Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2.

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Standard

Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2. / Henriksen, Dennis B; Alexandersen, Peter; Byrjalsen, Inger; Hartmann, Bolette; Bone, Henry G; Christiansen, Claus; Holst, Jens Juul.

In: Bone, Vol. 34, No. 1, 2004, p. 140-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Henriksen, DB, Alexandersen, P, Byrjalsen, I, Hartmann, B, Bone, HG, Christiansen, C & Holst, JJ 2004, 'Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2.', Bone, vol. 34, no. 1, pp. 140-7.

APA

Henriksen, D. B., Alexandersen, P., Byrjalsen, I., Hartmann, B., Bone, H. G., Christiansen, C., & Holst, J. J. (2004). Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2. Bone, 34(1), 140-7.

Vancouver

Henriksen DB, Alexandersen P, Byrjalsen I, Hartmann B, Bone HG, Christiansen C et al. Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2. Bone. 2004;34(1):140-7.

Author

Henriksen, Dennis B ; Alexandersen, Peter ; Byrjalsen, Inger ; Hartmann, Bolette ; Bone, Henry G ; Christiansen, Claus ; Holst, Jens Juul. / Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2. In: Bone. 2004 ; Vol. 34, No. 1. pp. 140-7.

Bibtex

@article{f6528740ab5011ddb5e9000ea68e967b,
title = "Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2.",
abstract = "We have previously shown that a subcutaneous injection of glucagon-like peptide-2 (GLP-2) at 9 a.m. in fasting postmenopausal women results in a dose-dependent decrease in the serum concentration of fragments derived from the degradation of the C-terminal telopeptide region of collagen type I (s-CTX), a marker of bone resorption. In contrast, GLP-2 was found to have a neutral effect on bone formation, as assessed by serum osteocalcin. Since increased s-CTX levels are normally observed at night, we conducted bedtime studies in healthy postmenopausal women. The objective was to study the effect of GLP-2 injection on bone turnover given at bedtime. A total of 81 postmenopausal women were included in two randomised placebo-controlled studies. In conclusion, we found a dose-related reduction of s-CTX after injection of GLP-2 (P < 0.05) and osteocalcin levels was increased as compared to placebo (P = 0.07) by the treatment, suggestive of a stimulative effect on bone formation. An area under the curve (AUC0-10 h) analysis for s-CTX after GLP-2 injection confirmed the dose-related decrease as compared to placebo (P < 0.05).",
author = "Henriksen, {Dennis B} and Peter Alexandersen and Inger Byrjalsen and Bolette Hartmann and Bone, {Henry G} and Claus Christiansen and Holst, {Jens Juul}",
note = "Keywords: Bone Resorption; Collagen Type I; Dose-Response Relationship, Drug; Female; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Injections, Subcutaneous; Middle Aged; Osteocalcin; Peptides; Postmenopause",
year = "2004",
language = "English",
volume = "34",
pages = "140--7",
journal = "Bone",
issn = "8756-3282",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Reduction of nocturnal rise in bone resorption by subcutaneous GLP-2.

AU - Henriksen, Dennis B

AU - Alexandersen, Peter

AU - Byrjalsen, Inger

AU - Hartmann, Bolette

AU - Bone, Henry G

AU - Christiansen, Claus

AU - Holst, Jens Juul

N1 - Keywords: Bone Resorption; Collagen Type I; Dose-Response Relationship, Drug; Female; Glucagon-Like Peptide 2; Glucagon-Like Peptides; Humans; Injections, Subcutaneous; Middle Aged; Osteocalcin; Peptides; Postmenopause

PY - 2004

Y1 - 2004

N2 - We have previously shown that a subcutaneous injection of glucagon-like peptide-2 (GLP-2) at 9 a.m. in fasting postmenopausal women results in a dose-dependent decrease in the serum concentration of fragments derived from the degradation of the C-terminal telopeptide region of collagen type I (s-CTX), a marker of bone resorption. In contrast, GLP-2 was found to have a neutral effect on bone formation, as assessed by serum osteocalcin. Since increased s-CTX levels are normally observed at night, we conducted bedtime studies in healthy postmenopausal women. The objective was to study the effect of GLP-2 injection on bone turnover given at bedtime. A total of 81 postmenopausal women were included in two randomised placebo-controlled studies. In conclusion, we found a dose-related reduction of s-CTX after injection of GLP-2 (P < 0.05) and osteocalcin levels was increased as compared to placebo (P = 0.07) by the treatment, suggestive of a stimulative effect on bone formation. An area under the curve (AUC0-10 h) analysis for s-CTX after GLP-2 injection confirmed the dose-related decrease as compared to placebo (P < 0.05).

AB - We have previously shown that a subcutaneous injection of glucagon-like peptide-2 (GLP-2) at 9 a.m. in fasting postmenopausal women results in a dose-dependent decrease in the serum concentration of fragments derived from the degradation of the C-terminal telopeptide region of collagen type I (s-CTX), a marker of bone resorption. In contrast, GLP-2 was found to have a neutral effect on bone formation, as assessed by serum osteocalcin. Since increased s-CTX levels are normally observed at night, we conducted bedtime studies in healthy postmenopausal women. The objective was to study the effect of GLP-2 injection on bone turnover given at bedtime. A total of 81 postmenopausal women were included in two randomised placebo-controlled studies. In conclusion, we found a dose-related reduction of s-CTX after injection of GLP-2 (P < 0.05) and osteocalcin levels was increased as compared to placebo (P = 0.07) by the treatment, suggestive of a stimulative effect on bone formation. An area under the curve (AUC0-10 h) analysis for s-CTX after GLP-2 injection confirmed the dose-related decrease as compared to placebo (P < 0.05).

M3 - Journal article

C2 - 14751571

VL - 34

SP - 140

EP - 147

JO - Bone

JF - Bone

SN - 8756-3282

IS - 1

ER -

ID: 8418202