Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial. / Razquin, Cristina; Ruiz-Canela, Miguel; Toledo, Estefania; Clish, Clary B.; Guasch-Ferré, Marta; García-Gavilán, Jesús F.; Wittenbecher, Clemens; Alonso-Gómez, Angel; Fitó, Montse; Liang, Liming; Corella, Dolores; Gómez-Gracia, Enrique; Estruch, Ramon; Fiol, Miquel; Santos-Lozano, Jose M.; Serra-Majem, Luis; Ros, Emilio; Aros, Fernando; Salas-Salvadó, Jordi; Hu, Frank B.; Martínez-González, Miguel A.

In: International Journal of Molecular Sciences, Vol. 24, 270, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Razquin, C, Ruiz-Canela, M, Toledo, E, Clish, CB, Guasch-Ferré, M, García-Gavilán, JF, Wittenbecher, C, Alonso-Gómez, A, Fitó, M, Liang, L, Corella, D, Gómez-Gracia, E, Estruch, R, Fiol, M, Santos-Lozano, JM, Serra-Majem, L, Ros, E, Aros, F, Salas-Salvadó, J, Hu, FB & Martínez-González, MA 2023, 'Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial', International Journal of Molecular Sciences, vol. 24, 270. https://doi.org/10.3390/ijms24010270

APA

Razquin, C., Ruiz-Canela, M., Toledo, E., Clish, C. B., Guasch-Ferré, M., García-Gavilán, J. F., Wittenbecher, C., Alonso-Gómez, A., Fitó, M., Liang, L., Corella, D., Gómez-Gracia, E., Estruch, R., Fiol, M., Santos-Lozano, J. M., Serra-Majem, L., Ros, E., Aros, F., Salas-Salvadó, J., ... Martínez-González, M. A. (2023). Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial. International Journal of Molecular Sciences, 24, [270]. https://doi.org/10.3390/ijms24010270

Vancouver

Razquin C, Ruiz-Canela M, Toledo E, Clish CB, Guasch-Ferré M, García-Gavilán JF et al. Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial. International Journal of Molecular Sciences. 2023;24. 270. https://doi.org/10.3390/ijms24010270

Author

Razquin, Cristina ; Ruiz-Canela, Miguel ; Toledo, Estefania ; Clish, Clary B. ; Guasch-Ferré, Marta ; García-Gavilán, Jesús F. ; Wittenbecher, Clemens ; Alonso-Gómez, Angel ; Fitó, Montse ; Liang, Liming ; Corella, Dolores ; Gómez-Gracia, Enrique ; Estruch, Ramon ; Fiol, Miquel ; Santos-Lozano, Jose M. ; Serra-Majem, Luis ; Ros, Emilio ; Aros, Fernando ; Salas-Salvadó, Jordi ; Hu, Frank B. ; Martínez-González, Miguel A. / Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial. In: International Journal of Molecular Sciences. 2023 ; Vol. 24.

Bibtex

@article{85455ab7b5dc4daa8683f64d3274efb4,
title = "Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial",
abstract = "Effective prevention and risk prediction are important for peripheral artery disease (PAD) due to its poor prognosis and the huge disease burden it produces. Circulating amino acids (AA) and their metabolites may serve as biomarkers of PAD risk, but they have been scarcely investigated. The objective was to prospectively analyze the associations of baseline levels of plasma AA (and their pathways) with subsequent risk of PAD and the potential effect modification by a nutritional intervention with the Mediterranean diet (MedDiet). A matched case-control study was nested in the PREDIMED trial, in which participants were randomized to three arms: MedDiet with tree nut supplementation group, MedDiet with extra-virgin olive oil (EVOO) supplementation group or control group (low-fat diet). One hundred and sixty-seven PAD cases were matched with 250 controls. Plasma AA was measured with liquid chromatography/mass spectrometry at the Broad Institute. Baseline tryptophan, serine and threonine were inversely associated with PAD (ORfor 1 SD increase = 0.78 (0.61–0.99); 0.67 (0.51–0.86) and 0.75 (0.59–0.95), respectively) in a multivariable-adjusted conditional logistic regression model. The kynurenine/tryptophan ratio was directly associated with PAD (ORfor 1 SD increase = 1.50 (1.14–1.98)). The nutritional intervention with the MedDiet+nuts modified the association between threonine and PAD (p-value interaction = 0.018) compared with the control group. However, subjects allocated to the MedDiet+EVOO group were protected against PAD independently of baseline threonine. Plasma tryptophan, kynurenine/tryptophan ratio, serine and threonine might serve as early biomarkers of future PAD in subjects at a high risk of cardiovascular disease. The MedDiet supplemented with EVOO exerted a protective effect, regardless of baseline levels of threonine.",
keywords = "amino acids, case-cohort, metabolomics, peripheral artery disease, PREDIMED",
author = "Cristina Razquin and Miguel Ruiz-Canela and Estefania Toledo and Clish, {Clary B.} and Marta Guasch-Ferr{\'e} and Garc{\'i}a-Gavil{\'a}n, {Jes{\'u}s F.} and Clemens Wittenbecher and Angel Alonso-G{\'o}mez and Montse Fit{\'o} and Liming Liang and Dolores Corella and Enrique G{\'o}mez-Gracia and Ramon Estruch and Miquel Fiol and Santos-Lozano, {Jose M.} and Luis Serra-Majem and Emilio Ros and Fernando Aros and Jordi Salas-Salvad{\'o} and Hu, {Frank B.} and Mart{\'i}nez-Gonz{\'a}lez, {Miguel A.}",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2023",
doi = "10.3390/ijms24010270",
language = "English",
volume = "24",
journal = "International Journal of Molecular Sciences (Online)",
issn = "1661-6596",
publisher = "MDPI AG",

}

RIS

TY - JOUR

T1 - Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial

AU - Razquin, Cristina

AU - Ruiz-Canela, Miguel

AU - Toledo, Estefania

AU - Clish, Clary B.

