Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease

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Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease. / Guasch-Ferré, Marta; Hernández-Alonso, Pablo; Drouin-Chartier, Jean-Philippe; Ruiz-Canela, Miguel; Razquin, Cristina; Toledo, Estefanía; Li, Jun; Dennis, Courtney; Wittenbecher, Clemens; Corella, Dolores; Estruch, Ramon; Fitó, Montserrat; Ros, Emilio; Babio, Nancy; Bhupathiraju, Shilpa N; Clish, Clary B; Liang, Liming; Martínez-González, Miguel A; Hu, Frank B; Salas-Salvadó, Jordi.

In: The Journal of Nutrition, Vol. 151, No. 2, 2021, p. 303-311.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Guasch-Ferré, M, Hernández-Alonso, P, Drouin-Chartier, J-P, Ruiz-Canela, M, Razquin, C, Toledo, E, Li, J, Dennis, C, Wittenbecher, C, Corella, D, Estruch, R, Fitó, M, Ros, E, Babio, N, Bhupathiraju, SN, Clish, CB, Liang, L, Martínez-González, MA, Hu, FB & Salas-Salvadó, J 2021, 'Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease', The Journal of Nutrition, vol. 151, no. 2, pp. 303-311. https://doi.org/10.1093/jn/nxaa374

APA

Guasch-Ferré, M., Hernández-Alonso, P., Drouin-Chartier, J-P., Ruiz-Canela, M., Razquin, C., Toledo, E., Li, J., Dennis, C., Wittenbecher, C., Corella, D., Estruch, R., Fitó, M., Ros, E., Babio, N., Bhupathiraju, S. N., Clish, C. B., Liang, L., Martínez-González, M. A., Hu, F. B., & Salas-Salvadó, J. (2021). Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease. The Journal of Nutrition, 151(2), 303-311. https://doi.org/10.1093/jn/nxaa374

Vancouver

Guasch-Ferré M, Hernández-Alonso P, Drouin-Chartier J-P, Ruiz-Canela M, Razquin C, Toledo E et al. Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease. The Journal of Nutrition. 2021;151(2):303-311. https://doi.org/10.1093/jn/nxaa374

Author

Guasch-Ferré, Marta ; Hernández-Alonso, Pablo ; Drouin-Chartier, Jean-Philippe ; Ruiz-Canela, Miguel ; Razquin, Cristina ; Toledo, Estefanía ; Li, Jun ; Dennis, Courtney ; Wittenbecher, Clemens ; Corella, Dolores ; Estruch, Ramon ; Fitó, Montserrat ; Ros, Emilio ; Babio, Nancy ; Bhupathiraju, Shilpa N ; Clish, Clary B ; Liang, Liming ; Martínez-González, Miguel A ; Hu, Frank B ; Salas-Salvadó, Jordi. / Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease. In: The Journal of Nutrition. 2021 ; Vol. 151, No. 2. pp. 303-311.

Bibtex

@article{d9a4fbca595c40b08e8da992cbfae091,
title = "Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease",
abstract = "BackgroundWalnut consumption is associated with lower risk of type 2 diabetes (T2D) and cardiovascular disease (CVD). However, it is unknown whether plasma metabolites related to walnut consumption are also associated with lower risk of cardiometabolic diseases.ObjectivesThe study aimed to identify plasma metabolites associated with walnut consumption and evaluate the prospective associations between the identified profile and risk of T2D and CVD.MethodsThe discovery population included 1833 participants at high cardiovascular risk from the PREvenci{\'o}n con DIeta MEDiterr{\'a}nea (PREDIMED) study with available metabolomics data at baseline. The study population included 57% women (baseline mean BMI (in kg/m2): 29.9; mean age: 67 y). A total of 1522 participants also had available metabolomics data at year 1 and were used as the internal validation population. Plasma metabolomics analyses were performed using LC-MS. Cross-sectional associations between 385 known metabolites and walnut consumption were assessed using elastic net continuous regression analysis. A 10-cross-validation (CV) procedure was used, and Pearson correlation coefficients were assessed between metabolite weighted models and self-reported walnut consumption in each pair of training–validation data sets within the discovery population. We further estimated the prospective associations between the identified metabolite profile and incident T2D and CVD using multivariable Cox regression models.ResultsA total of 19 metabolites were significantly associated with walnut consumption, including lipids, purines, acylcarnitines, and amino acids. Ten-CV Pearson correlation coefficients between self-reported walnut consumption and the plasma metabolite profile were 0.16 (95% CI: 0.11, 0.20) in the discovery population and 0.15 (95% CI: 0.10, 0.20) in the validation population. The metabolite profile was inversely associated with T2D incidence (HR per 1 SD: 0.83; 95% CI: 0.71, 0.97; P = 0.02). For CVD incidence, the HR per 1-SD was 0.71 (95% CI: 0.60, 0.85; P < 0.001).ConclusionsA metabolite profile including 19 metabolites was associated with walnut consumption and with a lower risk of incident T2D and CVD in a Mediterranean population at high cardiovascular risk.",
author = "Marta Guasch-Ferr{\'e} and Pablo Hern{\'a}ndez-Alonso and Jean-Philippe Drouin-Chartier and Miguel Ruiz-Canela and Cristina Razquin and Estefan{\'i}a Toledo and Jun Li and Courtney Dennis and Clemens Wittenbecher and Dolores Corella and Ramon Estruch and Montserrat Fit{\'o} and Emilio Ros and Nancy Babio and Bhupathiraju, {Shilpa N} and Clish, {Clary B} and Liming Liang and Mart{\'i}nez-Gonz{\'a}lez, {Miguel A} and Hu, {Frank B} and Jordi Salas-Salvad{\'o}",
year = "2021",
doi = "10.1093/jn/nxaa374",
language = "English",
volume = "151",
pages = "303--311",
journal = "Journal of Nutrition",
issn = "0022-3166",
publisher = "American Society for Nutrition",
number = "2",

