Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Plasma metabolites of a healthy lifestyle in relation to mortality and longevity : Four prospective US cohort studies. / Tessier, Anne Julie; Wang, Fenglei; Liang, Liming; Wittenbecher, Clemens; Haslam, Danielle E.; Eliassen, A. Heather; Tobias, Deirdre K.; Li, Jun; Zeleznik, Oana A.; Ascherio, Alberto; Sun, Qi; Stampfer, Meir J.; Grodstein, Francine; Rexrode, Kathryn M.; Manson, Jo Ann E.; Balasubramanian, Raji; Clish, Clary B.; Martínez-González, Miguel A.; Chavarro, Jorge E.; Hu, Frank B.; Guasch-Ferré, Marta.

In: Med, Vol. 5, No. 3, 2024, p. 224-238.e5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tessier, AJ, Wang, F, Liang, L, Wittenbecher, C, Haslam, DE, Eliassen, AH, Tobias, DK, Li, J, Zeleznik, OA, Ascherio, A, Sun, Q, Stampfer, MJ, Grodstein, F, Rexrode, KM, Manson, JAE, Balasubramanian, R, Clish, CB, Martínez-González, MA, Chavarro, JE, Hu, FB & Guasch-Ferré, M 2024, 'Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies', Med, vol. 5, no. 3, pp. 224-238.e5. https://doi.org/10.1016/j.medj.2024.01.010

APA

Tessier, A. J., Wang, F., Liang, L., Wittenbecher, C., Haslam, D. E., Eliassen, A. H., Tobias, D. K., Li, J., Zeleznik, O. A., Ascherio, A., Sun, Q., Stampfer, M. J., Grodstein, F., Rexrode, K. M., Manson, J. A. E., Balasubramanian, R., Clish, C. B., Martínez-González, M. A., Chavarro, J. E., ... Guasch-Ferré, M. (2024). Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies. Med, 5(3), 224-238.e5. https://doi.org/10.1016/j.medj.2024.01.010

Vancouver

Tessier AJ, Wang F, Liang L, Wittenbecher C, Haslam DE, Eliassen AH et al. Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies. Med. 2024;5(3):224-238.e5. https://doi.org/10.1016/j.medj.2024.01.010

Author

Tessier, Anne Julie ; Wang, Fenglei ; Liang, Liming ; Wittenbecher, Clemens ; Haslam, Danielle E. ; Eliassen, A. Heather ; Tobias, Deirdre K. ; Li, Jun ; Zeleznik, Oana A. ; Ascherio, Alberto ; Sun, Qi ; Stampfer, Meir J. ; Grodstein, Francine ; Rexrode, Kathryn M. ; Manson, Jo Ann E. ; Balasubramanian, Raji ; Clish, Clary B. ; Martínez-González, Miguel A. ; Chavarro, Jorge E. ; Hu, Frank B. ; Guasch-Ferré, Marta. / Plasma metabolites of a healthy lifestyle in relation to mortality and longevity : Four prospective US cohort studies. In: Med. 2024 ; Vol. 5, No. 3. pp. 224-238.e5.

Bibtex

@article{ebae2fda3f1e4d0d9712ac85929c0ab8,
title = "Plasma metabolites of a healthy lifestyle in relation to mortality and longevity: Four prospective US cohort studies",
abstract = "Background: A healthy lifestyle is associated with a lower premature mortality risk and with longer life expectancy. However, the metabolic pathways of a healthy lifestyle and how they relate to mortality and longevity are unclear. We aimed to identify and replicate a healthy lifestyle metabolomic signature and examine how it is related to total and cause-specific mortality risk and longevity. Methods: In four large cohorts with 13,056 individuals and 28-year follow-up, we assessed five healthy lifestyle factors, used liquid chromatography mass spectrometry to profile plasma metabolites, and ascertained deaths with death certificates. The unique healthy lifestyle metabolomic signature was identified using an elastic regression. Multivariable Cox regressions were used to assess associations of the signature with mortality and longevity. Findings: The identified healthy lifestyle metabolomic signature was reflective of lipid metabolism pathways. Shorter and more saturated triacylglycerol and diacylglycerol metabolite sets were inversely associated with the healthy lifestyle score, whereas cholesteryl ester and phosphatidylcholine plasmalogen sets were positively associated. Participants with a higher healthy lifestyle metabolomic signature had a 17% lower risk of all-cause mortality, 19% for cardiovascular disease mortality, and 17% for cancer mortality and were 25% more likely to reach longevity. The healthy lifestyle metabolomic signature explained 38% of the association between the self-reported healthy lifestyle score and total mortality risk and 49% of the association with longevity. Conclusions: This study identifies a metabolomic signature that measures adherence to a healthy lifestyle and shows prediction of total and cause-specific mortality and longevity. Funding: This work was funded by the NIH, CIHR, AHA, Novo Nordisk Foundation, and SciLifeLab.",
keywords = "alcohol, BMI, diet, lifestyle, longevity, metabolome, metabolomics, mortality, physical activity, smoking, Translation to population health",
author = "Tessier, {Anne Julie} and Fenglei Wang and Liming Liang and Clemens Wittenbecher and Haslam, {Danielle E.} and Eliassen, {A. Heather} and Tobias, {Deirdre K.} and Jun Li and Zeleznik, {Oana A.} and Alberto Ascherio and Qi Sun and Stampfer, {Meir J.} and Francine Grodstein and Rexrode, {Kathryn M.} and Manson, {Jo Ann E.} and Raji Balasubramanian and Clish, {Clary B.} and Mart{\'i}nez-Gonz{\'a}lez, {Miguel A.} and Chavarro, {Jorge E.} and Hu, {Frank B.} and Marta Guasch-Ferr{\'e}",
note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",
year = "2024",
doi = "10.1016/j.medj.2024.01.010",
language = "English",
volume = "5",
pages = "224--238.e5",
journal = "Med",
issn = "2666-6359",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Plasma metabolites of a healthy lifestyle in relation to mortality and longevity

T2 - Four prospective US cohort studies

AU - Tessier, Anne Julie

AU - Wang, Fenglei

AU - Liang, Liming

AU - Wittenbecher, Clemens

AU - Haslam, Danielle E.

AU - Eliassen, A. Heather

AU - Tobias, Deirdre K.

AU - Li, Jun

AU - Zeleznik, Oana A.

AU - Ascherio, Alberto

AU - Sun, Qi

AU - Stampfer, Meir J.

AU - Grodstein, Francine

AU - Rexrode, Kathryn M.

AU - Manson, Jo Ann E.

AU - Balasubramanian, Raji

AU - Clish, Clary B.

AU - Martínez-González, Miguel A.

AU - Chavarro, Jorge E.

AU - Hu, Frank B.

AU - Guasch-Ferré, Marta

N1 - Publisher Copyright: © 2024 The Author(s)

PY - 2024

Y1 - 2024

N2 - Background: A healthy lifestyle is associated with a lower premature mortality risk and with longer life expectancy. However, the metabolic pathways of a healthy lifestyle and how they relate to mortality and longevity are unclear. We aimed to identify and replicate a healthy lifestyle metabolomic signature and examine how it is related to total and cause-specific mortality risk and longevity. Methods: In four large cohorts with 13,056 individuals and 28-year follow-up, we assessed five healthy lifestyle factors, used liquid chromatography mass spectrometry to profile plasma metabolites, and ascertained deaths with death certificates. The unique healthy lifestyle metabolomic signature was identified using an elastic regression. Multivariable Cox regressions were used to assess associations of the signature with mortality and longevity. Findings: The identified healthy lifestyle metabolomic signature was reflective of lipid metabolism pathways. Shorter and more saturated triacylglycerol and diacylglycerol metabolite sets were inversely associated with the healthy lifestyle score, whereas cholesteryl ester and phosphatidylcholine plasmalogen sets were positively associated. Participants with a higher healthy lifestyle metabolomic signature had a 17% lower risk of all-cause mortality, 19% for cardiovascular disease mortality, and 17% for cancer mortality and were 25% more likely to reach longevity. The healthy lifestyle metabolomic signature explained 38% of the association between the self-reported healthy lifestyle score and total mortality risk and 49% of the association with longevity. Conclusions: This study identifies a metabolomic signature that measures adherence to a healthy lifestyle and shows prediction of total and cause-specific mortality and longevity. Funding: This work was funded by the NIH, CIHR, AHA, Novo Nordisk Foundation, and SciLifeLab.

AB - Background: A healthy lifestyle is associated with a lower premature mortality risk and with longer life expectancy. However, the metabolic pathways of a healthy lifestyle and how they relate to mortality and longevity are unclear. We aimed to identify and replicate a healthy lifestyle metabolomic signature and examine how it is related to total and cause-specific mortality risk and longevity. Methods: In four large cohorts with 13,056 individuals and 28-year follow-up, we assessed five healthy lifestyle factors, used liquid chromatography mass spectrometry to profile plasma metabolites, and ascertained deaths with death certificates. The unique healthy lifestyle metabolomic signature was identified using an elastic regression. Multivariable Cox regressions were used to assess associations of the signature with mortality and longevity. Findings: The identified healthy lifestyle metabolomic signature was reflective of lipid metabolism pathways. Shorter and more saturated triacylglycerol and diacylglycerol metabolite sets were inversely associated with the healthy lifestyle score, whereas cholesteryl ester and phosphatidylcholine plasmalogen sets were positively associated. Participants with a higher healthy lifestyle metabolomic signature had a 17% lower risk of all-cause mortality, 19% for cardiovascular disease mortality, and 17% for cancer mortality and were 25% more likely to reach longevity. The healthy lifestyle metabolomic signature explained 38% of the association between the self-reported healthy lifestyle score and total mortality risk and 49% of the association with longevity. Conclusions: This study identifies a metabolomic signature that measures adherence to a healthy lifestyle and shows prediction of total and cause-specific mortality and longevity. Funding: This work was funded by the NIH, CIHR, AHA, Novo Nordisk Foundation, and SciLifeLab.

KW - alcohol

KW - BMI

KW - diet

KW - lifestyle

KW - longevity

KW - metabolome

KW - metabolomics

KW - mortality

KW - physical activity

KW - smoking

KW - Translation to population health

U2 - 10.1016/j.medj.2024.01.010

DO - 10.1016/j.medj.2024.01.010

M3 - Journal article

C2 - 38366602

AN - SCOPUS:85186352652

VL - 5

SP - 224-238.e5

JO - Med

JF - Med

SN - 2666-6359

IS - 3

ER -

ID: 386383060