheng, W ; Shu, X ; Deng, Hong ; Ikegami, H ; Krishnaveni, G V ; Sanghera, D K ; Chuang, L ; Liu, L ; Hu, R ; Kim, Y ; Daimon, M ; Hotta, K ; Jia, W ; Kooner, J S ; Chambers, J C ; Chandak, G R ; Ma, R C ; Maeda, S ; Dorajoo, R ; Yokota, M ; Takayanagi, R ; Kato, N ; Lin, Xue ; Loos, R J F. / Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. In: Diabetologia. 2012 ; Vol. 55, No. 4. pp. 981-95.

Bibtex

@article{e5671d1d4b89429f8fb5156f88ff6279,
title = "Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians",
abstract = "FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians.",
keywords = "Adult, Asian Continental Ancestry Group, Diabetes Mellitus, Type 2, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Male, Obesity, Polymorphism, Single Nucleotide, Proteins",
author = "H Li and {Oskari Kilpel{\"a}inen}, Tuomas and C Liu and Jie Zhu and Y Liu and C Hu and Z Yang and W Zhang and W Bao and Seung-Tae Cha and Y Wu and T Yang and A Sekine and Choi, {B Y} and Yajnik, {C S} and Dao Zhou and F Takeuchi and K Yamamoto and Chan, {J C} and Mani, {K R} and Been, {L F} and M Imamura and E Nakashima and N Lee and T Fujisawa and S Karasawa and Wan Wen and Joglekar, {C V} and W Lu and Y Chang and Y Xiang and Y Gao and S Liu and Y Song and Kwak, {S H} and Shin, {H D} and Kiwoo Park and Fall, {C H D} and Kim, {J Y} and Sham, {P C} and Lam, {K S L} and W Zheng and X Shu and Hong Deng and H Ikegami and Krishnaveni, {G V} and Sanghera, {D K} and L Chuang and L Liu and R Hu and Y Kim and M Daimon and K Hotta and W Jia and Kooner, {J S} and Chambers, {J C} and Chandak, {G R} and Ma, {R C} and S Maeda and R Dorajoo and M Yokota and R Takayanagi and N Kato and Xue Lin and Loos, {R J F}",
year = "2012",
month = apr,
doi = "10.1007/s00125-011-2370-7",
language = "English",
volume = "55",
pages = "981--95",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians

AU - Li, H

AU - Oskari Kilpeläinen, Tuomas

AU - Liu, C

AU - Zhu, Jie

AU - Liu, Y

AU - Hu, C

AU - Yang, Z

AU - Zhang, W

AU - Bao, W

AU - Cha, Seung-Tae

AU - Wu, Y

AU - Yang, T

AU - Sekine, A

AU - Choi, B Y

AU - Yajnik, C S

AU - Zhou, Dao

AU - Takeuchi, F

AU - Yamamoto, K

AU - Chan, J C

AU - Mani, K R

AU - Been, L F

AU - Imamura, M

AU - Nakashima, E

AU - Lee, N

AU - Fujisawa, T

AU - Karasawa, S

AU - Wen, Wan

AU - Joglekar, C V

AU - Lu, W

AU - Chang, Y

AU - Xiang, Y

AU - Gao, Y

AU - Liu, S

AU - Song, Y

AU - Kwak, S H

AU - Shin, H D

AU - Park, Kiwoo

AU - Fall, C H D

AU - Kim, J Y

AU - Sham, P C

AU - Lam, K S L

AU - Zheng, W

AU - Shu, X

AU - Deng, Hong

AU - Ikegami, H

AU - Krishnaveni, G V

AU - Sanghera, D K

AU - Chuang, L

AU - Liu, L

AU - Hu, R

AU - Kim, Y

AU - Daimon, M

AU - Hotta, K

AU - Jia, W

AU - Kooner, J S

AU - Chambers, J C

AU - Chandak, G R

AU - Ma, R C

AU - Maeda, S

AU - Dorajoo, R

AU - Yokota, M

AU - Takayanagi, R

AU - Kato, N

AU - Lin, Xue

AU - Loos, R J F

PY - 2012/4

Y1 - 2012/4

N2 - FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians.

AB - FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians.

KW - Adult

KW - Asian Continental Ancestry Group

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Genetic Association Studies

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Male

KW - Obesity

KW - Polymorphism, Single Nucleotide

KW - Proteins

U2 - 10.1007/s00125-011-2370-7

DO - 10.1007/s00125-011-2370-7

M3 - Journal article

C2 - 22109280

VL - 55

SP - 981

EP - 995

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 4

ER -

ID: 46278869