Metabolic Profiling Early Post-Allogeneic Haematopoietic Cell Transplantation in the Context of CMV Infection

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Metabolic Profiling Early Post-Allogeneic Haematopoietic Cell Transplantation in the Context of CMV Infection. / Rasmussen, Kirstine K.; dos Santos, Quenia; MacPherson, Cameron Ross; Zucco, Adrian G.; Gjærde, Lars Klingen; Ilett, Emma E.; Lodding, Isabelle; Helleberg, Marie; Lundgren, Jens D.; Nielsen, Susanne D.; Brix, Susanne; Sengeløv, Henrik; Murray, Daniel D.

In: Metabolites, Vol. 13, No. 9, 968, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rasmussen, KK, dos Santos, Q, MacPherson, CR, Zucco, AG, Gjærde, LK, Ilett, EE, Lodding, I, Helleberg, M, Lundgren, JD, Nielsen, SD, Brix, S, Sengeløv, H & Murray, DD 2023, 'Metabolic Profiling Early Post-Allogeneic Haematopoietic Cell Transplantation in the Context of CMV Infection', Metabolites, vol. 13, no. 9, 968. https://doi.org/10.3390/metabo13090968

APA

Rasmussen, K. K., dos Santos, Q., MacPherson, C. R., Zucco, A. G., Gjærde, L. K., Ilett, E. E., Lodding, I., Helleberg, M., Lundgren, J. D., Nielsen, S. D., Brix, S., Sengeløv, H., & Murray, D. D. (2023). Metabolic Profiling Early Post-Allogeneic Haematopoietic Cell Transplantation in the Context of CMV Infection. Metabolites, 13(9), [968]. https://doi.org/10.3390/metabo13090968

Vancouver

Rasmussen KK, dos Santos Q, MacPherson CR, Zucco AG, Gjærde LK, Ilett EE et al. Metabolic Profiling Early Post-Allogeneic Haematopoietic Cell Transplantation in the Context of CMV Infection. Metabolites. 2023;13(9). 968. https://doi.org/10.3390/metabo13090968

Author

Rasmussen, Kirstine K. ; dos Santos, Quenia ; MacPherson, Cameron Ross ; Zucco, Adrian G. ; Gjærde, Lars Klingen ; Ilett, Emma E. ; Lodding, Isabelle ; Helleberg, Marie ; Lundgren, Jens D. ; Nielsen, Susanne D. ; Brix, Susanne ; Sengeløv, Henrik ; Murray, Daniel D. / Metabolic Profiling Early Post-Allogeneic Haematopoietic Cell Transplantation in the Context of CMV Infection. In: Metabolites. 2023 ; Vol. 13, No. 9.

Bibtex

@article{aa206141408d46919509e91da5fd6187,
title = "Metabolic Profiling Early Post-Allogeneic Haematopoietic Cell Transplantation in the Context of CMV Infection",
abstract = "Immune dysfunction resulting from allogeneic haematopoietic stem cell transplantation (aHSCT) predisposes one to an elevated risk of cytomegalovirus (CMV) infection. Changes in metabolism have been associated with adverse outcomes, and in this study, we explored the associations between metabolic profiles and post-transplantation CMV infection using plasma samples collected 7–33 days after aHSCT. We included 68 aHSCT recipients from Rigshospitalet, Denmark, 50% of whom experienced CMV infection between days 34–100 post-transplantation. First, we investigated whether 12 metabolites selected based on the literature were associated with an increased risk of post-transplantation CMV infection. Second, we conducted an exploratory network-based analysis of the complete metabolic and lipidomic profiles in relation to clinical phenotypes and biological pathways. Lower levels of trimethylamine N-oxide were associated with subsequent CMV infection (multivariable logistic regression: OR = 0.63; 95% CI = [0.41; 0.87]; p = 0.01). Explorative analysis revealed 12 clusters of metabolites or lipids, among which one was predictive of CMV infection, and the others were associated with conditioning regimens, age upon aHSCT, CMV serostatus, and/or sex. Our results provide evidence for an association between the metabolome and CMV infection post-aHSCT that is independent of known risk factors.",
keywords = "aHSCT, CMV, correlation network analysis, cytomegalovirus, lipidomics, metabolomics, TMAO, WGCNA",
author = "Rasmussen, {Kirstine K.} and {dos Santos}, Quenia and MacPherson, {Cameron Ross} and Zucco, {Adrian G.} and Gj{\ae}rde, {Lars Klingen} and Ilett, {Emma E.} and Isabelle Lodding and Marie Helleberg and Lundgren, {Jens D.} and Nielsen, {Susanne D.} and Susanne Brix and Henrik Sengel{\o}v and Murray, {Daniel D.}",
note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",
year = "2023",
doi = "10.3390/metabo13090968",
language = "English",
volume = "13",
journal = "Metabolites",
issn = "2218-1989",
publisher = "M D P I AG",
number = "9",

