Normal physical activity obliterates the deleterious effects of high-caloric intake

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Normal physical activity obliterates the deleterious effects of high-caloric intake. / Krogh-Madsen, Rikke; Pedersen, Maria; Solomon, Thomas; Knudsen, Sine Haugaard; Hansen, Louise Seier; Karstoft, Kristian; Lehrskov-Schmidt, Louise; Pedersen, Karin Kaereby; Thomsen, Carsten; Holst, Jens Juul; Pedersen, Bente K.

In: Journal of Applied Physiology, Vol. 116, No. 3, 07.11.2013, p. 231-239.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Krogh-Madsen, R, Pedersen, M, Solomon, T, Knudsen, SH, Hansen, LS, Karstoft, K, Lehrskov-Schmidt, L, Pedersen, KK, Thomsen, C, Holst, JJ & Pedersen, BK 2013, 'Normal physical activity obliterates the deleterious effects of high-caloric intake', Journal of Applied Physiology, vol. 116, no. 3, pp. 231-239. https://doi.org/10.1152/japplphysiol.00155.2013

APA

Krogh-Madsen, R., Pedersen, M., Solomon, T., Knudsen, S. H., Hansen, L. S., Karstoft, K., Lehrskov-Schmidt, L., Pedersen, K. K., Thomsen, C., Holst, J. J., & Pedersen, B. K. (2013). Normal physical activity obliterates the deleterious effects of high-caloric intake. Journal of Applied Physiology, 116(3), 231-239. https://doi.org/10.1152/japplphysiol.00155.2013

Vancouver

Krogh-Madsen R, Pedersen M, Solomon T, Knudsen SH, Hansen LS, Karstoft K et al. Normal physical activity obliterates the deleterious effects of high-caloric intake. Journal of Applied Physiology. 2013 Nov 7;116(3):231-239. https://doi.org/10.1152/japplphysiol.00155.2013

Author

Krogh-Madsen, Rikke ; Pedersen, Maria ; Solomon, Thomas ; Knudsen, Sine Haugaard ; Hansen, Louise Seier ; Karstoft, Kristian ; Lehrskov-Schmidt, Louise ; Pedersen, Karin Kaereby ; Thomsen, Carsten ; Holst, Jens Juul ; Pedersen, Bente K. / Normal physical activity obliterates the deleterious effects of high-caloric intake. In: Journal of Applied Physiology. 2013 ; Vol. 116, No. 3. pp. 231-239.

Bibtex

@article{5f64789a0d0e4011a27652b389603635,
title = "Normal physical activity obliterates the deleterious effects of high-caloric intake",
abstract = "A high-caloric intake combined with a sedentary lifestyle is an important player in the development of type 2 diabetes mellitus (T2DM). The present study was undertaken to examine if the level of physical activity has impact on the metabolic effects of a high-caloric (+2,000 kcal/day) intake. Therefore, healthy individuals on a high caloric intake were randomized to either 10,000 or 1,500 steps per day for 14 days. Step-number, total energy expenditure, dietary records, neuropsychological tests, maximal oxygen uptake (VO2max), whole body dual-energy X-ray absorptiometry (DXA)- and abdominal magnetic resonance imaging (MRI)- scans, continuous glucose monitoring (CGM), and oral glucose tolerance tests (OGTT) with stable isotopes were performed before and after the intervention. Both study groups gained the same amount of body weight. However, the inactive group accumulated significantly more visceral fat compared to the active group. Following the two-week period, the inactive group also experienced a poorer glycaemic control, increased endogenous glucose production, decreased hepatic insulin extraction, increased baseline plasma levels of total cholesterol and LDL, and a decreased cognitive function with regard to capacity of attention. In conclusion, we find evidence to support that habitual physical activity may prevent pathophysiological symptoms associated with diet-induced obesity.",
author = "Rikke Krogh-Madsen and Maria Pedersen and Thomas Solomon and Knudsen, {Sine Haugaard} and Hansen, {Louise Seier} and Kristian Karstoft and Louise Lehrskov-Schmidt and Pedersen, {Karin Kaereby} and Carsten Thomsen and Holst, {Jens Juul} and Pedersen, {Bente K}",
year = "2013",
month = nov,
day = "7",
doi = "10.1152/japplphysiol.00155.2013",
language = "English",
volume = "116",
pages = "231--239",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "3",

}

RIS

TY - JOUR

T1 - Normal physical activity obliterates the deleterious effects of high-caloric intake

AU - Krogh-Madsen, Rikke

AU - Pedersen, Maria

AU - Solomon, Thomas

AU - Knudsen, Sine Haugaard

AU - Hansen, Louise Seier

AU - Karstoft, Kristian

AU - Lehrskov-Schmidt, Louise

AU - Pedersen, Karin Kaereby

AU - Thomsen, Carsten

AU - Holst, Jens Juul

AU - Pedersen, Bente K

PY - 2013/11/7

Y1 - 2013/11/7

N2 - A high-caloric intake combined with a sedentary lifestyle is an important player in the development of type 2 diabetes mellitus (T2DM). The present study was undertaken to examine if the level of physical activity has impact on the metabolic effects of a high-caloric (+2,000 kcal/day) intake. Therefore, healthy individuals on a high caloric intake were randomized to either 10,000 or 1,500 steps per day for 14 days. Step-number, total energy expenditure, dietary records, neuropsychological tests, maximal oxygen uptake (VO2max), whole body dual-energy X-ray absorptiometry (DXA)- and abdominal magnetic resonance imaging (MRI)- scans, continuous glucose monitoring (CGM), and oral glucose tolerance tests (OGTT) with stable isotopes were performed before and after the intervention. Both study groups gained the same amount of body weight. However, the inactive group accumulated significantly more visceral fat compared to the active group. Following the two-week period, the inactive group also experienced a poorer glycaemic control, increased endogenous glucose production, decreased hepatic insulin extraction, increased baseline plasma levels of total cholesterol and LDL, and a decreased cognitive function with regard to capacity of attention. In conclusion, we find evidence to support that habitual physical activity may prevent pathophysiological symptoms associated with diet-induced obesity.

AB - A high-caloric intake combined with a sedentary lifestyle is an important player in the development of type 2 diabetes mellitus (T2DM). The present study was undertaken to examine if the level of physical activity has impact on the metabolic effects of a high-caloric (+2,000 kcal/day) intake. Therefore, healthy individuals on a high caloric intake were randomized to either 10,000 or 1,500 steps per day for 14 days. Step-number, total energy expenditure, dietary records, neuropsychological tests, maximal oxygen uptake (VO2max), whole body dual-energy X-ray absorptiometry (DXA)- and abdominal magnetic resonance imaging (MRI)- scans, continuous glucose monitoring (CGM), and oral glucose tolerance tests (OGTT) with stable isotopes were performed before and after the intervention. Both study groups gained the same amount of body weight. However, the inactive group accumulated significantly more visceral fat compared to the active group. Following the two-week period, the inactive group also experienced a poorer glycaemic control, increased endogenous glucose production, decreased hepatic insulin extraction, increased baseline plasma levels of total cholesterol and LDL, and a decreased cognitive function with regard to capacity of attention. In conclusion, we find evidence to support that habitual physical activity may prevent pathophysiological symptoms associated with diet-induced obesity.

U2 - 10.1152/japplphysiol.00155.2013

DO - 10.1152/japplphysiol.00155.2013

M3 - Journal article

C2 - 24201706

VL - 116

SP - 231

EP - 239

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 3

ER -

ID: 74154283