TY - JOUR

T1 - Plasma lipidome patterns associated with cardiovascular risk in the PREDIMED trial

T2 - A case-cohort study

AU - Razquin, Cristina

AU - Liang, Liming

AU - Toledo, Estefanía

AU - Clish, Clary B.

AU - Ruiz-Canela, Miguel

AU - Zheng, Yan

AU - Wang, Dong D.

AU - Corella, Dolores

AU - Castaner, Olga

AU - Ros, Emilio

AU - Aros, Fernando

AU - Gomez-Gracia, Enrique

AU - Fiol, Miquel

AU - Santos-Lozano, José Manuel

AU - Guasch-Ferre, Marta

AU - Serra-Majem, Lluis

AU - Sala-Vila, Aleix

AU - Buil-Cosiales, Pilar

AU - Bullo, Monica

AU - Fito, Montserrat

AU - Portoles, Olga

AU - Estruch, Ramon

AU - Salas-Salvado, Jordi

AU - Hu, Frank B.

AU - Martinez-Gonzalez, Miguel A.

N1 - Publisher Copyright: © 2017 Elsevier B.V.

PY - 2018

Y1 - 2018

N2 - Background The study of the plasma lipidome may help to better characterize molecular mechanisms underlying cardiovascular disease. The identification of new lipid biomarkers could provide future targets for prevention and innovative therapeutic approaches. In the frame of the PREDIMED trial, our aim was to examine the associations of baseline lipidome patterns or their changes with the risk of clinical CVD events. Methods We included 983 participants in our case-cohort study. The end-point was the incidence of major CVD during 4.8 years of median follow-up. We repeatedly measured 202 plasma known lipid metabolites at baseline and after 1-year of intervention. Principal component analysis was used to identify lipidome factors. Among the 15 identified factors, 7 were significantly associated with CVD. Considering common patterns among factors, lipids were grouped (summed) into scores. Results After adjustment for traditional CVD risk factors, scores of baseline polyunsaturated phosphatidylcholines (PC)/lysoPC/PC-plasmalogens and polyunsaturated cholesterol esters (CE) showed inverse associations with CVD (p = 0.036 and 0.012, respectively); whereas scores of monoacylglycerols (MAGs)/diacylglycerols (DAGs) and short triacylglycerols (TAGs) showed a direct association with CVD (p = 0.026 and 0.037, respectively). Baseline phosphatidylethanolamines (PEs) and their 1-y changes tended to be associated with higher CVD risk (p = 0.066 and 0.081, respectively). We did not find a significant effect of the intervention with the Mediterranean Diet on these scores. Conclusions Our study suggests that polyunsaturated PCs and CEs may confer protection against CVD. In contrast, MAGs, DAGs, TAGs and PEs appeared to be associated with higher CVD risk.

AB - Background The study of the plasma lipidome may help to better characterize molecular mechanisms underlying cardiovascular disease. The identification of new lipid biomarkers could provide future targets for prevention and innovative therapeutic approaches. In the frame of the PREDIMED trial, our aim was to examine the associations of baseline lipidome patterns or their changes with the risk of clinical CVD events. Methods We included 983 participants in our case-cohort study. The end-point was the incidence of major CVD during 4.8 years of median follow-up. We repeatedly measured 202 plasma known lipid metabolites at baseline and after 1-year of intervention. Principal component analysis was used to identify lipidome factors. Among the 15 identified factors, 7 were significantly associated with CVD. Considering common patterns among factors, lipids were grouped (summed) into scores. Results After adjustment for traditional CVD risk factors, scores of baseline polyunsaturated phosphatidylcholines (PC)/lysoPC/PC-plasmalogens and polyunsaturated cholesterol esters (CE) showed inverse associations with CVD (p = 0.036 and 0.012, respectively); whereas scores of monoacylglycerols (MAGs)/diacylglycerols (DAGs) and short triacylglycerols (TAGs) showed a direct association with CVD (p = 0.026 and 0.037, respectively). Baseline phosphatidylethanolamines (PEs) and their 1-y changes tended to be associated with higher CVD risk (p = 0.066 and 0.081, respectively). We did not find a significant effect of the intervention with the Mediterranean Diet on these scores. Conclusions Our study suggests that polyunsaturated PCs and CEs may confer protection against CVD. In contrast, MAGs, DAGs, TAGs and PEs appeared to be associated with higher CVD risk.

KW - Cardiovascular disease

KW - Case-cohort

KW - Lipidomics

KW - Mediterranean diet

KW - Primary prevention

U2 - 10.1016/j.ijcard.2017.10.026

DO - 10.1016/j.ijcard.2017.10.026

M3 - Journal article

C2 - 29306452

AN - SCOPUS:85039958073

VL - 253

SP - 126

EP - 132

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -