Exercise and browning of white adipose tissue - a translational perspective

Research output: Contribution to journal › Journal article › Research › peer-review

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Exercise and browning of white adipose tissue - a translational perspective. / Severinsen, Mai Charlotte Krogh; Scheele, Camilla; Pedersen, Bente Klarlund.

In: Current Opinion in Pharmacology, Vol. 52, 2020, p. 18-24.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Severinsen, MCK, Scheele, C & Pedersen, BK 2020, 'Exercise and browning of white adipose tissue - a translational perspective', Current Opinion in Pharmacology, vol. 52, pp. 18-24. https://doi.org/10.1016/j.coph.2020.04.004

APA

Severinsen, M. C. K., Scheele, C., & Pedersen, B. K. (2020). Exercise and browning of white adipose tissue - a translational perspective. Current Opinion in Pharmacology, 52, 18-24. https://doi.org/10.1016/j.coph.2020.04.004

Vancouver

Severinsen MCK, Scheele C, Pedersen BK. Exercise and browning of white adipose tissue - a translational perspective. Current Opinion in Pharmacology. 2020;52:18-24. https://doi.org/10.1016/j.coph.2020.04.004

Author

Severinsen, Mai Charlotte Krogh ; Scheele, Camilla ; Pedersen, Bente Klarlund. / Exercise and browning of white adipose tissue - a translational perspective. In: Current Opinion in Pharmacology. 2020 ; Vol. 52. pp. 18-24.

Bibtex

@article{1435caa2c40d4d75b55cb6bddeb94544,
title = "Exercise and browning of white adipose tissue - a translational perspective",
abstract = "Browning of white adipose tissue is a cold-induced phenomenon in rodents, constituted by the differentiation of a subset of thermogenic adipocytes among existing white adipocytes. Emerging evidence in the literature points at additional factors and environmental conditions stimulating browning in rodents, including physical exercise training. Exercise engages sympathetic activation which during cold activation promotes proliferation and differentiation of brown preadipocytes. Exercise also stimulates the release of multiple growth factors and cytokines. Importantly, there are clear discrepancies between human and rodents with regard to thermogenic capacity and browning potential. Here we provide a translational perspective on exercise-induced browning and review recent findings on the role of myokines and hepatokines in this process.",
keywords = "INSULIN SENSITIVITY, GENE-EXPRESSION, FAT, INTERLEUKIN-6, OXIDATION, IRISIN, HUMANS, FGF21, BONE",
author = "Severinsen, {Mai Charlotte Krogh} and Camilla Scheele and Pedersen, {Bente Klarlund}",
year = "2020",
doi = "10.1016/j.coph.2020.04.004",
language = "English",
volume = "52",
pages = "18--24",
journal = "Current Opinion in Pharmacology",
issn = "1471-4892",
publisher = "Elsevier Ltd. * Current Opinion Journals",

}

RIS

TY - JOUR

T1 - Exercise and browning of white adipose tissue - a translational perspective

AU - Severinsen, Mai Charlotte Krogh

AU - Scheele, Camilla

AU - Pedersen, Bente Klarlund

PY - 2020

Y1 - 2020

N2 - Browning of white adipose tissue is a cold-induced phenomenon in rodents, constituted by the differentiation of a subset of thermogenic adipocytes among existing white adipocytes. Emerging evidence in the literature points at additional factors and environmental conditions stimulating browning in rodents, including physical exercise training. Exercise engages sympathetic activation which during cold activation promotes proliferation and differentiation of brown preadipocytes. Exercise also stimulates the release of multiple growth factors and cytokines. Importantly, there are clear discrepancies between human and rodents with regard to thermogenic capacity and browning potential. Here we provide a translational perspective on exercise-induced browning and review recent findings on the role of myokines and hepatokines in this process.

AB - Browning of white adipose tissue is a cold-induced phenomenon in rodents, constituted by the differentiation of a subset of thermogenic adipocytes among existing white adipocytes. Emerging evidence in the literature points at additional factors and environmental conditions stimulating browning in rodents, including physical exercise training. Exercise engages sympathetic activation which during cold activation promotes proliferation and differentiation of brown preadipocytes. Exercise also stimulates the release of multiple growth factors and cytokines. Importantly, there are clear discrepancies between human and rodents with regard to thermogenic capacity and browning potential. Here we provide a translational perspective on exercise-induced browning and review recent findings on the role of myokines and hepatokines in this process.

KW - INSULIN SENSITIVITY

KW - GENE-EXPRESSION

KW - FAT

KW - INTERLEUKIN-6

KW - OXIDATION

KW - IRISIN

KW - HUMANS

KW - FGF21

KW - BONE

U2 - 10.1016/j.coph.2020.04.004

DO - 10.1016/j.coph.2020.04.004

M3 - Journal article

C2 - 32480032

VL - 52

SP - 18

EP - 24

JO - Current Opinion in Pharmacology

JF - Current Opinion in Pharmacology

SN - 1471-4892

ER -

ID: 249862537