Microbial regulation of enteroendocrine cells

Research output: Contribution to journal › Review › Research › peer-review

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Microbial regulation of enteroendocrine cells. / Arora, Tulika; Vanslette, Amanda Marie; Hjorth, Siv Annegrethe; Backhed, Fredrik.

In: Med, Vol. 2, No. 5, 2021, p. 553-570.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Arora, T, Vanslette, AM, Hjorth, SA & Backhed, F 2021, 'Microbial regulation of enteroendocrine cells', Med, vol. 2, no. 5, pp. 553-570. https://doi.org/10.1016/j.medj.2021.03.018

APA

Arora, T., Vanslette, A. M., Hjorth, S. A., & Backhed, F. (2021). Microbial regulation of enteroendocrine cells. Med, 2(5), 553-570. https://doi.org/10.1016/j.medj.2021.03.018

Vancouver

Arora T, Vanslette AM, Hjorth SA, Backhed F. Microbial regulation of enteroendocrine cells. Med. 2021;2(5):553-570. https://doi.org/10.1016/j.medj.2021.03.018

Author

Arora, Tulika ; Vanslette, Amanda Marie ; Hjorth, Siv Annegrethe ; Backhed, Fredrik. / Microbial regulation of enteroendocrine cells. In: Med. 2021 ; Vol. 2, No. 5. pp. 553-570.

Bibtex

@article{3e62d0176f944bf49a1006e204e671eb,
title = "Microbial regulation of enteroendocrine cells",
abstract = "There has been an enormous interest to investigate impact of gut microbiota on host physiology over the past decade. To further understand its role at organismal level, it is important to delineate host-microbiota interaction at tissue and cell level. Diet, antibiotics, disease, or surgery produce shifts in composition of the gut microbiota that further alter levels of microbial-derived metabolites. Enteroendocrine cells (EEGs) are specialized hormone-producing cells in the gut epithelium that sense changes in the intestinal milieu through chemosensing G protein-coupled receptors. Accordingly, microbial metabolites interact with the EECs to stimulate or suppress hormone secretion, which act through endocrine and paracrine signaling to regulate local intestinal and diverse physiological functions and impact overall host metabolism. The remarkable success of glucagon-like peptide-1-based drugs for treatment of type 2 diabetes and obesity highlights the relevance to investigate microbial regulation of EEGs to tackle metabolic diseases through novel microbiota-based therapies.",
keywords = "GLUCAGON-LIKE PEPTIDE-1, CHAIN FATTY-ACIDS, PROTEIN-COUPLED RECEPTOR, Y GASTRIC BYPASS, VERTICAL SLEEVE GASTRECTOMY, HUMAN GUT MICROBIOME, GLUCOSE-TOLERANCE, BILE-ACIDS, INSULIN-SECRETION, GLP-1 SECRETION",
author = "Tulika Arora and Vanslette, {Amanda Marie} and Hjorth, {Siv Annegrethe} and Fredrik Backhed",
year = "2021",
doi = "10.1016/j.medj.2021.03.018",
language = "English",
volume = "2",
pages = "553--570",
journal = "Med",
issn = "2666-6359",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Microbial regulation of enteroendocrine cells

AU - Arora, Tulika

AU - Vanslette, Amanda Marie

AU - Hjorth, Siv Annegrethe

AU - Backhed, Fredrik

PY - 2021

Y1 - 2021

N2 - There has been an enormous interest to investigate impact of gut microbiota on host physiology over the past decade. To further understand its role at organismal level, it is important to delineate host-microbiota interaction at tissue and cell level. Diet, antibiotics, disease, or surgery produce shifts in composition of the gut microbiota that further alter levels of microbial-derived metabolites. Enteroendocrine cells (EEGs) are specialized hormone-producing cells in the gut epithelium that sense changes in the intestinal milieu through chemosensing G protein-coupled receptors. Accordingly, microbial metabolites interact with the EECs to stimulate or suppress hormone secretion, which act through endocrine and paracrine signaling to regulate local intestinal and diverse physiological functions and impact overall host metabolism. The remarkable success of glucagon-like peptide-1-based drugs for treatment of type 2 diabetes and obesity highlights the relevance to investigate microbial regulation of EEGs to tackle metabolic diseases through novel microbiota-based therapies.

AB - There has been an enormous interest to investigate impact of gut microbiota on host physiology over the past decade. To further understand its role at organismal level, it is important to delineate host-microbiota interaction at tissue and cell level. Diet, antibiotics, disease, or surgery produce shifts in composition of the gut microbiota that further alter levels of microbial-derived metabolites. Enteroendocrine cells (EEGs) are specialized hormone-producing cells in the gut epithelium that sense changes in the intestinal milieu through chemosensing G protein-coupled receptors. Accordingly, microbial metabolites interact with the EECs to stimulate or suppress hormone secretion, which act through endocrine and paracrine signaling to regulate local intestinal and diverse physiological functions and impact overall host metabolism. The remarkable success of glucagon-like peptide-1-based drugs for treatment of type 2 diabetes and obesity highlights the relevance to investigate microbial regulation of EEGs to tackle metabolic diseases through novel microbiota-based therapies.

KW - GLUCAGON-LIKE PEPTIDE-1

KW - CHAIN FATTY-ACIDS

KW - PROTEIN-COUPLED RECEPTOR

KW - Y GASTRIC BYPASS

KW - VERTICAL SLEEVE GASTRECTOMY

KW - HUMAN GUT MICROBIOME

KW - GLUCOSE-TOLERANCE

KW - BILE-ACIDS

KW - INSULIN-SECRETION

KW - GLP-1 SECRETION

U2 - 10.1016/j.medj.2021.03.018

DO - 10.1016/j.medj.2021.03.018

M3 - Review

VL - 2

SP - 553

EP - 570

JO - Med

JF - Med

SN - 2666-6359

IS - 5

ER -

ID: 273015469