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Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. / Paternoster, Lavinia; Standl, Marie; Waage, Johannes; Baurecht, Hansjörg; Hotze, Melanie; Strachan, David P; Curtin, John A; Bønnelykke, Klaus; Tian, Chao; Takahashi, Atsushi; Esparza-Gordillo, Jorge; Alves, Alexessander Couto; Thyssen, Jacob P; den Dekker, Herman T; Ferreira, Manuel A; Altmaier, Elisabeth; Sleiman, Patrick M A; Xiao, Feng Li; Gonzalez, Juan R; Marenholz, Ingo; Kalb, Birgit; Pino-Yanes, Maria; Xu, Cheng-Jian; Carstensen, Lisbeth; Groen-Blokhuis, Maria M; Venturini, Cristina; Pennell, Craig E; Barton, Sheila J; Levin, Albert M; Curjuric, Ivan; Bustamante, Mariona; Kreiner-Møller, Eskil; Lockett, Gabrielle A; Bacelis, Jonas; Bunyavanich, Supinda; Myers, Rachel A; Matanovic, Anja; Kumar, Ashish; Tung, Joyce Y; Hirota, Tomomitsu; Kubo, Michiaki; McArdle, Wendy L; Henderson, A John; Kemp, John P; Zheng, Jie; Smith, George Davey; Grarup, Niels; Bisgaard, Hans; Melbye, Mads; Linneberg, Allan; Australian Asthma Genetics Consortium (AAGC).
In:
Nature Genetics, Vol. 47, No. 12, 12.2015, p. 1449-56.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Paternoster, L, Standl, M, Waage, J, Baurecht, H, Hotze, M, Strachan, DP, Curtin, JA, Bønnelykke, K, Tian, C, Takahashi, A, Esparza-Gordillo, J, Alves, AC
, Thyssen, JP, den Dekker, HT, Ferreira, MA, Altmaier, E, Sleiman, PMA, Xiao, FL, Gonzalez, JR, Marenholz, I, Kalb, B, Pino-Yanes, M, Xu, C-J, Carstensen, L, Groen-Blokhuis, MM, Venturini, C, Pennell, CE, Barton, SJ, Levin, AM, Curjuric, I, Bustamante, M, Kreiner-Møller, E, Lockett, GA, Bacelis, J, Bunyavanich, S, Myers, RA, Matanovic, A, Kumar, A, Tung, JY, Hirota, T, Kubo, M, McArdle, WL, Henderson, AJ, Kemp, JP, Zheng, J, Smith, GD
, Grarup, N, Bisgaard, H, Melbye, M
, Linneberg, A & Australian Asthma Genetics Consortium (AAGC) 2015, '
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis',
Nature Genetics, vol. 47, no. 12, pp. 1449-56.
https://doi.org/10.1038/ng.3424APA
Paternoster, L., Standl, M., Waage, J., Baurecht, H., Hotze, M., Strachan, D. P., Curtin, J. A., Bønnelykke, K., Tian, C., Takahashi, A., Esparza-Gordillo, J., Alves, A. C.
, Thyssen, J. P., den Dekker, H. T., Ferreira, M. A., Altmaier, E., Sleiman, P. M. A., Xiao, F. L., Gonzalez, J. R., ... Australian Asthma Genetics Consortium (AAGC) (2015).
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
Nature Genetics,
47(12), 1449-56.
https://doi.org/10.1038/ng.3424Vancouver
Paternoster L, Standl M, Waage J, Baurecht H, Hotze M, Strachan DP et al.
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
Nature Genetics. 2015 Dec;47(12):1449-56.
https://doi.org/10.1038/ng.3424Author
Paternoster, Lavinia ; Standl, Marie ; Waage, Johannes ; Baurecht, Hansjörg ; Hotze, Melanie ; Strachan, David P ; Curtin, John A ; Bønnelykke, Klaus ; Tian, Chao ; Takahashi, Atsushi ; Esparza-Gordillo, Jorge ; Alves, Alexessander Couto ; Thyssen, Jacob P ; den Dekker, Herman T ; Ferreira, Manuel A ; Altmaier, Elisabeth ; Sleiman, Patrick M A ; Xiao, Feng Li ; Gonzalez, Juan R ; Marenholz, Ingo ; Kalb, Birgit ; Pino-Yanes, Maria ; Xu, Cheng-Jian ; Carstensen, Lisbeth ; Groen-Blokhuis, Maria M ; Venturini, Cristina ; Pennell, Craig E ; Barton, Sheila J ; Levin, Albert M ; Curjuric, Ivan ; Bustamante, Mariona ; Kreiner-Møller, Eskil ; Lockett, Gabrielle A ; Bacelis, Jonas ; Bunyavanich, Supinda ; Myers, Rachel A ; Matanovic, Anja ; Kumar, Ashish ; Tung, Joyce Y ; Hirota, Tomomitsu ; Kubo, Michiaki ; McArdle, Wendy L ; Henderson, A John ; Kemp, John P ; Zheng, Jie ; Smith, George Davey ; Grarup, Niels ; Bisgaard, Hans ; Melbye, Mads ; Linneberg, Allan ; Australian Asthma Genetics Consortium (AAGC). / Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. In: Nature Genetics. 2015 ; Vol. 47, No. 12. pp. 1449-56.
