Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial
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Changes in arginine are inversely associated with type 2 diabetes : A case-cohort study in the PREDIMED trial. / Yu, Edward; Ruiz-Canela, Miguel; Razquin, Cristina; Guasch-Ferré, Marta; Toledo, Estefania; Wang, Dong D.; Papandreou, Christopher; Dennis, Courtney; Clish, Clary; Liang, Liming; Bullo, Monica; Corella, Dolores; Fitó, Montserrat; Gutiérrez-Bedmar, Mario; Lapetra, José; Estruch, Ramón; Ros, Emilio; Cofán, Montserrat; Arós, Fernando; Romaguera, Dora; Serra-Majem, Lluis; Sorlí, Jose V.; Salas-Salvadó, Jordi; Hu, Frank B.; Martínez-González, Miguel A.
In: Diabetes, Obesity and Metabolism, Vol. 21, No. 2, 2019, p. 397-401.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Changes in arginine are inversely associated with type 2 diabetes
T2 - A case-cohort study in the PREDIMED trial
AU - Yu, Edward
AU - Ruiz-Canela, Miguel
AU - Razquin, Cristina
AU - Guasch-Ferré, Marta
AU - Toledo, Estefania
AU - Wang, Dong D.
AU - Papandreou, Christopher
AU - Dennis, Courtney
AU - Clish, Clary
AU - Liang, Liming
AU - Bullo, Monica
AU - Corella, Dolores
AU - Fitó, Montserrat
AU - Gutiérrez-Bedmar, Mario
AU - Lapetra, José
AU - Estruch, Ramón
AU - Ros, Emilio
AU - Cofán, Montserrat
AU - Arós, Fernando
AU - Romaguera, Dora
AU - Serra-Majem, Lluis
AU - Sorlí, Jose V.
AU - Salas-Salvadó, Jordi
AU - Hu, Frank B.
AU - Martínez-González, Miguel A.
N1 - Publisher Copyright: © 2018 John Wiley & Sons Ltd
PY - 2019
Y1 - 2019
N2 - The associations between arginine-based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case-cohort design, nested within the PREDIMED trial, to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA] and N-monomethyl-l-arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. The 1-year changes in arginine (adjusted hazard ratio [HR] per SD 0.68, 95% confidence interval [CI] 0.49, 0.95; Q4 vs. Q1 0.46, 95% CI 0.21, 1.04; P trend = 0.02) and arginine/ADMA ratio (adjusted HR per SD 0.73, 95% CI 0.51, 1.04; Q4 vs. Q1 0.52, 95% CI 0.22, 1.25; P trend = 0.04) were associated with a lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1-year changes in homeostatic model assessment of insulin resistance. Individuals in the low-fat-diet group had a higher risk of T2D for 1-year changes in NMMA than individuals in Mediterranean-diet groups (P interaction = 0.02). We conclude that arginine bioavailability is important in T2D pathophysiology.
AB - The associations between arginine-based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case-cohort design, nested within the PREDIMED trial, to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA] and N-monomethyl-l-arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. The 1-year changes in arginine (adjusted hazard ratio [HR] per SD 0.68, 95% confidence interval [CI] 0.49, 0.95; Q4 vs. Q1 0.46, 95% CI 0.21, 1.04; P trend = 0.02) and arginine/ADMA ratio (adjusted HR per SD 0.73, 95% CI 0.51, 1.04; Q4 vs. Q1 0.52, 95% CI 0.22, 1.25; P trend = 0.04) were associated with a lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1-year changes in homeostatic model assessment of insulin resistance. Individuals in the low-fat-diet group had a higher risk of T2D for 1-year changes in NMMA than individuals in Mediterranean-diet groups (P interaction = 0.02). We conclude that arginine bioavailability is important in T2D pathophysiology.
KW - cohort study
KW - dietary intervention
KW - insulin resistance
KW - observational study
KW - population study, type 2 diabetes
U2 - 10.1111/dom.13514
DO - 10.1111/dom.13514
M3 - Journal article
C2 - 30146690
AN - SCOPUS:85054304430
VL - 21
SP - 397
EP - 401
JO - Diabetes, Obesity and Metabolism
JF - Diabetes, Obesity and Metabolism
SN - 1462-8902
IS - 2
ER -
ID: 358090574