Exercise and browning of white adipose tissue - a translational perspective
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Exercise and browning of white adipose tissue - a translational perspective. / Severinsen, Mai Charlotte Krogh; Scheele, Camilla; Pedersen, Bente Klarlund.
In: Current Opinion in Pharmacology, Vol. 52, 2020, p. 18-24.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Exercise and browning of white adipose tissue - a translational perspective
AU - Severinsen, Mai Charlotte Krogh
AU - Scheele, Camilla
AU - Pedersen, Bente Klarlund
PY - 2020
Y1 - 2020
N2 - Browning of white adipose tissue is a cold-induced phenomenon in rodents, constituted by the differentiation of a subset of thermogenic adipocytes among existing white adipocytes. Emerging evidence in the literature points at additional factors and environmental conditions stimulating browning in rodents, including physical exercise training. Exercise engages sympathetic activation which during cold activation promotes proliferation and differentiation of brown preadipocytes. Exercise also stimulates the release of multiple growth factors and cytokines. Importantly, there are clear discrepancies between human and rodents with regard to thermogenic capacity and browning potential. Here we provide a translational perspective on exercise-induced browning and review recent findings on the role of myokines and hepatokines in this process.
AB - Browning of white adipose tissue is a cold-induced phenomenon in rodents, constituted by the differentiation of a subset of thermogenic adipocytes among existing white adipocytes. Emerging evidence in the literature points at additional factors and environmental conditions stimulating browning in rodents, including physical exercise training. Exercise engages sympathetic activation which during cold activation promotes proliferation and differentiation of brown preadipocytes. Exercise also stimulates the release of multiple growth factors and cytokines. Importantly, there are clear discrepancies between human and rodents with regard to thermogenic capacity and browning potential. Here we provide a translational perspective on exercise-induced browning and review recent findings on the role of myokines and hepatokines in this process.
KW - INSULIN SENSITIVITY
KW - GENE-EXPRESSION
KW - FAT
KW - INTERLEUKIN-6
KW - OXIDATION
KW - IRISIN
KW - HUMANS
KW - FGF21
KW - BONE
U2 - 10.1016/j.coph.2020.04.004
DO - 10.1016/j.coph.2020.04.004
M3 - Journal article
C2 - 32480032
VL - 52
SP - 18
EP - 24
JO - Current Opinion in Pharmacology
JF - Current Opinion in Pharmacology
SN - 1471-4892
ER -
ID: 249862537