Depletion of mucosal substance P in acute otitis media.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Depletion of mucosal substance P in acute otitis media. / Cayé-Thomasen, Per; Schmidt, Peter Thelin; Hermansson, Ann; Holst, Jens Juul; Thomsen, Jens.

In: Acta Oto-Laryngologica, Vol. 124, No. 7, 2004, p. 794-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Cayé-Thomasen, P, Schmidt, PT, Hermansson, A, Holst, JJ & Thomsen, J 2004, 'Depletion of mucosal substance P in acute otitis media.', Acta Oto-Laryngologica, vol. 124, no. 7, pp. 794-7. https://doi.org/10.1080/00016480410017972

APA

Cayé-Thomasen, P., Schmidt, P. T., Hermansson, A., Holst, J. J., & Thomsen, J. (2004). Depletion of mucosal substance P in acute otitis media. Acta Oto-Laryngologica, 124(7), 794-7. https://doi.org/10.1080/00016480410017972

Vancouver

Cayé-Thomasen P, Schmidt PT, Hermansson A, Holst JJ, Thomsen J. Depletion of mucosal substance P in acute otitis media. Acta Oto-Laryngologica. 2004;124(7):794-7. https://doi.org/10.1080/00016480410017972

Author

Cayé-Thomasen, Per ; Schmidt, Peter Thelin ; Hermansson, Ann ; Holst, Jens Juul ; Thomsen, Jens. / Depletion of mucosal substance P in acute otitis media. In: Acta Oto-Laryngologica. 2004 ; Vol. 124, No. 7. pp. 794-7.

Bibtex

@article{afd9e8d0ab5011ddb5e9000ea68e967b,
title = "Depletion of mucosal substance P in acute otitis media.",
abstract = "OBJECTIVE: The neuropeptide substance P (SP) is an inducer of neurogenic inflammation and bone resorption in the middle ear. Resorption of the bone tissue structures surrounding the middle ear cavity is a distinct feature of the initial stage of acute otitis media (AOM), which may be due to nerve fiber release of SP. MATERIAL AND METHODS: To investigate possible release of SP in the middle ear mucosa during AOM, we used a well-established rat model of AOM caused by Streptococcus pneumoniae. Following tissue extraction on Days 1, 3 and 6 post-inoculation, the mucosal concentration of SP was measured using a radioimmunoassay. RESULTS: Compared to sham-inoculated control ears, the concentration of SP was significantly reduced on Day 1 and even further reduced on Day 3, whereas partial replenishment was found on Day 6. CONCLUSION: SP seems to be depleted in the rat middle ear mucosa in the hyperacute phase of AOM. This depletion is followed by replenishment and the concentration of SP approaches its normal level 6 days post-inoculation. The release of SP may be the trigger of the concurrent bone resorption and may further augment the inflammatory response to the bacterial colonization.",
author = "Per Cay{\'e}-Thomasen and Schmidt, {Peter Thelin} and Ann Hermansson and Holst, {Jens Juul} and Jens Thomsen",
note = "Keywords: Acute Disease; Animals; Bone Resorption; Disease Models, Animal; Male; Mucous Membrane; Otitis Media; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P; Time Factors",
year = "2004",
doi = "10.1080/00016480410017972",
language = "English",
volume = "124",
pages = "794--7",
journal = "Acta Oto-Laryngologica",
issn = "0001-6489",
publisher = "Taylor & Francis",
number = "7",

}

RIS

TY - JOUR

T1 - Depletion of mucosal substance P in acute otitis media.

AU - Cayé-Thomasen, Per

AU - Schmidt, Peter Thelin

AU - Hermansson, Ann

AU - Holst, Jens Juul

AU - Thomsen, Jens

N1 - Keywords: Acute Disease; Animals; Bone Resorption; Disease Models, Animal; Male; Mucous Membrane; Otitis Media; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Substance P; Time Factors

PY - 2004

Y1 - 2004

N2 - OBJECTIVE: The neuropeptide substance P (SP) is an inducer of neurogenic inflammation and bone resorption in the middle ear. Resorption of the bone tissue structures surrounding the middle ear cavity is a distinct feature of the initial stage of acute otitis media (AOM), which may be due to nerve fiber release of SP. MATERIAL AND METHODS: To investigate possible release of SP in the middle ear mucosa during AOM, we used a well-established rat model of AOM caused by Streptococcus pneumoniae. Following tissue extraction on Days 1, 3 and 6 post-inoculation, the mucosal concentration of SP was measured using a radioimmunoassay. RESULTS: Compared to sham-inoculated control ears, the concentration of SP was significantly reduced on Day 1 and even further reduced on Day 3, whereas partial replenishment was found on Day 6. CONCLUSION: SP seems to be depleted in the rat middle ear mucosa in the hyperacute phase of AOM. This depletion is followed by replenishment and the concentration of SP approaches its normal level 6 days post-inoculation. The release of SP may be the trigger of the concurrent bone resorption and may further augment the inflammatory response to the bacterial colonization.

AB - OBJECTIVE: The neuropeptide substance P (SP) is an inducer of neurogenic inflammation and bone resorption in the middle ear. Resorption of the bone tissue structures surrounding the middle ear cavity is a distinct feature of the initial stage of acute otitis media (AOM), which may be due to nerve fiber release of SP. MATERIAL AND METHODS: To investigate possible release of SP in the middle ear mucosa during AOM, we used a well-established rat model of AOM caused by Streptococcus pneumoniae. Following tissue extraction on Days 1, 3 and 6 post-inoculation, the mucosal concentration of SP was measured using a radioimmunoassay. RESULTS: Compared to sham-inoculated control ears, the concentration of SP was significantly reduced on Day 1 and even further reduced on Day 3, whereas partial replenishment was found on Day 6. CONCLUSION: SP seems to be depleted in the rat middle ear mucosa in the hyperacute phase of AOM. This depletion is followed by replenishment and the concentration of SP approaches its normal level 6 days post-inoculation. The release of SP may be the trigger of the concurrent bone resorption and may further augment the inflammatory response to the bacterial colonization.

U2 - 10.1080/00016480410017972

DO - 10.1080/00016480410017972

M3 - Journal article

C2 - 15370562

VL - 124

SP - 794

EP - 797

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

SN - 0001-6489

IS - 7

ER -

ID: 8418131