Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism. / Papandreou, Christopher; Li, Jun; Liang, Liming; Bulló, Mònica; Zheng, Yan; Ruiz-Canela, Miguel; Yu, Edward; Guasch-Ferré, Marta; Razquin, Cristina; Clish, Clary; Corella, Dolores; Estruch, Ramon; Ros, Emilio; Fitó, Montserrat; Arós, Fernando; Serra-Majem, Lluís; Rosique, Nuria; Martínez-González, Miguel A.; Hu, Frank B.; Salas-Salvadó, Jordi.

In: Scientific Reports, Vol. 9, No. 1, 2892, 2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Papandreou, C, Li, J, Liang, L, Bulló, M, Zheng, Y, Ruiz-Canela, M, Yu, E, Guasch-Ferré, M, Razquin, C, Clish, C, Corella, D, Estruch, R, Ros, E, Fitó, M, Arós, F, Serra-Majem, L, Rosique, N, Martínez-González, MA, Hu, FB & Salas-Salvadó, J 2019, 'Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism', Scientific Reports, vol. 9, no. 1, 2892. https://doi.org/10.1038/s41598-019-39441-6

APA

Papandreou, C., Li, J., Liang, L., Bulló, M., Zheng, Y., Ruiz-Canela, M., Yu, E., Guasch-Ferré, M., Razquin, C., Clish, C., Corella, D., Estruch, R., Ros, E., Fitó, M., Arós, F., Serra-Majem, L., Rosique, N., Martínez-González, M. A., Hu, F. B., & Salas-Salvadó, J. (2019). Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism. Scientific Reports, 9(1), [2892]. https://doi.org/10.1038/s41598-019-39441-6

Vancouver

Papandreou C, Li J, Liang L, Bulló M, Zheng Y, Ruiz-Canela M et al. Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism. Scientific Reports. 2019;9(1). 2892. https://doi.org/10.1038/s41598-019-39441-6

Author

Papandreou, Christopher ; Li, Jun ; Liang, Liming ; Bulló, Mònica ; Zheng, Yan ; Ruiz-Canela, Miguel ; Yu, Edward ; Guasch-Ferré, Marta ; Razquin, Cristina ; Clish, Clary ; Corella, Dolores ; Estruch, Ramon ; Ros, Emilio ; Fitó, Montserrat ; Arós, Fernando ; Serra-Majem, Lluís ; Rosique, Nuria ; Martínez-González, Miguel A. ; Hu, Frank B. ; Salas-Salvadó, Jordi. / Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism. In: Scientific Reports. 2019 ; Vol. 9, No. 1.

Bibtex

@article{4b35340af43d495aa917281979b799c8,
title = "Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism",
abstract = "Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated.",
author = "Christopher Papandreou and Jun Li and Liming Liang and M{\`o}nica Bull{\'o} and Yan Zheng and Miguel Ruiz-Canela and Edward Yu and Marta Guasch-Ferr{\'e} and Cristina Razquin and Clary Clish and Dolores Corella and Ramon Estruch and Emilio Ros and Montserrat Fit{\'o} and Fernando Ar{\'o}s and Llu{\'i}s Serra-Majem and Nuria Rosique and Mart{\'i}nez-Gonz{\'a}lez, {Miguel A.} and Hu, {Frank B.} and Jordi Salas-Salvad{\'o}",
note = "Publisher Copyright: {\textcopyright} 2019, The Author(s).",
year = "2019",
doi = "10.1038/s41598-019-39441-6",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism

AU - Papandreou, Christopher

AU - Li, Jun

AU - Liang, Liming

AU - Bulló, Mònica

AU - Zheng, Yan

AU - Ruiz-Canela, Miguel

AU - Yu, Edward

AU - Guasch-Ferré, Marta

AU - Razquin, Cristina

AU - Clish, Clary

AU - Corella, Dolores

AU - Estruch, Ramon

AU - Ros, Emilio

AU - Fitó, Montserrat

AU - Arós, Fernando

AU - Serra-Majem, Lluís

AU - Rosique, Nuria

AU - Martínez-González, Miguel A.

AU - Hu, Frank B.

AU - Salas-Salvadó, Jordi

N1 - Publisher Copyright: © 2019, The Author(s).

PY - 2019

Y1 - 2019

N2 - Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated.

AB - Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated.

U2 - 10.1038/s41598-019-39441-6

DO - 10.1038/s41598-019-39441-6

M3 - Journal article

C2 - 30814579

AN - SCOPUS:85062293680

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 2892

ER -

ID: 357996423