SOCS-1 deficiency does not prevent diet-induced insulin resistance
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
SOCS-1 deficiency does not prevent diet-induced insulin resistance. / Emanuelli, Brice; Macotela, Yazmin; Boucher, Jérémie; Ronald Kahn, C.
In: Biochemical and Biophysical Research Communications, Vol. 377, No. 2, 12.12.2008, p. 447-52.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - SOCS-1 deficiency does not prevent diet-induced insulin resistance
AU - Emanuelli, Brice
AU - Macotela, Yazmin
AU - Boucher, Jérémie
AU - Ronald Kahn, C
PY - 2008/12/12
Y1 - 2008/12/12
N2 - Obesity is associated with inflammation and increased expression of suppressor of cytokine signaling (SOCS) proteins, which inhibit cytokine and insulin signaling. Thus, reducing SOCS expression could prevent the development of obesity-induced insulin resistance. Using SOCS-1 knockout mice, we investigated the contribution of SOCS-1 in the development of insulin resistance induced by a high-fat diet (HFD). SOCS-1 knockout mice on HFD gained 70% more weight, displayed a 2.3-fold increase in epididymal fat pads mass and increased hepatic lipid content. This was accompanied by increased mRNA expression of leptin and the macrophage marker CD68 in white adipose tissue and of SREBP1c and FAS in liver. HFD also induced hyperglycemia in SOCS-1 deficient mice with impairment of glucose and insulin tolerance tests. Thus, despite the role of SOCS proteins in obesity-related insulin resistance, SOCS-1 deficiency alone is not able to prevent insulin resistance induced by a diet rich in fat.
AB - Obesity is associated with inflammation and increased expression of suppressor of cytokine signaling (SOCS) proteins, which inhibit cytokine and insulin signaling. Thus, reducing SOCS expression could prevent the development of obesity-induced insulin resistance. Using SOCS-1 knockout mice, we investigated the contribution of SOCS-1 in the development of insulin resistance induced by a high-fat diet (HFD). SOCS-1 knockout mice on HFD gained 70% more weight, displayed a 2.3-fold increase in epididymal fat pads mass and increased hepatic lipid content. This was accompanied by increased mRNA expression of leptin and the macrophage marker CD68 in white adipose tissue and of SREBP1c and FAS in liver. HFD also induced hyperglycemia in SOCS-1 deficient mice with impairment of glucose and insulin tolerance tests. Thus, despite the role of SOCS proteins in obesity-related insulin resistance, SOCS-1 deficiency alone is not able to prevent insulin resistance induced by a diet rich in fat.
KW - Animals
KW - DNA-Binding Proteins
KW - Diet
KW - Dietary Fats
KW - Fatty Liver
KW - Gene Expression
KW - Insulin Resistance
KW - Mice
KW - Mice, Knockout
KW - Obesity
KW - Suppressor of Cytokine Signaling Proteins
U2 - 10.1016/j.bbrc.2008.09.158
DO - 10.1016/j.bbrc.2008.09.158
M3 - Journal article
C2 - 18929539
VL - 377
SP - 447
EP - 452
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -
ID: 143328590