Strenuous physical exercise adversely affects monocyte chemotaxis
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Strenuous physical exercise adversely affects monocyte chemotaxis. / Czepluch, Frauke S; Barres, Romain; Caidahl, Kenneth; Olieslagers, Servé; Krook, Anna; Rickenlund, Anette; Zierath, Juleen R; Waltenberger, Johannes.
In: Thrombosis and Haemostasis, Vol. 105, No. 1, 01.2011, p. 122-30.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Strenuous physical exercise adversely affects monocyte chemotaxis
AU - Czepluch, Frauke S
AU - Barres, Romain
AU - Caidahl, Kenneth
AU - Olieslagers, Servé
AU - Krook, Anna
AU - Rickenlund, Anette
AU - Zierath, Juleen R
AU - Waltenberger, Johannes
PY - 2011/1
Y1 - 2011/1
N2 - Physical exercise is important for proper cardiovascular function and disease prevention, but it may influence the immune system. We evaluated the effect of strenuous exercise on monocyte chemotaxis. Monocytes were isolated from blood of 13 young, healthy, sedentary individuals participating in a three-week training program which consisted of repeated exercise bouts. Monocyte chemotaxis and serological biomarkers were investigated at baseline, after three weeks training and after four weeks recovery. Chemotaxis towards vascular endothelial growth factor-A (VEGF-A) and transforming growth factor-ß1 (TGF-ß1) was completely inhibited immediately after training (p
AB - Physical exercise is important for proper cardiovascular function and disease prevention, but it may influence the immune system. We evaluated the effect of strenuous exercise on monocyte chemotaxis. Monocytes were isolated from blood of 13 young, healthy, sedentary individuals participating in a three-week training program which consisted of repeated exercise bouts. Monocyte chemotaxis and serological biomarkers were investigated at baseline, after three weeks training and after four weeks recovery. Chemotaxis towards vascular endothelial growth factor-A (VEGF-A) and transforming growth factor-ß1 (TGF-ß1) was completely inhibited immediately after training (p
KW - Adaptation, Physiological
KW - Body Mass Index
KW - Chemokine CCL2
KW - Chemotaxis, Leukocyte
KW - Exercise
KW - Humans
KW - Lipids
KW - Monocytes
KW - Nitric Oxide
KW - Observation
KW - Respiratory Function Tests
KW - Transforming Growth Factor beta1
KW - Vascular Endothelial Growth Factor A
U2 - 10.1160/TH10-06-0363
DO - 10.1160/TH10-06-0363
M3 - Journal article
C2 - 20978713
VL - 105
SP - 122
EP - 130
JO - Thrombosis et diathesis haemorrhagica
JF - Thrombosis et diathesis haemorrhagica
SN - 0340-6245
IS - 1
ER -
ID: 45577246