AU - Guasch-Ferré, Marta

AU - García-Gavilán, Jesús F.

AU - Wittenbecher, Clemens

AU - Alonso-Gómez, Angel

AU - Fitó, Montse

AU - Liang, Liming

AU - Corella, Dolores

AU - Gómez-Gracia, Enrique

AU - Estruch, Ramon

AU - Fiol, Miquel

AU - Santos-Lozano, Jose M.

AU - Serra-Majem, Luis

AU - Ros, Emilio

AU - Aros, Fernando

AU - Salas-Salvadó, Jordi

AU - Hu, Frank B.

AU - Martínez-González, Miguel A.

N1 - Publisher Copyright: © 2022 by the authors.

PY - 2023

Y1 - 2023

N2 - Effective prevention and risk prediction are important for peripheral artery disease (PAD) due to its poor prognosis and the huge disease burden it produces. Circulating amino acids (AA) and their metabolites may serve as biomarkers of PAD risk, but they have been scarcely investigated. The objective was to prospectively analyze the associations of baseline levels of plasma AA (and their pathways) with subsequent risk of PAD and the potential effect modification by a nutritional intervention with the Mediterranean diet (MedDiet). A matched case-control study was nested in the PREDIMED trial, in which participants were randomized to three arms: MedDiet with tree nut supplementation group, MedDiet with extra-virgin olive oil (EVOO) supplementation group or control group (low-fat diet). One hundred and sixty-seven PAD cases were matched with 250 controls. Plasma AA was measured with liquid chromatography/mass spectrometry at the Broad Institute. Baseline tryptophan, serine and threonine were inversely associated with PAD (ORfor 1 SD increase = 0.78 (0.61–0.99); 0.67 (0.51–0.86) and 0.75 (0.59–0.95), respectively) in a multivariable-adjusted conditional logistic regression model. The kynurenine/tryptophan ratio was directly associated with PAD (ORfor 1 SD increase = 1.50 (1.14–1.98)). The nutritional intervention with the MedDiet+nuts modified the association between threonine and PAD (p-value interaction = 0.018) compared with the control group. However, subjects allocated to the MedDiet+EVOO group were protected against PAD independently of baseline threonine. Plasma tryptophan, kynurenine/tryptophan ratio, serine and threonine might serve as early biomarkers of future PAD in subjects at a high risk of cardiovascular disease. The MedDiet supplemented with EVOO exerted a protective effect, regardless of baseline levels of threonine.

AB - Effective prevention and risk prediction are important for peripheral artery disease (PAD) due to its poor prognosis and the huge disease burden it produces. Circulating amino acids (AA) and their metabolites may serve as biomarkers of PAD risk, but they have been scarcely investigated. The objective was to prospectively analyze the associations of baseline levels of plasma AA (and their pathways) with subsequent risk of PAD and the potential effect modification by a nutritional intervention with the Mediterranean diet (MedDiet). A matched case-control study was nested in the PREDIMED trial, in which participants were randomized to three arms: MedDiet with tree nut supplementation group, MedDiet with extra-virgin olive oil (EVOO) supplementation group or control group (low-fat diet). One hundred and sixty-seven PAD cases were matched with 250 controls. Plasma AA was measured with liquid chromatography/mass spectrometry at the Broad Institute. Baseline tryptophan, serine and threonine were inversely associated with PAD (ORfor 1 SD increase = 0.78 (0.61–0.99); 0.67 (0.51–0.86) and 0.75 (0.59–0.95), respectively) in a multivariable-adjusted conditional logistic regression model. The kynurenine/tryptophan ratio was directly associated with PAD (ORfor 1 SD increase = 1.50 (1.14–1.98)). The nutritional intervention with the MedDiet+nuts modified the association between threonine and PAD (p-value interaction = 0.018) compared with the control group. However, subjects allocated to the MedDiet+EVOO group were protected against PAD independently of baseline threonine. Plasma tryptophan, kynurenine/tryptophan ratio, serine and threonine might serve as early biomarkers of future PAD in subjects at a high risk of cardiovascular disease. The MedDiet supplemented with EVOO exerted a protective effect, regardless of baseline levels of threonine.

KW - amino acids

KW - case-cohort

KW - metabolomics

KW - peripheral artery disease

KW - PREDIMED

U2 - 10.3390/ijms24010270

DO - 10.3390/ijms24010270

M3 - Journal article

C2 - 36613713

AN - SCOPUS:85146040518

VL - 24

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

M1 - 270

ER -

ID: 336604627