Dynamic epigenetic responses to muscle contraction
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Dynamic epigenetic responses to muscle contraction. / Rasmussen, Morten; Zierath, Juleen R; Barrès, Romain.
In: Drug Discovery Today, Vol. 19, No. 7, 19.07.2014, p. 1010-4.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Dynamic epigenetic responses to muscle contraction
AU - Rasmussen, Morten
AU - Zierath, Juleen R
AU - Barrès, Romain
PY - 2014/7/19
Y1 - 2014/7/19
N2 - Skeletal muscle is a malleable organ that responds to a single acute exercise bout by inducing the expression of genes involved in structural, metabolic and functional adaptations. Several epigenetic mechanisms including histone H4 deacetylation and loss of promoter methylation have been implicated in modifying exercise-responsive gene expression. These transient changes suggest that epigenetic mechanisms are not restricted to early stages of human development but are broad dynamic controllers of genomic plasticity in response to environmental factors.
AB - Skeletal muscle is a malleable organ that responds to a single acute exercise bout by inducing the expression of genes involved in structural, metabolic and functional adaptations. Several epigenetic mechanisms including histone H4 deacetylation and loss of promoter methylation have been implicated in modifying exercise-responsive gene expression. These transient changes suggest that epigenetic mechanisms are not restricted to early stages of human development but are broad dynamic controllers of genomic plasticity in response to environmental factors.
U2 - 10.1016/j.drudis.2014.03.003
DO - 10.1016/j.drudis.2014.03.003
M3 - Review
C2 - 24631681
VL - 19
SP - 1010
EP - 1014
JO - Drug Discovery Today: BIOSILICO
JF - Drug Discovery Today: BIOSILICO
SN - 1359-6446
IS - 7
ER -
ID: 120782007