Role of sociodemographic, clinical, behavioral, and molecular factors in precision prevention of type 2 diabetes: a systematic review
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Role of sociodemographic, clinical, behavioral, and molecular factors in precision prevention of type 2 diabetes : a systematic review. / Bodhini, Dhanasekaran; Morton, Robert W; Santhakumar, Vanessa; Nakabuye, Mariam; Pomares-Millan, Hugo; Clemmensen, Christoffer; Fitzpatrick, Stephanie L; Guasch-Ferre, Marta; Pankow, James S; Ried-Larsen, Mathias; Franks, Paul W; Tobias, Deirdre K; Merino, Jordi; Mohan, Viswanathan; Loos, Ruth J F; ADA/EASD Precision Medicine in Diabetes Initiative.
medRxiv, 2023.Research output: Working paper › Preprint › Research
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TY - UNPB
T1 - Role of sociodemographic, clinical, behavioral, and molecular factors in precision prevention of type 2 diabetes
T2 - a systematic review
AU - Bodhini, Dhanasekaran
AU - Morton, Robert W
AU - Santhakumar, Vanessa
AU - Nakabuye, Mariam
AU - Pomares-Millan, Hugo
AU - Clemmensen, Christoffer
AU - Fitzpatrick, Stephanie L
AU - Guasch-Ferre, Marta
AU - Pankow, James S
AU - Ried-Larsen, Mathias
AU - Franks, Paul W
AU - Tobias, Deirdre K
AU - Merino, Jordi
AU - Mohan, Viswanathan
AU - Loos, Ruth J F
AU - ADA/EASD Precision Medicine in Diabetes Initiative
PY - 2023
Y1 - 2023
N2 - The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular characteristics modify the efficacy of dietary or lifestyle interventions to prevent T2D. Among the 80 publications that met our criteria for inclusion, the evidence was low to very low to attribute variability in intervention effectiveness to individual characteristics such as age, sex, BMI, race/ethnicity, socioeconomic status, baseline behavioral factors, or genetic predisposition. We found evidence, albeit low certainty, to support conclusions that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Our synthesis highlights the need for purposefully designed clinical trials to inform whether individual factors influence the success of T2D prevention strategies.
AB - The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular characteristics modify the efficacy of dietary or lifestyle interventions to prevent T2D. Among the 80 publications that met our criteria for inclusion, the evidence was low to very low to attribute variability in intervention effectiveness to individual characteristics such as age, sex, BMI, race/ethnicity, socioeconomic status, baseline behavioral factors, or genetic predisposition. We found evidence, albeit low certainty, to support conclusions that those with poorer health status, particularly those with prediabetes at baseline, tend to benefit more from T2D prevention strategies compared to healthier counterparts. Our synthesis highlights the need for purposefully designed clinical trials to inform whether individual factors influence the success of T2D prevention strategies.
U2 - 10.1101/2023.05.03.23289433
DO - 10.1101/2023.05.03.23289433
M3 - Preprint
C2 - 37205385
BT - Role of sociodemographic, clinical, behavioral, and molecular factors in precision prevention of type 2 diabetes
PB - medRxiv
ER -
ID: 347809952