Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians

Research output: Contribution to journalJournal articleResearchpeer-review

  • H Li
  • C Liu
  • Jie Zhu
  • Y Liu
  • C Hu
  • Z Yang
  • W Zhang
  • W Bao
  • Seung-Tae Cha
  • Y Wu
  • T Yang
  • A Sekine
  • B Y Choi
  • C S Yajnik
  • Dao Zhou
  • F Takeuchi
  • K Yamamoto
  • J C Chan
  • K R Mani
  • L F Been
  • M Imamura
  • E Nakashima
  • N Lee
  • T Fujisawa
  • S Karasawa
  • Wan Wen
  • C V Joglekar
  • W Lu
  • Y Chang
  • Y Xiang
  • Y Gao
  • S Liu
  • Y Song
  • S H Kwak
  • H D Shin
  • Kiwoo Park
  • C H D Fall
  • J Y Kim
  • P C Sham
  • K S L Lam
  • W Zheng
  • X Shu
  • Hong Deng
  • H Ikegami
  • G V Krishnaveni
  • D K Sanghera
  • L Chuang
  • L Liu
  • R Hu
  • Y Kim
  • M Daimon
  • K Hotta
  • W Jia
  • J S Kooner
  • J C Chambers
  • G R Chandak
  • R C Ma
  • S Maeda
  • R Dorajoo
  • M Yokota
  • R Takayanagi
  • N Kato
  • Xue Lin
  • R J F Loos
FTO harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for FTO in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the FTO locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians.
Original languageEnglish
JournalDiabetologia
Volume55
Issue number4
Pages (from-to)981-95
Number of pages15
ISSN0012-186X
DOIs
Publication statusPublished - Apr 2012

    Research areas

  • Adult, Asian Continental Ancestry Group, Diabetes Mellitus, Type 2, Female, Genetic Association Studies, Genetic Predisposition to Disease, Genotype, Humans, Male, Obesity, Polymorphism, Single Nucleotide, Proteins

ID: 46278869