Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations

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Standard

Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes : findings from two independent populations. / Li, Mengying; Rahman, Mohammad L.; Wu, Jing; DIng, Ming; Chavarro, Jorge E.; Lin, Yuan; Ley, Sylvia H.; Bao, Wei; Grunnet, Louise G.; Hinkle, Stefanie N.; Thuesen, Anne Cathrine B.; Yeung, Edwina; Gore-Langton, Robert E.; Sherman, Seth; Hjort, Line; Kampmann, Freja Bach; Bjerregaard, Anne Ahrendt; Damm, Peter; Tekola-Ayele, Fasil; Liu, Aiyi; Mills, James L.; Vaag, Allan; Olsen, Sjurdur F.; Hu, Frank B.; Zhang, Cuilin.

In: B M J Open Diabetes Research & Care, Vol. 8, No. 1, e000850, 02.2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Li, M, Rahman, ML, Wu, J, DIng, M, Chavarro, JE, Lin, Y, Ley, SH, Bao, W, Grunnet, LG, Hinkle, SN, Thuesen, ACB, Yeung, E, Gore-Langton, RE, Sherman, S, Hjort, L, Kampmann, FB, Bjerregaard, AA, Damm, P, Tekola-Ayele, F, Liu, A, Mills, JL, Vaag, A, Olsen, SF, Hu, FB & Zhang, C 2020, 'Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations', B M J Open Diabetes Research & Care, vol. 8, no. 1, e000850. https://doi.org/10.1136/bmjdrc-2019-000850

APA

Li, M., Rahman, M. L., Wu, J., DIng, M., Chavarro, J. E., Lin, Y., Ley, S. H., Bao, W., Grunnet, L. G., Hinkle, S. N., Thuesen, A. C. B., Yeung, E., Gore-Langton, R. E., Sherman, S., Hjort, L., Kampmann, F. B., Bjerregaard, A. A., Damm, P., Tekola-Ayele, F., ... Zhang, C. (2020). Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations. B M J Open Diabetes Research & Care, 8(1), [e000850]. https://doi.org/10.1136/bmjdrc-2019-000850

Vancouver

Li M, Rahman ML, Wu J, DIng M, Chavarro JE, Lin Y et al. Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations. B M J Open Diabetes Research & Care. 2020 Feb;8(1). e000850. https://doi.org/10.1136/bmjdrc-2019-000850

Author

Li, Mengying ; Rahman, Mohammad L. ; Wu, Jing ; DIng, Ming ; Chavarro, Jorge E. ; Lin, Yuan ; Ley, Sylvia H. ; Bao, Wei ; Grunnet, Louise G. ; Hinkle, Stefanie N. ; Thuesen, Anne Cathrine B. ; Yeung, Edwina ; Gore-Langton, Robert E. ; Sherman, Seth ; Hjort, Line ; Kampmann, Freja Bach ; Bjerregaard, Anne Ahrendt ; Damm, Peter ; Tekola-Ayele, Fasil ; Liu, Aiyi ; Mills, James L. ; Vaag, Allan ; Olsen, Sjurdur F. ; Hu, Frank B. ; Zhang, Cuilin. / Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes : findings from two independent populations. In: B M J Open Diabetes Research & Care. 2020 ; Vol. 8, No. 1.

Bibtex

@article{a4460c59c6a94208896eb5fd98cf0d29,
title = "Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes: findings from two independent populations",
abstract = "Objective Women with a history of gestational diabetes mellitus (GDM) have an exceptionally high risk for type 2 diabetes (T2D). Yet, little is known about genetic determinants for T2D in this population. We examined the association of a genetic risk score (GRS) with risk of T2D in two independent populations of women with a history of GDM and how this association might be modified by non-genetic determinants for T2D. Research design and methods This cohort study included 2434 white women with a history of GDM from the Nurses' Health Study II (NHSII, n=1884) and the Danish National Birth Cohort (DNBC, n=550). A GRS for T2D was calculated using 59 candidate single nucleotide polymorphisms for T2D identified from genome-wide association studies in European populations. An alternate healthy eating index (AHEI) score was derived to reflect dietary quality after the pregnancy affected by GDM. Results Women on average were followed for 21 years in NHSII and 13 years in DNBC, during which 446 (23.7%) and 155 (28.2%) developed T2D, respectively. The GRS was generally positively associated with T2D risk in both cohorts. In the pooled analysis, the relative risks (RRs) for increasing quartiles of GRS were 1.00, 0.97, 1.25 and 1.19 (p trend=0.02). In both cohorts, the association appeared to be stronger among women with poorer (AHEI ",
keywords = "dietary quality, genetic risk score, gestational diabetes, prospective cohort studies, type 2 diabetes",
author = "Mengying Li and Rahman, {Mohammad L.} and Jing Wu and Ming DIng and Chavarro, {Jorge E.} and Yuan Lin and Ley, {Sylvia H.} and Wei Bao and Grunnet, {Louise G.} and Hinkle, {Stefanie N.} and Thuesen, {Anne Cathrine B.} and Edwina Yeung and Gore-Langton, {Robert E.} and Seth Sherman and Line Hjort and Kampmann, {Freja Bach} and Bjerregaard, {Anne Ahrendt} and Peter Damm and Fasil Tekola-Ayele and Aiyi Liu and Mills, {James L.} and Allan Vaag and Olsen, {Sjurdur F.} and Hu, {Frank B.} and Cuilin Zhang",
year = "2020",
month = feb,
doi = "10.1136/bmjdrc-2019-000850",
language = "English",
volume = "8",
journal = "B M J Open Diabetes Research & Care",
issn = "2052-4897",
publisher = "B M J Group",
number = "1",

