A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. / Brandt, Julia P; Aziz-Zaman, Sonya; Juozaityte, Vaida; Martinez-Velazquez, Luis A; Petersen, Jakob Gramstrup; Pocock, Roger David John; Ringstad, Niels.

In: PLOS ONE, Vol. 7, No. 3, 2012, p. e34014.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Brandt, JP, Aziz-Zaman, S, Juozaityte, V, Martinez-Velazquez, LA, Petersen, JG, Pocock, RDJ & Ringstad, N 2012, 'A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity', PLOS ONE, vol. 7, no. 3, pp. e34014. https://doi.org/10.1371/journal.pone.0034014

APA

Brandt, J. P., Aziz-Zaman, S., Juozaityte, V., Martinez-Velazquez, L. A., Petersen, J. G., Pocock, R. D. J., & Ringstad, N. (2012). A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. PLOS ONE, 7(3), e34014. https://doi.org/10.1371/journal.pone.0034014

Vancouver

Brandt JP, Aziz-Zaman S, Juozaityte V, Martinez-Velazquez LA, Petersen JG, Pocock RDJ et al. A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. PLOS ONE. 2012;7(3):e34014. https://doi.org/10.1371/journal.pone.0034014

Author

Brandt, Julia P ; Aziz-Zaman, Sonya ; Juozaityte, Vaida ; Martinez-Velazquez, Luis A ; Petersen, Jakob Gramstrup ; Pocock, Roger David John ; Ringstad, Niels. / A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity. In: PLOS ONE. 2012 ; Vol. 7, No. 3. pp. e34014.

Bibtex

@article{749d707d9170463b99567aa0db6b26a9,
title = "A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity",
abstract = "Many animals possess neurons specialized for the detection of carbon dioxide (CO(2)), which acts as a cue to elicit behavioral responses and is also an internally generated product of respiration that regulates animal physiology. In many organisms how such neurons detect CO(2) is poorly understood. We report here a mechanism that endows C. elegans neurons with the ability to detect CO(2). The ETS-5 transcription factor is necessary for the specification of CO(2)-sensing BAG neurons. Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO(2)-detection and transforms neurons into CO(2)-sensing neurons. Because ETS-5 and GCY-9 are members of gene families that are conserved between nematodes and vertebrates, a similar mechanism might act in the specification of CO(2)-sensing neurons in other phyla.",
keywords = "Alleles, Animals, Behavior, Animal, Binding Sites, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Carbon Dioxide, Gene Deletion, Gene Expression Regulation, Guanylate Cyclase, Microscopy, Fluorescence, Mutation, Neurons, Plasmids, Proto-Oncogene Proteins c-ets, Receptors, Guanylate Cyclase-Coupled, Sensory Receptor Cells",
author = "Brandt, {Julia P} and Sonya Aziz-Zaman and Vaida Juozaityte and Martinez-Velazquez, {Luis A} and Petersen, {Jakob Gramstrup} and Pocock, {Roger David John} and Niels Ringstad",
year = "2012",
doi = "10.1371/journal.pone.0034014",
language = "English",
volume = "7",
pages = "e34014",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - A single gene target of an ETS-family transcription factor determines neuronal CO2-chemosensitivity

AU - Brandt, Julia P

AU - Aziz-Zaman, Sonya

AU - Juozaityte, Vaida

AU - Martinez-Velazquez, Luis A

AU - Petersen, Jakob Gramstrup

AU - Pocock, Roger David John

AU - Ringstad, Niels

PY - 2012

Y1 - 2012

N2 - Many animals possess neurons specialized for the detection of carbon dioxide (CO(2)), which acts as a cue to elicit behavioral responses and is also an internally generated product of respiration that regulates animal physiology. In many organisms how such neurons detect CO(2) is poorly understood. We report here a mechanism that endows C. elegans neurons with the ability to detect CO(2). The ETS-5 transcription factor is necessary for the specification of CO(2)-sensing BAG neurons. Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO(2)-detection and transforms neurons into CO(2)-sensing neurons. Because ETS-5 and GCY-9 are members of gene families that are conserved between nematodes and vertebrates, a similar mechanism might act in the specification of CO(2)-sensing neurons in other phyla.

AB - Many animals possess neurons specialized for the detection of carbon dioxide (CO(2)), which acts as a cue to elicit behavioral responses and is also an internally generated product of respiration that regulates animal physiology. In many organisms how such neurons detect CO(2) is poorly understood. We report here a mechanism that endows C. elegans neurons with the ability to detect CO(2). The ETS-5 transcription factor is necessary for the specification of CO(2)-sensing BAG neurons. Expression of a single ETS-5 target gene, gcy-9, which encodes a receptor-type guanylate cyclase, is sufficient to bypass a requirement for ets-5 in CO(2)-detection and transforms neurons into CO(2)-sensing neurons. Because ETS-5 and GCY-9 are members of gene families that are conserved between nematodes and vertebrates, a similar mechanism might act in the specification of CO(2)-sensing neurons in other phyla.

KW - Alleles

KW - Animals

KW - Behavior, Animal

KW - Binding Sites

KW - Caenorhabditis elegans

KW - Caenorhabditis elegans Proteins

KW - Carbon Dioxide

KW - Gene Deletion

KW - Gene Expression Regulation

KW - Guanylate Cyclase

KW - Microscopy, Fluorescence

KW - Mutation

KW - Neurons

KW - Plasmids

KW - Proto-Oncogene Proteins c-ets

KW - Receptors, Guanylate Cyclase-Coupled

KW - Sensory Receptor Cells

U2 - 10.1371/journal.pone.0034014

DO - 10.1371/journal.pone.0034014

M3 - Journal article

C2 - 22479504

VL - 7

SP - e34014

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 3

ER -

ID: 105451355