MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. / Lüttichau, H R; Gerstoft, J; Schwartz, T W.

In: Journal of Leukocyte Biology, Vol. 70, No. 2, 2001, p. 277-82.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lüttichau, HR, Gerstoft, J & Schwartz, TW 2001, 'MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8', Journal of Leukocyte Biology, vol. 70, no. 2, pp. 277-82.

APA

Lüttichau, H. R., Gerstoft, J., & Schwartz, T. W. (2001). MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. Journal of Leukocyte Biology, 70(2), 277-82.

Vancouver

Lüttichau HR, Gerstoft J, Schwartz TW. MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. Journal of Leukocyte Biology. 2001;70(2):277-82.

Author

Lüttichau, H R ; Gerstoft, J ; Schwartz, T W. / MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8. In: Journal of Leukocyte Biology. 2001 ; Vol. 70, No. 2. pp. 277-82.

Bibtex

@article{e0af998074c711dbbee902004c4f4f50,
title = "MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8",
abstract = "The viral CC chemokines MC148, encoded by the poxvirus molluscum contagiosum, and viral macrophage inflammatory protein (vMIP)-I and vMIP-II, encoded by human herpesvirus 8, were probed on the murine CC receptor (CCR) 8 in parallel with human CCR8. In calcium mobilization assays, vMIP-I acted as a high-affinity agonist, whereas vMIP-II acted as a low-affinity antagonist on the murine CCR8 as well as the human CCR8. MC148 was found to bind and block responses through the human CCR8 with high affinity, but surprisingly MC148 was unable to bind and block responses through the murine CCR8. Because MC148 is the only high-affinity antagonist known to target and be selective for CCR8, MC148 is a valuable tool to decipher the role played by CCR8 in the immune system. This study shows that MC148 could not be used in murine inflammatory models; however, it will be interesting to see whether it can be used in other animal models to delineate the role played by CCR8.",
author = "L{\"u}ttichau, {H R} and J Gerstoft and Schwartz, {T W}",
note = "Keywords: Amino Acid Sequence; Animals; Calcium Signaling; Cell Line; Chemokines; Chemokines, CC; Herpesvirus 8, Human; Humans; Macrophage Inflammatory Proteins; Mice; Molecular Sequence Data; Molluscum contagiosum virus; Receptors, CCR8; Receptors, Chemokine; Sequence Alignment; Species Specificity; Transfection; Viral Proteins",
year = "2001",
language = "English",
volume = "70",
pages = "277--82",
journal = "Journal of Leukocyte Biology",
issn = "0741-5400",
publisher = "Federation of American Societies for Experimental Biology",
number = "2",

}

RIS

TY - JOUR

T1 - MC148 encoded by human molluscum contagiosum poxvirus is an antagonist for human but not murine CCR8

AU - Lüttichau, H R

AU - Gerstoft, J

AU - Schwartz, T W

N1 - Keywords: Amino Acid Sequence; Animals; Calcium Signaling; Cell Line; Chemokines; Chemokines, CC; Herpesvirus 8, Human; Humans; Macrophage Inflammatory Proteins; Mice; Molecular Sequence Data; Molluscum contagiosum virus; Receptors, CCR8; Receptors, Chemokine; Sequence Alignment; Species Specificity; Transfection; Viral Proteins

PY - 2001

Y1 - 2001

N2 - The viral CC chemokines MC148, encoded by the poxvirus molluscum contagiosum, and viral macrophage inflammatory protein (vMIP)-I and vMIP-II, encoded by human herpesvirus 8, were probed on the murine CC receptor (CCR) 8 in parallel with human CCR8. In calcium mobilization assays, vMIP-I acted as a high-affinity agonist, whereas vMIP-II acted as a low-affinity antagonist on the murine CCR8 as well as the human CCR8. MC148 was found to bind and block responses through the human CCR8 with high affinity, but surprisingly MC148 was unable to bind and block responses through the murine CCR8. Because MC148 is the only high-affinity antagonist known to target and be selective for CCR8, MC148 is a valuable tool to decipher the role played by CCR8 in the immune system. This study shows that MC148 could not be used in murine inflammatory models; however, it will be interesting to see whether it can be used in other animal models to delineate the role played by CCR8.

AB - The viral CC chemokines MC148, encoded by the poxvirus molluscum contagiosum, and viral macrophage inflammatory protein (vMIP)-I and vMIP-II, encoded by human herpesvirus 8, were probed on the murine CC receptor (CCR) 8 in parallel with human CCR8. In calcium mobilization assays, vMIP-I acted as a high-affinity agonist, whereas vMIP-II acted as a low-affinity antagonist on the murine CCR8 as well as the human CCR8. MC148 was found to bind and block responses through the human CCR8 with high affinity, but surprisingly MC148 was unable to bind and block responses through the murine CCR8. Because MC148 is the only high-affinity antagonist known to target and be selective for CCR8, MC148 is a valuable tool to decipher the role played by CCR8 in the immune system. This study shows that MC148 could not be used in murine inflammatory models; however, it will be interesting to see whether it can be used in other animal models to delineate the role played by CCR8.

M3 - Journal article

C2 - 11493620

VL - 70

SP - 277

EP - 282

JO - Journal of Leukocyte Biology

JF - Journal of Leukocyte Biology

SN - 0741-5400

IS - 2

ER -

ID: 174246