}

RIS

TY - JOUR

T1 - Genetic factors and risk of type 2 diabetes among women with a history of gestational diabetes

T2 - findings from two independent populations

AU - Li, Mengying

AU - Rahman, Mohammad L.

AU - Wu, Jing

AU - DIng, Ming

AU - Chavarro, Jorge E.

AU - Lin, Yuan

AU - Ley, Sylvia H.

AU - Bao, Wei

AU - Grunnet, Louise G.

AU - Hinkle, Stefanie N.

AU - Thuesen, Anne Cathrine B.

AU - Yeung, Edwina

AU - Gore-Langton, Robert E.

AU - Sherman, Seth

AU - Hjort, Line

AU - Kampmann, Freja Bach

AU - Bjerregaard, Anne Ahrendt

AU - Damm, Peter

AU - Tekola-Ayele, Fasil

AU - Liu, Aiyi

AU - Mills, James L.

AU - Vaag, Allan

AU - Olsen, Sjurdur F.

AU - Hu, Frank B.

AU - Zhang, Cuilin

PY - 2020/2

Y1 - 2020/2

N2 - Objective Women with a history of gestational diabetes mellitus (GDM) have an exceptionally high risk for type 2 diabetes (T2D). Yet, little is known about genetic determinants for T2D in this population. We examined the association of a genetic risk score (GRS) with risk of T2D in two independent populations of women with a history of GDM and how this association might be modified by non-genetic determinants for T2D. Research design and methods This cohort study included 2434 white women with a history of GDM from the Nurses' Health Study II (NHSII, n=1884) and the Danish National Birth Cohort (DNBC, n=550). A GRS for T2D was calculated using 59 candidate single nucleotide polymorphisms for T2D identified from genome-wide association studies in European populations. An alternate healthy eating index (AHEI) score was derived to reflect dietary quality after the pregnancy affected by GDM. Results Women on average were followed for 21 years in NHSII and 13 years in DNBC, during which 446 (23.7%) and 155 (28.2%) developed T2D, respectively. The GRS was generally positively associated with T2D risk in both cohorts. In the pooled analysis, the relative risks (RRs) for increasing quartiles of GRS were 1.00, 0.97, 1.25 and 1.19 (p trend=0.02). In both cohorts, the association appeared to be stronger among women with poorer (AHEI

AB - Objective Women with a history of gestational diabetes mellitus (GDM) have an exceptionally high risk for type 2 diabetes (T2D). Yet, little is known about genetic determinants for T2D in this population. We examined the association of a genetic risk score (GRS) with risk of T2D in two independent populations of women with a history of GDM and how this association might be modified by non-genetic determinants for T2D. Research design and methods This cohort study included 2434 white women with a history of GDM from the Nurses' Health Study II (NHSII, n=1884) and the Danish National Birth Cohort (DNBC, n=550). A GRS for T2D was calculated using 59 candidate single nucleotide polymorphisms for T2D identified from genome-wide association studies in European populations. An alternate healthy eating index (AHEI) score was derived to reflect dietary quality after the pregnancy affected by GDM. Results Women on average were followed for 21 years in NHSII and 13 years in DNBC, during which 446 (23.7%) and 155 (28.2%) developed T2D, respectively. The GRS was generally positively associated with T2D risk in both cohorts. In the pooled analysis, the relative risks (RRs) for increasing quartiles of GRS were 1.00, 0.97, 1.25 and 1.19 (p trend=0.02). In both cohorts, the association appeared to be stronger among women with poorer (AHEI

KW - dietary quality

KW - genetic risk score

KW - gestational diabetes

KW - prospective cohort studies

KW - type 2 diabetes

U2 - 10.1136/bmjdrc-2019-000850

DO - 10.1136/bmjdrc-2019-000850

M3 - Journal article

C2 - 31958311

AN - SCOPUS:85078595471

VL - 8

JO - B M J Open Diabetes Research & Care

JF - B M J Open Diabetes Research & Care

SN - 2052-4897

IS - 1

M1 - e000850

ER -

ID: 243379691