}

RIS

TY - JOUR

T1 - Metabolic Profiling Early Post-Allogeneic Haematopoietic Cell Transplantation in the Context of CMV Infection

AU - Rasmussen, Kirstine K.

AU - dos Santos, Quenia

AU - MacPherson, Cameron Ross

AU - Zucco, Adrian G.

AU - Gjærde, Lars Klingen

AU - Ilett, Emma E.

AU - Lodding, Isabelle

AU - Helleberg, Marie

AU - Lundgren, Jens D.

AU - Nielsen, Susanne D.

AU - Brix, Susanne

AU - Sengeløv, Henrik

AU - Murray, Daniel D.

N1 - Publisher Copyright: © 2023 by the authors.

PY - 2023

Y1 - 2023

N2 - Immune dysfunction resulting from allogeneic haematopoietic stem cell transplantation (aHSCT) predisposes one to an elevated risk of cytomegalovirus (CMV) infection. Changes in metabolism have been associated with adverse outcomes, and in this study, we explored the associations between metabolic profiles and post-transplantation CMV infection using plasma samples collected 7–33 days after aHSCT. We included 68 aHSCT recipients from Rigshospitalet, Denmark, 50% of whom experienced CMV infection between days 34–100 post-transplantation. First, we investigated whether 12 metabolites selected based on the literature were associated with an increased risk of post-transplantation CMV infection. Second, we conducted an exploratory network-based analysis of the complete metabolic and lipidomic profiles in relation to clinical phenotypes and biological pathways. Lower levels of trimethylamine N-oxide were associated with subsequent CMV infection (multivariable logistic regression: OR = 0.63; 95% CI = [0.41; 0.87]; p = 0.01). Explorative analysis revealed 12 clusters of metabolites or lipids, among which one was predictive of CMV infection, and the others were associated with conditioning regimens, age upon aHSCT, CMV serostatus, and/or sex. Our results provide evidence for an association between the metabolome and CMV infection post-aHSCT that is independent of known risk factors.

AB - Immune dysfunction resulting from allogeneic haematopoietic stem cell transplantation (aHSCT) predisposes one to an elevated risk of cytomegalovirus (CMV) infection. Changes in metabolism have been associated with adverse outcomes, and in this study, we explored the associations between metabolic profiles and post-transplantation CMV infection using plasma samples collected 7–33 days after aHSCT. We included 68 aHSCT recipients from Rigshospitalet, Denmark, 50% of whom experienced CMV infection between days 34–100 post-transplantation. First, we investigated whether 12 metabolites selected based on the literature were associated with an increased risk of post-transplantation CMV infection. Second, we conducted an exploratory network-based analysis of the complete metabolic and lipidomic profiles in relation to clinical phenotypes and biological pathways. Lower levels of trimethylamine N-oxide were associated with subsequent CMV infection (multivariable logistic regression: OR = 0.63; 95% CI = [0.41; 0.87]; p = 0.01). Explorative analysis revealed 12 clusters of metabolites or lipids, among which one was predictive of CMV infection, and the others were associated with conditioning regimens, age upon aHSCT, CMV serostatus, and/or sex. Our results provide evidence for an association between the metabolome and CMV infection post-aHSCT that is independent of known risk factors.

KW - aHSCT

KW - CMV

KW - correlation network analysis

KW - cytomegalovirus

KW - lipidomics

KW - metabolomics

KW - TMAO

KW - WGCNA

U2 - 10.3390/metabo13090968

DO - 10.3390/metabo13090968

M3 - Journal article

C2 - 37755248

AN - SCOPUS:85172475835

VL - 13

JO - Metabolites

JF - Metabolites

SN - 2218-1989

IS - 9

M1 - 968

ER -

ID: 369290817