High anti-SARS-CoV-2 seroprevalence among unvaccinated mother-child pairs from a rural setting of north-eastern Tanzania during the second wave of COVID-19

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

High anti-SARS-CoV-2 seroprevalence among unvaccinated mother-child pairs from a rural setting of north-eastern Tanzania during the second wave of COVID-19. / Msemo, Omari Abdul; Pérez-Alós, Laura; Minja, Daniel T R; Hansen, Cecilie Bo; Gesase, Samwel; Mtove, George; Mbwana, Joyce; Larsen, Victoria Marie Linderod; Bøgestad, Emilie Caroline Skuladottir; Grunnet, Louise Groth; Christensen, Dirk Lund; Bygbjerg, Ib Christian; Burgner, David; Schmiegelow, Christentze; Garred, Peter; Hjort, Line.

In: IJID Regions (Online), Vol. 6, 2023, p. 48-57.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Msemo, OA, Pérez-Alós, L, Minja, DTR, Hansen, CB, Gesase, S, Mtove, G, Mbwana, J, Larsen, VML, Bøgestad, ECS, Grunnet, LG, Christensen, DL, Bygbjerg, IC, Burgner, D, Schmiegelow, C, Garred, P & Hjort, L 2023, 'High anti-SARS-CoV-2 seroprevalence among unvaccinated mother-child pairs from a rural setting of north-eastern Tanzania during the second wave of COVID-19', IJID Regions (Online), vol. 6, pp. 48-57. https://doi.org/10.1016/j.ijregi.2022.11.011

APA

Msemo, O. A., Pérez-Alós, L., Minja, D. T. R., Hansen, C. B., Gesase, S., Mtove, G., Mbwana, J., Larsen, V. M. L., Bøgestad, E. C. S., Grunnet, L. G., Christensen, D. L., Bygbjerg, I. C., Burgner, D., Schmiegelow, C., Garred, P., & Hjort, L. (2023). High anti-SARS-CoV-2 seroprevalence among unvaccinated mother-child pairs from a rural setting of north-eastern Tanzania during the second wave of COVID-19. IJID Regions (Online), 6, 48-57. https://doi.org/10.1016/j.ijregi.2022.11.011

Vancouver

Msemo OA, Pérez-Alós L, Minja DTR, Hansen CB, Gesase S, Mtove G et al. High anti-SARS-CoV-2 seroprevalence among unvaccinated mother-child pairs from a rural setting of north-eastern Tanzania during the second wave of COVID-19. IJID Regions (Online). 2023;6:48-57. https://doi.org/10.1016/j.ijregi.2022.11.011

Author

Msemo, Omari Abdul ; Pérez-Alós, Laura ; Minja, Daniel T R ; Hansen, Cecilie Bo ; Gesase, Samwel ; Mtove, George ; Mbwana, Joyce ; Larsen, Victoria Marie Linderod ; Bøgestad, Emilie Caroline Skuladottir ; Grunnet, Louise Groth ; Christensen, Dirk Lund ; Bygbjerg, Ib Christian ; Burgner, David ; Schmiegelow, Christentze ; Garred, Peter ; Hjort, Line. / High anti-SARS-CoV-2 seroprevalence among unvaccinated mother-child pairs from a rural setting of north-eastern Tanzania during the second wave of COVID-19. In: IJID Regions (Online). 2023 ; Vol. 6. pp. 48-57.

Bibtex

@article{cd5f8ffc5dc64e09a4161796a61ba680,
title = "High anti-SARS-CoV-2 seroprevalence among unvaccinated mother-child pairs from a rural setting of north-eastern Tanzania during the second wave of COVID-19",
abstract = "BACKGROUND: The reported infection rates, and the burden of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in low- and middle-income countries, including sub-Saharan Africa, are relatively low compared to Europe and America, partly due to limited testing capabilities. Unlike many countries, in Tanzania, neither mass screening nor restrictive measures such as lockdowns have been implemented to date. The prevalence of SARS-CoV-2 infection in rural mainland Tanzania is largely unknown.METHODS: Between April and October 2021, we conducted a cross-sectional study to assess anti-SARS-CoV-2 seroprevalence among mother-child pairs ( n=634 children, n=518 mothers) in a rural setting of north-eastern Tanzania. FINDINGS: We found a very high prevalence of anti-SARS-CoV-2 antibody titres with seroprevalence rates ranging from 29% among mothers and 40% among children, with a dynamic peak in seropositivity incidence at the end of July/early in August being revealed. Significant differences in age, socioeconomic status and body composition were associated with seropositivity in mothers and children. No significant associations were observed between seropositivity and comorbidities, including anaemia, diabetes, malaria, and HIV.INTERPRETATIONS: The SARS-CoV-2 transmission in a rural region of Tanzania during 2021 was high, indicating a much higher infection rate in rural Tanzania compared to that reported in the UK and USA during the same period. Ongoing immune surveillance may be vital to monitoring the burden of viral infection in rural settings without access to molecular genotyping where a load of communicable diseases may mask COVID-19. Surveillance could be implemented in tandem with the intensification of vaccination strategies.",
author = "Msemo, {Omari Abdul} and Laura P{\'e}rez-Al{\'o}s and Minja, {Daniel T R} and Hansen, {Cecilie Bo} and Samwel Gesase and George Mtove and Joyce Mbwana and Larsen, {Victoria Marie Linderod} and B{\o}gestad, {Emilie Caroline Skuladottir} and Grunnet, {Louise Groth} and Christensen, {Dirk Lund} and Bygbjerg, {Ib Christian} and David Burgner and Christentze Schmiegelow and Peter Garred and Line Hjort",
note = "{\textcopyright} 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.",
year = "2023",
doi = "10.1016/j.ijregi.2022.11.011",
language = "English",
volume = "6",
pages = "48--57",
journal = "IJID Regions (Online)",
issn = "2772-7076",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - High anti-SARS-CoV-2 seroprevalence among unvaccinated mother-child pairs from a rural setting of north-eastern Tanzania during the second wave of COVID-19

