Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: A randomized controlled trial

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk : A randomized controlled trial. / Hernáez, Álvaro; Lassale, Camille; Castro-Barquero, Sara; Ros, Emilio; Tresserra-Rimbau, Anna; Castañer, Olga; Pintó, Xavier; Vázquez-Ruiz, Zenaida; Sorlí, José V.; Salas-Salvadó, Jordi; Lapetra, José; Gómez-Gracia, Enrique; Alonso-Gómez, Ángel M.; Fiol, Miquel; Serra-Majem, Lluis; Sacanella, Emilio; Razquin, Cristina; Corella, Dolores; Guasch-Ferré, Marta; Cofán, Montserrat; Estruch, Ramón.

In: Nutrients, Vol. 13, No. 2, 559, 2021, p. 1-13.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hernáez, Á, Lassale, C, Castro-Barquero, S, Ros, E, Tresserra-Rimbau, A, Castañer, O, Pintó, X, Vázquez-Ruiz, Z, Sorlí, JV, Salas-Salvadó, J, Lapetra, J, Gómez-Gracia, E, Alonso-Gómez, ÁM, Fiol, M, Serra-Majem, L, Sacanella, E, Razquin, C, Corella, D, Guasch-Ferré, M, Cofán, M & Estruch, R 2021, 'Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: A randomized controlled trial', Nutrients, vol. 13, no. 2, 559, pp. 1-13. https://doi.org/10.3390/nu13020559

APA

Hernáez, Á., Lassale, C., Castro-Barquero, S., Ros, E., Tresserra-Rimbau, A., Castañer, O., Pintó, X., Vázquez-Ruiz, Z., Sorlí, J. V., Salas-Salvadó, J., Lapetra, J., Gómez-Gracia, E., Alonso-Gómez, Á. M., Fiol, M., Serra-Majem, L., Sacanella, E., Razquin, C., Corella, D., Guasch-Ferré, M., ... Estruch, R. (2021). Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: A randomized controlled trial. Nutrients, 13(2), 1-13. [559]. https://doi.org/10.3390/nu13020559

Vancouver

Hernáez Á, Lassale C, Castro-Barquero S, Ros E, Tresserra-Rimbau A, Castañer O et al. Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: A randomized controlled trial. Nutrients. 2021;13(2):1-13. 559. https://doi.org/10.3390/nu13020559

Author

Hernáez, Álvaro ; Lassale, Camille ; Castro-Barquero, Sara ; Ros, Emilio ; Tresserra-Rimbau, Anna ; Castañer, Olga ; Pintó, Xavier ; Vázquez-Ruiz, Zenaida ; Sorlí, José V. ; Salas-Salvadó, Jordi ; Lapetra, José ; Gómez-Gracia, Enrique ; Alonso-Gómez, Ángel M. ; Fiol, Miquel ; Serra-Majem, Lluis ; Sacanella, Emilio ; Razquin, Cristina ; Corella, Dolores ; Guasch-Ferré, Marta ; Cofán, Montserrat ; Estruch, Ramón. / Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk : A randomized controlled trial. In: Nutrients. 2021 ; Vol. 13, No. 2. pp. 1-13.

Bibtex

@article{8ce32075451e4eadaf7b29c5d2f6ba21,
title = "Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk: A randomized controlled trial",
abstract = "There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvenci{\'o}n con DIeta MEDiterr{\'a}nea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.",
keywords = "Mediterranean diet, Platelet count, Prevention, Randomized controlled trial, Thrombocytopenia",
author = "{\'A}lvaro Hern{\'a}ez and Camille Lassale and Sara Castro-Barquero and Emilio Ros and Anna Tresserra-Rimbau and Olga Casta{\~n}er and Xavier Pint{\'o} and Zenaida V{\'a}zquez-Ruiz and Sorl{\'i}, {Jos{\'e} V.} and Jordi Salas-Salvad{\'o} and Jos{\'e} Lapetra and Enrique G{\'o}mez-Gracia and Alonso-G{\'o}mez, {{\'A}ngel M.} and Miquel Fiol and Lluis Serra-Majem and Emilio Sacanella and Cristina Razquin and Dolores Corella and Marta Guasch-Ferr{\'e} and Montserrat Cof{\'a}n and Ram{\'o}n Estruch",
note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
doi = "10.3390/nu13020559",
language = "English",
volume = "13",
pages = "1--13",
journal = "Nutrients",
issn = "2072-6643",
publisher = "M D P I AG",
number = "2",

}

RIS

TY - JOUR

T1 - Mediterranean diet maintained platelet count within a healthy range and decreased thrombocytopenia-related mortality risk

T2 - A randomized controlled trial

AU - Hernáez, Álvaro

AU - Lassale, Camille

AU - Castro-Barquero, Sara

AU - Ros, Emilio

AU - Tresserra-Rimbau, Anna

AU - Castañer, Olga

AU - Pintó, Xavier

AU - Vázquez-Ruiz, Zenaida

AU - Sorlí, José V.

AU - Salas-Salvadó, Jordi

AU - Lapetra, José

AU - Gómez-Gracia, Enrique

AU - Alonso-Gómez, Ángel M.

AU - Fiol, Miquel

AU - Serra-Majem, Lluis

AU - Sacanella, Emilio

AU - Razquin, Cristina

AU - Corella, Dolores

AU - Guasch-Ferré, Marta

AU - Cofán, Montserrat

AU - Estruch, Ramón

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021

Y1 - 2021

N2 - There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.

AB - There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: −3.20·109 units/L·year [−5.81; −0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.

KW - Mediterranean diet

KW - Platelet count

KW - Prevention

KW - Randomized controlled trial

KW - Thrombocytopenia

U2 - 10.3390/nu13020559

DO - 10.3390/nu13020559

M3 - Journal article

C2 - 33567733

AN - SCOPUS:85100548480

VL - 13

SP - 1

EP - 13

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 2

M1 - 559

ER -

ID: 357885024