Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes. / Bowman, Pamela; Patel, Kashyap A.; McDonald, Timothy J.; Holst, Jens J.; Hartmann, Bolette; Leveridge, Maria; Shields, Beverley M.; Hammersley, Suzie; Spaull, Steve R.; Knight, Bridget A.; Flanagan, Sarah E.; Shepherd, Maggie H.; Andrews, Rob C.; Hattersley, Andrew T.

In: Journal of Diabetes Investigation, Vol. 14, No. 12, 2023, p. 1378-1382.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bowman, P, Patel, KA, McDonald, TJ, Holst, JJ, Hartmann, B, Leveridge, M, Shields, BM, Hammersley, S, Spaull, SR, Knight, BA, Flanagan, SE, Shepherd, MH, Andrews, RC & Hattersley, AT 2023, 'Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes', Journal of Diabetes Investigation, vol. 14, no. 12, pp. 1378-1382. https://doi.org/10.1111/jdi.14071

APA

Bowman, P., Patel, K. A., McDonald, T. J., Holst, J. J., Hartmann, B., Leveridge, M., Shields, B. M., Hammersley, S., Spaull, S. R., Knight, B. A., Flanagan, S. E., Shepherd, M. H., Andrews, R. C., & Hattersley, A. T. (2023). Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes. Journal of Diabetes Investigation, 14(12), 1378-1382. https://doi.org/10.1111/jdi.14071

Vancouver

Bowman P, Patel KA, McDonald TJ, Holst JJ, Hartmann B, Leveridge M et al. Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes. Journal of Diabetes Investigation. 2023;14(12):1378-1382. https://doi.org/10.1111/jdi.14071

Author

Bowman, Pamela ; Patel, Kashyap A. ; McDonald, Timothy J. ; Holst, Jens J. ; Hartmann, Bolette ; Leveridge, Maria ; Shields, Beverley M. ; Hammersley, Suzie ; Spaull, Steve R. ; Knight, Bridget A. ; Flanagan, Sarah E. ; Shepherd, Maggie H. ; Andrews, Rob C. ; Hattersley, Andrew T. / Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes. In: Journal of Diabetes Investigation. 2023 ; Vol. 14, No. 12. pp. 1378-1382.

Bibtex

@article{1bb0d0bdcf0445559ccb1703ddec3654,
title = "Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes",
abstract = "The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are thought to be the main drivers of insulin secretion in individuals with sulfonylurea (SU)-treated KCNJ11 permanent neonatal diabetes. The aim of this study was to assess for the first time the incretin hormone response to carbohydrate and protein/fat in adults with sulfonylurea-treated KCNJ11 permanent neonatal diabetes compared with that of controls without diabetes. Participants were given a breakfast high in carbohydrate and an isocaloric breakfast high in protein/fat on two different mornings. Incremental area under the curve and total area under the curve (0-240 minutes) for total GLP-1 and GIP were compared between groups, using non-parametric statistical methods. Post-meal GLP-1 and GIP secretion were similar in cases and controls, suggesting this process is adenosine triphosphate-sensitive potassium channel-independent. Future research will investigate whether treatments targeting the incretin pathway are effective in individuals with KCNJ11 permanent neonatal diabetes who do not have good glycemic control on sulfonylurea alone.",
keywords = "GIP, GLP-1, incretin hormones, Neonatal diabetes, sulfonylurea",
author = "Pamela Bowman and Patel, {Kashyap A.} and McDonald, {Timothy J.} and Holst, {Jens J.} and Bolette Hartmann and Maria Leveridge and Shields, {Beverley M.} and Suzie Hammersley and Spaull, {Steve R.} and Knight, {Bridget A.} and Flanagan, {Sarah E.} and Shepherd, {Maggie H.} and Andrews, {Rob C.} and Hattersley, {Andrew T.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.",
year = "2023",
doi = "10.1111/jdi.14071",
language = "English",
volume = "14",
pages = "1378--1382",
journal = "Journal of Diabetes Investigation",
issn = "2040-1116",
publisher = "Wiley-Blackwell Publishing Asia",
number = "12",

}

RIS

TY - JOUR

T1 - Incretin hormone responses to carbohydrate and protein/fat are preserved in adults with sulfonylurea-treated KCNJ11 neonatal diabetes

AU - Bowman, Pamela

AU - Patel, Kashyap A.

AU - McDonald, Timothy J.

AU - Holst, Jens J.

AU - Hartmann, Bolette

AU - Leveridge, Maria

AU - Shields, Beverley M.

AU - Hammersley, Suzie

AU - Spaull, Steve R.

AU - Knight, Bridget A.

AU - Flanagan, Sarah E.

AU - Shepherd, Maggie H.

AU - Andrews, Rob C.

AU - Hattersley, Andrew T.

N1 - Publisher Copyright: © 2023 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.

PY - 2023

Y1 - 2023

N2 - The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are thought to be the main drivers of insulin secretion in individuals with sulfonylurea (SU)-treated KCNJ11 permanent neonatal diabetes. The aim of this study was to assess for the first time the incretin hormone response to carbohydrate and protein/fat in adults with sulfonylurea-treated KCNJ11 permanent neonatal diabetes compared with that of controls without diabetes. Participants were given a breakfast high in carbohydrate and an isocaloric breakfast high in protein/fat on two different mornings. Incremental area under the curve and total area under the curve (0-240 minutes) for total GLP-1 and GIP were compared between groups, using non-parametric statistical methods. Post-meal GLP-1 and GIP secretion were similar in cases and controls, suggesting this process is adenosine triphosphate-sensitive potassium channel-independent. Future research will investigate whether treatments targeting the incretin pathway are effective in individuals with KCNJ11 permanent neonatal diabetes who do not have good glycemic control on sulfonylurea alone.

AB - The incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are thought to be the main drivers of insulin secretion in individuals with sulfonylurea (SU)-treated KCNJ11 permanent neonatal diabetes. The aim of this study was to assess for the first time the incretin hormone response to carbohydrate and protein/fat in adults with sulfonylurea-treated KCNJ11 permanent neonatal diabetes compared with that of controls without diabetes. Participants were given a breakfast high in carbohydrate and an isocaloric breakfast high in protein/fat on two different mornings. Incremental area under the curve and total area under the curve (0-240 minutes) for total GLP-1 and GIP were compared between groups, using non-parametric statistical methods. Post-meal GLP-1 and GIP secretion were similar in cases and controls, suggesting this process is adenosine triphosphate-sensitive potassium channel-independent. Future research will investigate whether treatments targeting the incretin pathway are effective in individuals with KCNJ11 permanent neonatal diabetes who do not have good glycemic control on sulfonylurea alone.

KW - GIP

KW - GLP-1

KW - incretin hormones

KW - Neonatal diabetes

KW - sulfonylurea

U2 - 10.1111/jdi.14071

DO - 10.1111/jdi.14071

M3 - Journal article

C2 - 37602910

AN - SCOPUS:85168469971

VL - 14

SP - 1378

EP - 1382

JO - Journal of Diabetes Investigation

JF - Journal of Diabetes Investigation

SN - 2040-1116

IS - 12

ER -

ID: 371567165