Changes in arginine are inversely associated with type 2 diabetes: A case-cohort study in the PREDIMED trial
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The associations between arginine-based metabolites and incident type 2 diabetes (T2D) are unknown. We employed a case-cohort design, nested within the PREDIMED trial, to examine six plasma metabolites (arginine, citrulline, ornithine, asymmetric dimethylarginine [ADMA], symmetric dimethylarginine [SDMA] and N-monomethyl-l-arginine [NMMA]) among 892 individuals (251 cases) for associations with incident T2D and insulin resistance. Weighted Cox models with robust variance were used. The 1-year changes in arginine (adjusted hazard ratio [HR] per SD 0.68, 95% confidence interval [CI] 0.49, 0.95; Q4 vs. Q1 0.46, 95% CI 0.21, 1.04; P trend = 0.02) and arginine/ADMA ratio (adjusted HR per SD 0.73, 95% CI 0.51, 1.04; Q4 vs. Q1 0.52, 95% CI 0.22, 1.25; P trend = 0.04) were associated with a lower risk of T2D. Positive changes of citrulline and ornithine, and negative changes in SDMA and arginine/(ornithine + citrulline) were associated with concurrent 1-year changes in homeostatic model assessment of insulin resistance. Individuals in the low-fat-diet group had a higher risk of T2D for 1-year changes in NMMA than individuals in Mediterranean-diet groups (P interaction = 0.02). We conclude that arginine bioavailability is important in T2D pathophysiology.
Original language | English |
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Journal | Diabetes, Obesity and Metabolism |
Volume | 21 |
Issue number | 2 |
Pages (from-to) | 397-401 |
Number of pages | 5 |
ISSN | 1462-8902 |
DOIs | |
Publication status | Published - 2019 |
Externally published | Yes |
Bibliographical note
Publisher Copyright:
© 2018 John Wiley & Sons Ltd
- cohort study, dietary intervention, insulin resistance, observational study, population study, type 2 diabetes
Research areas
ID: 358090574