}

RIS

TY - JOUR

T1 - Walnut Consumption, Plasma Metabolomics, and Risk of Type 2 Diabetes and Cardiovascular Disease

AU - Guasch-Ferré, Marta

AU - Hernández-Alonso, Pablo

AU - Drouin-Chartier, Jean-Philippe

AU - Ruiz-Canela, Miguel

AU - Razquin, Cristina

AU - Toledo, Estefanía

AU - Li, Jun

AU - Dennis, Courtney

AU - Wittenbecher, Clemens

AU - Corella, Dolores

AU - Estruch, Ramon

AU - Fitó, Montserrat

AU - Ros, Emilio

AU - Babio, Nancy

AU - Bhupathiraju, Shilpa N

AU - Clish, Clary B

AU - Liang, Liming

AU - Martínez-González, Miguel A

AU - Hu, Frank B

AU - Salas-Salvadó, Jordi

PY - 2021

Y1 - 2021

N2 - BackgroundWalnut consumption is associated with lower risk of type 2 diabetes (T2D) and cardiovascular disease (CVD). However, it is unknown whether plasma metabolites related to walnut consumption are also associated with lower risk of cardiometabolic diseases.ObjectivesThe study aimed to identify plasma metabolites associated with walnut consumption and evaluate the prospective associations between the identified profile and risk of T2D and CVD.MethodsThe discovery population included 1833 participants at high cardiovascular risk from the PREvención con DIeta MEDiterránea (PREDIMED) study with available metabolomics data at baseline. The study population included 57% women (baseline mean BMI (in kg/m2): 29.9; mean age: 67 y). A total of 1522 participants also had available metabolomics data at year 1 and were used as the internal validation population. Plasma metabolomics analyses were performed using LC-MS. Cross-sectional associations between 385 known metabolites and walnut consumption were assessed using elastic net continuous regression analysis. A 10-cross-validation (CV) procedure was used, and Pearson correlation coefficients were assessed between metabolite weighted models and self-reported walnut consumption in each pair of training–validation data sets within the discovery population. We further estimated the prospective associations between the identified metabolite profile and incident T2D and CVD using multivariable Cox regression models.ResultsA total of 19 metabolites were significantly associated with walnut consumption, including lipids, purines, acylcarnitines, and amino acids. Ten-CV Pearson correlation coefficients between self-reported walnut consumption and the plasma metabolite profile were 0.16 (95% CI: 0.11, 0.20) in the discovery population and 0.15 (95% CI: 0.10, 0.20) in the validation population. The metabolite profile was inversely associated with T2D incidence (HR per 1 SD: 0.83; 95% CI: 0.71, 0.97; P = 0.02). For CVD incidence, the HR per 1-SD was 0.71 (95% CI: 0.60, 0.85; P < 0.001).ConclusionsA metabolite profile including 19 metabolites was associated with walnut consumption and with a lower risk of incident T2D and CVD in a Mediterranean population at high cardiovascular risk.

AB - BackgroundWalnut consumption is associated with lower risk of type 2 diabetes (T2D) and cardiovascular disease (CVD). However, it is unknown whether plasma metabolites related to walnut consumption are also associated with lower risk of cardiometabolic diseases.ObjectivesThe study aimed to identify plasma metabolites associated with walnut consumption and evaluate the prospective associations between the identified profile and risk of T2D and CVD.MethodsThe discovery population included 1833 participants at high cardiovascular risk from the PREvención con DIeta MEDiterránea (PREDIMED) study with available metabolomics data at baseline. The study population included 57% women (baseline mean BMI (in kg/m2): 29.9; mean age: 67 y). A total of 1522 participants also had available metabolomics data at year 1 and were used as the internal validation population. Plasma metabolomics analyses were performed using LC-MS. Cross-sectional associations between 385 known metabolites and walnut consumption were assessed using elastic net continuous regression analysis. A 10-cross-validation (CV) procedure was used, and Pearson correlation coefficients were assessed between metabolite weighted models and self-reported walnut consumption in each pair of training–validation data sets within the discovery population. We further estimated the prospective associations between the identified metabolite profile and incident T2D and CVD using multivariable Cox regression models.ResultsA total of 19 metabolites were significantly associated with walnut consumption, including lipids, purines, acylcarnitines, and amino acids. Ten-CV Pearson correlation coefficients between self-reported walnut consumption and the plasma metabolite profile were 0.16 (95% CI: 0.11, 0.20) in the discovery population and 0.15 (95% CI: 0.10, 0.20) in the validation population. The metabolite profile was inversely associated with T2D incidence (HR per 1 SD: 0.83; 95% CI: 0.71, 0.97; P = 0.02). For CVD incidence, the HR per 1-SD was 0.71 (95% CI: 0.60, 0.85; P < 0.001).ConclusionsA metabolite profile including 19 metabolites was associated with walnut consumption and with a lower risk of incident T2D and CVD in a Mediterranean population at high cardiovascular risk.

U2 - 10.1093/jn/nxaa374

DO - 10.1093/jn/nxaa374

M3 - Journal article

VL - 151

SP - 303

EP - 311

JO - Journal of Nutrition

JF - Journal of Nutrition

SN - 0022-3166

IS - 2

ER -

ID: 347786681