Bibtex
@article{dfcfbc59613d4dd5a84b4e2c62b27db7,
title = "Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis",
abstract = "Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.",
author = "Lavinia Paternoster and Marie Standl and Johannes Waage and Hansj{\"o}rg Baurecht and Melanie Hotze and Strachan, {David P} and Curtin, {John A} and Klaus B{\o}nnelykke and Chao Tian and Atsushi Takahashi and Jorge Esparza-Gordillo and Alves, {Alexessander Couto} and Thyssen, {Jacob P} and {den Dekker}, {Herman T} and Ferreira, {Manuel A} and Elisabeth Altmaier and Sleiman, {Patrick M A} and Xiao, {Feng Li} and Gonzalez, {Juan R} and Ingo Marenholz and Birgit Kalb and Maria Pino-Yanes and Cheng-Jian Xu and Lisbeth Carstensen and Groen-Blokhuis, {Maria M} and Cristina Venturini and Pennell, {Craig E} and Barton, {Sheila J} and Levin, {Albert M} and Ivan Curjuric and Mariona Bustamante and Eskil Kreiner-M{\o}ller and Lockett, {Gabrielle A} and Jonas Bacelis and Supinda Bunyavanich and Myers, {Rachel A} and Anja Matanovic and Ashish Kumar and Tung, {Joyce Y} and Tomomitsu Hirota and Michiaki Kubo and McArdle, {Wendy L} and Henderson, {A John} and Kemp, {John P} and Jie Zheng and Smith, {George Davey} and Niels Grarup and Hans Bisgaard and Mads Melbye and Allan Linneberg and {Australian Asthma Genetics Consortium (AAGC)}",
year = "2015",
month = dec,
doi = "10.1038/ng.3424",
language = "English",
volume = "47",
pages = "1449--56",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "12",
}
RIS
TY - JOUR
T1 - Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
AU - Paternoster, Lavinia
AU - Standl, Marie
AU - Waage, Johannes
AU - Baurecht, Hansjörg
AU - Hotze, Melanie
AU - Strachan, David P
AU - Curtin, John A
AU - Bønnelykke, Klaus
AU - Tian, Chao
AU - Takahashi, Atsushi
AU - Esparza-Gordillo, Jorge
AU - Alves, Alexessander Couto
AU - Thyssen, Jacob P
AU - den Dekker, Herman T
AU - Ferreira, Manuel A
AU - Altmaier, Elisabeth
AU - Sleiman, Patrick M A
AU - Xiao, Feng Li
AU - Gonzalez, Juan R
AU - Marenholz, Ingo
AU - Kalb, Birgit
AU - Pino-Yanes, Maria
AU - Xu, Cheng-Jian
AU - Carstensen, Lisbeth
AU - Groen-Blokhuis, Maria M
AU - Venturini, Cristina
AU - Pennell, Craig E
AU - Barton, Sheila J
AU - Levin, Albert M
AU - Curjuric, Ivan
AU - Bustamante, Mariona
AU - Kreiner-Møller, Eskil
AU - Lockett, Gabrielle A
AU - Bacelis, Jonas
AU - Bunyavanich, Supinda
AU - Myers, Rachel A
AU - Matanovic, Anja
AU - Kumar, Ashish
AU - Tung, Joyce Y
AU - Hirota, Tomomitsu
AU - Kubo, Michiaki
AU - McArdle, Wendy L
AU - Henderson, A John
AU - Kemp, John P
AU - Zheng, Jie
AU - Smith, George Davey
AU - Grarup, Niels
AU - Bisgaard, Hans
AU - Melbye, Mads
AU - Linneberg, Allan
AU - Australian Asthma Genetics Consortium (AAGC)
PY - 2015/12
Y1 - 2015/12
N2 - Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.
AB - Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.
U2 - 10.1038/ng.3424
DO - 10.1038/ng.3424
M3 - Journal article
C2 - 26482879
VL - 47
SP - 1449
EP - 1456
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 12
ER -