AU - Msemo, Omari Abdul

AU - Pérez-Alós, Laura

AU - Minja, Daniel T R

AU - Hansen, Cecilie Bo

AU - Gesase, Samwel

AU - Mtove, George

AU - Mbwana, Joyce

AU - Larsen, Victoria Marie Linderod

AU - Bøgestad, Emilie Caroline Skuladottir

AU - Grunnet, Louise Groth

AU - Christensen, Dirk Lund

AU - Bygbjerg, Ib Christian

AU - Burgner, David

AU - Schmiegelow, Christentze

AU - Garred, Peter

AU - Hjort, Line

N1 - © 2022 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.

PY - 2023

Y1 - 2023

N2 - BACKGROUND: The reported infection rates, and the burden of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in low- and middle-income countries, including sub-Saharan Africa, are relatively low compared to Europe and America, partly due to limited testing capabilities. Unlike many countries, in Tanzania, neither mass screening nor restrictive measures such as lockdowns have been implemented to date. The prevalence of SARS-CoV-2 infection in rural mainland Tanzania is largely unknown.METHODS: Between April and October 2021, we conducted a cross-sectional study to assess anti-SARS-CoV-2 seroprevalence among mother-child pairs ( n=634 children, n=518 mothers) in a rural setting of north-eastern Tanzania. FINDINGS: We found a very high prevalence of anti-SARS-CoV-2 antibody titres with seroprevalence rates ranging from 29% among mothers and 40% among children, with a dynamic peak in seropositivity incidence at the end of July/early in August being revealed. Significant differences in age, socioeconomic status and body composition were associated with seropositivity in mothers and children. No significant associations were observed between seropositivity and comorbidities, including anaemia, diabetes, malaria, and HIV.INTERPRETATIONS: The SARS-CoV-2 transmission in a rural region of Tanzania during 2021 was high, indicating a much higher infection rate in rural Tanzania compared to that reported in the UK and USA during the same period. Ongoing immune surveillance may be vital to monitoring the burden of viral infection in rural settings without access to molecular genotyping where a load of communicable diseases may mask COVID-19. Surveillance could be implemented in tandem with the intensification of vaccination strategies.

AB - BACKGROUND: The reported infection rates, and the burden of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in low- and middle-income countries, including sub-Saharan Africa, are relatively low compared to Europe and America, partly due to limited testing capabilities. Unlike many countries, in Tanzania, neither mass screening nor restrictive measures such as lockdowns have been implemented to date. The prevalence of SARS-CoV-2 infection in rural mainland Tanzania is largely unknown.METHODS: Between April and October 2021, we conducted a cross-sectional study to assess anti-SARS-CoV-2 seroprevalence among mother-child pairs ( n=634 children, n=518 mothers) in a rural setting of north-eastern Tanzania. FINDINGS: We found a very high prevalence of anti-SARS-CoV-2 antibody titres with seroprevalence rates ranging from 29% among mothers and 40% among children, with a dynamic peak in seropositivity incidence at the end of July/early in August being revealed. Significant differences in age, socioeconomic status and body composition were associated with seropositivity in mothers and children. No significant associations were observed between seropositivity and comorbidities, including anaemia, diabetes, malaria, and HIV.INTERPRETATIONS: The SARS-CoV-2 transmission in a rural region of Tanzania during 2021 was high, indicating a much higher infection rate in rural Tanzania compared to that reported in the UK and USA during the same period. Ongoing immune surveillance may be vital to monitoring the burden of viral infection in rural settings without access to molecular genotyping where a load of communicable diseases may mask COVID-19. Surveillance could be implemented in tandem with the intensification of vaccination strategies.

U2 - 10.1016/j.ijregi.2022.11.011

DO - 10.1016/j.ijregi.2022.11.011

M3 - Journal article

C2 - 36466214

VL - 6

SP - 48

EP - 57

JO - IJID Regions (Online)

JF - IJID Regions (Online)

SN - 2772-7076

ER -

ID: 328426307