Exercise training alters the genomic response to acute exercise in human adipose tissue

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Exercise training alters the genomic response to acute exercise in human adipose tissue. / Fabre, Odile; Ingerslev, Lars R.; Garde, Christian; Donkin, Ida; Simar, David; Barrès, Romain.

In: Epigenomics, Vol. 10, No. 8, 2018, p. 1033-1050.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fabre, O, Ingerslev, LR, Garde, C, Donkin, I, Simar, D & Barrès, R 2018, 'Exercise training alters the genomic response to acute exercise in human adipose tissue', Epigenomics, vol. 10, no. 8, pp. 1033-1050. https://doi.org/10.2217/epi-2018-0039

APA

Fabre, O., Ingerslev, L. R., Garde, C., Donkin, I., Simar, D., & Barrès, R. (2018). Exercise training alters the genomic response to acute exercise in human adipose tissue. Epigenomics, 10(8), 1033-1050. https://doi.org/10.2217/epi-2018-0039

Vancouver

Fabre O, Ingerslev LR, Garde C, Donkin I, Simar D, Barrès R. Exercise training alters the genomic response to acute exercise in human adipose tissue. Epigenomics. 2018;10(8):1033-1050. https://doi.org/10.2217/epi-2018-0039

Author

Fabre, Odile ; Ingerslev, Lars R. ; Garde, Christian ; Donkin, Ida ; Simar, David ; Barrès, Romain. / Exercise training alters the genomic response to acute exercise in human adipose tissue. In: Epigenomics. 2018 ; Vol. 10, No. 8. pp. 1033-1050.

Bibtex

@article{517765c5c9e34396b469e4213f2ba354,
title = "Exercise training alters the genomic response to acute exercise in human adipose tissue",
abstract = "AIM: To determine the genomic mechanisms by which adipose tissue responds to acute and chronic exercise.METHODS: We profiled the transcriptomic and epigenetic response to acute exercise in human adipose tissue collected before and after endurance training.RESULTS: Although acute exercises were performed at same relative intensities, the magnitude of transcriptomic changes after acute exercise was reduced by endurance training. DNA methylation remodeling induced by acute exercise was more prominent in trained versus untrained state. We found an overlap between gene expression and DNA methylation changes after acute exercise for 32 genes pre-training and six post-training, notably at adipocyte-specific genes.CONCLUSION: Training status differentially affects the epigenetic and transcriptomic response to acute exercise in human adipose tissue.",
keywords = "adipose tissue, DNA methylation, epigenetics, exercise, human, mRNA, transcriptomic",
author = "Odile Fabre and Ingerslev, {Lars R.} and Christian Garde and Ida Donkin and David Simar and Romain Barr{\`e}s",
year = "2018",
doi = "10.2217/epi-2018-0039",
language = "English",
volume = "10",
pages = "1033--1050",
journal = "Epigenomics",
issn = "1750-1911",
publisher = "Future Medicine Ltd.",
number = "8",

}

RIS

TY - JOUR

T1 - Exercise training alters the genomic response to acute exercise in human adipose tissue

AU - Fabre, Odile

AU - Ingerslev, Lars R.

AU - Garde, Christian

AU - Donkin, Ida

AU - Simar, David

AU - Barrès, Romain

PY - 2018

Y1 - 2018

N2 - AIM: To determine the genomic mechanisms by which adipose tissue responds to acute and chronic exercise.METHODS: We profiled the transcriptomic and epigenetic response to acute exercise in human adipose tissue collected before and after endurance training.RESULTS: Although acute exercises were performed at same relative intensities, the magnitude of transcriptomic changes after acute exercise was reduced by endurance training. DNA methylation remodeling induced by acute exercise was more prominent in trained versus untrained state. We found an overlap between gene expression and DNA methylation changes after acute exercise for 32 genes pre-training and six post-training, notably at adipocyte-specific genes.CONCLUSION: Training status differentially affects the epigenetic and transcriptomic response to acute exercise in human adipose tissue.

AB - AIM: To determine the genomic mechanisms by which adipose tissue responds to acute and chronic exercise.METHODS: We profiled the transcriptomic and epigenetic response to acute exercise in human adipose tissue collected before and after endurance training.RESULTS: Although acute exercises were performed at same relative intensities, the magnitude of transcriptomic changes after acute exercise was reduced by endurance training. DNA methylation remodeling induced by acute exercise was more prominent in trained versus untrained state. We found an overlap between gene expression and DNA methylation changes after acute exercise for 32 genes pre-training and six post-training, notably at adipocyte-specific genes.CONCLUSION: Training status differentially affects the epigenetic and transcriptomic response to acute exercise in human adipose tissue.

KW - adipose tissue

KW - DNA methylation

KW - epigenetics

KW - exercise

KW - human

KW - mRNA

KW - transcriptomic

U2 - 10.2217/epi-2018-0039

DO - 10.2217/epi-2018-0039

M3 - Journal article

C2 - 29671347

VL - 10

SP - 1033

EP - 1050

JO - Epigenomics

JF - Epigenomics

SN - 1750-1911

IS - 8

ER -

ID: 201301671