The Emerging Role of Epigenetics in Inflammation and Immunometabolism

Research output: Contribution to journal › Review › Research › peer-review

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The Emerging Role of Epigenetics in Inflammation and Immunometabolism. / Raghuraman, Sukanya; Donkin, Ida; Versteyhe, Soetkin; Barrès, Romain; Simar, David.

In: Trends in Endocrinology and Metabolism, Vol. 27, No. 11, 18.07.2016, p. 782-795.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Raghuraman, S, Donkin, I, Versteyhe, S, Barrès, R & Simar, D 2016, 'The Emerging Role of Epigenetics in Inflammation and Immunometabolism', Trends in Endocrinology and Metabolism, vol. 27, no. 11, pp. 782-795. https://doi.org/10.1016/j.tem.2016.06.008

APA

Raghuraman, S., Donkin, I., Versteyhe, S., Barrès, R., & Simar, D. (2016). The Emerging Role of Epigenetics in Inflammation and Immunometabolism. Trends in Endocrinology and Metabolism, 27(11), 782-795. https://doi.org/10.1016/j.tem.2016.06.008

Vancouver

Raghuraman S, Donkin I, Versteyhe S, Barrès R, Simar D. The Emerging Role of Epigenetics in Inflammation and Immunometabolism. Trends in Endocrinology and Metabolism. 2016 Jul 18;27(11):782-795. https://doi.org/10.1016/j.tem.2016.06.008

Author

Raghuraman, Sukanya ; Donkin, Ida ; Versteyhe, Soetkin ; Barrès, Romain ; Simar, David. / The Emerging Role of Epigenetics in Inflammation and Immunometabolism. In: Trends in Endocrinology and Metabolism. 2016 ; Vol. 27, No. 11. pp. 782-795.

Bibtex

@article{cbb4d37d381240f18046097fad15d420,
title = "The Emerging Role of Epigenetics in Inflammation and Immunometabolism",
abstract = "Recent research developments have shed light on the risk factors contributing to metabolic complications, implicating both genetic and environmental factors, potentially integrated by epigenetic mechanisms. Distinct epigenetic changes in immune cells are frequently observed in obesity and type 2 diabetes mellitus, and these are associated with alterations in the phenotype, function, and trafficking patterns of these cells. The first step in the development of effective therapeutic strategies is the identification of distinct epigenetic signatures associated with metabolic disorders. In this review we provide an overview of the epigenetic mechanisms influencing immune cell phenotype and function, summarize current knowledge about epigenetic changes affecting immune functions in the context of metabolic diseases, and discuss the therapeutic options currently available to counteract epigenetically driven metabolic complications.",
author = "Sukanya Raghuraman and Ida Donkin and Soetkin Versteyhe and Romain Barr{\`e}s and David Simar",
note = "Copyright {\textcopyright} 2016 Elsevier Ltd. All rights reserved.",
year = "2016",
month = jul,
day = "18",
doi = "10.1016/j.tem.2016.06.008",
language = "English",
volume = "27",
pages = "782--795",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Ltd. * Trends Journals",
number = "11",

}

RIS

TY - JOUR

T1 - The Emerging Role of Epigenetics in Inflammation and Immunometabolism

AU - Raghuraman, Sukanya

AU - Donkin, Ida

AU - Versteyhe, Soetkin

AU - Barrès, Romain

AU - Simar, David

N1 - Copyright © 2016 Elsevier Ltd. All rights reserved.

PY - 2016/7/18

Y1 - 2016/7/18

N2 - Recent research developments have shed light on the risk factors contributing to metabolic complications, implicating both genetic and environmental factors, potentially integrated by epigenetic mechanisms. Distinct epigenetic changes in immune cells are frequently observed in obesity and type 2 diabetes mellitus, and these are associated with alterations in the phenotype, function, and trafficking patterns of these cells. The first step in the development of effective therapeutic strategies is the identification of distinct epigenetic signatures associated with metabolic disorders. In this review we provide an overview of the epigenetic mechanisms influencing immune cell phenotype and function, summarize current knowledge about epigenetic changes affecting immune functions in the context of metabolic diseases, and discuss the therapeutic options currently available to counteract epigenetically driven metabolic complications.

AB - Recent research developments have shed light on the risk factors contributing to metabolic complications, implicating both genetic and environmental factors, potentially integrated by epigenetic mechanisms. Distinct epigenetic changes in immune cells are frequently observed in obesity and type 2 diabetes mellitus, and these are associated with alterations in the phenotype, function, and trafficking patterns of these cells. The first step in the development of effective therapeutic strategies is the identification of distinct epigenetic signatures associated with metabolic disorders. In this review we provide an overview of the epigenetic mechanisms influencing immune cell phenotype and function, summarize current knowledge about epigenetic changes affecting immune functions in the context of metabolic diseases, and discuss the therapeutic options currently available to counteract epigenetically driven metabolic complications.

U2 - 10.1016/j.tem.2016.06.008

DO - 10.1016/j.tem.2016.06.008

M3 - Review

C2 - 27444065

VL - 27

SP - 782

EP - 795

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 11

ER -

ID: 166679666